Myeloperoxidase: a leukocyte-derived protagonist of inflammation and cardiovascular disease.

abstract：AIMS:The usefulness of estrogen replacement therapy (ERT) in preventing oxidative stress associated with menopause is controversial. We aimed to study if there is a critical time window for effective treatment of the effects of ovariectomy with estrogens at the molecular, metabolic, and cellular level. RESULTS:Our mai...

journal_title：Antioxidants & redox signaling

authors： López-Grueso R,Gambini J,Abdelaziz KM,Monleón D,Díaz A,El Alami M,Bonet-Costa V,Borrás C,Viña J

更新日期：2014-01-10 00:00:00

abstract：:The decision to remove or refold oxidized, denatured, or misfolded proteins by heat shock protein 70 and its binding partners is critical to determine cell fate under pathophysiological conditions. Overexpression of the ubiquitin ligase C-terminus of HSC70 interacting protein (CHIP) can compensate for failure of other...

journal_title：Antioxidants & redox signaling

authors： Stankowski JN,Zeiger SL,Cohen EL,DeFranco DB,Cai J,McLaughlin B

更新日期：2011-05-15 00:00:00

abstract：:Tissue oxygen plays a crucial role in maintaining tissue viability and in various diseases, including responses to therapy. Useful knowledge has been gained by methods that can give limited snapshots of tissue oxygen (e.g., oxygen electrodes) or evidence of a history of tissue hypoxia (e.g., EF5) or even indirect evid...

journal_title：Antioxidants & redox signaling

authors： Khan N,Williams BB,Hou H,Li H,Swartz HM

更新日期：2007-08-01 00:00:00

abstract：:It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch points where disturbed blood flow (d-flow) predisposes to the development of plaques. Investigations both in vivo and in vitro have shown that d-flow is pro-atherogenic by promoting oxidative and inflammatory states in the a...

journal_title：Antioxidants & redox signaling

authors： Nigro P,Abe J,Berk BC

更新日期：2011-09-01 00:00:00

abstract：AIMS:Once dismissed as an inert byproduct of nitric oxide (NO) auto-oxidation, nitrite (NO(2)(-)) is now accepted as an endocrine reservoir of NO that elicits biological responses in major organs. While it is known that tissue nitrite is derived from NO oxidation and the diet, little is known about how nitrite is metab...

journal_title：Antioxidants & redox signaling

authors： Curtis E,Hsu LL,Noguchi AC,Geary L,Shiva S

更新日期：2012-10-01 00:00:00

abstract：:The application of electronic structure methods to the prediction of geometries, spin densities, and hyperfine couplings for biologically relevant quinones and semiquinones is reviewed. It is demonstrated that hybrid-type density functional methods are particularly suitable for such studies. Hydrogen bonding to the se...

journal_title：Antioxidants & redox signaling

authors： O'Malley PJ

更新日期：2001-10-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is frequently observed in Alzheimer's disease (AD) and is characterized by deposition of amyloid beta (Aβ) in leptomeningeal and cortical brain vasculature. In 40% of AD cases, Aβ mainly accumulates in cortical capillaries, a phenomenon referred to as capillary CAA (capCAA). The aim o...

journal_title：Antioxidants & redox signaling

authors： Carrano A,Hoozemans JJ,van der Vies SM,Rozemuller AJ,van Horssen J,de Vries HE

更新日期：2011-09-01 00:00:00

abstract：:The small GTPase rac1 controls actin redistribution to membrane ruffles in fibroblasts and other cell types, as well as the activation of the NADPH oxidase in phagocytes. We explored the possibility that these two processes could be related. We used a replication-deficient adenoviral vector to overexpress the constitu...

journal_title：Antioxidants & redox signaling

authors： Moldovan L,Irani K,Moldovan NI,Finkel T,Goldschmidt-Clermont PJ

更新日期：1999-04-01 00:00:00

abstract：:Loss of redox homeostasis and formation of excessive free radicals play an important role in the pathogenesis of kidney disease and hypertension. Free radicals such as reactive oxygen species (ROS) are necessary in physiologic processes. However, loss of redox homeostasis contributes to proinflammatory and profibrotic...

