Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.

abstract：:Enhanced production of reactive oxygen species (ROS) such as H(2)O(2) and a failure in ROS removal by scavenging systems are hallmarks of several cardiovascular diseases such as atherosclerosis and hypertension. ROS act as second messengers that play a prominent role in intracellular signaling and cellular function. I...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S

更新日期：2003-12-01 00:00:00

abstract：:The phagocytic NADPH oxidase is recognized as a critical component of innate immunity, responsible for generation of microbicidal reactive oxygen species (ROS). This enzyme is one representative of the Nox family of oxidases (Nox1-Nox5, Duox1, and Duox2) that exhibit diverse expression patterns and appear to serve a v...

journal_title：Antioxidants & redox signaling

authors： Leto TL,Geiszt M

更新日期：2006-09-01 00:00:00

abstract：AIM:TNF (tumor necrosis factor)-related apoptosis-inducing ligand (TRAIL), is a selective killer of tumor cells, although its potential is limited by the development of resistance. In this article, we investigated whether the polyherbal preparation Zyflamend(®) can sensitize tumor cells to TRAIL. RESULTS:We found that...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Park B,Gupta SC,Kannappan R,Sung B,Aggarwal BB

更新日期：2012-03-01 00:00:00

abstract：:Insulin resistance is a major causative factor for type 2 diabetes and is associated with increased risk of cardiovascular disease. Despite intense investigation for a number of years, molecular mechanisms underlying insulin resistance remain to be determined. Recently, chronic inflammation has been highlighted as a c...

journal_title：Antioxidants & redox signaling

authors： Kaneki M,Shimizu N,Yamada D,Chang K

更新日期：2007-03-01 00:00:00

abstract：:Although the essential role of selenium for cellular immune responses is obvious, delineation of the functions is lacking because selenium can either promote or inhibit cell growth, cytokine production, and activation of transcription factor nuclear factor-kappaB (NF-kappaB). Studies with human thioredoxin-1 (Trx-1)-t...

journal_title：Antioxidants & redox signaling

authors： Ueno H,Kajihara H,Nakamura H,Yodoi J,Nakamuro K

更新日期：2007-01-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthe...

journal_title：Antioxidants & redox signaling

authors： Bendall JK,Douglas G,McNeill E,Channon KM,Crabtree MJ

更新日期：2014-06-20 00:00:00

abstract：:Ischemia followed by reperfusion is the primary cause of tissue injury and infarction during heart attack and stroke. The initiating stimulus is believed to involve reactive oxygen species that are produced during reperfusion when electron transport resumes in the mitochondria after suppression by ischemia. Programmed...

journal_title：Antioxidants & redox signaling

authors： Webster KA,Graham RM,Thompson JW,Spiga MG,Frazier DP,Wilson A,Bishopric NH

更新日期：2006-09-01 00:00:00

abstract：:The application of electronic structure methods to the prediction of geometries, spin densities, and hyperfine couplings for biologically relevant quinones and semiquinones is reviewed. It is demonstrated that hybrid-type density functional methods are particularly suitable for such studies. Hydrogen bonding to the se...

journal_title：Antioxidants & redox signaling

authors： O'Malley PJ

更新日期：2001-10-01 00:00:00

abstract：SIGNIFICANCE:Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to posttranslational modifications of proteins or the production of second messengers. Either as a primary cause or as a secondary component of the pat...

journal_title：Antioxidants & redox signaling

authors： Pehar M,Harlan BA,Killoy KM,Vargas MR

更新日期：2018-06-20 00:00:00

abstract：AIMS:Astrocytes have been revealed as a controller of synaptic plasticity and memory via releasing gliotransmitters. Our recent findings showed that reactive sulfur species (RSS), including hydrogen sulfide (H2S) and polysulfide (H2Sn), regulated the availability of d-serine, which is a well-known gliotransmitter that ...

journal_title：Antioxidants & redox signaling

authors： Luo H,Wu PF,Han QQ,Cao Y,Deng SL,Wang J,Deng Q,Wang F,Chen JG

更新日期：2019-06-01 00:00:00

abstract：:The ability to couple photosynthetic electron transport and redox poise to plastid gene expression enables plants to respond to environmental conditions and coordinate nuclear and chloroplast activities in order to maintain photosynthetic efficiency. The plastid redox regulatory system serves as a paradigm for underst...

