Factors regulating isoprostane formation in vivo.

abstract：:Aging is associated not only with oxidant stress, but also with increased interleukin-6 (IL-6) levels. To determine if oxidative stress could contribute to the age-associated increase IL-6 expression, we exposed LNCaP prostate carcinoma cells and HeLa cervical carcinoma cells to H2O2 as an oxidant challenge. We found ...

journal_title：Antioxidants & redox signaling

authors： Zhang J,Johnston G,Stebler B,Keller ET

更新日期：2001-06-01 00:00:00

abstract：: Significance: Heme oxygenase-1 (HO-1) is a ubiquitous 32-kDa protein expressed in many tissues and highly inducible. They catalyze the degradation of the heme group and the release of free iron, carbon monoxide, and biliverdin; the latter converted to bilirubin by biliverd...

journal_title：Antioxidants & redox signaling

authors： Medina MV,Sapochnik D,Garcia Solá M,Coso O

更新日期：2020-05-10 00:00:00

abstract：SIGNIFICANCE:Chronic noncommunicable diseases (NCDs) are the leading causes of disability and death worldwide. NCDs mainly comprise diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and neurological degenerative diseases, which kill more than 80% of population, especially the el...

journal_title：Antioxidants & redox signaling

authors： Pacifici F,Della Morte D,Capuani B,Pastore D,Bellia A,Sbraccia P,Di Daniele N,Lauro R,Lauro D

更新日期：2019-01-20 00:00:00

abstract：:Reactive oxygen species (ROS) can directly induce or enhance tumor necrosis factor (TNF)-mediated apoptosis in a number of different cell lines. To test the relevance of intracellular ROS in modulating apoptotic signaling in vivo, we evaluated hepatocellular apoptosis mediated by the TNF or Fas receptor in wild-type a...

journal_title：Antioxidants & redox signaling

authors： Bajt ML,Ho YS,Vonderfecht SL,Jaeschke H

更新日期：2002-10-01 00:00:00

abstract：:Secretory and transmembrane proteins are correctly folded or processed in the endoplasmic reticulum (ER). Various stresses disturb ER function and provoke the accumulation of unfolded proteins in the ER lumen. This condition is termed ER stress. Recently, ER stress has been linked to neuronal death in various neurodeg...

journal_title：Antioxidants & redox signaling

authors： Saito A,Hino S,Murakami T,Kondo S,Imaizumi K

更新日期：2007-05-01 00:00:00

abstract：:Hypoxia and its corollaries pose both negative and positive pressures to multicellular eukaryotes. Evolutionarily, life developed under hypoxia, and the building blocks were established under conditions close to anaerobiosis; therefore, reason exists to expect that certain biologic processes may perform preferentially...

journal_title：Antioxidants & redox signaling

authors： Webster KA

更新日期：2007-09-01 00:00:00

abstract：:Cellular redox balance is vital in health and disease. In this Forum, we highlight the importance of reactive oxygen species (ROS) in the regulation of redox balance in different organ systems of the body and ROS contribution to the development of hypertension. The Forum examines interactions between oxidative and nit...

journal_title：Antioxidants & redox signaling

authors： Francis J,Davisson RL

更新日期：2014-01-01 00:00:00

abstract：SIGNIFICANCE:Sessile plants respond to oxidative stress caused by internal and external stimuli by producing diverse forms of enzymatic and nonenzymatic antioxidant molecules. Peroxiredoxins (Prxs) in plants, including the Prx1, Prx5, Prx6, and PrxQ isoforms, constitute a family of antioxidant enzymes and play importan...

journal_title：Antioxidants & redox signaling

authors： Lee ES,Kang CH,Park JH,Lee SY

更新日期：2018-03-01 00:00:00

abstract：SIGNIFICANCE:Extranuclear sirtuins in cytosol (SIRT2) and mitochondria (SIRT3, SIRT4, and SIRT5) are key regulators of metabolic enzymes and the antioxidative defense mechanisms. They play an important role in the adjustment of metabolic pathways in alterations of the nutritional status. Recent Advances: Recent studies...

journal_title：Antioxidants & redox signaling

authors： Elkhwanky MS,Hakkola J

更新日期：2018-03-10 00:00:00

abstract：:The role of free radicals in aging has been a long-standing theory that has now been extended to include both reactive oxygen and nitrogen species. The original concepts that overwhelming oxidative stress depleted antioxidants and thus damaged intracellular targets is being supplanted by the hypothesis that the reacti...

