Abstract：
BACKGROUND:Although studies have reported an association between air pollutants and increased allergic airway diseases, such as allergic rhinitis and nasal polyposis, the underlying mechanisms are not fully understood. A limited number of studies have suggested that diesel exhaust particles (DEP) play a role in atopy and the pathogenesis of allergic upper airway diseases. The aim of this study was to investigate the effect of DEP on inflammatory cytokine release, and mRNA expression of transcription factors such as JNK and NF-β in primary nasal epithelial cells (NECs), in vitro. METHODS:NECs from non-atopic, non-rhinitic subjects (controls) and patients with allergic rhinitis and nasal polyps were cultured and incubated with 0-100μg/ml DEP for 24h. ELISA and RT-PCR were used to assess the release of IL-8, GM-CSF, and RANTES, and mRNA expression for JNK and NF-κB, respectively. RESULTS:Compared to control cells, NECs from subjects with atopic polyps released significantly greater amounts of IL-8 (median=887 vs. 176.6pg/μg cellular protein; p<0.0001) and RANTES (median=0.191 vs. 0.02pg/μg cellular protein; p<0.001). While 50μg/ml DEP induced release of RANTES in NECs from patients with allergic rhinitis, 100μg/ml DEP decreased IL-8 levels in NECs from both control and allergic rhinitic subjects. DEP did not affect mRNA expression for JNK and NF-κB from NECs of subjects with polyps. CONCLUSIONS:NECs from subjects with various pathologies may respond differently to DEP.
journal_name
Allergol Immunopathol (Madr)journal_title
Allergologia et immunopathologiaauthors
Ozturk AB,Bayraktar R,Gogebakan B,Mumbuc S,Bayram Hdoi
10.1016/j.aller.2016.10.015subject
Has Abstractpub_date
2017-01-01 00:00:00pages
473-481issue
5eissn
0301-0546issn
1578-1267pii
S0301-0546(17)30006-Xjournal_volume
45pub_type
杂志文章abstract：BACKGROUND:Visual Analogue Scale (VAS) has been proposed as a useful tool for assessing the perception of asthma symptoms, a cornerstone in disease management. While airway flow limitation and its reversibility are thought to be a useful marker of disease severity, there are very few studies that evaluated the response...
journal_title：Allergologia et immunopathologia
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND:Asthma morbidity and mortality have been increasing. Data of asthma and respiratory mortality rates in Brazil are scarse. METHODS:We studied asthma and respiratory disease mortality rates in the state of So Paulo (capital and country side) from 1970 to 1996, as its relation with sales of drugs usually used ...
journal_title：Allergologia et immunopathologia
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doi：10.1016/s0301-0546(02)79084-8
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abstract：:Five patients with atopic dermatitis, three males and two females, aged 2 to 17 years, had positive reactions to air allergens (Dermatophagoides pteronyssinus and/or farinae). All the patients suffered from severe recurrent dermatophytosis that responded poorly to antifungal treatment. The results of immunologic evalu...
journal_title：Allergologia et immunopathologia
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abstract：BACKGROUND:Due to the high prevalence of recurrent wheezing in the pediatric population, it is important to be able to identify environmental risk factors that may affect the etiology of asthma in several regions. OBJECTIVE:to identify possible risk factors associated with asthma in children (9-12 years old) in Passo ...