journal_title：Antioxidants & redox signaling

authors： Barnes D,Mayfield SP

更新日期：2003-02-01 00:00:00

abstract：AIMS:Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychiatric diseases. NADPH oxidases (NOXs) are a major so...

journal_title：Antioxidants & redox signaling

authors： Colaianna M,Schiavone S,Zotti M,Tucci P,Morgese MG,Bäckdahl L,Holmdahl R,Krause KH,Cuomo V,Trabace L

更新日期：2013-04-20 00:00:00

abstract：:Endoplasmic reticulum (ER) stress induces an adaptive program called the unfolded protein response (UPR), which affects activity of an array of kinases and transcription factors. Previous reports provided evidence for activation of nuclear factor-kappaB (NF-kappaB), the major transcription factor regulating inflammato...

journal_title：Antioxidants & redox signaling

authors： Kitamura M

更新日期：2009-09-01 00:00:00

abstract：: Aims: Endothelial dysfunction appears in early diabetes mellitus partially because of epidermal growth factor receptor (EGFR) abnormal activation and downstream oxidative stress. The aim of this study was to determine whether Y396, a synthesized analog of rhynchophylline, ...

journal_title：Antioxidants & redox signaling

authors： Wang ZJ,Chang LL,Wu J,Pan HM,Zhang QY,Wang MJ,Xin XM,Luo SS,Chen JA,Gu XF,Guo W,Zhu YZ

更新日期：2020-04-10 00:00:00

abstract：SIGNIFICANCE:Chagas disease (CD) affects several million people in Latin America and is spreading beyond its classical boundaries due to the migration of infected host and insect vectors, HIV co-infection, and blood transfusion. The current therapy is not adequate for treatment of the chronic phase of CD, and new drugs...

journal_title：Antioxidants & redox signaling

authors： Piacenza L,Peluffo G,Alvarez MN,Martínez A,Radi R

更新日期：2013-09-01 00:00:00

abstract：AIMS:Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases involved in oxidant defense and signal transduction. Despite much study, the precise roles of conserved residues remain poorly defined. In this study, we carried out extensive functional and structural characterization of 10 variants of such residues ...

journal_title：Antioxidants & redox signaling

authors： Nelson KJ,Perkins A,Van Swearingen AED,Hartman S,Brereton AE,Parsonage D,Salsbury FR Jr,Karplus PA,Poole LB

更新日期：2018-03-01 00:00:00

abstract：:The Arc two-component system is a complex signal transduction system that plays a key role in regulating energy metabolism at the level of transcription in bacteria. This system comprises the ArcB protein, a tripartite membrane-associated sensor kinase, and the ArcA protein, a typical response regulator. Under anoxic ...

journal_title：Antioxidants & redox signaling

authors： Malpica R,Sandoval GR,Rodríguez C,Franco B,Georgellis D

更新日期：2006-05-01 00:00:00

abstract：:Free-radicals and other reactive oxygen species (ROS) have been implicated as being major damaging species in pathology and they have been widely investigated. Using 1,1'-diphenyl-2-picrylhydrazyl (DPPH), we estimated total free radical scavenging activity in the low-molecular-weight nonenzymatic fraction (LMNEF) of h...

journal_title：Antioxidants & redox signaling

authors： Atsumi T,Iwakura I,Kashiwagi Y,Fujisawa S,Ueha T

更新日期：1999-01-01 00:00:00

abstract：SIGNIFICANCE:The rising global prevalence of diabetes and its debilitating complications give rise to significant disability and premature mortality. Due to the silent nature of diabetes and its vascular complications, and limitations in current methods for detection, there is a need for novel biomarkers for early dete...

journal_title：Antioxidants & redox signaling

authors： Fan B,Luk AOY,Chan JCN,Ma RCW

更新日期：2018-10-10 00:00:00

abstract：SIGNIFICANCE:There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated a...