journal_title：Antioxidants & redox signaling

authors： Darley-Usmar V,Starke-Reed PE

更新日期：2000-10-01 00:00:00

abstract：SIGNIFICANCE:Selenoprotein K (SelK) is an endoplasmic reticulum (ER) membrane protein, and its expression is sensitive to dietary selenium levels. A recently described role for SelK as a cofactor in catalyzing protein palmitoylation reactions provides an important link between low dietary selenium intake and suboptimal...

journal_title：Antioxidants & redox signaling

authors： Fredericks GJ,Hoffmann PR

更新日期：2015-10-01 00:00:00

abstract：SIGNIFICANCE:Reactive oxygen species (ROS) are not only essential for the cell's normal functions, but also mediate many pathological effects. When cells experience oxidative stress, proteins are modulated by redox changes and ultimately generate novel signaling patterns. It remains elusive how proteins are modulated, ...

journal_title：Antioxidants & redox signaling

authors： Wang Y,Yang J,Yi J

更新日期：2012-04-01 00:00:00

abstract：SIGNIFICANCE:Many cardiovascular disorders are accompanied by a deregulated cellular redox balance resulting in elevated levels of intracellular reactive oxygen species (ROS). One major antioxidative cellular molecule is thioredoxin-1 (Trx-1). Its indispensability is demonstrated by the embryonic lethality of Trx-1 def...

journal_title：Antioxidants & redox signaling

authors： Zschauer TC,Matsushima S,Altschmied J,Shao D,Sadoshima J,Haendeler J

更新日期：2013-03-20 00:00:00

abstract：: Significance: Humans cannot synthesize ascorbic acid (AscH2) (vitamin C), so deficiencies in dietary AscH2 cause the life-threatening disease of scurvy and many other diseases. After oral ingestion, plasma AscH2 concentrations are strictly controlled by transporters, which...

journal_title：Antioxidants & redox signaling

authors： Pozzer D,Invernizzi RW,Blaauw B,Cantoni O,Zito E

更新日期：2020-01-22 00:00:00

abstract：AIMS:Carbon monoxide (CO)-releasing molecules (CORMs) are candidates for animal and antimicrobial therapeutics. We aimed to probe the antimicrobial potential of a novel manganese CORM. RESULTS:[Mn(CO)4S2CNMe(CH2CO2H)], CORM-401, inhibits growth of Escherichia coli and several antibiotic-resistant clinical pathogens. C...

journal_title：Antioxidants & redox signaling

authors： Wareham LK,McLean S,Begg R,Rana N,Ali S,Kendall JJ,Sanguinetti G,Mann BE,Poole RK

更新日期：2018-05-10 00:00:00

abstract：:Disruption of the oxidant/antioxidant balance in the lung is thought to be a key step in the development of many airway pathologies. Hence, antioxidant enzymes play key roles in controlling or preventing pulmonary diseases related to oxidative stress. The superoxide dismutases (SOD) are a family of enzymes that play a...

journal_title：Antioxidants & redox signaling

authors： Gao F,Kinnula VL,Myllärniemi M,Oury TD

更新日期：2008-02-01 00:00:00

abstract：:Methamphetamine (METH) increases the oxidative DNA lesion 8-oxoguanine (8-oxoG) in fetal mouse brain, and causes postnatal motor coordination deficits after in utero exposure. Like oxoguanine glycosylase 1 (OGG1), the Cockayne syndrome B (CSB) protein is involved in the repair of oxidatively damaged DNA, although its ...

journal_title：Antioxidants & redox signaling

authors： McCallum GP,Wong AW,Wells PG

更新日期：2011-03-01 00:00:00

abstract：:The 6(th) COSTAM/SFRR (ASEAN/Malaysia) workshop, "Micronutrients, Oxidative Stress, and the Environment," was held from June 29 to July 2 at Holiday Inn Damai Beach Resort in Kuching, Sarawak. Two hundred twenty participants from 17 countries presented recent advances on natural antioxidants in the area of oxidative s...

journal_title：Antioxidants & redox signaling

authors： Nesaretnam K,Sies H

更新日期：2006-11-01 00:00:00

abstract：:Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•-) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aortic endothelial cells, ...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Jen N,Ai L,Hamilton R,Wang S,Holmes K,Dharbandi F,Khalsa B,Bressler S,Barr ML,Li R,Hsiai TK

更新日期：2011-09-01 00:00:00

abstract：:The signaling networks that mediate activation, proliferation, or programmed cell death of T lymphocytes are dependent on complex redox and metabolic pathways. T lymphocytes are primarily activated through the T-cell receptor and co-stimulatory molecules. Although activation results in lymphokine production, prolifera...

