Tetrahydrobiopterin in cardiovascular health and disease.

abstract：:Apoptosis is a highly regulated process essential for the development and homeostasis of multicellular organisms. Whereas caspases, a large family of intracellular cysteine proteases, play central roles in the execution of apoptosis, other proapoptotic and antiapoptotic regulators such as the members of the Bcl-2 fami...

journal_title：Antioxidants & redox signaling

authors： Takeda K,Naguro I,Nishitoh H,Matsuzawa A,Ichijo H

更新日期：2011-08-01 00:00:00

abstract：:Neutrophils have a short half-life and high tendency to undergo apoptosis. One feature that may influence these characteristics is the antioxidant/oxidant balance of these cells. There are few studies on the levels of antioxidant enzymes in human neutrophils. We have analyzed by immunohistochemistry of paraffin-embedd...

journal_title：Antioxidants & redox signaling

authors： Kinnula VL,Soini Y,Kvist-Mäkelä K,Savolainen ER,Koistinen P

更新日期：2002-02-01 00:00:00

abstract：:Since the initial report of nitric oxide (NO) activity, enormous progress has been made over the last two decades in the field of NO research. Whereas most physiological responses triggered by moderate concentrations of NO are mediated by soluble guanylate cyclase activation and the subsequent production of cyclic GMP...

journal_title：Antioxidants & redox signaling

authors： Donnini S,Ziche M

更新日期：2002-10-01 00:00:00

abstract：:The decision to remove or refold oxidized, denatured, or misfolded proteins by heat shock protein 70 and its binding partners is critical to determine cell fate under pathophysiological conditions. Overexpression of the ubiquitin ligase C-terminus of HSC70 interacting protein (CHIP) can compensate for failure of other...

journal_title：Antioxidants & redox signaling

authors： Stankowski JN,Zeiger SL,Cohen EL,DeFranco DB,Cai J,McLaughlin B

更新日期：2011-05-15 00:00:00

abstract：:Reductions in brain glucose metabolism and increased oxidative stress invariably occur in Alzheimer's disease (AD) and thiamine (vitamin B1) deficiency. Both conditions cause irreversible cognitive impairment; their behavioral consequences overlap but are not identical. Thiamine-dependent processes are critical in glu...

journal_title：Antioxidants & redox signaling

authors： Gibson GE,Blass JP

更新日期：2007-10-01 00:00:00

abstract：SIGNIFICANCE:Abnormal lung development in the perinatal period can result in severe neonatal complications, including persistent pulmonary hypertension (PH) of the newborn and bronchopulmonary dysplasia. Reactive oxygen species (ROS) play a substantive role in the development of PH associated with these diseases. ROS i...

journal_title：Antioxidants & redox signaling

authors： Wedgwood S,Steinhorn RH

更新日期：2014-11-01 00:00:00

abstract：AIMS:Mesenchymal stromal cells (MSCs) are heterogeneous cells from adult tissues that are able to differentiate in vitro into adipocytes, osteoblasts, or chondrocytes. Such cells are widely studied in regenerative medicine. However, the success of cellular therapy depends on the cell survival. Heme oxygenase-1 (HO-1, e...

journal_title：Antioxidants & redox signaling

authors： Nowak WN,Taha H,Kachamakova-Trojanowska N,Stępniewski J,Markiewicz JA,Kusienicka A,Szade K,Szade A,Bukowska-Strakova K,Hajduk K,Klóska D,Kopacz A,Grochot-Przęczek A,Barthenheier K,Cauvin C,Dulak J,Józkowicz A

更新日期：2018-07-10 00:00:00

abstract：:Intraorgan communication in the cardiovascular system is exerted not only by direct cell-cell contacts but also by locally released factors, which modulate neighboring cells by paracrine signals (e.g., NO, vascular endothelial growth factor, adenosine, reactive oxygen species). Moreover, cells in close proximity to th...

journal_title：Antioxidants & redox signaling

authors： Gödecke A,Haendeler J

更新日期：2017-04-20 00:00:00

abstract：:The small GTPase rac1 controls actin redistribution to membrane ruffles in fibroblasts and other cell types, as well as the activation of the NADPH oxidase in phagocytes. We explored the possibility that these two processes could be related. We used a replication-deficient adenoviral vector to overexpress the constitu...

