Intra- and Interorgan Communication in the Cardiovascular System: A Special View on Redox Regulation.

abstract：:Reactive oxygen species (ROS) have multifaceted roles in the orchestration of plant gene expression and gene-product regulation. Cellular redox homeostasis is considered to be an "integrator" of information from metabolism and the environment controlling plant growth and acclimation responses, as well as cell suicide ...

journal_title：Antioxidants & redox signaling

authors： Foyer CH,Noctor G

更新日期：2009-04-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：:The aim of the present study is to examine the effects of dietary saturated fatty acids on liver adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) in ethanol-administered animals and in ethanol-exposed cultured hepatic cells, and to explore the underlying molecular mechanisms. The mRNA and protein ...

journal_title：Antioxidants & redox signaling

authors： Liang X,Hu M,Rogers CQ,Shen Z,You M

更新日期：2011-07-15 00:00:00

abstract：:The application of electronic structure methods to the prediction of geometries, spin densities, and hyperfine couplings for biologically relevant quinones and semiquinones is reviewed. It is demonstrated that hybrid-type density functional methods are particularly suitable for such studies. Hydrogen bonding to the se...

journal_title：Antioxidants & redox signaling

authors： O'Malley PJ

更新日期：2001-10-01 00:00:00

abstract：SIGNIFICANCE:Studies of sporadic cases, toxin models, and genetic causes of Parkinson's disease suggest that mitochondrial dysfunction may be an early feature of pathogenesis. RECENT ADVANCES:Compelling evidence of a causal relationship between mitochondrial function and disease was found with the identification of se...

journal_title：Antioxidants & redox signaling

authors： McCoy MK,Cookson MR

更新日期：2012-05-01 00:00:00

abstract：:Secretory and transmembrane proteins are correctly folded or processed in the endoplasmic reticulum (ER). Various stresses disturb ER function and provoke the accumulation of unfolded proteins in the ER lumen. This condition is termed ER stress. Recently, ER stress has been linked to neuronal death in various neurodeg...

journal_title：Antioxidants & redox signaling

authors： Saito A,Hino S,Murakami T,Kondo S,Imaizumi K

更新日期：2007-05-01 00:00:00

abstract：AIMS:Emerging lines of evidence indicate that oxidants such as hydrogen peroxide exert specific signaling functions during the processing of chronic pain. However, the mechanisms by which oxidants regulate pain processing in vivo remain poorly understood. Here, we investigated whether cyclic guanosine monophosphate (cG...

journal_title：Antioxidants & redox signaling

authors： Lorenz JE,Kallenborn-Gerhardt W,Lu R,Syhr KM,Eaton P,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：:The small GTPase rac1 controls actin redistribution to membrane ruffles in fibroblasts and other cell types, as well as the activation of the NADPH oxidase in phagocytes. We explored the possibility that these two processes could be related. We used a replication-deficient adenoviral vector to overexpress the constitu...

journal_title：Antioxidants & redox signaling

authors： Moldovan L,Irani K,Moldovan NI,Finkel T,Goldschmidt-Clermont PJ

更新日期：1999-04-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the progressive development of involuntary choreiform movements, cognitive impairment, neuropsychiatric symptoms, and premature death. These phenotypes reflect neuronal dysfunction and ultimately death in selected brain regions, the...

journal_title：Antioxidants & redox signaling

authors： Browne SE,Beal MF

更新日期：2006-11-01 00:00:00

abstract：:Sirtuin-1 (SIRT1) is an NAD(+)-dependent protein deacetylase that is sensitive to oxidative signals. Our purpose was to determine whether SIRT1 activity is sensitive to the low molecular weight nitrosothiol, S-nitrosoglutathione (GSNO), which can transduce oxidative signals into physiological responses. SIRT1 formed m...

journal_title：Antioxidants & redox signaling

authors： Zee RS,Yoo CB,Pimentel DR,Perlman DH,Burgoyne JR,Hou X,McComb ME,Costello CE,Cohen RA,Bachschmid MM

