6th COSTAM/SFRR (ASEAN/Malaysia) International Workshop on Micronutrients, Oxidative Stress, and the Environment.

abstract：:DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has homologs in nearly all organisms. Because of its connection to parkinsonism and cancer, human DJ-1 has been intensely studied for over a decade. The current view is that DJ-1 is a multifunctional oxidative stress response protein that...

journal_title：Antioxidants & redox signaling

authors： Wilson MA

更新日期：2011-07-01 00:00:00

abstract：: Aims: Oxidative stress is causally linked to male reproductive pathologies, driven primarily by lipid peroxidation and an attendant production of highly reactive lipid aldehydes, such as 4-hydroxynonenal (4HNE) within the male germ line. In somatic cells, 4HNE dysregulates...

journal_title：Antioxidants & redox signaling

authors： Cafe SL,Nixon B,Dun MD,Roman SD,Bernstein IR,Bromfield EG

更新日期：2020-03-10 00:00:00

abstract：:Aging is the accumulation of changes that increase the risk of death. Aging changes can be attributed to development, genetic defects, the environment, disease, and an inborn process: the aging process. The latter is the major risk factor for disease and death after age 28 in the developed countries. In these countrie...

journal_title：Antioxidants & redox signaling

authors： Harman D

更新日期：2003-10-01 00:00:00

abstract：:Glutathione peroxidases and thioredoxin reductases are the main selenoproteins expressed by endothelial cells. These enzymes reduce hydroperoxides, their role in endothelial cell physiology, however, by far exceeds prevention of oxidative damage. Reactive oxygen and nitrogen species, especially superoxide, hydroperoxi...

journal_title：Antioxidants & redox signaling

authors： Brigelius-Flohé R,Banning A,Schnurr K

更新日期：2003-04-01 00:00:00

abstract：SIGNIFICANCE:The rising global prevalence of diabetes and its debilitating complications give rise to significant disability and premature mortality. Due to the silent nature of diabetes and its vascular complications, and limitations in current methods for detection, there is a need for novel biomarkers for early dete...

journal_title：Antioxidants & redox signaling

authors： Fan B,Luk AOY,Chan JCN,Ma RCW

更新日期：2018-10-10 00:00:00

abstract：SIGNIFICANCE:Chagas disease (CD) affects several million people in Latin America and is spreading beyond its classical boundaries due to the migration of infected host and insect vectors, HIV co-infection, and blood transfusion. The current therapy is not adequate for treatment of the chronic phase of CD, and new drugs...

journal_title：Antioxidants & redox signaling

authors： Piacenza L,Peluffo G,Alvarez MN,Martínez A,Radi R

更新日期：2013-09-01 00:00:00

abstract：: Aims: To ascertain if human pericytes produce SPARC (acronym for Secreted Protein Acidic and Cysteine Rich), a matricellular protein implicated in the regulation of cell proliferation, migration, and cell-matrix interactions; clarify if SPARC expression in cardiac pericyte...

journal_title：Antioxidants & redox signaling

authors： Avolio E,Mangialardi G,Slater SC,Alvino VV,Gu Y,Cathery W,Beltrami AP,Katare R,Heesom K,Caputo M,Madeddu P

更新日期：2020-11-23 00:00:00

abstract：:The signaling for activation of protein tyrosine kinases (PTKs) is usually started by binding of ligands to cell-surface receptors. However, recent evidence suggests the presence of ligand binding-independent signaling pathways that are mediated by oxidative stress. Oxidation and reduction of protein cysteine sulfhydr...

journal_title：Antioxidants & redox signaling

authors： Nakashima I,Kato M,Akhand AA,Suzuki H,Takeda K,Hossain K,Kawamoto Y

更新日期：2002-06-01 00:00:00

abstract：SIGNIFICANCE:The protein tyrosine phosphatases (PTPs) are a family of proteins that play critical roles in cellular signaling and influence many aspects of human health and disease. Although a wealth of information has been collected about PTPs since their discovery, many questions regarding their regulation and functi...

journal_title：Antioxidants & redox signaling

authors： Stanford SM,Ahmed V,Barrios AM,Bottini N

更新日期：2014-05-10 00:00:00

abstract：:The ability to couple photosynthetic electron transport and redox poise to plastid gene expression enables plants to respond to environmental conditions and coordinate nuclear and chloroplast activities in order to maintain photosynthetic efficiency. The plastid redox regulatory system serves as a paradigm for underst...

