Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease.

abstract：AIMS:Glutathione peroxidase (GPX) mimic ebselen and superoxide dismutase (SOD) mimic copper diisopropylsalicylate (CuDIPs) were used to rescue impaired glucose-stimulated insulin secretion (GSIS) in islets of GPX1 and(or) SOD1-knockout mice. RESULTS:Ebselen improved GSIS in islets of all four tested genotypes. The res...

journal_title：Antioxidants & redox signaling

authors： Wang X,Yun JW,Lei XG

更新日期：2014-01-10 00:00:00

abstract：AIMS:Mesenchymal stromal cells (MSCs) are heterogeneous cells from adult tissues that are able to differentiate in vitro into adipocytes, osteoblasts, or chondrocytes. Such cells are widely studied in regenerative medicine. However, the success of cellular therapy depends on the cell survival. Heme oxygenase-1 (HO-1, e...

journal_title：Antioxidants & redox signaling

authors： Nowak WN,Taha H,Kachamakova-Trojanowska N,Stępniewski J,Markiewicz JA,Kusienicka A,Szade K,Szade A,Bukowska-Strakova K,Hajduk K,Klóska D,Kopacz A,Grochot-Przęczek A,Barthenheier K,Cauvin C,Dulak J,Józkowicz A

更新日期：2018-07-10 00:00:00

abstract：:Liver fibrosis is the consequence of chronic liver injury of any etiology. When advanced, fibrosis causes portal hypertension and liver insufficiency, and is a risk factor for developing hepatocellular carcinoma. In the last decade, there have been major advances in the knowledge of the pathogenesis of hepatic fibrosi...

journal_title：Antioxidants & redox signaling

authors： Bataller R,Sancho-Bru P,Ginès P,Brenner DA

更新日期：2005-09-01 00:00:00

abstract：:The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calor...

journal_title：Antioxidants & redox signaling

authors： Redman LM,Ravussin E

更新日期：2011-01-15 00:00:00

abstract：:A model has been developed for the hemopexin receptor-mediated heme transport system based on iron uptake in yeast. Two steps are required: reduction followed by oxidation by a multi-copper-oxidase. Furthermore, in the hemopexin system, the surface redox events have been linked with gene regulation. The impermeable Cu...

journal_title：Antioxidants & redox signaling

authors： Sung L,Shibata M,Eskew JD,Shipulina N,Morales PJ,Smith A

更新日期：2000-01-01 00:00:00

abstract：SIGNIFICANCE:Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling mechanism triggered by Ca2+ depletion of the endoplasmic reticulum (ER) and by a variety of cellular stresses. Reactive oxygen species (ROS) are often concomitantly produced in response to these stresses, however, the relationship between redo...

journal_title：Antioxidants & redox signaling

authors： Nunes P,Demaurex N

更新日期：2014-08-20 00:00:00

abstract：:Extensive literature exists supporting a role for mitochondrial dysfunction and oxidative damage in the pathogenesis of Alzheimer's disease. Mitochondria are a major source of intracellular reactive oxygen species and are particularly vulnerable to oxidative stress. This review discusses evidence supporting the notion...

journal_title：Antioxidants & redox signaling

authors： Moreira PI,Santos MS,Oliveira CR

更新日期：2007-10-01 00:00:00

abstract：:Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glyco...

journal_title：Antioxidants & redox signaling

authors： Abdel-Fatah T,Arora A,Gorguc I,Abbotts R,Beebeejaun S,Storr S,Mohan V,Hawkes C,Soomro I,Lobo DN,Parsons SL,Madhusudan S

更新日期：2013-06-20 00:00:00

abstract：:Intestinal detection of nutrients is a crucial step to inform the whole body of the nutritional status. In this paradigm, peripheral information generated by nutrients is transferred to the brain, which in turn controls physiological functions, including glucose metabolism. Here, we investigated the effect of enteric ...

journal_title：Antioxidants & redox signaling

authors： Duparc T,Naslain D,Colom A,Muccioli GG,Massaly N,Delzenne NM,Valet P,Cani PD,Knauf C

更新日期：2011-02-01 00:00:00

abstract：:Zinc/cysteine coordination environments in proteins are redox-active. Oxidation of the sulfur ligands mobilizes zinc, while reduction of the oxidized ligands enhances zinc binding, providing redox control over the availability of zinc ions. Some zinc proteins are redox sensors, in which zinc release is coupled to conf...