journal_title：Antioxidants & redox signaling

authors： Moldovan L,Irani K,Moldovan NI,Finkel T,Goldschmidt-Clermont PJ

更新日期：1999-04-01 00:00:00

abstract：:In response to tissue damage and inflammation induced by a variety of xenobiotics including acetaminophen, carbon tetrachloride, ethanol, galactosamine, and endotoxin, as well as disease states such as viral hepatitis, and postischemic and regenerative injury, the liver produces large quantities of nitric oxide. Indee...

journal_title：Antioxidants & redox signaling

authors： Laskin JD,Heck DE,Gardner CR,Laskin DL

更新日期：2001-04-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to regulate a variety of physiological functions, including vascular tone. The inhibition of NO synthase by N(omega)-nitro-L-arginine methyl ester (L-NAME) has been reported to increase arterial blood pressure. The present studies were undertaken to investigate if the increased blood p...

journal_title：Antioxidants & redox signaling

authors： Anand-Srivastava MB,Di Fusco F

更新日期：2004-04-01 00:00:00

abstract：AIMS:S-glutathionylation of cysteine residues, catalyzed by glutathione S-transferase Pi (GSTP), alters structure/function characteristics of certain targeted proteins. Our goal is to characterize how S-glutathionylation of proteins within the endoplasmic reticulum (ER) impact cell sensitivity to ER-stress inducing dru...

journal_title：Antioxidants & redox signaling

authors： Ye ZW,Zhang J,Ancrum T,Manevich Y,Townsend DM,Tew KD

更新日期：2017-02-20 00:00:00

abstract：:Zinc/cysteine coordination environments in proteins are redox-active. Oxidation of the sulfur ligands mobilizes zinc, while reduction of the oxidized ligands enhances zinc binding, providing redox control over the availability of zinc ions. Some zinc proteins are redox sensors, in which zinc release is coupled to conf...

journal_title：Antioxidants & redox signaling

authors： Maret W

更新日期：2006-09-01 00:00:00

abstract：:Vascular complications in diabetes are a significant source of human morbidity and mortality, affecting multiple organ systems and persisting despite tight glucose control. Many of these complications can be linked to impairments in vasculogenesis, the process by which circulating and bone marrow-derived endothelial p...

journal_title：Antioxidants & redox signaling

authors： Callaghan MJ,Ceradini DJ,Gurtner GC

更新日期：2005-11-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a fundamental process, paradigmatic of the concept of cell plasticity, that leads epithelial cells to lose their polarization and specialized junctional structures, to undergo cytoskeleton reorganization, and to acquire morphological and functional features of mesenchymal-...

journal_title：Antioxidants & redox signaling

authors： Cannito S,Novo E,di Bonzo LV,Busletta C,Colombatto S,Parola M

更新日期：2010-06-15 00:00:00

abstract：:Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents. After phosphorylation and dissociation from the cytoplasmic inhibitor, Kelch-...

journal_title：Antioxidants & redox signaling

authors： Cho HY,Reddy SP,Kleeberger SR

更新日期：2006-01-01 00:00:00

abstract：: Aims: In this study, we investigate the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune diseases. We focus on oxidative regulation at the interaction between antigen-presenting cells (APCs) and T cells, and consequent effect of ROS a...

journal_title：Antioxidants & redox signaling

authors： Zhong J,Yau ACY,Holmdahl R

更新日期：2020-01-20 00:00:00

abstract：SIGNIFICANCE:The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through...

journal_title：Antioxidants & redox signaling

authors： Sevilla E,Bes MT,González A,Peleato ML,Fillat MF

更新日期：2019-05-01 00:00:00

abstract：SIGNIFICANCE:Mitochondria are complex dynamic organelles pivotal for cellular physiology and human health. Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders. Furthermore, a decline in mitochondrial health is prevalent with...

journal_title：Antioxidants & redox signaling

authors： Bohovych I,Chan SS,Khalimonchuk O

更新日期：2015-04-20 00:00:00

abstract：:Oxidative stress plays a significant role in the pathogenesis of coronary artery disease (CAD). A p22(phox)-based NAD(P)H oxidase acts as a potent superoxide-generating system in the vasculature. We studied the association of the A640G and the C242T polymorphisms with clinical risk factors, endothelial function, and s...

journal_title：Antioxidants & redox signaling

authors： Zafari AM,Davidoff MN,Austin H,Valppu L,Cotsonis G,Lassègue B,Griendling KK

更新日期：2002-08-01 00:00:00

abstract：AIMS:Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to eliminate Her2high disease. RESULTS:We demonstrate that Her2high cells and t...