journal_title：Allergologia et immunopathologia
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doi：10.1016/j.aller.2019.07.003
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journal_title：Allergologia et immunopathologia
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abstract：:It is suggested that increased reactivity in asthma is not limited to the bronchi but also exists in the mediator releasing system. We have previously observed that the basophils of atopic asthmatics are degranulated by polymyxin B in vitro. The present study attempts to relate this basophil degranulation to atopy. Th...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：:A lot of recent works point out the role of the eosinophil as one of the most harmful cells in asthma. Eosinophilic granules contain strongly basiec cytotoxic proteins. Some of these proteins were shown to damage airway epithelial cells and degranulate basophils and mast cells. The concentration of eosinophil-derived ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1989-03-01 00:00:00
abstract：:Leguminous are a cheap source of protein that are cultivated practically throughout the world. They are the main source of food in developing countries. In the Mediterranean area and Middle East, the most commonly consumed legumes are lentils and chickpea. In the United States, United Kingdom and south-east Asia, the ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
abstract：:This study was undertaken for two reasons: 1) It is more difficult to diagnose hypersensitivity to molds than to other allergens, so an evaluation of diagnostic tests was needed. 2) Alternaria is the principal cause of mold sensitization in our area. Sixty-six patients (20 +/- 4 years) were selected and divided into t...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-07-01 00:00:00
abstract：:The protease-antiprotease balance and concentration of immunoglobulin was evaluated in some respiratory tract diseases. Analysis was carried out on 24 patients with atopic bronchial asthma, 21 with chronic bronchitis, 27 with bronchiectasis and 18 healthy smokers volunteers. In examination of BAL fluid some selective ...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
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更新日期：2008-11-01 00:00:00
abstract：:Shellfish is one of the most frequent causes of food allergy. We studied 48 patients (25 male and 23 female) with a mean age of 24.2 +/- 1.8 with shellfish hypersensitivity. A clinical questionnaire was carried out and prick tests were performed using a series of aeroallergens and a battery of extracts of squid, shrim...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
doi：
更新日期：1994-03-01 00:00:00
abstract：BACKGROUND:It is considered that farm areas protect young patients from allergy and asthma due to high exposure to endotoxins. AIM:To compare CD4+/CD25+ T-regulatory cells and forkhead transcription factor Foxp3 expression in asthmatic children allergic to house dust mites (HDM) living in rural and farm areas. MATERI...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2018.04.003
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1985-11-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：BACKGROUND:The objective was to estimate the incidence of asthma in young adults from 13-15 years old to 23-25 years old, and associated factors. METHODS:In 2012, a population-based prospective cohort study was carried out in Castellon from the cohort who had participated in the International Study of Asthma and Aller...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：10.1016/j.aller.2017.03.003
更新日期：2018-01-01 00:00:00
abstract：:The importance of insect dust as inhalant allergen (e.g. locust, cockroach, mite, butterfly, bee, fly, etc.) is frequently underestimated as a cause of allergic conjunctivitis, rhinitis and bronchial asthma. The high allergenic potency of insect dust is demonstrated in cases of occupational allergy against locust. Thi...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:A 25 year old, 70 kg female chimpanzee had a 12 year history of intermittent signs of upper respiratory tract allergic disease. In June 1987, she was given Terfenadinea, 60 mg b.i.d., with excellent resolution of symptoms. During her annual physical examination, while maintained under ketamine anesthesia, the chimp wa...
journal_title：Allergologia et immunopathologia
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doi：
更新日期：1989-09-01 00:00:00
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journal_title：Allergologia et immunopathologia
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Atopic dermatitis (AD) is a multifaceted disease that involves a complex interplay between the skin and the immune system. The course of the disease depends strongly on the genetic background of the patient and on yet poorly-defined environmental factors. Changes in lifestyle could be behind the dramatic rise in the p...
journal_title：Allergologia et immunopathologia
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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更新日期：2013-11-01 00:00:00
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doi：
更新日期：1984-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：
更新日期：1989-05-01 00:00:00
abstract：:Common variable immunodeficiency is a disorder characterised by hypogammaglobulinemia with B-lymphocytes in peripheral blood and repeated infections. We report a child with a diagnosis of diabetes mellitus and celiac disease during lactation, and in whom common variable immunodeficiency was diagnosed at the age of 5. ...
journal_title：Allergologia et immunopathologia
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doi：
更新日期：2000-11-01 00:00:00
abstract：:Scabies is observed with relatively high frequency in Allergy and Dermatology clinics in developing countries where poor sanitary conditions are prevalent and increasingly in some areas of the world with increased immigrant populations. Since the immunological response to scabies mites includes the production of IgE c...
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更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Egg is the most frequent cause of food allergy in children. The bird-egg syndrome, found in a group of patients sensitized to egg through bird proteins, was infrequent in children. We report a patient with former history of hypersensitivity to egg who developed episodes of angioedema after ingestion of hen m...
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doi：10.1016/s0301-0546(03)79164-2
更新日期：2003-01-01 00:00:00
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journal_title：Allergologia et immunopathologia
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doi：10.1016/j.aller.2017.01.013
更新日期：2017-01-01 00:00:00
