Abstract:
:In a quest for direct evidence of oscillation entrainment, we analyzed intracerebral electroencephalographic recordings obtained during intracranial electrical stimulation in a cohort of three medication-resistant epilepsy patients tested pre-surgically. Spectral analyses of non-epileptogenic cerebral sites stimulated directly with high frequency electrical bursts yielded episodic local enhancements of frequency-specific rhythmic activity, phase-locked to each individual pulse. These outcomes reveal an entrainment of physiological oscillatory activity within a frequency band dictated by the rhythm of the stimulation source. Our results support future uses of rhythmic stimulation to elucidate the causal contributions of synchrony to specific aspects of human cognition and to further develop the therapeutic manipulation of dysfunctional rhythmic activity subtending the symptoms of some neuropsychiatric conditions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Amengual JL,Vernet M,Adam C,Valero-Cabré Adoi
10.1038/srep41908subject
Has Abstractpub_date
2017-03-03 00:00:00pages
41908issn
2045-2322pii
srep41908journal_volume
7pub_type
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