Role of reactive oxygen species in neonatal pulmonary vascular disease.

abstract：:This brief review first touches on the origins of the earth's oxygen. It then identifies and locates the principal oxygen sensor in vertebrates, the carotid body (CB). The CB is unique in that in human subjects, it is the only sensor of lower than normal levels in the partial pressure of oxygen (hypoxia, HH). Another ...

journal_title：Antioxidants & redox signaling

authors： Fitzgerald RS,Shirahata M,Balbir A,Grossman CE

更新日期：2007-06-01 00:00:00

abstract：:Ebselen is a selanazal drug recently revealed as a highly efficient peroxiredoxin mimic catalyzing the hydroperoxide reduction by the mammalian thioredoxin system [thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH]. The mammalian Trx system is a dehydroascorbic acid reductase recycling ascorbic acid essential...

journal_title：Antioxidants & redox signaling

authors： Zhao R,Holmgren A

更新日期：2004-02-01 00:00:00

abstract：:The 6(th) COSTAM/SFRR (ASEAN/Malaysia) workshop, "Micronutrients, Oxidative Stress, and the Environment," was held from June 29 to July 2 at Holiday Inn Damai Beach Resort in Kuching, Sarawak. Two hundred twenty participants from 17 countries presented recent advances on natural antioxidants in the area of oxidative s...

journal_title：Antioxidants & redox signaling

authors： Nesaretnam K,Sies H

更新日期：2006-11-01 00:00:00

abstract：:Mitochondrial ferritin (MtFt) is a newly identified H-ferritin-like protein expressed only in mitochondria. Previous studies have shown that its overexpression markedly affects intracellular iron homeostasis and rescues defects caused by frataxin deficiency. To assess how MtFt exerts its function under oxidative stres...

journal_title：Antioxidants & redox signaling

authors： Lu Z,Nie G,Li Y,Soe-Lin S,Tao Y,Cao Y,Zhang Z,Liu N,Ponka P,Zhao B

更新日期：2009-08-01 00:00:00

abstract：:Increasing evidence indicates that disequilibrium of the alveolar oxidant-antioxidant balance may play a role in the pathogenesis of chronic fibrosing lung diseases. Excessive production of oxidants and a differential regulation of antioxidant enzymes have been described under these conditions. We characterized for th...

journal_title：Antioxidants & redox signaling

authors： Markart P,Luboeinski T,Korfei M,Schmidt R,Wygrecka M,Mahavadi P,Mayer K,Wilhelm J,Seeger W,Guenther A,Ruppert C

更新日期：2009-02-01 00:00:00

abstract：SIGNIFICANCE:MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality...

journal_title：Antioxidants & redox signaling

authors： Miguel V,Cui JY,Daimiel L,Espinosa-Díez C,Fernández-Hernando C,Kavanagh TJ,Lamas S

更新日期：2018-03-20 00:00:00

abstract：:An increase of mitochondrial-derived reactive oxygen species (ROS) occurs in nerve growth factor (NGF)-deprived sympathetic neurons undergoing apoptotic death. It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen-activated protein kinase kinase (MEK)/mi...

journal_title：Antioxidants & redox signaling

authors： Kirkland RA,Franklin JL

更新日期：2003-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and a progressive neurodegeneration that appears to result from multiple pathogenic mechanisms (including protein misfolding/aggregation, involved in both amyloid β-dependent senile plaques and tau-dependent neurofibrillary tangles), metabolic and mitochond...

journal_title：Antioxidants & redox signaling

authors： von Bernhardi R,Eugenín J

更新日期：2012-05-01 00:00:00

abstract：:Accumulating evidence suggests that oxidative stress associated with impaired metabolism of the antioxidant glutathione (GSH) plays a key role in the pathophysiology of schizophrenia. Magnetic resonance spectroscopy (MRS) is one of the brain-imaging techniques that can quantitatively measure bioactive substances such ...

journal_title：Antioxidants & redox signaling

authors： Matsuzawa D,Hashimoto K

更新日期：2011-10-01 00:00:00

abstract：SIGNIFICANCE:Extranuclear sirtuins in cytosol (SIRT2) and mitochondria (SIRT3, SIRT4, and SIRT5) are key regulators of metabolic enzymes and the antioxidative defense mechanisms. They play an important role in the adjustment of metabolic pathways in alterations of the nutritional status. Recent Advances: Recent studies...

