15d-PGJ2 upregulates synthesis of IL-8 in endothelial cells through induction of oxidative stress.

abstract：:5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has become apparent that AMPK plays also an important role in long-term decisions that determine cell fate,...

journal_title：Antioxidants & redox signaling

authors： Weisová P,Dávila D,Tuffy LP,Ward MW,Concannon CG,Prehn JH

更新日期：2011-05-15 00:00:00

abstract：:Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins. Whereas optimal levels of Se in the diet have important health benefits, a recent clinical trial has suggested that supplemental intake of Se above the adequate level potentially may raise the risk ...

journal_title：Antioxidants & redox signaling

authors： Labunskyy VM,Lee BC,Handy DE,Loscalzo J,Hatfield DL,Gladyshev VN

更新日期：2011-06-15 00:00:00

abstract：SIGNIFICANCE:The accepted effects of aging in mammalian skeletal muscle are progressive atrophy and weakening, or sarcopenia. Canonical hallmarks of aging in skeletal muscle include a reduction in muscle fiber cross-sectional area, a loss in muscle fibers through apoptosis and denervation, and infiltration of connectiv...

journal_title：Antioxidants & redox signaling

authors： Lawler JM,Hindle A

更新日期：2011-11-01 00:00:00

abstract：AIMS:Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychiatric diseases. NADPH oxidases (NOXs) are a major so...

journal_title：Antioxidants & redox signaling

authors： Colaianna M,Schiavone S,Zotti M,Tucci P,Morgese MG,Bäckdahl L,Holmdahl R,Krause KH,Cuomo V,Trabace L

更新日期：2013-04-20 00:00:00

abstract：:It was recently found that age-related changes in SMP30 expression can be modulated by antioxidative action. In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter...

journal_title：Antioxidants & redox signaling

authors： Jung KJ,Maruyama N,Ishigami A,Yu BP,Chung HY

更新日期：2006-03-01 00:00:00

abstract：:Monothiol glutaredoxins (Grxs) with a noncanonical CGFS active site are found in all kingdoms of life. They include members with a single domain and thioredoxin-Grx fusion proteins. In Saccharomyces cerevisiae, the multidomain Grx3 and Grx4 play an essential role in intracellular iron trafficking. This crucial task is...

journal_title：Antioxidants & redox signaling

authors： Hoffmann B,Uzarska MA,Berndt C,Godoy JR,Haunhorst P,Lillig CH,Lill R,Mühlenhoff U

更新日期：2011-07-01 00:00:00

abstract：:The ability of iron to accept or donate electrons, coupled with the ability of oxygen to act as an electron acceptor, renders both elements essential to normal cellular biology. However, these same chemical properties allow free iron in solution to generate toxic free radicals, particularly in combination with oxygen....

journal_title：Antioxidants & redox signaling

authors： Mole DR

更新日期：2010-04-01 00:00:00

abstract：AIMS:We have tested the hypothesis that selenium (Se)-containing antioxidative enzymes protect thyroid epithelial cells from oxidative damage associated with enzymatic production of hydrogen peroxide required for thyroid hormone biosynthesis. Thyroid epithelial cells therefore express antioxidative enzymes, including c...

journal_title：Antioxidants & redox signaling

authors： Chiu-Ugalde J,Wirth EK,Klein MO,Sapin R,Fradejas-Villar N,Renko K,Schomburg L,Köhrle J,Schweizer U

更新日期：2012-09-15 00:00:00

abstract：:Free-radicals and other reactive oxygen species (ROS) have been implicated as being major damaging species in pathology and they have been widely investigated. Using 1,1'-diphenyl-2-picrylhydrazyl (DPPH), we estimated total free radical scavenging activity in the low-molecular-weight nonenzymatic fraction (LMNEF) of h...

journal_title：Antioxidants & redox signaling

authors： Atsumi T,Iwakura I,Kashiwagi Y,Fujisawa S,Ueha T

更新日期：1999-01-01 00:00:00

abstract：:Exposure of neonatal rat cardiac myocytes to palmitate and glucose produces apoptosis as seen by cytochrome c release, caspase 3-like activation, DNA laddering, and poly(ADP-ribose) polymerase cleavage. The purpose of this study was to understand the role of reactive oxygen species in the initiation of programmed cell...

