Local entrainment of oscillatory activity induced by direct brain stimulation in humans.

Abstract:

:In a quest for direct evidence of oscillation entrainment, we analyzed intracerebral electroencephalographic recordings obtained during intracranial electrical stimulation in a cohort of three medication-resistant epilepsy patients tested pre-surgically. Spectral analyses of non-epileptogenic cerebral sites stimulated directly with high frequency electrical bursts yielded episodic local enhancements of frequency-specific rhythmic activity, phase-locked to each individual pulse. These outcomes reveal an entrainment of physiological oscillatory activity within a frequency band dictated by the rhythm of the stimulation source. Our results support future uses of rhythmic stimulation to elucidate the causal contributions of synchrony to specific aspects of human cognition and to further develop the therapeutic manipulation of dysfunctional rhythmic activity subtending the symptoms of some neuropsychiatric conditions.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Amengual JL,Vernet M,Adam C,Valero-Cabré A

doi

10.1038/srep41908

subject

Has Abstract

pub_date

2017-03-03 00:00:00

pages

41908

issn

2045-2322

pii

srep41908

journal_volume

7

pub_type

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