Impacts of dietary selenium deficiency on metabolic phenotypes of diet-restricted GPX1-overexpressing mice.

abstract：AIMS:Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychiatric diseases. NADPH oxidases (NOXs) are a major so...

journal_title：Antioxidants & redox signaling

authors： Colaianna M,Schiavone S,Zotti M,Tucci P,Morgese MG,Bäckdahl L,Holmdahl R,Krause KH,Cuomo V,Trabace L

更新日期：2013-04-20 00:00:00

abstract：:Intraorgan communication in the cardiovascular system is exerted not only by direct cell-cell contacts but also by locally released factors, which modulate neighboring cells by paracrine signals (e.g., NO, vascular endothelial growth factor, adenosine, reactive oxygen species). Moreover, cells in close proximity to th...

journal_title：Antioxidants & redox signaling

authors： Gödecke A,Haendeler J

更新日期：2017-04-20 00:00:00

abstract：:Lipoic acid (LA) and its reduced product dihydrolipoic acid (DHLA) are potent antioxidants with capacity to scavenge reactive oxygen species (ROS) and recycle endogenous antioxidants. LA may increase cellular glutathione (GSH), an antioxidant lacking in the lung's epithelial lining fluid in lung disorders such as idio...

journal_title：Antioxidants & redox signaling

authors： O'Neill HC,Rancourt RC,White CW

更新日期：2008-02-01 00:00:00

abstract：:Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•-) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aortic endothelial cells, ...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Jen N,Ai L,Hamilton R,Wang S,Holmes K,Dharbandi F,Khalsa B,Bressler S,Barr ML,Li R,Hsiai TK

更新日期：2011-09-01 00:00:00

abstract：SIGNIFICANCE:Decrypting the cellular response to oxidative stress relies on a comprehensive understanding of the redox signaling pathways stimulated under oxidizing conditions. Redox signaling events can be divided into upstream sensing of oxidants, midstream redox signaling of protein function, and downstream transcri...

journal_title：Antioxidants & redox signaling

authors： Young D,Pedre B,Ezeriņa D,De Smet B,Lewandowska A,Tossounian MA,Bodra N,Huang J,Astolfi Rosado L,Van Breusegem F,Messens J

更新日期：2019-04-01 00:00:00

abstract：:Protein and amine halogenation is a type of oxidative stress induced by phagocytic overstimulation, and its role in Parkinson's disease (PD) has not been discerned. We have detected that advanced oxidized protein products, markers of protein halogenation, are reliably enhanced in serum of patients with PD (n=60) relat...

journal_title：Antioxidants & redox signaling

authors： García-Moreno JM,Martín de Pablos A,García-Sánchez MI,Méndez-Lucena C,Damas-Hermoso F,Rus M,Chacón J,Fernández E

更新日期：2013-04-10 00:00:00

abstract：AIMS:Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that UCP2-mediated uncoupl...

journal_title：Antioxidants & redox signaling

authors： Ježek J,Dlasková A,Zelenka J,Jabůrek M,Ježek P

更新日期：2015-10-20 00:00:00

abstract：:DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has homologs in nearly all organisms. Because of its connection to parkinsonism and cancer, human DJ-1 has been intensely studied for over a decade. The current view is that DJ-1 is a multifunctional oxidative stress response protein that...

journal_title：Antioxidants & redox signaling

authors： Wilson MA

更新日期：2011-07-01 00:00:00

abstract：SIGNIFICANCE:Atrial fibrillation (AF) is a burgeoning health-care problem, and the currently available therapeutic armamentarium is barely efficient. Experimental and clinical evidence implicates inflammation and myocardial oxidative stress in the pathogenesis of AF. RECENT ADVANCES:Local and systemic inflammation has...

journal_title：Antioxidants & redox signaling

authors： Pinho-Gomes AC,Reilly S,Brandes RP,Casadei B

更新日期：2014-03-10 00:00:00

abstract：:High affinity for NADH, and low affinity for NADPH, for reduction of endogenous coenzyme Q10 (CoQ10) by pig liver plasma membrane is reported in the present work. CoQ reduction in plasma membrane is carried out, in addition to other mechanisms, by plasma membrane coenzyme Q reductase (PMQR). We show that PMQR-catalyze...