journal_title：Antioxidants & redox signaling

authors： Sparagna GC,Hickson-Bick DL,Buja LM,McMillin JB

更新日期：2001-02-01 00:00:00

abstract：SIGNIFICANCE:Reactive oxygen and nitrogen species contributing to homeostatic regulation and the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, endothelial dysfunction, and cardiac hypertrophy, is well established. The ability of oxidant species to mediate such effects is in p...

journal_title：Antioxidants & redox signaling

authors： Pimentel D,Haeussler DJ,Matsui R,Burgoyne JR,Cohen RA,Bachschmid MM

更新日期：2012-03-15 00:00:00

abstract：:Reductions in brain glucose metabolism and increased oxidative stress invariably occur in Alzheimer's disease (AD) and thiamine (vitamin B1) deficiency. Both conditions cause irreversible cognitive impairment; their behavioral consequences overlap but are not identical. Thiamine-dependent processes are critical in glu...

journal_title：Antioxidants & redox signaling

authors： Gibson GE,Blass JP

更新日期：2007-10-01 00:00:00

abstract：:The diabetogenic agent alloxan is a triketone that selectively destroys pancreatic beta cells. To investigate the importance of the triketone structure of alloxan for its cytotoxic potency, alloxan was compared with ninhydrin, also a triketone, and the amino derivative of alloxan uramil, which is not a triketone, beca...

journal_title：Antioxidants & redox signaling

authors： Elsner M,Gurgul-Convey E,Lenzen S

更新日期：2008-04-01 00:00:00

abstract：:The aim of the present study is to examine the effects of dietary saturated fatty acids on liver adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) in ethanol-administered animals and in ethanol-exposed cultured hepatic cells, and to explore the underlying molecular mechanisms. The mRNA and protein ...

journal_title：Antioxidants & redox signaling

authors： Liang X,Hu M,Rogers CQ,Shen Z,You M

更新日期：2011-07-15 00:00:00

abstract：:Nox family NADPH oxidases serve a variety of functions requiring reactive oxygen species (ROS) generation, including antimicrobial defense, biosynthetic processes, oxygen sensing, and redox-based cellular signaling. We explored targeting, assembly, and activation of several Nox family oxidases, since ROS production ap...

journal_title：Antioxidants & redox signaling

authors： Leto TL,Morand S,Hurt D,Ueyama T

更新日期：2009-10-01 00:00:00

abstract：:Apoptosis is a highly regulated process essential for the development and homeostasis of multicellular organisms. Whereas caspases, a large family of intracellular cysteine proteases, play central roles in the execution of apoptosis, other proapoptotic and antiapoptotic regulators such as the members of the Bcl-2 fami...

journal_title：Antioxidants & redox signaling

authors： Takeda K,Naguro I,Nishitoh H,Matsuzawa A,Ichijo H

更新日期：2011-08-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seems to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed "vitagenes," among these, the heat shock system, a highly co...

journal_title：Antioxidants & redox signaling

authors： Calabrese V,Stella AM,Butterfield DA,Scapagnini G

更新日期：2004-10-01 00:00:00

abstract：:Aging is associated not only with oxidant stress, but also with increased interleukin-6 (IL-6) levels. To determine if oxidative stress could contribute to the age-associated increase IL-6 expression, we exposed LNCaP prostate carcinoma cells and HeLa cervical carcinoma cells to H2O2 as an oxidant challenge. We found ...

journal_title：Antioxidants & redox signaling

authors： Zhang J,Johnston G,Stebler B,Keller ET

更新日期：2001-06-01 00:00:00

abstract：:Enhanced production of reactive oxygen species (ROS) such as H(2)O(2) and a failure in ROS removal by scavenging systems are hallmarks of several cardiovascular diseases such as atherosclerosis and hypertension. ROS act as second messengers that play a prominent role in intracellular signaling and cellular function. I...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S

更新日期：2003-12-01 00:00:00

abstract：:This Forum issue "Heme Oxygenase" (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual rol...

