Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease.

abstract：:A model has been developed for the hemopexin receptor-mediated heme transport system based on iron uptake in yeast. Two steps are required: reduction followed by oxidation by a multi-copper-oxidase. Furthermore, in the hemopexin system, the surface redox events have been linked with gene regulation. The impermeable Cu...

journal_title：Antioxidants & redox signaling

authors： Sung L,Shibata M,Eskew JD,Shipulina N,Morales PJ,Smith A

更新日期：2000-01-01 00:00:00

abstract：: Significance: Hydrogen sulfide (H2S), the "new entry" in the series of endogenous gasotransmitters, plays a fundamental role in regulating the biological functions of various organs and systems. Consequently, the lack of adequate levels of H2S may represent the etiopathoge...

journal_title：Antioxidants & redox signaling

authors： Martelli A,Citi V,Testai L,Brogi S,Calderone V

更新日期：2020-01-10 00:00:00

abstract：SIGNIFICANCE:The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins that accumulate oxidative post-translational modifications only if these detected modifications are co...

journal_title：Antioxidants & redox signaling

authors： Feeney MB,Schöneich C

更新日期：2012-12-01 00:00:00

abstract：SIGNIFICANCE:MicroRNAs (miRNAs) are important regulators of gene expression and define part of the epigenetic signature. Their influence on every realm of biomedicine is established and progressively increasing. The impact of environment on human health is enormous. Among environmental risk factors impinging on quality...

journal_title：Antioxidants & redox signaling

authors： Miguel V,Cui JY,Daimiel L,Espinosa-Díez C,Fernández-Hernando C,Kavanagh TJ,Lamas S

更新日期：2018-03-20 00:00:00

abstract：:The small GTPase rac1 controls actin redistribution to membrane ruffles in fibroblasts and other cell types, as well as the activation of the NADPH oxidase in phagocytes. We explored the possibility that these two processes could be related. We used a replication-deficient adenoviral vector to overexpress the constitu...

journal_title：Antioxidants & redox signaling

authors： Moldovan L,Irani K,Moldovan NI,Finkel T,Goldschmidt-Clermont PJ

更新日期：1999-04-01 00:00:00

abstract：SIGNIFICANCE:Stiffness of endothelial cells is closely linked to the function of the vasculature as it regulates the release of vasoactive substances such as nitric oxide (NO) and reactive oxygen species. The outer layer of endothelial cells, consisting of the glycocalyx above and the cortical zone beneath the plasma m...

journal_title：Antioxidants & redox signaling

authors： Fels J,Kusche-Vihrog K

更新日期：2019-03-01 00:00:00

abstract：: Significance: Type 2 diabetes development involves multiple changes in β-cells, related to the oxidative stress and impaired redox signaling, beginning frequently by sustained overfeeding due to the resulting lipotoxicity and glucotoxicity. Uncovering relationships among t...

journal_title：Antioxidants & redox signaling

authors： Ježek P,Jabůrek M,Plecitá-Hlavatá L

更新日期：2019-10-01 00:00:00

abstract：SIGNIFICANCE:Accumulating evidence indicates that the success of some anticancer treatments (select chemotherapies or radiotherapy or trastuzumab) could be related to the stimulation of an anticancer immune response through the induction of an immunogenic tumor cell death (ICD). RECENT ADVANCES:Preclinical data reveal...

journal_title：Antioxidants & redox signaling

authors： Ladoire S,Hannani D,Vetizou M,Locher C,Aymeric L,Apetoh L,Kepp O,Kroemer G,Ghiringhelli F,Zitvogel L

更新日期：2014-03-01 00:00:00

abstract：:The ability to couple photosynthetic electron transport and redox poise to plastid gene expression enables plants to respond to environmental conditions and coordinate nuclear and chloroplast activities in order to maintain photosynthetic efficiency. The plastid redox regulatory system serves as a paradigm for underst...

journal_title：Antioxidants & redox signaling

authors： Barnes D,Mayfield SP

更新日期：2003-02-01 00:00:00

abstract：AIMS:Myocardial ischemia/reperfusion (I/R) is associated with mitochondrial dysfunction and subsequent cardiomyocyte death. The generation of excessive quantities of reactive oxygen species (ROS) and resultant damage to mitochondrial enzymes is considered an important mechanism underlying reperfusion injury. Mitochondr...