journal_title：Antioxidants & redox signaling

authors： Elkhwanky MS,Hakkola J

更新日期：2018-03-10 00:00:00

abstract：SIGNIFICANCE:Oxidative stress and damage are well-established components of neurodegenerative diseases, contributing to neuronal death during disease progression. Here, we consider key K(+) channels as target proteins that can undergo oxidative modulation, describe what is understood about how this influences disease p...

journal_title：Antioxidants & redox signaling

authors： Peers C,Boyle JP

更新日期：2015-02-20 00:00:00

abstract：SIGNIFICANCE:Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific comm...

journal_title：Antioxidants & redox signaling

authors： Parrow NL,Leshin JA,Levine M

更新日期：2013-12-10 00:00:00

abstract：:Discovery of the F2-isoprostanes, a group of prostaglandin F2-like compounds biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel facet of free radical biology. Some of these compounds are bioactive and thus may mediate adverse effects associated with oxidant stress. F2-Isoprostanes hav...

journal_title：Antioxidants & redox signaling

authors： Basu S,Helmersson J

更新日期：2005-01-01 00:00:00

abstract：SIGNIFICANCE:Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of mitochondria in the development of insulin resistance. RECENT ADVANCES:Refined methodology of ex vivo high-resolution respirometry and...

journal_title：Antioxidants & redox signaling

authors： Jelenik T,Roden M

更新日期：2013-07-20 00:00:00

abstract：SIGNIFICANCE:Reactive oxygen and nitrogen species contributing to homeostatic regulation and the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, endothelial dysfunction, and cardiac hypertrophy, is well established. The ability of oxidant species to mediate such effects is in p...

journal_title：Antioxidants & redox signaling

authors： Pimentel D,Haeussler DJ,Matsui R,Burgoyne JR,Cohen RA,Bachschmid MM

更新日期：2012-03-15 00:00:00

abstract：SIGNIFICANCE:Cardiovascular diseases are the main cause of death worldwide and pose an immense economical burden. In most cases, the underlying problem is vascular occlusion by atherosclerotic plaques. Importantly, different cell types of the vascular wall and the immune system play crucial roles in atherosclerosis at ...

journal_title：Antioxidants & redox signaling

authors： Kohlgrüber S,Upadhye A,Dyballa-Rukes N,McNamara CA,Altschmied J

更新日期：2017-05-01 00:00:00

abstract：:Scholarly peer review represents the linchpin of academic publishing. Recognized benefits of the peer review system are manifold. Critics raise several valid concerns that deserve attention. Several studies show that the current peer review system lacks robustness and is subject to bias in favor of well-established re...

journal_title：Antioxidants & redox signaling

authors： Sen CK

更新日期：2012-02-15 00:00:00

abstract：:An overview is provided of the use of cyclic voltammetry and electrochemical detectors for HPLC to characterize antioxidants that are active as reducing agents at inert electrodes. Results are presented for cyclic voltammetry at a glassy carbon electrode in 50% methanol, 50% 0.1 M HClO4, a solution typically used in H...

journal_title：Antioxidants & redox signaling

authors： Kilmartin PA

更新日期：2001-12-01 00:00:00

abstract：:In the CNS, the heme oxygenase (HO) system has been reported to be active and to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge. We have recently shown that both curcumin and caffeic acid phenethyl ester, two phenolic natural compounds, potently induce HO-1 expression and acti...

journal_title：Antioxidants & redox signaling

authors： Scapagnini G,Butterfield DA,Colombrita C,Sultana R,Pascale A,Calabrese V

更新日期：2004-10-01 00:00:00

abstract：AIMS:Macrophages are of key importance for tissue repair after myocardial infarction (MI). Hydrogen sulfide (H2S) has been shown to exert cardioprotective effects in MI. However, the mechanisms by which H2S modulates cardiac remodeling and repair post-MI remain to be clarified. RESULTS:In our current study, we showed ...

journal_title：Antioxidants & redox signaling

authors： Miao L,Shen X,Whiteman M,Xin H,Shen Y,Xin X,Moore PK,Zhu YZ

更新日期：2016-08-10 00:00:00

abstract：AIMS:Recent studies have revealed that autophagy is induced under various disease conditions; however, the role of autophagy in pathological states is controversial. NAD(P)H:quinone oxidoreductase 1 (NQO1) is a highly inducible cytoprotective gene that regulates reactive oxygen species (ROS) generation. In this study,...

