Abstract:
:Increasing evidence indicates that disequilibrium of the alveolar oxidant-antioxidant balance may play a role in the pathogenesis of chronic fibrosing lung diseases. Excessive production of oxidants and a differential regulation of antioxidant enzymes have been described under these conditions. We characterized for the first time numerous nonenzymatic low-molecular-weight antioxidants in bronchoalveolar lavage fluids from patients with different forms of lung fibrosis initiated either by injury to the alveolar epithelium (idiopathic pulmonary fibrosis, IPF) or by inflammation (chronic sarcoidosis/hypersensitivity pneumonitis). Footprints of oxidative stress accompanied by an increase in the majority of antioxidants assessed were observed in all patient groups: elevated levels of uric acid, ascorbic acid, retinol, and alpha-tocopherol were noted, whereas glutathione levels were unchanged. The expression of Nrf2, an important redox-sensitive transcriptional regulator of antioxidants, was increased in IPF lungs. Our findings were corroborated in the bleomycin model of lung fibrosis where--aside from uric acid--nonenzymatic antioxidants were elevated during the fibrotic phase. In conclusion, alveolar levels of nonenzymatic antioxidants are elevated in fibrosing lung diseases, but are incapable of restoring oxidative balance. This increase may be part of an adaptive response to oxidative stress. However, a leakage from the blood may also contribute to our findings.
journal_name
Antioxid Redox Signaljournal_title
Antioxidants & redox signalingauthors
Markart P,Luboeinski T,Korfei M,Schmidt R,Wygrecka M,Mahavadi P,Mayer K,Wilhelm J,Seeger W,Guenther A,Ruppert Cdoi
10.1089/ars.2008.2105subject
Has Abstractpub_date
2009-02-01 00:00:00pages
227-40issue
2eissn
1523-0864issn
1557-7716journal_volume
11pub_type
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journal_title:Antioxidants & redox signaling
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doi:10.1089/ars.2011.3930
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journal_title:Antioxidants & redox signaling
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doi:10.1089/ars.2016.6842
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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doi:10.1089/ars.2009.2826
更新日期:2010-02-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
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journal_title:Antioxidants & redox signaling
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doi:10.1089/ars.2007.1890
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2007.1968
更新日期:2008-07-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2007.1546
更新日期:2007-06-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2006.8.1003
更新日期:2006-05-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/ars.2007.1610
更新日期:2007-07-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2012.5167
更新日期:2013-12-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/ars.2017.6988
更新日期:2017-04-20 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/ars.2006.8.1419
更新日期:2006-09-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/152308603768295168
更新日期:2003-08-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/ars.2016.6630
更新日期:2017-06-10 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/ars.2010.3679
更新日期:2011-09-01 00:00:00
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journal_title:Antioxidants & redox signaling
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更新日期:2014-06-20 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
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更新日期:2005-11-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2008.2306
更新日期:2009-08-01 00:00:00
abstract::The 6(th) COSTAM/SFRR (ASEAN/Malaysia) workshop, "Micronutrients, Oxidative Stress, and the Environment," was held from June 29 to July 2 at Holiday Inn Damai Beach Resort in Kuching, Sarawak. Two hundred twenty participants from 17 countries presented recent advances on natural antioxidants in the area of oxidative s...
journal_title:Antioxidants & redox signaling
pub_type:
doi:10.1089/ars.2006.8.2175
更新日期:2006-11-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/ars.2006.8.559
更新日期:2006-03-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
doi:10.1089/ars.2004.6.895
更新日期:2004-10-01 00:00:00
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journal_title:Antioxidants & redox signaling
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doi:10.1089/15230860050192242
更新日期:2000-10-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2018.7503
更新日期:2019-06-01 00:00:00
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2013.5314
更新日期:2014-01-01 00:00:00
abstract:: Aims: Normal mitochondrial function and integrity are crucial for cellular physiology. Given the paramount role of mitochondrial quality control proteases in these processes, our study focused on investigating mechanisms by which the activity of a key quality control prote...
journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2018.7642
更新日期:2019-08-20 00:00:00