journal_title：Antioxidants & redox signaling

authors： Gorenkova N,Robinson E,Grieve DJ,Galkin A

更新日期：2013-11-01 00:00:00

abstract：:Previous reports have shown that the human immunodeficiency virus (HIV) regulatory protein Tat has both pro-oxidant and pro-inflammatory properties, suggesting that Tat might contribute to the neurological complications of HIV. However, the intracellular mechanisms whereby Tat triggers free radical production and infl...

journal_title：Antioxidants & redox signaling

authors： Turchan-Cholewo J,Dimayuga VM,Gupta S,Gorospe RM,Keller JN,Bruce-Keller AJ

更新日期：2009-02-01 00:00:00

abstract：: Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays a significant role in the control of redox balance, which is crucial in cancer cells. NRF2 a...

journal_title：Antioxidants & redox signaling

authors： Smolková K,Mikó E,Kovács T,Leguina-Ruzzi A,Sipos A,Bai P

更新日期：2020-11-01 00:00:00

abstract：:An increase of mitochondrial-derived reactive oxygen species (ROS) occurs in nerve growth factor (NGF)-deprived sympathetic neurons undergoing apoptotic death. It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen-activated protein kinase kinase (MEK)/mi...

journal_title：Antioxidants & redox signaling

authors： Kirkland RA,Franklin JL

更新日期：2003-10-01 00:00:00

abstract：SIGNIFICANCE:There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated a...

journal_title：Antioxidants & redox signaling

authors： Alexandrou AT,Li JJ

更新日期：2014-03-20 00:00:00

abstract：SIGNIFICANCE:Chagas disease (CD) affects several million people in Latin America and is spreading beyond its classical boundaries due to the migration of infected host and insect vectors, HIV co-infection, and blood transfusion. The current therapy is not adequate for treatment of the chronic phase of CD, and new drugs...

journal_title：Antioxidants & redox signaling

authors： Piacenza L,Peluffo G,Alvarez MN,Martínez A,Radi R

更新日期：2013-09-01 00:00:00

abstract：:Clinical heart failure has been defined for a long time as a clinical syndrome with symptoms and signs including shortness of breath, cyanosis, ascites, and edema. However, in recent years, with the thought of promoting early diagnosis and heart-failure prevention, the concept of heart failure has often been defined s...

journal_title：Antioxidants & redox signaling

authors： Jameel MN,Zhang J

更新日期：2009-08-01 00:00:00

abstract：SIGNIFICANCE:Oxidative (reactive oxygen species [ROS]) and nitrosative (reactive nitrogen species [RNS]) stress affects many physiological processes, including survival and death. Although high levels of ROS/RNS mainly causes cell death, low levels of free radicals directly modulate the activities of transcriptional fa...

journal_title：Antioxidants & redox signaling

authors： Kaminskyy VO,Zhivotovsky B

更新日期：2014-07-01 00:00:00

abstract：SIGNIFICANCE:The accepted effects of aging in mammalian skeletal muscle are progressive atrophy and weakening, or sarcopenia. Canonical hallmarks of aging in skeletal muscle include a reduction in muscle fiber cross-sectional area, a loss in muscle fibers through apoptosis and denervation, and infiltration of connectiv...

journal_title：Antioxidants & redox signaling

authors： Lawler JM,Hindle A

更新日期：2011-11-01 00:00:00

abstract：AIMS:Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases mitochondrial ATP levels. Here, we investigate the mechanistic connection between SIRT3 and energy homeost...

journal_title：Antioxidants & redox signaling

authors： Vassilopoulos A,Pennington JD,Andresson T,Rees DM,Bosley AD,Fearnley IM,Ham A,Flynn CR,Hill S,Rose KL,Kim HS,Deng CX,Walker JE,Gius D