journal_title：Antioxidants & redox signaling

authors： Maret W

更新日期：2006-09-01 00:00:00

abstract：: Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and they constitute an ever-growing global burden that has a c...

journal_title：Antioxidants & redox signaling

authors： Gianazza E,Brioschi M,Martinez Fernandez A,Casalnuovo F,Altomare A,Aldini G,Banfi C

更新日期：2021-01-01 00:00:00

abstract：:This work rests on our previous report (J Cereb Blood Flow Metab 30: 1275-1287, 2010) recognizing that glutamate (Glu) oxaloacetate transaminase (GOT) is induced when brain tissue hypoxia is corrected during acute ischemic stroke (AIS). GOT can metabolize Glu into tricarboxylic acid cycle intermediates and may therefo...

journal_title：Antioxidants & redox signaling

authors： Rink C,Gnyawali S,Peterson L,Khanna S

更新日期：2011-05-15 00:00:00

abstract：:NADPH oxidase is known to modulate the arterial tone, but the role of its specific subunits is still unclear. The objective of this study was to compare the role of p47 and gp91phox (NOX2) on artery dilatation. We conducted a multicenter study enrolling 30 patients with chronic granulomatous disease (CGD) (25 with NOX...

journal_title：Antioxidants & redox signaling

authors： Loffredo L,Carnevale R,Sanguigni V,Plebani A,Rossi P,Pignata C,De Mattia D,Finocchi A,Martire B,Pietrogrande MC,Martino S,Gambineri E,Giardino G,Soresina AR,Martino F,Pignatelli P,Violi F

更新日期：2013-04-20 00:00:00

abstract：:The herbicide paraquat (PQ) has been implicated as a potential risk factor for the development of Parkinson's disease. In this study, PQ (0.5-1 microM) was shown to be selectively toxic to dopaminergic (DA) neurons through the activation of microglial NADPH oxidase and the generation of superoxide. Neuron-glia culture...

journal_title：Antioxidants & redox signaling

authors： Wu XF,Block ML,Zhang W,Qin L,Wilson B,Zhang WQ,Veronesi B,Hong JS

更新日期：2005-05-01 00:00:00

abstract：:Epidemiological studies have shown that advancing age is associated with an increased prevalence of cardiovascular disease (CVD). Vascular smooth muscle cells (VSMC) comprise the major arterial cell population, and changes in VSMC behavior, function, and redox status with age contribute to alterations in vascular remo...

journal_title：Antioxidants & redox signaling

authors： Li M,Fukagawa NK

更新日期：2010-03-01 00:00:00

abstract：:Hypoxia is sensed by all mammalian cells and elicits a variety of adaptive and pathophysiological responses at the molecular and cellular level. For the pulmonary vasculature, hypoxia causes increased vasoconstriction and vessel-wall remodeling. These responses are mediated by complex intracellular cascades leading to...

journal_title：Antioxidants & redox signaling

authors： Kourembanas S

更新日期：2002-04-01 00:00:00

abstract：:Mitochondria contain two aqueous compartments: the matrix and the intermembrane space. Whereas many of the biologic functions of the matrix were well characterized in the past, it became clear very recently that the intermembrane space plays a pivotal role in the coordination of mitochondrial activities with other cel...

journal_title：Antioxidants & redox signaling

authors： Herrmann JM,Riemer J

更新日期：2010-11-01 00:00:00

abstract：:The endothelium is essential for the maintenance of vascular homeostasis. Central to this role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the endothelial isoform of nitric oxide synthase (eNOS). Endothelial dysfunction, manifested as impaired EDNO bioactivity, is an important early ev...

journal_title：Antioxidants & redox signaling

authors： Thomas SR,Witting PK,Drummond GR

更新日期：2008-10-01 00:00:00

abstract：:Trisulfides and other oligosulfides are widely distributed in the biological world. In plants, for example, garlic, trisulfides are associated with potentially beneficial properties. However, an extra neutral sulfur atom covalently bound between the two sulfur atoms of a pair of cysteines is not a common post-translat...