更新日期：2010-10-01 00:00:00

abstract：:Methionine residues are susceptible to oxidation, but this damage may be reversed by methionine sulfoxide reductases MsrA and MsrB. Mammals contain one MsrA and three MsrBs, including a selenoprotein MsrB1. Here, we show that MsrB1 is the major methionine sulfoxide reductase in liver of mice and it is among the protei...

journal_title：Antioxidants & redox signaling

authors： Novoselov SV,Kim HY,Hua D,Lee BC,Astle CM,Harrison DE,Friguet B,Moustafa ME,Carlson BA,Hatfield DL,Gladyshev VN

更新日期：2010-04-01 00:00:00

abstract：SIGNIFICANCE:The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through...

journal_title：Antioxidants & redox signaling

authors： Sevilla E,Bes MT,González A,Peleato ML,Fillat MF

更新日期：2019-05-01 00:00:00

abstract：:Glutathione peroxidases and thioredoxin reductases are the main selenoproteins expressed by endothelial cells. These enzymes reduce hydroperoxides, their role in endothelial cell physiology, however, by far exceeds prevention of oxidative damage. Reactive oxygen and nitrogen species, especially superoxide, hydroperoxi...

journal_title：Antioxidants & redox signaling

authors： Brigelius-Flohé R,Banning A,Schnurr K

更新日期：2003-04-01 00:00:00

abstract：: Significance: Excessive and prolonged proinflammatory responses are associated with oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such condition favors tissue destruction and consequently bacterial spread. A tissue remodeling program is als...

journal_title：Antioxidants & redox signaling

authors： Amaral EP,Vinhaes CL,Oliveira-de-Souza D,Nogueira B,Akrami KM,Andrade BB

更新日期：2021-02-20 00:00:00

abstract：:Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by redox chemotherapeutics. This review will present an update on drug discovery, target ...

journal_title：Antioxidants & redox signaling

authors： Wondrak GT

更新日期：2009-12-01 00:00:00

abstract：:Accumulating evidence suggests that oxidative stress associated with impaired metabolism of the antioxidant glutathione (GSH) plays a key role in the pathophysiology of schizophrenia. Magnetic resonance spectroscopy (MRS) is one of the brain-imaging techniques that can quantitatively measure bioactive substances such ...

journal_title：Antioxidants & redox signaling

authors： Matsuzawa D,Hashimoto K

更新日期：2011-10-01 00:00:00

abstract：: Significance: Humans cannot synthesize ascorbic acid (AscH2) (vitamin C), so deficiencies in dietary AscH2 cause the life-threatening disease of scurvy and many other diseases. After oral ingestion, plasma AscH2 concentrations are strictly controlled by transporters, which...

journal_title：Antioxidants & redox signaling

authors： Pozzer D,Invernizzi RW,Blaauw B,Cantoni O,Zito E

更新日期：2020-01-22 00:00:00

abstract：:Hypoxia and its corollaries pose both negative and positive pressures to multicellular eukaryotes. Evolutionarily, life developed under hypoxia, and the building blocks were established under conditions close to anaerobiosis; therefore, reason exists to expect that certain biologic processes may perform preferentially...

journal_title：Antioxidants & redox signaling

authors： Webster KA

更新日期：2007-09-01 00:00:00

abstract：:Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently. Proteins that share the similar active-site sequence, -Cys-Xxx-Yyy-Cys-, are called the Trx family, and the number of Trx family members is increasing. Trx reductase, which reduces oxidized Trx in cooperation with NADPH, has th...

journal_title：Antioxidants & redox signaling

authors： Nakamura H

更新日期：2005-05-01 00:00:00

abstract：AIMS:Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to investigate hypoxia-induced miR-210 regulation ...

journal_title：Antioxidants & redox signaling

authors： Zaccagnini G,Maimone B,Di Stefano V,Fasanaro P,Greco S,Perfetti A,Capogrossi MC,Gaetano C,Martelli F

更新日期：2014-09-10 00:00:00

abstract：:Discovery of the F2-isoprostanes, a group of prostaglandin F2-like compounds biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel facet of free radical biology. Some of these compounds are bioactive and thus may mediate adverse effects associated with oxidant stress. F2-Isoprostanes hav...

