Protective effect of Andrographis paniculata and andrographolide on cyclophosphamide-induced urothelial toxicity.

Abstract:

:The protective effect of Andrograhis paniculata and andrographolide (ANDLE) against cyclophosphamide (CTX)-induced urothelial toxicity was investigated in this study. Pretreatment of Swiss albino mice with A paniculata extract (10 mg/dose/animal intraperitoneally [ip]) and ANDLE (500 microg/dose/animal ip) could significantly reduce CTX (1.5 nmol/kg body weight)-induced urothelial toxicity. Morphological and histopathological analysis of urinary bladder of CTX-treated mice showed severe inflammation and dark coloration, whereas A paniculata and ANDLE-treated mice showed almost normal bladder morphology. Elevation of urinary protein level (7.33 +/- 0.3 g/L) by CTX administration was reduced by A paniculata (3.78 +/- 0.4 g/L) and ANDLE treatment (4.19 +/- 0.1 g/L). Urinary urea N2 level, which was elevated after 48 hours of CTX administration (24.25 +/- 0.2 g/L) was found to be reduced by the treatment with A paniculata (14.19 +/- 0.5 g/L) and ANDLE (15.79 +/- 0.4 g/L). A decreased level of reduced glutahione (GSH) content in liver (2.81 +/- 0.1 nmol/mg protein) and bladder (1.20 +/- 0.2 nmol/mg protein) after CTX administration was also increased by the treatment with A paniculata (liver: 5.78 +/- 0.3 nmol/mg protein; bladder: 2.96 +/- 0.2 nmol/mg protein) and ANDLE (liver: 5.14 +/- 0.3 nmol/mg protein; bladder: 2.84 +/- 0.2 nmol/mg protein). Production of the proinflammatory cytokine, tumor necrosis factor-alpha, which was elevated during CTX administration, was found to be inhibited by A paniculata and ANDLE treatment. The lowered level of interleukin-2 and interferon-gamma during CTX treatment was elevated by the administration of A paniculata and ANDLE.

journal_name

Integr Cancer Ther

authors

Sheeja K,Kuttan G

doi

10.1177/1534735406291984

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

244-51

issue

3

eissn

1534-7354

issn

1552-695X

pii

5/3/244

journal_volume

5

pub_type

杂志文章
  • Antimetastatic effects of Celastrus orbiculatus on human gastric adenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-κB/snail signaling pathway.

    abstract:AIM OF THE STUDY:Celastrus orbiculatus has been used as a folk medicine in China for the treatment of many diseases. In the laboratory, the ethyl acetate extract of Celastrus orbiculatus (COE) displays a wide range of anticancer functions. However, the inhibition of the metastasis mechanism of COE in gastric cancer cel...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735415572880

    authors: Zhu Y,Liu Y,Qian Y,Dai X,Yang L,Chen J,Guo S,Hisamitsu T

    更新日期:2015-05-01 00:00:00

  • Eupatorin Suppressed Tumor Progression and Enhanced Immunity in a 4T1 Murine Breast Cancer Model.

    abstract::Eupatorin is a polymethoxy flavone extracted from Orthosiphon stamineus and was reported to exhibit cytotoxic effects on several cancer cell lines. However, its effect as an anti-breast cancer agent in vivo has yet to be determined. This study aims to elucidate the potential of eupatorin as an anti-breast cancer agent...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735420935625

    authors: Abd Razak N,Yeap SK,Alitheen NB,Ho WY,Yong CY,Tan SW,Tan WS,Long K

    更新日期:2020-01-01 00:00:00

  • Immunotherapy of Cancer: Developments and Reference Points, an Unorthodox Approach.

    abstract::Oncology is currently a sector of medical science with accelerated progress due to rapid technological development, the advancement in molecular biology, and the invention of many innovative therapies. Immunotherapy partially accounts for this advance, since it is increasingly playing an important role in the treatmen...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735419827090

    authors: Nikolaou M,Nikolaou G,Digklia A,Pontas C,Tsoukalas N,Kyrgias G,Tolia M

    更新日期:2019-01-01 00:00:00

  • Development of an Individualized Yoga Intervention to Address Fatigue in Hospitalized Children Undergoing Intensive Chemotherapy.

    abstract::Purpose Fatigue is an important problem in children receiving intensive chemotherapy and hematopoietic stem cell transplantation (HSCT). Exercise may be an effective intervention for fatigue. Individualized yoga represents an ideal intervention because it can be tailored according to an individual child's needs. Littl...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735416630806

    authors: Diorio C,Celis Ekstrand A,Hesser T,O'Sullivan C,Lee M,Schechter T,Sung L

