Organic Isothiocyanates as Hydrogen Sulfide Donors.

abstract：:15-Deoxy-Delta(12,14)-prostaglandin-J(2) (15d-PGJ(2)) is a cyclopentenone prostaglandin regarded as antiinflammatory mediator, which can act through peroxisome proliferator-activated receptor-gamma (PPARgamma) or through G protein-coupled surface receptors. It has been demonstrated that 15d-PGJ(2) potently increases t...

journal_title：Antioxidants & redox signaling

authors： Jozkowicz A,Was H,Taha H,Kotlinowski J,Mleczko K,Cisowski J,Weigel G,Dulak J

更新日期：2008-12-01 00:00:00

abstract：:Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides. Peroxides oxidize the peroxidatic Cys-SH to Cys-SOH, which then reacts with another cysteine residue (typically the resolving Cys [C(R)]) to fo...

journal_title：Antioxidants & redox signaling

authors： Rhee SG,Woo HA

更新日期：2011-08-01 00:00:00

abstract：:Oxidative stress plays a significant role in the pathogenesis of coronary artery disease (CAD). A p22(phox)-based NAD(P)H oxidase acts as a potent superoxide-generating system in the vasculature. We studied the association of the A640G and the C242T polymorphisms with clinical risk factors, endothelial function, and s...

journal_title：Antioxidants & redox signaling

authors： Zafari AM,Davidoff MN,Austin H,Valppu L,Cotsonis G,Lassègue B,Griendling KK

更新日期：2002-08-01 00:00:00

abstract：:The RING (really interesting new gene) finger proteins containing a characteristic C3HC4 or C3H2C3 motif appear to act as E3 ubiquitin ligase and play important roles in many processes, including cell-cycle progression, oncogenesis, signal transduction, and development. This review is focused on SAG/ROC/Rbx/Hrt (sensi...

journal_title：Antioxidants & redox signaling

authors： Sun Y,Tan M,Duan H,Swaroop M

更新日期：2001-08-01 00:00:00

abstract：SIGNIFICANCE:The circadian clock, an internal timekeeping system, is implicated in the regulation of metabolism and physiology, and circadian dysfunctions are associated with pathological changes in model organisms and increased risk of some diseases in humans. RECENT ADVANCES:Data obtained in different organisms, inc...

journal_title：Antioxidants & redox signaling

authors： Patel SA,Velingkaar NS,Kondratov RV

更新日期：2014-06-20 00:00:00

abstract：SIGNIFICANCE:Chronic myeloid leukemia (CML) involves the malignant transformation of hematopoietic stem cells, defined largely by the Philadelphia chromosome and expression of the breakpoint cluster region-Abelson (BCR-ABL) oncoprotein. Pharmacological tyrosine kinase inhibitors (TKIs), including imatinib mesylate, hav...

journal_title：Antioxidants & redox signaling

authors： Tortorella SM,Hung A,Karagiannis TC

更新日期：2015-06-01 00:00:00

abstract：:The endothelium is essential for the maintenance of vascular homeostasis. Central to this role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the endothelial isoform of nitric oxide synthase (eNOS). Endothelial dysfunction, manifested as impaired EDNO bioactivity, is an important early ev...

journal_title：Antioxidants & redox signaling

authors： Thomas SR,Witting PK,Drummond GR

更新日期：2008-10-01 00:00:00

abstract：SIGNIFICANCE:The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. R...

journal_title：Antioxidants & redox signaling

authors： Nussbaum C,Klinke A,Adam M,Baldus S,Sperandio M

更新日期：2013-02-20 00:00:00

abstract：AIMS:Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro us...

journal_title：Antioxidants & redox signaling

authors： Manta B,Pavan C,Sturlese M,Medeiros A,Crispo M,Berndt C,Krauth-Siegel RL,Bellanda M,Comini MA

更新日期：2013-09-01 00:00:00

abstract：:Increased free radical generation and decreased efficiency of the reparative/degradative mechanisms both primarily contribute to age-related elevation in the level of oxidative stress and brain damage. Excess formation of reactive oxygen and nitrogen species can cause proteasomal dysfunction and protein overloading. T...