journal_title：Antioxidants & redox signaling

authors： Alexandrou AT,Li JJ

更新日期：2014-03-20 00:00:00

abstract：:Increased oxidative stress and impaired heat shock protein (HSP) synthesis may contribute to diabetic nephropathy. The question of whether 8-week thiol antioxidant alpha-lipoic acid (LA) supplementation modulates HSP response and oxidative stress was studied in the kidney of streptozotocin-induced diabetic (SID) and n...

journal_title：Antioxidants & redox signaling

authors： Oksala NK,Lappalainen J,Laaksonen DE,Khanna S,Kaarniranta K,Sen CK,Atalay M

更新日期：2007-04-01 00:00:00

abstract：SIGNIFICANCE:Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific comm...

journal_title：Antioxidants & redox signaling

authors： Parrow NL,Leshin JA,Levine M

更新日期：2013-12-10 00:00:00

abstract：:The cellular redox state is associated with major cellular processes including differentiation, transformation, and apoptosis. Glutaredoxin 2 (Grx2) is a mitochondrial oxidoreductase suggested to play a critical role in protection against apoptotic stimuli. An alternative Grx2 transcript variant encoding a nonmitochon...

journal_title：Antioxidants & redox signaling

authors： Lönn ME,Hudemann C,Berndt C,Cherkasov V,Capani F,Holmgren A,Lillig CH

更新日期：2008-03-01 00:00:00

abstract：: Aims: In this study, we investigate the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune diseases. We focus on oxidative regulation at the interaction between antigen-presenting cells (APCs) and T cells, and consequent effect of ROS a...

journal_title：Antioxidants & redox signaling

authors： Zhong J,Yau ACY,Holmdahl R

更新日期：2020-01-20 00:00:00

abstract：:Cells oxidize molecules to generate energy and to make the materials to build and support the structures and functions needed for life. However, unwanted oxidations can damage these same structures and impair function. Lipids (the lipids in membranes and lipoproteins) are targets of unwanted oxidations. The primary me...

journal_title：Antioxidants & redox signaling

authors： Venkataraman S,Schafer FQ,Buettner GR

更新日期：2004-06-01 00:00:00

abstract：:Cellular compartments differ dramatically in their redox potentials. This translates directly into variations in the extent of disulfide bond formation within proteins, depending on their cellular localization. It has long been assumed that proteins that are present in the reducing environment of the cytosol do not po...

journal_title：Antioxidants & redox signaling

authors： Linke K,Jakob U

更新日期：2003-08-01 00:00:00

abstract：:Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium i...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Morel S,Berthonneche C,Toufektsian MC,de Lorgeril M,Ducros V,Tosaki A,de Leiris J,Boucher F

更新日期：2004-08-01 00:00:00

abstract：SIGNIFICANCE:Half a century of research provided unambiguous proof that superoxide and species derived from it-reactive oxygen species (ROS)-play a central role in many diseases and degenerative processes. This stimulated the search for pharmaceutical agents that are capable of preventing oxidative damage, and methods ...

journal_title：Antioxidants & redox signaling

authors： Tovmasyan A,Reboucas JS,Benov L

更新日期：2014-05-20 00:00:00

abstract：:Reactive oxygen species (ROS) can directly induce or enhance tumor necrosis factor (TNF)-mediated apoptosis in a number of different cell lines. To test the relevance of intracellular ROS in modulating apoptotic signaling in vivo, we evaluated hepatocellular apoptosis mediated by the TNF or Fas receptor in wild-type a...

journal_title：Antioxidants & redox signaling

authors： Bajt ML,Ho YS,Vonderfecht SL,Jaeschke H

更新日期：2002-10-01 00:00:00

abstract：: Aims: Clinical use of cisplatin (Cisp), one of the most widely used, common, and effective chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Previous studies suggest that hydrogen sulfide (H2S) alleviates Cisp-i...

journal_title：Antioxidants & redox signaling

authors： Yuan Y,Zhu L,Li L,Liu J,Chen Y,Cheng J,Peng T,Lu Y

更新日期：2019-12-01 00:00:00