    更新日期:2016-09-01 00:00:00

  • Taiwanofungus camphoratus (Syn Antrodia camphorata) extract and amphotericin B exert adjuvant effects via mitochondrial apoptotic pathway.

    abstract::The use of multiple drugs in cancer therapy increases the efficacy of the potential therapeutic effects. In this study, the authors investigated the adjuvant effects of an ethanol extract of solid-state cultivated Taiwanofungus camphoratus (TCEE) and amphotericin B (AmB) in the human cancer cell lines RPMI7951 and MG6...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735412442379

    authors: Chen LY,Sheu MT,Liao CK,Tsai FC,Kao WY,Su CH

    更新日期:2013-03-01 00:00:00

  • The effect of EEG biofeedback on reducing postcancer cognitive impairment.

    abstract:UNLABELLED:BACKGROUND AND HYPOTHESES: Postcancer cognitive impairment (PCCI) is observed in a substantial number of breast cancer survivors, persisting for as long as 20 years in some subgroups. Although compensatory strategies are frequently suggested, no restorative interventions have yet been identified. This study ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735413477192

    authors: Alvarez J,Meyer FL,Granoff DL,Lundy A

    更新日期:2013-11-01 00:00:00

  • An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients.

    abstract:BACKGROUND:Conventional anticancer therapies still cause difficulties with selective eradication and accompanying side effects that reduce patients' quality of life (QOL). Fucoidan is extracted from seaweeds and has already exhibited broad bioactivities, including anticancer and anti-inflammatory properties, in basic s...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735417692097

    authors: Takahashi H,Kawaguchi M,Kitamura K,Narumiya S,Kawamura M,Tengan I,Nishimoto S,Hanamure Y,Majima Y,Tsubura S,Teruya K,Shirahata S

    更新日期:2018-06-01 00:00:00

  • Total alkaloids of Rubus alceifolius Poir shows anti-angiogenic activity in vivo and in vitro.

    abstract::Total alkaloids is an active ingredient of the natural plant Rubus alceifolius Poir, commonly used for the treatment of various cancers. Antitumor effects may be mediated through anti-angiogenic mechanisms. As such, the goal of the present study was to investigate and evaluate the effect of total alkaloids in Rubus al...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735414547109

    authors: Zhao J,Lin W,Zhuang Q,Zhong X,Cao Z,Hong Z,Peng J

    更新日期:2014-11-01 00:00:00

  • Patient responses to Cytoluminescent Therapy for cancer: an investigative report of early experiences and adverse effects of an unconventional form of photodynamic therapy.

    abstract::Cytoluminescent Therapy (CLT) is an unconventional form of photodynamic therapy (PDT), utilizing a second-generation chlorophyll-derived photosensitizing agent and whole-body illumination. Starting in late 2002, CLT was administered in Ireland to 48 patients. Illumination with lasers and light-emitting diodes followed...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735403259325

    authors: Moss RW

    更新日期:2003-12-01 00:00:00

  • Integrative medicine consultation service in a comprehensive cancer center: findings and outcomes.

    abstract:OBJECTIVES:This study portrays the characteristics of patients who attended an integrative oncology clinic at a large comprehensive cancer center and evaluated whether this service addressed patients' concerns about complementary and integrative medicine (CIM). METHODS:Patient information was collected prior to an int...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735410378663

    authors: Frenkel M,Cohen L,Peterson N,Palmer JL,Swint K,Bruera E

    更新日期:2010-09-01 00:00:00

  • Physical Activity as a Nonpharmacological Symptom Management Approach in Myeloproliferative Neoplasms: Recommendations for Future Research.

    abstract:PURPOSE:Essential thrombocythemia, polycythemia vera, and myelofibrosis are rare chronic hematological malignancies known as myeloproliferative neoplasms (MPNs) and are characterized by deregulated myeloid lineage cell production, splenomegaly, and heterogeneous symptom profiles. MPN patients suffer from a significant ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735416661417

    authors: Eckert R,Huberty J,Gowin K,Mesa R,Marks L

    更新日期:2017-12-01 00:00:00

  • Integrated Cancer Treatment in the Course of Metastatic Pancreatic Cancer: Complete Resolution in 2 Cases.

    abstract::Pancreatic cancer (PC) has a very low average survival, but its prognosis is further reduced in the case of metastatic spread. Medical therapy in these cases is the only applicable methodology in the international guidelines. During anticancer treatments, common side effects are nausea, vomiting, arthralgia, neuropath...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735418755479

    authors: Bonucci M,Pastore C,Ferrera V,Fiorentini C,Fabbri A

    更新日期:2018-09-01 00:00:00

  • Sport Medicine in the Prevention and Management of Cancer.