journal_title：Antioxidants & redox signaling

authors： Nistala R,Whaley-Connell A,Sowers JR

更新日期：2008-12-01 00:00:00

abstract：SIGNIFICANCE:Currently, calcific aortic valve disease (CAVD) is only treatable through surgical intervention because the specific mechanisms leading to the disease remain unclear. In this review, we explore the forces and structure of the valve, as well as the mechanosensors and downstream signaling in the valve endoth...

journal_title：Antioxidants & redox signaling

authors： Fernández Esmerats J,Heath J,Jo H

更新日期：2016-09-01 00:00:00

abstract：AIM:Our previous studies have shown that NOD-like receptor protein (NALP3) inflammasome activation is importantly involved in podocyte dysfunction and glomerular sclerosis induced by hyperhomocysteinemia (hHcys). The present study was designed to test whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-...

journal_title：Antioxidants & redox signaling

authors： Abais JM,Zhang C,Xia M,Liu Q,Gehr TW,Boini KM,Li PL

更新日期：2013-05-01 00:00:00

abstract：:The production of reactive oxygen and reactive nitrogen intermediates is an important host defense mechanism mediated in response to infection by bacterial pathogens. Not surprisingly, intracellular pathogens have evolved numerous defense strategies to protect themselves against the damaging effects of these agents. I...

journal_title：Antioxidants & redox signaling

authors： Zahrt TC,Deretic V

更新日期：2002-02-01 00:00:00

abstract：SIGNIFICANCE:Studies of sporadic cases, toxin models, and genetic causes of Parkinson's disease suggest that mitochondrial dysfunction may be an early feature of pathogenesis. RECENT ADVANCES:Compelling evidence of a causal relationship between mitochondrial function and disease was found with the identification of se...

journal_title：Antioxidants & redox signaling

authors： McCoy MK,Cookson MR

更新日期：2012-05-01 00:00:00

abstract：:Hypoxia is sensed by all mammalian cells and elicits a variety of adaptive and pathophysiological responses at the molecular and cellular level. For the pulmonary vasculature, hypoxia causes increased vasoconstriction and vessel-wall remodeling. These responses are mediated by complex intracellular cascades leading to...

journal_title：Antioxidants & redox signaling

authors： Kourembanas S

更新日期：2002-04-01 00:00:00

abstract：:The unfolded protein response (UPR) is an adaptive stress response in which cells recover from the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) by increasing its protein-folding capacity. The IRE1 pathway in the UPR is evolutionarily conserved from yeast to human, and two other path...

journal_title：Antioxidants & redox signaling

authors： Kohno K

更新日期：2007-12-01 00:00:00

abstract：:5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has become apparent that AMPK plays also an important role in long-term decisions that determine cell fate,...

journal_title：Antioxidants & redox signaling

authors： Weisová P,Dávila D,Tuffy LP,Ward MW,Concannon CG,Prehn JH

更新日期：2011-05-15 00:00:00

abstract：:The endothelium is essential for the maintenance of vascular homeostasis. Central to this role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the endothelial isoform of nitric oxide synthase (eNOS). Endothelial dysfunction, manifested as impaired EDNO bioactivity, is an important early ev...

journal_title：Antioxidants & redox signaling

authors： Thomas SR,Witting PK,Drummond GR

更新日期：2008-10-01 00:00:00

abstract：SIGNIFICANCE:Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there ...

journal_title：Antioxidants & redox signaling

authors： Hatem E,El Banna N,Huang ME

更新日期：2017-11-20 00:00:00

abstract：UNLABELLED:In living systems, the mechanisms of inheritance involving gene expression are operated by (i) the traditional model of genetics where the deoxyribonucleic acid (DNA) transcription and messenger ribonucleic acid stability are influenced by the DNA sequences and any aberrations in the primary DNA sequences an...

journal_title：Antioxidants & redox signaling

authors： Malireddy S,Kotha SR,Secor JD,Gurney TO,Abbott JL,Maulik G,Maddipati KR,Parinandi NL

更新日期：2012-07-15 00:00:00

abstract：AIMS:The immune system is critical for protection against infections and cancer, but requires scrupulous regulation to limit self-reactivity and autoimmunity. Our group has utilized a manganese porphyrin catalytic antioxidant (MnTE-2-PyP(5+), MnP) as a potential immunoregulatory therapy for type 1 diabetes. MnP has pre...