journal_title：Antioxidants & redox signaling

authors： Calabrese V,Butterfield DA,Scapagnini G,Stella AM,Maines MD

更新日期：2006-03-01 00:00:00

abstract：:To test the hypothesis that the inducible nitric oxide synthase (iNOS) is involved in mediating the toll-like receptor 4-dependent effects on the liver in the onset of fructose-induced steatosis, wild-type and iNOS knockout (iNOS(-/-)) mice were either fed tap water or 30% fructose solution for 8 weeks. Chronic consum...

journal_title：Antioxidants & redox signaling

authors： Spruss A,Kanuri G,Uebel K,Bischoff SC,Bergheim I

更新日期：2011-06-01 00:00:00

abstract：:Fluid shear stress plays a critical role in the regulation of vascular biology and its pathology, such as atherosclerosis, via modulation of redox balance. Both pro-atherogenic (either oscillatory or turbulent, nonunidirectional) shear stress and anti-atherogenic (either steady or pulsatile, unidirectional laminar) sh...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Warabi E,Noguchi N

更新日期：2011-09-01 00:00:00

abstract：:Junctional adhesion molecules are transmembrane proteins that belong to the immunoglobulin superfamily. In addition to their localization in close proximity to the tight junctions in endothelial and epithelial cells, junctional adhesion molecules are also expressed in circulating cells that do not form junctions, such...

journal_title：Antioxidants & redox signaling

authors： Bazzoni G

更新日期：2011-09-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthe...

journal_title：Antioxidants & redox signaling

authors： Bendall JK,Douglas G,McNeill E,Channon KM,Crabtree MJ

更新日期：2014-06-20 00:00:00

abstract：:Although there is an abundance of evidence suggesting that insulin resistance plays a significant role in the vasculature, the precise mechanistic role involved still remains unclear. In this review, we discuss the current background of insulin resistance in the context of insulin signaling and action in the vasculatu...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S,Motley ED

更新日期：2005-07-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress induces an adaptive program called the unfolded protein response (UPR), which affects activity of an array of kinases and transcription factors. Previous reports provided evidence for activation of nuclear factor-kappaB (NF-kappaB), the major transcription factor regulating inflammato...

journal_title：Antioxidants & redox signaling

authors： Kitamura M

更新日期：2009-09-01 00:00:00

abstract：:In striated muscle, the sarcoplasmic reticulum (SR) is the major storage compartment of intracellular Ca2+ that controls cytosolic free Ca2+ (Cai) and developed force by sequestering and releasing Ca2+ during each contraction. Ca2+ release from the SR occurs through high-conductance Ca2+ release channels or ryanodine ...

journal_title：Antioxidants & redox signaling

authors： Salama G,Menshikova EV,Abramson JJ

更新日期：2000-04-01 00:00:00

abstract：SIGNIFICANCE:A mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow--hypoxic vasodilation--occur in an attempt to restore oxygen supply. Nitric oxide (NO) is a major signaling...

journal_title：Antioxidants & redox signaling

authors： Umbrello M,Dyson A,Feelisch M,Singer M

更新日期：2013-11-10 00:00:00

abstract：AIMS:Nuclear factor-erythroid-related factor 2 (Nrf2) is a critical transcriptional factor that is used in regulating cellular defense against oxidative stress. This study is aimed at investigating new interacting protein partners of Nrf2 using One-strep tag pull-down coupled with LTQ Orbitrap LC/MS/MS, and at examinin...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Xu EY,Sacks DB,Lee J,Shu L,Xia B,Kong AN

更新日期：2013-07-10 00:00:00

abstract：SIGNIFICANCE:In bacteria, transcriptional responses to reactive oxygen and nitrogen species (ROS and RNS, respectively) are typically coordinated by regulatory proteins that employ metal centers or reactive thiols to detect the presence of those species. This review is focused on the structure, function and mechanism o...