    abstract::Physical inactivity is a major concern in cancer patients despite the established preventative and therapeutic effects of regular physical exercise for this patient group. Sport not only plays an important role in supporting the development and maintenance of a physically active lifestyle but also is increasingly used...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735419894063

    authors: Luo H,Galvão DA,Newton RU,Fairman CM,Taaffe DR

    更新日期:2019-01-01 00:00:00

  • Conventional Western Treatment Associated With Chinese Herbal Medicine Ameliorates the Incidence of Head and Neck Cancer Among Patients With Esophageal Cancer.

    abstract:BACKGROUND:Because of advances in medical treatment, the survival of cancer patients is prolonged. In line with the prolonged survival time of cancer the incidence of second primary cancer has increased. There is currently no effective way to prevent the occurrence of secondary primary cancer (SPC). OBJECTIVES:The aim...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735419834353

    authors: Chang CC,Bi KW,Lin HJ,Su YC,Wang WL,Lin CY,Ting CF,Sun MF,Huang ST

    更新日期:2019-01-01 00:00:00

  • A Proposed Revision of the International Classification of Diseases, 11th Revision, Chapter 26.

    abstract::In 2019, the World Health Assembly approved the International Classification of Diseases, 11th Revision (ICD-11), which included a traditional medicine chapter. This means that traditional medicine (TM) is incorporated into the mainstream medicine of the world. For TM to contribute to human health, the role of ICD-11,...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735420908334

    authors: Choi SH

    更新日期:2020-01-01 00:00:00

  • Attachment and cancer: a conceptual integration.

    abstract::Cancer traditionally has been explained by the biomedical model; however, it is limited in comprehensively accounting for all factors in this disease. Recently, it has been suggested that a broader theoretical framework that includes psychosocial components in cancer is needed to complement the traditional approach. T...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735402238188

    authors: Tacón AM

    更新日期:2002-12-01 00:00:00

  • A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results.

    abstract::Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammati...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735419846400

    authors: Pasanisi P,Gariboldi M,Verderio P,Signoroni S,Mancini A,Rivoltini L,Milione M,Masci E,Ciniselli CM,Bruno E,Macciotta A,Belfiore A,Ricci MT,Gargano G,Morelli D,Apolone G,Vitellaro M

    更新日期:2019-01-01 00:00:00

  • Traditional herbal medicine as adjunctive therapy for nasopharyngeal cancer: a systematic review and meta-analysis.

    abstract::The effectiveness of traditional herbal medicine (THM) as treatment for nasopharyngeal cancer (NPC) has not been clearly demonstrated. The aim of this study is to assess the effectiveness of THM as adjunctive therapies for NPC using the results of randomized controlled trials (RCTs). Five electronic databases, includi...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,meta分析,评审

    doi:10.1177/1534735415572881

    authors: Kim W,Lee WB,Lee J,Min BI,Lee H,Cho SH

    更新日期:2015-05-01 00:00:00

  • A comparative review of thermography as a breast cancer screening technique.

    abstract::Breast cancer is the most frequently diagnosed cancer of women in North America. Despite advances in treatment that have reduced mortality, breast cancer remains the second leading cause of cancer induced death. Several well established tools are used to screen for breast cancer including clinical breast exams, mammog...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735408326171

    authors: Kennedy DA,Lee T,Seely D

    更新日期:2009-03-01 00:00:00

  • A Randomized Controlled Study to Observe the Efficacy of External Treatment With a Traditional Chinese Medicine Herbal Ointment on Malignant Plural Effusion: Outcome Report and Design Review.

    abstract:BACKGROUND:Malignant pleural effusion (MPE) is a common complication in most malignancies. Despite its frequent occurrence, current knowledge of MPE remains limited and the effect of the management is still unsatisfying. Traditional Chinese medicine (TCM) external treatment has unique advantages, such as quicker effica...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/1534735416660193

    authors: Feize W,Meng L,Yanni L,Yuan L,Liqun J,Tong L,Guowang Y,Huijuan C,Donggui W,Zhiqiang C,Lei Z

    更新日期:2017-12-01 00:00:00

  • Hesperidin inhibits cyclophosphamide-induced tumor growth delay in mice.