journal_title：Antioxidants & redox signaling

authors： Barnes D,Mayfield SP

更新日期：2003-02-01 00:00:00

abstract：SIGNIFICANCE:Abnormal lung development in the perinatal period can result in severe neonatal complications, including persistent pulmonary hypertension (PH) of the newborn and bronchopulmonary dysplasia. Reactive oxygen species (ROS) play a substantive role in the development of PH associated with these diseases. ROS i...

journal_title：Antioxidants & redox signaling

authors： Wedgwood S,Steinhorn RH

更新日期：2014-11-01 00:00:00

abstract：:Signal transduction via PI 3-kinases plays an important role in regulating the cellular processes of cell growth, survival, proliferation, and motility. The stimulated generation of reactive oxygen species is a necessary component of the signal transduction mechanisms by which many growth factors and cytokines activat...

journal_title：Antioxidants & redox signaling

authors： Leslie NR

更新日期：2006-09-01 00:00:00

abstract：:Liver fibrosis is the consequence of chronic liver injury of any etiology. When advanced, fibrosis causes portal hypertension and liver insufficiency, and is a risk factor for developing hepatocellular carcinoma. In the last decade, there have been major advances in the knowledge of the pathogenesis of hepatic fibrosi...

journal_title：Antioxidants & redox signaling

authors： Bataller R,Sancho-Bru P,Ginès P,Brenner DA

更新日期：2005-09-01 00:00:00

abstract：AIMS:Chronic metabolic impairment and oxidative stress are associated with the pathogenesis of axonal dysfunction in a growing number of neurodegenerative conditions. To investigate the intertwining of both noxious factors, we have chosen the mouse model of adrenoleukodystrophy (X-ALD), which exhibits axonal degenerati...

journal_title：Antioxidants & redox signaling

authors： Galino J,Ruiz M,Fourcade S,Schlüter A,López-Erauskin J,Guilera C,Jove M,Naudi A,García-Arumí E,Andreu AL,Starkov AA,Pamplona R,Ferrer I,Portero-Otin M,Pujol A

更新日期：2011-10-15 00:00:00

abstract：SIGNIFICANCE:In bacteria, transcriptional responses to reactive oxygen and nitrogen species (ROS and RNS, respectively) are typically coordinated by regulatory proteins that employ metal centers or reactive thiols to detect the presence of those species. This review is focused on the structure, function and mechanism o...

journal_title：Antioxidants & redox signaling

authors： Spiro S,D'Autréaux B

更新日期：2012-11-01 00:00:00

abstract：SIGNIFICANCE:Mitochondrial dynamics is a complex process that impacts on mitochondrial biology. RECENT ADVANCES:Recent evidence indicates that proteins participating in mitochondrial dynamics have additional cellular roles. Mitofusin 2 (Mfn2) is a potent modulator of mitochondrial metabolism with an impact on energy m...

journal_title：Antioxidants & redox signaling

authors： Zorzano A,Hernández-Alvarez MI,Sebastián D,Muñoz JP

更新日期：2015-04-20 00:00:00

abstract：:The nuclear factor-kappaB (NF-kappaB) is a transcription factor that plays a pivotal role in the induction of genes involved in physiological processes, as well as in the response to inflammation. In this study, we used a selective nonpeptidyl superoxide dismutase mimetic, M40403, to investigate the role of superoxide...

journal_title：Antioxidants & redox signaling

authors： Cuzzocrea S,Pisano B,Dugo L,Ianaro A,Ndengele M,Salvemini D

更新日期：2004-08-01 00:00:00

abstract：:Epidemiological studies have shown that advancing age is associated with an increased prevalence of cardiovascular disease (CVD). Vascular smooth muscle cells (VSMC) comprise the major arterial cell population, and changes in VSMC behavior, function, and redox status with age contribute to alterations in vascular remo...

journal_title：Antioxidants & redox signaling

authors： Li M,Fukagawa NK

更新日期：2010-03-01 00:00:00

abstract：SIGNIFICANCE:The discovery of the oxidoreductase disulfide bond protein A (DsbA) in 1991 opened the way to the unraveling of the pathways of disulfide bond formation in the periplasm of Escherichia coli and other Gram-negative bacteria. Correct oxidative protein folding in the E. coli envelope depends on both the DsbA/...

journal_title：Antioxidants & redox signaling

authors： Denoncin K,Collet JF

更新日期：2013-07-01 00:00:00

abstract：SIGNIFICANCE:Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor radioresistance. RECENT ADVANCES:Two main types of hypoxia exist in the tumor microenvironment: chronic and cycling hypoxia. Chronic hypoxia re...