journal_title：Antioxidants & redox signaling

authors： Arroyo A,Kagan VE,Tyurin VA,Burgess JR,de Cabo R,Navas P,Villalba JM

更新日期：2000-07-01 00:00:00

abstract：SIGNIFICANCE:Oxidative (reactive oxygen species [ROS]) and nitrosative (reactive nitrogen species [RNS]) stress affects many physiological processes, including survival and death. Although high levels of ROS/RNS mainly causes cell death, low levels of free radicals directly modulate the activities of transcriptional fa...

journal_title：Antioxidants & redox signaling

authors： Kaminskyy VO,Zhivotovsky B

更新日期：2014-07-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00

abstract：:Methionine residues are susceptible to oxidation, but this damage may be reversed by methionine sulfoxide reductases MsrA and MsrB. Mammals contain one MsrA and three MsrBs, including a selenoprotein MsrB1. Here, we show that MsrB1 is the major methionine sulfoxide reductase in liver of mice and it is among the protei...

journal_title：Antioxidants & redox signaling

authors： Novoselov SV,Kim HY,Hua D,Lee BC,Astle CM,Harrison DE,Friguet B,Moustafa ME,Carlson BA,Hatfield DL,Gladyshev VN

更新日期：2010-04-01 00:00:00

abstract：:Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins. Whereas optimal levels of Se in the diet have important health benefits, a recent clinical trial has suggested that supplemental intake of Se above the adequate level potentially may raise the risk ...

journal_title：Antioxidants & redox signaling

authors： Labunskyy VM,Lee BC,Handy DE,Loscalzo J,Hatfield DL,Gladyshev VN

更新日期：2011-06-15 00:00:00

abstract：AIMS:Myocardial ischemia/reperfusion (I/R) is associated with mitochondrial dysfunction and subsequent cardiomyocyte death. The generation of excessive quantities of reactive oxygen species (ROS) and resultant damage to mitochondrial enzymes is considered an important mechanism underlying reperfusion injury. Mitochondr...

journal_title：Antioxidants & redox signaling

authors： Gorenkova N,Robinson E,Grieve DJ,Galkin A

更新日期：2013-11-01 00:00:00

abstract：:Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifac...

journal_title：Antioxidants & redox signaling

authors： Okouchi M,Ekshyyan O,Maracine M,Aw TY

更新日期：2007-08-01 00:00:00

abstract：:The role of free radicals in aging has been a long-standing theory that has now been extended to include both reactive oxygen and nitrogen species. The original concepts that overwhelming oxidative stress depleted antioxidants and thus damaged intracellular targets is being supplanted by the hypothesis that the reacti...

journal_title：Antioxidants & redox signaling

authors： Darley-Usmar V,Starke-Reed PE

更新日期：2000-10-01 00:00:00

abstract：:Physiological levels of reactive oxygen species (ROS) play an important regulatory role through various signaling transduction pathways in folliculogenesis, oocyte maturation, endometrial cycle, luteolysis, implantation, embryogenesis, and pregnancy. Persistent and elevated generation of ROS leads to a disturbance of ...

journal_title：Antioxidants & redox signaling

authors： Agarwal A,Gupta S,Sekhon L,Shah R

更新日期：2008-08-01 00:00:00

abstract：:Molecular chaperones play key roles in protein quality control, signal transduction, proliferation, and cell death, and confer cytoprotection and assure survival after environmental stress. The heat-shock response is implicated in a variety of conditions including ischemic diseases, infection and immunity, neurodegene...

journal_title：Antioxidants & redox signaling

authors： Putics A,Végh EM,Csermely P,Soti C

更新日期：2008-01-01 00:00:00

abstract：:Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides. Peroxides oxidize the peroxidatic Cys-SH to Cys-SOH, which then reacts with another cysteine residue (typically the resolving Cys [C(R)]) to fo...

journal_title：Antioxidants & redox signaling

authors： Rhee SG,Woo HA

更新日期：2011-08-01 00:00:00

abstract：: Significance: Hydrogen sulfide (H2S), the "new entry" in the series of endogenous gasotransmitters, plays a fundamental role in regulating the biological functions of various organs and systems. Consequently, the lack of adequate levels of H2S may represent the etiopathoge...