journal_title：Antioxidants & redox signaling

authors： Kim TW,Kim YJ,Kim HT,Park SR,Lee MY,Park YD,Lee CH,Jung JY

更新日期：2016-05-20 00:00:00

abstract：:Our aim is to deliver an authoritative and challenging perspective of current concepts in plant redox signaling, focusing particularly on the complex interface between the redox and hormone-signaling pathways that allow precise control of plant growth and defense in response to metabolic triggers and environmental con...

journal_title：Antioxidants & redox signaling

authors： Foyer CH,Noctor G

更新日期：2013-06-01 00:00:00

abstract：:Oxidative stress is implicated as one of the major underlying mechanisms behind many acute and chronic diseases, and involved in normal aging. However, the measurement of free radicals or their end products is complicated. Thus, proof of association of free radicals in pathologic conditions has been absent. Isoprostan...

journal_title：Antioxidants & redox signaling

authors： Basu S

更新日期：2008-08-01 00:00:00

abstract：:Thiol peroxidases comprise glutathione peroxidases (GPx) and peroxiredoxins (Prx). The enzymes of both families reduce hydroperoxides with thiols by enzyme-substitution mechanisms. H(2)O(2) and organic hydroperoxides are reduced by all thiol peroxidases, most efficiently by SecGPxs, whereas fast peroxynitrite reductio...

journal_title：Antioxidants & redox signaling

authors： Flohé L,Toppo S,Cozza G,Ursini F

更新日期：2011-08-01 00:00:00

abstract：SIGNIFICANCE:Hydrogen sulfide (H2S) is likely to join nitric oxide (NO) and carbon monoxide (CO) as the third gaseous transmitter, influencing an array of intracellular signaling cascades. Thus, H2S is implicated in numerous physiological processes and in the pathology of various diseases. RECENT ADVANCES:H2S-donating...

journal_title：Antioxidants & redox signaling

authors： Kashfi K

更新日期：2014-02-10 00:00:00

abstract：: Aims: Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolism of reactive oxygen species (ROS). Increased oxidative stress in adipose tissue contributes to the development of insulin resistance and metabolic syndrome in obesity. This study aimed to...

journal_title：Antioxidants & redox signaling

authors： Piao L,Dorotea D,Jiang S,Koh EH,Oh GT,Ha H

更新日期：2019-12-20 00:00:00

abstract：UNLABELLED:In living systems, the mechanisms of inheritance involving gene expression are operated by (i) the traditional model of genetics where the deoxyribonucleic acid (DNA) transcription and messenger ribonucleic acid stability are influenced by the DNA sequences and any aberrations in the primary DNA sequences an...

journal_title：Antioxidants & redox signaling

authors： Malireddy S,Kotha SR,Secor JD,Gurney TO,Abbott JL,Maulik G,Maddipati KR,Parinandi NL

更新日期：2012-07-15 00:00:00

abstract：: Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway essential for generation of energy and biosynthetic intermediates. Alterations of the TCA cycle play a pivotal role in oncogenesis and inflammation. As such, some metabolic vulnerabilities...

journal_title：Antioxidants & redox signaling

authors： Scagliola A,Mainini F,Cardaci S

更新日期：2020-04-20 00:00:00

abstract：AIMS:Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known safety in humans using a hippocampal neuroblast line expressing a reporter...

journal_title：Antioxidants & redox signaling

authors： Aleyasin H,Karuppagounder SS,Kumar A,Sleiman S,Basso M,Ma T,Siddiq A,Chinta SJ,Brochier C,Langley B,Haskew-Layton R,Bane SL,Riggins GJ,Gazaryan I,Starkov AA,Andersen JK,Ratan RR

更新日期：2015-01-10 00:00:00

abstract：AIMS:The potential receptor for hydrogen sulfide (H2S) remains unknown. RESULTS:H2S could directly activate vascular endothelial growth factor receptor 2 (VEGFR2) and that a small interfering RNA (siRNA)-mediated knockdown of VEGFR2 inhibited H2S-induced migration of human vascular endothelial cells. H2S promoted angi...

journal_title：Antioxidants & redox signaling

authors： Tao BB,Liu SY,Zhang CC,Fu W,Cai WJ,Wang Y,Shen Q,Wang MJ,Chen Y,Zhang LJ,Zhu YZ,Zhu YC

更新日期：2013-08-10 00:00:00