journal_title：Antioxidants & redox signaling

authors： Facchinetti MM

更新日期：2020-06-10 00:00:00

abstract：: Significance: Since the discovery of vascular stem cells, there has been considerable advancement in comprehending the nature and functions of these cells. Due to their differentiation potential to repair endothelial cells and to participate in lesion formation during vasc...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Sun X,Deng J,Hu Y,Xu Q

更新日期：2021-01-19 00:00:00

abstract：:BLNK (B cell linker protein) represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways. In this study, we have investigated the role of BLNK in oxidative stress signaling in B cells. H2O2 treatment of B cells induced a rapid tyrosine phosphorylation ...

journal_title：Antioxidants & redox signaling

authors： Han W,Takano T,He J,Ding J,Gao S,Noda C,Yanagi S,Yamamura H

更新日期：2001-12-01 00:00:00

abstract：AIMS:The usefulness of estrogen replacement therapy (ERT) in preventing oxidative stress associated with menopause is controversial. We aimed to study if there is a critical time window for effective treatment of the effects of ovariectomy with estrogens at the molecular, metabolic, and cellular level. RESULTS:Our mai...

journal_title：Antioxidants & redox signaling

authors： López-Grueso R,Gambini J,Abdelaziz KM,Monleón D,Díaz A,El Alami M,Bonet-Costa V,Borrás C,Viña J

更新日期：2014-01-10 00:00:00

abstract：AIMS:Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro us...

journal_title：Antioxidants & redox signaling

authors： Manta B,Pavan C,Sturlese M,Medeiros A,Crispo M,Berndt C,Krauth-Siegel RL,Bellanda M,Comini MA

更新日期：2013-09-01 00:00:00

abstract：SIGNIFICANCE:Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there ...

journal_title：Antioxidants & redox signaling

authors： Hatem E,El Banna N,Huang ME

更新日期：2017-11-20 00:00:00

abstract：:Clinical heart failure has been defined for a long time as a clinical syndrome with symptoms and signs including shortness of breath, cyanosis, ascites, and edema. However, in recent years, with the thought of promoting early diagnosis and heart-failure prevention, the concept of heart failure has often been defined s...

journal_title：Antioxidants & redox signaling

authors： Jameel MN,Zhang J

更新日期：2009-08-01 00:00:00

abstract：:Nitric oxide (NO) mediates cellular signaling pathways that regulate a plethora of physiological processes. One of the signaling mechanisms mediated by NO is through S-nitrosylation of cysteine residues in target proteins, which is now regarded as an important redox-based physiological action. Deregulation of the prot...

journal_title：Antioxidants & redox signaling

authors： Shahani N,Sawa A

更新日期：2011-04-15 00:00:00

abstract：AIMS:Endothelium-dependent vasorelaxation is mediated by endothelium-derived relaxing factor and endothelium-derived hyperpolarizing factor (EDHF). However, the molecular entity of EDHF remains unclear. The present study examined whether hydrogen sulfide (H₂S) acts as EDHF and how H₂S mediates EDHF pathways from endoth...

journal_title：Antioxidants & redox signaling

authors： Tang G,Yang G,Jiang B,Ju Y,Wu L,Wang R

更新日期：2013-11-10 00:00:00

abstract：SIGNIFICANCE:Disturbance of glutathione (GSH) metabolism is a hallmark of numerous diseases, yet GSH functions are poorly understood. One key to this question is to consider its functional compartmentation. GSH is present in the endoplasmic reticulum (ER), where it competes with substrates for oxidation by the oxidativ...

journal_title：Antioxidants & redox signaling

authors： Delaunay-Moisan A,Ponsero A,Toledano MB

更新日期：2017-11-20 00:00:00

abstract：:Homeostasis within the central nervous system (CNS) is a prerequisite to elicit proper neuronal function. The CNS is tightly sealed from the changeable milieu of the blood stream by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). Whereas the BBB is established by specialized endo...

journal_title：Antioxidants & redox signaling

authors： Coisne C,Engelhardt B

更新日期：2011-09-01 00:00:00