Abstract:
:Loss of redox homeostasis and formation of excessive free radicals play an important role in the pathogenesis of kidney disease and hypertension. Free radicals such as reactive oxygen species (ROS) are necessary in physiologic processes. However, loss of redox homeostasis contributes to proinflammatory and profibrotic pathways in the kidney, which in turn lead to reduced vascular compliance and proteinuria. The kidney is susceptible to the influence of various extracellular and intracellular cues, including the renin-angiotensin-aldosterone system (RAAS), hyperglycemia, lipid peroxidation, inflammatory cytokines, and growth factors. Redox control of kidney function is a dynamic process with reversible pro- and anti-free radical processes. The imbalance of redox homeostasis within the kidney is integral in hypertension and the progression of kidney disease. An emerging paradigm exists for renal redox contribution to hypertension.
journal_name
Antioxid Redox Signaljournal_title
Antioxidants & redox signalingauthors
Nistala R,Whaley-Connell A,Sowers JRdoi
10.1089/ars.2008.2034subject
Has Abstractpub_date
2008-12-01 00:00:00pages
2047-89issue
12eissn
1523-0864issn
1557-7716journal_volume
10pub_type
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章,评审
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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更新日期:2016-05-01 00:00:00
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journal_title:Antioxidants & redox signaling
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doi:10.1089/ars.2006.1477
更新日期:2007-03-01 00:00:00
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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pub_type: 社论
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