journal_title：Antioxidants & redox signaling

authors： Martelli A,Citi V,Testai L,Brogi S,Calderone V

更新日期：2020-01-10 00:00:00

abstract：:Vitamin K epoxide, a by-product of the carboxylation of blood coagulation factors, is reduced to vitamin K by an enzymatic system possessing vitamin K epoxide reductase (VKOR) activity. This system is the target of coumarin-derived drugs widely used in thrombosis therapy and prophylaxis. Recently, the key protein of t...

journal_title：Antioxidants & redox signaling

authors： Oldenburg J,Bevans CG,Müller CR,Watzka M

更新日期：2006-03-01 00:00:00

abstract：:Carica papaya Linn is widely known as a medicinal fruit. We sought to study a standardized fermented papaya preparation (FPP) for its effects on wound healing in adult obese diabetic (db/db) mice. FPP blunted the gain in blood glucose and improved the lipid profile after 8 weeks of oral supplementation. However, FPP d...

journal_title：Antioxidants & redox signaling

authors： Collard E,Roy S

更新日期：2010-09-01 00:00:00

abstract：: Aims: Severe acute pancreatitis (AP) is a serious condition without specific treatment. Mitochondrial dysfunction plays a crucial role in the pathogenesis of AP. Irisin, a novel exercise-induced hormone, contributes to many health benefits of physical activity. We and othe...

journal_title：Antioxidants & redox signaling

authors： Ren Y,Qiu M,Zhang J,Bi J,Wang M,Hu L,Du Z,Li T,Zhang L,Wang Y,Lv Y,Wu Z,Wu R

更新日期：2019-10-10 00:00:00

abstract：SIGNIFICANCE:Worldwide demand has driven the development of hemoglobin (Hb)-based oxygen carriers (HBOCs) as potential acellular oxygen therapeutics. HBOCs have the potential to provide an oxygen bridge to patients and minimize current problems associated with supply and storage of donated blood. However, to date, safe...

journal_title：Antioxidants & redox signaling

authors： Strader MB,Alayash AI

更新日期：2017-05-10 00:00:00

abstract：:Studies from many laboratories have shown that overexpression of manganese superoxide dismutase (MnSOD) inhibits the growth of numerous tumor cell types. The inhibition of tumor cell growth can be attributed to the increase in the steady-state levels of H2O2 as a result of the increased dismuting activity of MnSOD. He...

journal_title：Antioxidants & redox signaling

authors： Kim KH,Rodriguez AM,Carrico PM,Melendez JA

更新日期：2001-06-01 00:00:00

abstract：:Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport chain triggers several pathways of injury involved in the pathogenesis of diabetic complications [protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product (AGE) formation] by inhibiting glyceralde...

journal_title：Antioxidants & redox signaling

authors： Pacher P,Szabó C

更新日期：2005-11-01 00:00:00

abstract：:It was recently found that age-related changes in SMP30 expression can be modulated by antioxidative action. In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter...

journal_title：Antioxidants & redox signaling

authors： Jung KJ,Maruyama N,Ishigami A,Yu BP,Chung HY

更新日期：2006-03-01 00:00:00

abstract：:Enhanced production of reactive oxygen species (ROS) such as H(2)O(2) and a failure in ROS removal by scavenging systems are hallmarks of several cardiovascular diseases such as atherosclerosis and hypertension. ROS act as second messengers that play a prominent role in intracellular signaling and cellular function. I...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S

更新日期：2003-12-01 00:00:00

abstract：AIMS:Oxidative stress is thought to be involved in Friedreich's ataxia (FRDA), yet it has not been demonstrated in the target neurons that are first to degenerate. Using the YG8R mouse model of FRDA, microarray and neuritic growth experiments were carried out in the dorsal root ganglion (DRG), the primary site of neuro...

journal_title：Antioxidants & redox signaling

authors： Shan Y,Schoenfeld RA,Hayashi G,Napoli E,Akiyama T,Iodi Carstens M,Carstens EE,Pook MA,Cortopassi GA

更新日期：2013-11-01 00:00:00