journal_title：Antioxidants & redox signaling

authors： Perl A,Gergely P Jr,Puskas F,Banki K

更新日期：2002-06-01 00:00:00

abstract：SIGNIFICANCE:Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to posttranslational modifications of proteins or the production of second messengers. Either as a primary cause or as a secondary component of the pat...

journal_title：Antioxidants & redox signaling

authors： Pehar M,Harlan BA,Killoy KM,Vargas MR

更新日期：2018-06-20 00:00:00

abstract：:Protection of ischemic myocardium is an important unmet need in reperfusion therapy of acute myocardial infarction. Myocardial ischemia and reperfusion induce necrosis and apoptosis in cardiomyocytes. Caspase processing and activation are critical steps in most receptor and nonreceptor pathways of apoptosis. Caspase i...

journal_title：Antioxidants & redox signaling

authors： Li HL,Karwatowska-Prokopczuk E,Mutomba M,Wu J,Karanewsky D,Valentino K,Engler RL,Gottlieb RA

更新日期：2001-02-01 00:00:00

abstract：:Cardiac surgery is associated with release of the pleiotropic cytokine macrophage migration inhibitory factor (MIF). The trigger for MIF release has not yet been elucidated. Owing to its intrinsic antioxidative activity, MIF might reduce oxidative stress and protect from myocardial ischemia and reperfusion (I/R) injur...

journal_title：Antioxidants & redox signaling

authors： Stoppe C,Werker T,Rossaint R,Dollo F,Lue H,Wonisch W,Menon A,Goetzenich A,Bruells CS,Coburn M,Kopp R,Bucala R,Bernhagen J,Rex S

更新日期：2013-07-20 00:00:00

abstract：: Aims: Nuclear factor (erythroid-derived 2)-like-2 factor (NRF-2) is a transcription factor well known to provide an advantage for cancer growth and survival regulating the cellular redox pathway. In breast cancer cells, we recently identified the monomeric heme-globin neur...

journal_title：Antioxidants & redox signaling

authors： Solar Fernandez V,Cipolletti M,Ascenzi P,Marino M,Fiocchetti M

更新日期：2020-02-01 00:00:00

abstract：:Lipoic acid (LA) and its reduced product dihydrolipoic acid (DHLA) are potent antioxidants with capacity to scavenge reactive oxygen species (ROS) and recycle endogenous antioxidants. LA may increase cellular glutathione (GSH), an antioxidant lacking in the lung's epithelial lining fluid in lung disorders such as idio...

journal_title：Antioxidants & redox signaling

authors： O'Neill HC,Rancourt RC,White CW

更新日期：2008-02-01 00:00:00

abstract：: Significance: Since the discovery of vascular stem cells, there has been considerable advancement in comprehending the nature and functions of these cells. Due to their differentiation potential to repair endothelial cells and to participate in lesion formation during vasc...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Sun X,Deng J,Hu Y,Xu Q

更新日期：2021-01-19 00:00:00

abstract：:Carica papaya Linn is widely known as a medicinal fruit. We sought to study a standardized fermented papaya preparation (FPP) for its effects on wound healing in adult obese diabetic (db/db) mice. FPP blunted the gain in blood glucose and improved the lipid profile after 8 weeks of oral supplementation. However, FPP d...

journal_title：Antioxidants & redox signaling

authors： Collard E,Roy S

更新日期：2010-09-01 00:00:00

abstract：SIGNIFICANCE:Pyridine dinucleotides, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), were discovered more than 100 years ago as necessary cofactors for fermentation in yeast extracts. Since that time, these molecules have been recognized as fundamental players in a variet...

journal_title：Antioxidants & redox signaling

authors： Fessel JP,Oldham WM

更新日期：2018-01-20 00:00:00

abstract：:Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium i...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Morel S,Berthonneche C,Toufektsian MC,de Lorgeril M,Ducros V,Tosaki A,de Leiris J,Boucher F

更新日期：2004-08-01 00:00:00

abstract：SIGNIFICANCE:Understanding isoform- and context-specific subcellular Nox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase compartmentalization allows relevant functional inferences. This review addresses the interplay between Nox NADPH oxidases and the endoplasmic reticulum (ER), an increasingly evid...

journal_title：Antioxidants & redox signaling

authors： Laurindo FR,Araujo TL,Abrahão TB

更新日期：2014-06-10 00:00:00