journal_title：Antioxidants & redox signaling

authors： Rohlenova K,Sachaphibulkij K,Stursa J,Bezawork-Geleta A,Blecha J,Endaya B,Werner L,Cerny J,Zobalova R,Goodwin J,Spacek T,Alizadeh Pesdar E,Yan B,Nguyen MN,Vondrusova M,Sobol M,Jezek P,Hozak P,Truksa J,Rohlena J,Do

更新日期：2017-01-10 00:00:00

abstract：:The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood. In this study, we investigated the effect of AngII on aortic smooth muscle from wild-type and NOX1-deficient mice. NOX1-deficient cells sho...

journal_title：Antioxidants & redox signaling

authors： Basset O,Deffert C,Foti M,Bedard K,Jaquet V,Ogier-Denis E,Krause KH

更新日期：2009-10-01 00:00:00

abstract：AIMS:Heart failure (HF) is characterized by regionalized contractile alterations resulting in loss of the transmural contractile gradient across the left ventricular free wall. We tested whether a regional alteration in mitochondrial oxidative metabolism during HF could affect myofilament function through protein kinas...

journal_title：Antioxidants & redox signaling

authors： Andre L,Fauconnier J,Reboul C,Feillet-Coudray C,Meschin P,Farah C,Fouret G,Richard S,Lacampagne A,Cazorla O

更新日期：2013-03-20 00:00:00

abstract：:Protein thiolation is elicited by oxidation by different mechanisms and is involved in a variety of biological processes. Thiols, protein SH (PSH) and non-protein SH groups (NPSH, namely GSH), are in competition in all biological environments in the regulation of oxidant homeostasis because oxidants thiolate proteins,...

journal_title：Antioxidants & redox signaling

authors： Di Simplicio P,Frosali S,Priora R,Summa D,Cherubini Di Simplicio F,Di Giuseppe D,Di Stefano A

更新日期：2005-07-01 00:00:00

abstract：:The endothelium is essential for the maintenance of vascular homeostasis. Central to this role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the endothelial isoform of nitric oxide synthase (eNOS). Endothelial dysfunction, manifested as impaired EDNO bioactivity, is an important early ev...

journal_title：Antioxidants & redox signaling

authors： Thomas SR,Witting PK,Drummond GR

更新日期：2008-10-01 00:00:00

abstract：AIMS:Endothelium-dependent vasorelaxation is mediated by endothelium-derived relaxing factor and endothelium-derived hyperpolarizing factor (EDHF). However, the molecular entity of EDHF remains unclear. The present study examined whether hydrogen sulfide (H₂S) acts as EDHF and how H₂S mediates EDHF pathways from endoth...

journal_title：Antioxidants & redox signaling

authors： Tang G,Yang G,Jiang B,Ju Y,Wu L,Wang R

更新日期：2013-11-10 00:00:00

abstract：AIMS:To evaluate mechanisms underlying modulation of inflammatory chemokines in primary human keratinocytes (normal human epidermal keratinocytes) and repair-related processes in wound models by plant polyphenols (PPs) with antioxidant and superoxide scavenging properties (verbascoside [Vb], resveratrol [Rv], polydatin...

journal_title：Antioxidants & redox signaling

authors： Pastore S,Lulli D,Fidanza P,Potapovich AI,Kostyuk VA,De Luca C,Mikhal'chik E,Korkina LG

更新日期：2012-02-15 00:00:00

abstract：SIGNIFICANCE:Cardiovascular diseases are the main cause of death worldwide and pose an immense economical burden. In most cases, the underlying problem is vascular occlusion by atherosclerotic plaques. Importantly, different cell types of the vascular wall and the immune system play crucial roles in atherosclerosis at ...

journal_title：Antioxidants & redox signaling

authors： Kohlgrüber S,Upadhye A,Dyballa-Rukes N,McNamara CA,Altschmied J

更新日期：2017-05-01 00:00:00

abstract：AIMS:Cystathionine β-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of three major enzymes responsible for the biogenesis of H2S, a signaling molecule. We have previously demonstrated that CBS is activated in cel...

journal_title：Antioxidants & redox signaling

authors： Niu WN,Yadav PK,Adamec J,Banerjee R

更新日期：2015-02-10 00:00:00

abstract：AIMS:Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to investigate hypoxia-induced miR-210 regulation ...

journal_title：Antioxidants & redox signaling

authors： Zaccagnini G,Maimone B,Di Stefano V,Fasanaro P,Greco S,Perfetti A,Capogrossi MC,Gaetano C,Martelli F

更新日期：2014-09-10 00:00:00