更新日期：2014-08-01 00:00:00

abstract：:The production of reactive oxygen and reactive nitrogen intermediates is an important host defense mechanism mediated in response to infection by bacterial pathogens. Not surprisingly, intracellular pathogens have evolved numerous defense strategies to protect themselves against the damaging effects of these agents. I...

journal_title：Antioxidants & redox signaling

authors： Zahrt TC,Deretic V

更新日期：2002-02-01 00:00:00

abstract：SIGNIFICANCE:Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of mitochondria in the development of insulin resistance. RECENT ADVANCES:Refined methodology of ex vivo high-resolution respirometry and...

journal_title：Antioxidants & redox signaling

authors： Jelenik T,Roden M

更新日期：2013-07-20 00:00:00

abstract：AIMS:Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to eliminate Her2high disease. RESULTS:We demonstrate that Her2high cells and t...

journal_title：Antioxidants & redox signaling

authors： Rohlenova K,Sachaphibulkij K,Stursa J,Bezawork-Geleta A,Blecha J,Endaya B,Werner L,Cerny J,Zobalova R,Goodwin J,Spacek T,Alizadeh Pesdar E,Yan B,Nguyen MN,Vondrusova M,Sobol M,Jezek P,Hozak P,Truksa J,Rohlena J,Do

更新日期：2017-01-10 00:00:00

abstract：SIGNIFICANCE:The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. R...

journal_title：Antioxidants & redox signaling

authors： Nussbaum C,Klinke A,Adam M,Baldus S,Sperandio M

更新日期：2013-02-20 00:00:00

abstract：SIGNIFICANCE:Protein degradation has been identified as being deregulated in numerous human diseases. Hence, proteins involved in proteasomal as well as lysosomal degradation are regarded as interesting potential drug targets and are thoroughly investigated in clinical studies. RECENT ADVANCES:Technical advances in th...

journal_title：Antioxidants & redox signaling

authors： Engelke R,Becker AC,Dengjel J

更新日期：2012-09-01 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：: Aims: Nuclear factor (erythroid-derived 2)-like-2 factor (NRF-2) is a transcription factor well known to provide an advantage for cancer growth and survival regulating the cellular redox pathway. In breast cancer cells, we recently identified the monomeric heme-globin neur...

journal_title：Antioxidants & redox signaling

authors： Solar Fernandez V,Cipolletti M,Ascenzi P,Marino M,Fiocchetti M

更新日期：2020-02-01 00:00:00

abstract：SIGNIFICANCE:Alzheimer's disease is a neurodegenerative disorder that is projected to exceed more than 100 million cases worldwide by 2050. Aging is considered the primary risk factor for some 90% of Alzheimer's cases but a significant 10% of patients suffer from aggressive, early-onset forms of the disease. There is c...

journal_title：Antioxidants & redox signaling

authors： Bonet-Costa V,Pomatto LC,Davies KJ

更新日期：2016-12-01 00:00:00

abstract：:Mitochondrial uncoupling proteins (UCPs), a subfamily of the mitochondrial transporter family, are related by sequence homology to UCP1. This protein, which is located in the inner mitochondrial membrane, dissipates the proton gradient between the intermembrane space and the mitochondrial matrix to uncouple electron t...

journal_title：Antioxidants & redox signaling

authors： Kim-Han JS,Dugan LL

更新日期：2005-09-01 00:00:00

abstract：SIGNIFICANCE:Cystic fibrosis (CF) is the most common lethal genetic disorder in the Caucasian people. It is due to the mutation of cystic fibrosis transmembrane conductance regulator (CFTR) gene located on the long arm of the chromosome 7, which encodes for CFTR protein. The latter, an adenosine triphosphate binding ca...

journal_title：Antioxidants & redox signaling

authors： Kleme ML,Levy E

更新日期：2015-03-01 00:00:00

abstract：:The development of multidrug resistance to cancer chemotherapy is a major obstacle to the effective treatment of human malignancies. It has been established that membrane proteins, notably multidrug resistance (MDR), multidrug resistance protein (MRP), and breast cancer resistance protein (BCRP) of the ATP binding cas...

journal_title：Antioxidants & redox signaling

authors： Kuo MT

更新日期：2009-01-01 00:00:00