    abstract::Hesperidin is a natural compound that has chemoprotective effects in tumor cell lines and protective effects against hematotoxicity induced by cyclophosphamide. The aim of this study was to evaluate the effect of hesperidin on the antitumor effect of cyclophosphamide in tumor-bearing mice. Administration of hesperidin...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735412448959

    authors: Hosseinimehr SJ,Jalayer Z,Naghshvar F,Mahmoudzadeh A

    更新日期:2012-09-01 00:00:00

  • Physical Activity Behavior After a Diagnosis of Lung Cancer Differs Between Countries: An Observational Cohort Study.

    abstract:INTRODUCTION:Physical activity (PA) is important in lung cancer. OBJECTIVES:To investigate PA levels and health-related quality of life (HRQoL) of patients with lung cancer in China and compare this to a similar cohort in Australia. METHODS:Prospective cohort study. 71 patients from China (group CH) and 90 patients f...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735417699513

    authors: Ni J,Denehy L,Feng J,Xu L,Wu Y,Granger CL

    更新日期:2018-06-01 00:00:00

  • Bursera copallifera Extracts Have Cytotoxic and Migration-Inhibitory Effects in Breast Cancer Cell Lines.

    abstract::Plants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Bursera genus include li...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735418766416

    authors: Domínguez F,Maycotte P,Acosta-Casique A,Rodríguez-Rodríguez S,Moreno DA,Ferreres F,Flores-Alonso JC,Delgado-López MG,Pérez-Santos M,Anaya-Ruiz M

    更新日期:2018-09-01 00:00:00

  • Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity.

    abstract::Acute doxorubicin (DOX) cardiotoxicity can be attenuated by exercise preconditioning, but little is known of whether this cardioprotection continues beyond 10 days post-DOX administration. The purpose of this study was to determine the effects of exercise preconditioning on early chronic DOX-induced cardiotoxicity. Ma...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735410392577

    authors: Hydock DS,Lien CY,Jensen BT,Schneider CM,Hayward R

    更新日期:2011-03-01 00:00:00

  • Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway.

    abstract::This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non-small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of A549 cells. In addition, glabridin also decreased ...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735410384860

    authors: Tsai YM,Yang CJ,Hsu YL,Wu LY,Tsai YC,Hung JY,Lien CT,Huang MS,Kuo PL

    更新日期:2011-12-01 00:00:00

  • A Polyphenol-Rich Extract From Muscadine Grapes Inhibits Triple-Negative Breast Tumor Growth.

    abstract::Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that tends to affect young women and has a high propensity to metastasize. No targeted treatments are available for this type of breast cancer due to a lack of estrogen or progesterone receptors or overexpression of human epidermal growth f...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735420917444

    authors: Collard M,Gallagher PE,Tallant EA

    更新日期:2020-01-01 00:00:00

  • Proposal for an integrated evaluation model for the study of whole systems health care in cancer.

    abstract::For more than 200 years, biomedicine has approached the treatment of disease by studying disease processes (patho-genesis), inferring causal connections and developing specific approaches for therapeutically interfering with those processes. This pathogenic approach has been highly successful in acute and traumatic di...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735406295565

    authors: Jonas WB,Beckner W,Coulter I

    更新日期:2006-12-01 00:00:00

  • Detoxifying cancer causing agents to prevent cancer.

    abstract::Different vitamins and other micronutrients in vegetables, fruits, and other natural plant products may prevent cancer development (carcinogenesis) by interfering with detrimental actions of mutagens, carcinogens, and tumor promoters. The goal of current studies in cancer prevention is to determine the mechanisms of s...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章,评审

    doi:10.1177/1534735403002002005

    authors: Hanausek M,Walaszek Z,Slaga TJ

    更新日期:2003-06-01 00:00:00

  • Per2 is a C/EBP target gene implicated in myeloid leukemia.

    abstract::Circadian rhythms are endogenous biological clocks that govern fundamental physiological and behavioral functions. Consequently, perturbations of these rhythms have been associated with pathogenic conditions, such as depression, diabetes, and cancer. CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcripti...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735409352084

    authors: Gery S,Koeffler HP

    更新日期:2009-12-01 00:00:00

  • Vitamin E (α-Tocopherol) Exhibits Antitumour Activity on Oral Squamous Carcinoma Cells ORL-48.

    abstract::Cancers involving the oral cavity, head, and neck regions are often treated with cisplatin. In cancer therapy, the main target is to eliminate unwanted cancerous cells. However, reports on the nonselective nature of this drug have raised few concerns. Incorrect nutritional habits and lifestyle practices have been dire...

    journal_title:Integrative cancer therapies

    pub_type: 杂志文章

    doi:10.1177/1534735416675950

    authors: Zulkapli R,Abdul Razak F,Zain RB

    更新日期:2017-09-01 00:00:00