journal_title：Antioxidants & redox signaling

authors： Nielsen RW,Tachibana C,Hansen NE,Winther JR

更新日期：2011-07-01 00:00:00

abstract：:5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has become apparent that AMPK plays also an important role in long-term decisions that determine cell fate,...

journal_title：Antioxidants & redox signaling

authors： Weisová P,Dávila D,Tuffy LP,Ward MW,Concannon CG,Prehn JH

更新日期：2011-05-15 00:00:00

abstract：:Reductions in brain glucose metabolism and increased oxidative stress invariably occur in Alzheimer's disease (AD) and thiamine (vitamin B1) deficiency. Both conditions cause irreversible cognitive impairment; their behavioral consequences overlap but are not identical. Thiamine-dependent processes are critical in glu...

journal_title：Antioxidants & redox signaling

authors： Gibson GE,Blass JP

更新日期：2007-10-01 00:00:00

abstract：AIMS:Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the impact of targeted disruption of Txnrd2 on tumor growth. RESULTS:Tumor...

journal_title：Antioxidants & redox signaling

authors： Hellfritsch J,Kirsch J,Schneider M,Fluege T,Wortmann M,Frijhoff J,Dagnell M,Fey T,Esposito I,Kölle P,Pogoda K,Angeli JP,Ingold I,Kuhlencordt P,Östman A,Pohl U,Conrad M,Beck H

更新日期：2015-04-10 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：:The DNA base excision-repair pathway is responsible for the repair of DNA damage caused by oxidation/alkylation and protects cells against the effects of endogenous and exogenous agents. Removal of the damaged base creates a baseless (AP) site. AP endonuclease1 (Ape1) acts on this site to continue the BER-pathway repa...

journal_title：Antioxidants & redox signaling

authors： Luo M,Delaplane S,Jiang A,Reed A,He Y,Fishel M,Nyland RL 2nd,Borch RF,Qiao X,Georgiadis MM,Kelley MR

更新日期：2008-11-01 00:00:00

abstract：:Increased free radical generation and decreased efficiency of the reparative/degradative mechanisms both primarily contribute to age-related elevation in the level of oxidative stress and brain damage. Excess formation of reactive oxygen and nitrogen species can cause proteasomal dysfunction and protein overloading. T...

journal_title：Antioxidants & redox signaling

authors： Calabrese V,Butterfield DA,Scapagnini G,Stella AM,Maines MD

更新日期：2006-03-01 00:00:00

abstract：:From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemis...

journal_title：Antioxidants & redox signaling

authors： San Martin A,Griendling KK

更新日期：2014-06-10 00:00:00

abstract：:The application of electronic structure methods to the prediction of geometries, spin densities, and hyperfine couplings for biologically relevant quinones and semiquinones is reviewed. It is demonstrated that hybrid-type density functional methods are particularly suitable for such studies. Hydrogen bonding to the se...

journal_title：Antioxidants & redox signaling

authors： O'Malley PJ

更新日期：2001-10-01 00:00:00

abstract：: Aims: Hemangioendothelioma (HE) may be benign or malignant. Mouse hemangioendothelioma endothelial (EOMA) cells are validated to study mechanisms in HE. This work demonstrates that EOMA cells heavily rely on mitochondria to thrive. Thus, a combination therapy, including we...

journal_title：Antioxidants & redox signaling

authors： Gordillo GM,Biswas A,Singh K,Sen A,Guda PR,Miller C,Pan X,Khanna S,Cadenas E,Sen CK

更新日期：2021-01-10 00:00:00

abstract：:Ischemia followed by reperfusion is the primary cause of tissue injury and infarction during heart attack and stroke. The initiating stimulus is believed to involve reactive oxygen species that are produced during reperfusion when electron transport resumes in the mitochondria after suppression by ischemia. Programmed...

journal_title：Antioxidants & redox signaling

authors： Webster KA,Graham RM,Thompson JW,Spiga MG,Frazier DP,Wilson A,Bishopric NH

更新日期：2006-09-01 00:00:00

abstract：SIGNIFICANCE:Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects ∼8% of the adult population worldwide. Pancreatic beta-cell dysfunction and loss are central to the disease process, although understanding of the underlying molecular mechanisms is still fragment...

journal_title：Antioxidants & redox signaling

authors： Gerber PA,Rutter GA

更新日期：2017-04-01 00:00:00