journal_title：Antioxidants & redox signaling

authors： Basu S,Helmersson J

更新日期：2005-01-01 00:00:00

abstract：AIMS:Aberrant Cdk5 (cyclin-dependent kinase 5) and oxidative stress are crucial components of diverse neurodegenerative disorders, including Alzheimer's disease (AD). We previously reported that a change in peroxiredoxin (Prx) expression is associated with protection from neuronal death. The aim of the current study wa...

journal_title：Antioxidants & redox signaling

authors： Park J,Kim B,Chae U,Lee DG,Kam MK,Lee SR,Lee S,Lee HS,Park JW,Lee DS

更新日期：2017-10-10 00:00:00

abstract：AIM:Antrodia Camphorate (AC) is a mushroom that is widely used in Asian countries to prevent and treat various diseases, including liver diseases. However, the active ingredients that contribute to the biological functions remain elusive. The purpose of the present study is to test the hepatoprotective effect of Antcin...

journal_title：Antioxidants & redox signaling

authors： Huo Y,Win S,Than TA,Yin S,Ye M,Hu H,Kaplowitz N

更新日期：2017-02-10 00:00:00

abstract：SIGNIFICANCE:Hydrogen sulfide (H2S) is likely to join nitric oxide (NO) and carbon monoxide (CO) as the third gaseous transmitter, influencing an array of intracellular signaling cascades. Thus, H2S is implicated in numerous physiological processes and in the pathology of various diseases. RECENT ADVANCES:H2S-donating...

journal_title：Antioxidants & redox signaling

authors： Kashfi K

更新日期：2014-02-10 00:00:00

abstract：:Cyclotides are plant proteins with exceptional stability owing to the presence of a cyclic backbone and three disulfide bonds arranged in a cystine knot motif. Accordingly, they have been proposed as templates to stabilize bioactive epitopes in drug-design applications. The two main subfamilies, referred to as the Möb...

journal_title：Antioxidants & redox signaling

authors： Gunasekera S,Daly NL,Clark RJ,Craik DJ

更新日期：2009-05-01 00:00:00

abstract：:Increasing evidence indicates that disequilibrium of the alveolar oxidant-antioxidant balance may play a role in the pathogenesis of chronic fibrosing lung diseases. Excessive production of oxidants and a differential regulation of antioxidant enzymes have been described under these conditions. We characterized for th...

journal_title：Antioxidants & redox signaling

authors： Markart P,Luboeinski T,Korfei M,Schmidt R,Wygrecka M,Mahavadi P,Mayer K,Wilhelm J,Seeger W,Guenther A,Ruppert C

更新日期：2009-02-01 00:00:00

abstract：:It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch points where disturbed blood flow (d-flow) predisposes to the development of plaques. Investigations both in vivo and in vitro have shown that d-flow is pro-atherogenic by promoting oxidative and inflammatory states in the a...

journal_title：Antioxidants & redox signaling

authors： Nigro P,Abe J,Berk BC

更新日期：2011-09-01 00:00:00

abstract：:The possibility of a plasma oxygen diffusion barrier implies a significant resistance to oxygen diffusion and the existence of capillary erythrocyte-associated transients of oxygen. This effect was analyzed by measuring intracapillary blood and tissue pO(2) in the hamster chamber window model using a noninvasive intra...

journal_title：Antioxidants & redox signaling

authors： Cabrales P,Intaglietta M

更新日期：2007-07-01 00:00:00

abstract：AIMS:Endothelium-dependent vasorelaxation is mediated by endothelium-derived relaxing factor and endothelium-derived hyperpolarizing factor (EDHF). However, the molecular entity of EDHF remains unclear. The present study examined whether hydrogen sulfide (H₂S) acts as EDHF and how H₂S mediates EDHF pathways from endoth...

journal_title：Antioxidants & redox signaling

authors： Tang G,Yang G,Jiang B,Ju Y,Wu L,Wang R

更新日期：2013-11-10 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has recently been viewed as an inflammation-dependent systemic disease. Oxidative modifications in the pulmonary microenvironment can result in a number of functional changes in pulmonary tissue as well as in the blood. Studies have been carried out to detect whether oxidat...

journal_title：Antioxidants & redox signaling

authors： Minetti M,Leto TL,Malorni W

更新日期：2008-04-01 00:00:00