journal_title：Antioxidants & redox signaling

authors： Delmastro-Greenwood MM,Votyakova T,Goetzman E,Marre ML,Previte DM,Tovmasyan A,Batinic-Haberle I,Trucco MM,Piganelli JD

更新日期：2013-12-01 00:00:00

abstract：SIGNIFICANCE:Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eicosanoids, steroids,...

journal_title：Antioxidants & redox signaling

authors： Deponte M

更新日期：2017-11-20 00:00:00

abstract：:Membrane (lipid) rafts and caveolae, a subset of rafts, are cellular domains that concentrate plasma membrane proteins and lipids involved in the regulation of cell function. In addition to providing signaling platforms for G-protein-coupled receptors and certain tyrosine kinase receptors, rafts/caveolae can influence...

journal_title：Antioxidants & redox signaling

authors： Patel HH,Insel PA

更新日期：2009-06-01 00:00:00

abstract：:Through hypoxia-inducible factor 1 (HIF-1), hypoxia regulates the expression of numerous genes and is a potent inducer of angiogenesis. However, interleukin-8 (IL-8), an important angiogenic mediator, has been reported to be downregulated by HIF-1, although the mechanisms have not been elucidated. HIF-1 was induced in...

journal_title：Antioxidants & redox signaling

authors： Loboda A,Stachurska A,Florczyk U,Rudnicka D,Jazwa A,Wegrzyn J,Kozakowska M,Stalinska K,Poellinger L,Levonen AL,Yla-Herttuala S,Jozkowicz A,Dulak J

更新日期：2009-07-01 00:00:00

abstract：SIGNIFICANCE:Chronic noncommunicable diseases (NCDs) are the leading causes of disability and death worldwide. NCDs mainly comprise diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and neurological degenerative diseases, which kill more than 80% of population, especially the el...

journal_title：Antioxidants & redox signaling

authors： Pacifici F,Della Morte D,Capuani B,Pastore D,Bellia A,Sbraccia P,Di Daniele N,Lauro R,Lauro D

更新日期：2019-01-20 00:00:00

abstract：:The diabetogenic agent alloxan is a triketone that selectively destroys pancreatic beta cells. To investigate the importance of the triketone structure of alloxan for its cytotoxic potency, alloxan was compared with ninhydrin, also a triketone, and the amino derivative of alloxan uramil, which is not a triketone, beca...

journal_title：Antioxidants & redox signaling

authors： Elsner M,Gurgul-Convey E,Lenzen S

更新日期：2008-04-01 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：SIGNIFICANCE:Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor radioresistance. RECENT ADVANCES:Two main types of hypoxia exist in the tumor microenvironment: chronic and cycling hypoxia. Chronic hypoxia re...

journal_title：Antioxidants & redox signaling

authors： Lee CT,Boss MK,Dewhirst MW

更新日期：2014-07-10 00:00:00

abstract：AIM:Antrodia Camphorate (AC) is a mushroom that is widely used in Asian countries to prevent and treat various diseases, including liver diseases. However, the active ingredients that contribute to the biological functions remain elusive. The purpose of the present study is to test the hepatoprotective effect of Antcin...

journal_title：Antioxidants & redox signaling

authors： Huo Y,Win S,Than TA,Yin S,Ye M,Hu H,Kaplowitz N

更新日期：2017-02-10 00:00:00

abstract：: Significance: Since the discovery of vascular stem cells, there has been considerable advancement in comprehending the nature and functions of these cells. Due to their differentiation potential to repair endothelial cells and to participate in lesion formation during vasc...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Sun X,Deng J,Hu Y,Xu Q

更新日期：2021-01-19 00:00:00

abstract：SIGNIFICANCE:Extranuclear sirtuins in cytosol (SIRT2) and mitochondria (SIRT3, SIRT4, and SIRT5) are key regulators of metabolic enzymes and the antioxidative defense mechanisms. They play an important role in the adjustment of metabolic pathways in alterations of the nutritional status. Recent Advances: Recent studies...

journal_title：Antioxidants & redox signaling

authors： Elkhwanky MS,Hakkola J

更新日期：2018-03-10 00:00:00