journal_title：Antioxidants & redox signaling

authors： Lee CT,Boss MK,Dewhirst MW

更新日期：2014-07-10 00:00:00

abstract：:Tumor necrosis factor (TNF) induces a caspase-independent but mitochondria-dependent cell death process in the mouse fibrosarcoma cell line L929. Mitochondria actively participate in this TNF-induced necrotic cell death by the generation of mitochondrial reactive oxygen species (ROS). The aim of this study was to iden...

journal_title：Antioxidants & redox signaling

authors： Goossens V,Stangé G,Moens K,Pipeleers D,Grooten J

更新日期：1999-10-01 00:00:00

abstract：:Cardiac surgery is associated with release of the pleiotropic cytokine macrophage migration inhibitory factor (MIF). The trigger for MIF release has not yet been elucidated. Owing to its intrinsic antioxidative activity, MIF might reduce oxidative stress and protect from myocardial ischemia and reperfusion (I/R) injur...

journal_title：Antioxidants & redox signaling

authors： Stoppe C,Werker T,Rossaint R,Dollo F,Lue H,Wonisch W,Menon A,Goetzenich A,Bruells CS,Coburn M,Kopp R,Bucala R,Bernhagen J,Rex S

更新日期：2013-07-20 00:00:00

abstract：:Although oxygen is essential for promoting energy metabolism and for enhancing cell proliferation, early mouse embryos are very sensitive to high oxygen concentration. Because the tissue-specificity and sequential changes of the expression of antioxidative enzymes in rodent embryos have not been investigated systemati...

journal_title：Antioxidants & redox signaling

authors： Kobayashi M,Nakamura H,Yodoi J,Shiota K

更新日期：2000-01-01 00:00:00

abstract：UNLABELLED:In living systems, the mechanisms of inheritance involving gene expression are operated by (i) the traditional model of genetics where the deoxyribonucleic acid (DNA) transcription and messenger ribonucleic acid stability are influenced by the DNA sequences and any aberrations in the primary DNA sequences an...

journal_title：Antioxidants & redox signaling

authors： Malireddy S,Kotha SR,Secor JD,Gurney TO,Abbott JL,Maulik G,Maddipati KR,Parinandi NL

更新日期：2012-07-15 00:00:00

abstract：SIGNIFICANCE:The therapeutic effects of current micellar and vesicular drug formulations are restricted by slow and inefficient drug release at the pathological site. The development of smart polymeric nanocarriers that release drugs upon arriving at the target site has received a tremendous amount of attention for can...

journal_title：Antioxidants & redox signaling

authors： Sun H,Meng F,Cheng R,Deng C,Zhong Z

更新日期：2014-08-10 00:00:00

abstract：AIMS:Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) are sufficient to increase ...

journal_title：Antioxidants & redox signaling

authors： Leuner K,Schütt T,Kurz C,Eckert SH,Schiller C,Occhipinti A,Mai S,Jendrach M,Eckert GP,Kruse SE,Palmiter RD,Brandt U,Dröse S,Wittig I,Willem M,Haass C,Reichert AS,Müller WE

更新日期：2012-06-15 00:00:00

abstract：AIMS:To evaluate mechanisms underlying modulation of inflammatory chemokines in primary human keratinocytes (normal human epidermal keratinocytes) and repair-related processes in wound models by plant polyphenols (PPs) with antioxidant and superoxide scavenging properties (verbascoside [Vb], resveratrol [Rv], polydatin...

journal_title：Antioxidants & redox signaling

authors： Pastore S,Lulli D,Fidanza P,Potapovich AI,Kostyuk VA,De Luca C,Mikhal'chik E,Korkina LG

更新日期：2012-02-15 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a gasotransmitter with multifaceted physiological functions, including the regulation of glucose metabolism. Methylglyoxal (MG) is an intermediate of glucose metabolism and plays an important role in the pathogenesis of insulin resistance syndromes. In the present study, we investigated the...

journal_title：Antioxidants & redox signaling

authors： Chang T,Untereiner A,Liu J,Wu L

更新日期：2010-05-01 00:00:00

abstract：:This Forum issue "Heme Oxygenase" (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual rol...

journal_title：Antioxidants & redox signaling

authors： Facchinetti MM

更新日期：2020-06-10 00:00:00

abstract：: Significance: Genomic instability, a hallmark of cancer, renders cancer cells susceptible to genomic stress from both endogenous and exogenous origins, resulting in the increased tendency to accrue DNA damage, chromosomal instability, or aberrant DNA localization. Apart fr...

journal_title：Antioxidants & redox signaling

authors： Pu C,Tao S,Xu J,Huang M

更新日期：2020-12-04 00:00:00