journal_title：Antioxidants & redox signaling

authors： Spiro S,D'Autréaux B

更新日期：2012-11-01 00:00:00

abstract：:Glycerophospholipids represent a common class of lipids critically important for integrity of cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes biological activities of phospholipids. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPL...

journal_title：Antioxidants & redox signaling

authors： Bochkov VN,Oskolkova OV,Birukov KG,Levonen AL,Binder CJ,Stöckl J

更新日期：2010-04-15 00:00:00

abstract：:Our laboratory demonstrated that hyperhomocysteinemia accelerates atherosclerosis in mouse models through ER stress and activation of the unfolded protein response (UPR). In this study, we tested the hypothesis that homocysteine-induced ER stress may arise from ER-Ca(2+) disequilibria. We found that homocysteine-induc...

journal_title：Antioxidants & redox signaling

authors： Dickhout JG,Sood SK,Austin RC

更新日期：2007-11-01 00:00:00

abstract：:In this study, we sought to investigate the putative association of the oxidized metabolites derived from linoleic acid (OXFAs) with pediatric nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). We studied 80 obese adolescents (age 13.3 ± 3.31 years; body mass index 33.0 ± 6.79 kg/m(2)), who underwent ...

journal_title：Antioxidants & redox signaling

authors： Santoro N,Caprio S,Giannini C,Kim G,Kursawe R,Pierpont B,Shaw MM,Feldstein AE

更新日期：2014-01-10 00:00:00

abstract：:Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glyco...

journal_title：Antioxidants & redox signaling

authors： Abdel-Fatah T,Arora A,Gorguc I,Abbotts R,Beebeejaun S,Storr S,Mohan V,Hawkes C,Soomro I,Lobo DN,Parsons SL,Madhusudan S

更新日期：2013-06-20 00:00:00

abstract：:Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/beta-catenin pathway, which itself regulates cell fate and earl...

journal_title：Antioxidants & redox signaling

authors： Funato Y,Miki H

更新日期：2007-08-01 00:00:00

abstract：:Toxic renal failure induced by gentamicin, glycerol, or cisplatin, as well as ischemic renal failure in vivo and hypoxia/reoxygenation of tubular epithelial cells in vitro, induces the production of reactive oxygen metabolites (ROM). Generation of ROM is responsible for the induction of tubular epithelial cell death, ...

journal_title：Antioxidants & redox signaling

authors： Basnakian AG,Kaushal GP,Shah SV

更新日期：2002-12-01 00:00:00

abstract：:Protection of ischemic myocardium is an important unmet need in reperfusion therapy of acute myocardial infarction. Myocardial ischemia and reperfusion induce necrosis and apoptosis in cardiomyocytes. Caspase processing and activation are critical steps in most receptor and nonreceptor pathways of apoptosis. Caspase i...

journal_title：Antioxidants & redox signaling

authors： Li HL,Karwatowska-Prokopczuk E,Mutomba M,Wu J,Karanewsky D,Valentino K,Engler RL,Gottlieb RA

更新日期：2001-02-01 00:00:00

abstract：:Clinical heart failure has been defined for a long time as a clinical syndrome with symptoms and signs including shortness of breath, cyanosis, ascites, and edema. However, in recent years, with the thought of promoting early diagnosis and heart-failure prevention, the concept of heart failure has often been defined s...

journal_title：Antioxidants & redox signaling

authors： Jameel MN,Zhang J

更新日期：2009-08-01 00:00:00

abstract：:Peroxisomes are multifunctional organelles with an important role in the generation and decomposition of reactive oxygen species (ROS). In this review, the ROS-producing enzymes, as well as the antioxidative defense system in mammalian peroxisomes, are described. In addition, various conditions leading to disturbances...

journal_title：Antioxidants & redox signaling

authors： Antonenkov VD,Grunau S,Ohlmeier S,Hiltunen JK

更新日期：2010-08-15 00:00:00

abstract：:Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle of an individual mitochondrion reveals several points where fusion, fission, and mitophagy interact. Mitochondrial fission can produce an...

journal_title：Antioxidants & redox signaling

authors： Twig G,Shirihai OS

更新日期：2011-05-15 00:00:00