Role of BLNK in oxidative stress signaling in B cells.

abstract：:This work rests on our previous report (J Cereb Blood Flow Metab 30: 1275-1287, 2010) recognizing that glutamate (Glu) oxaloacetate transaminase (GOT) is induced when brain tissue hypoxia is corrected during acute ischemic stroke (AIS). GOT can metabolize Glu into tricarboxylic acid cycle intermediates and may therefo...

journal_title：Antioxidants & redox signaling

authors： Rink C,Gnyawali S,Peterson L,Khanna S

更新日期：2011-05-15 00:00:00

abstract：AIMS:Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro us...

journal_title：Antioxidants & redox signaling

authors： Manta B,Pavan C,Sturlese M,Medeiros A,Crispo M,Berndt C,Krauth-Siegel RL,Bellanda M,Comini MA

更新日期：2013-09-01 00:00:00

abstract：AIMS:Carbon monoxide is a respiratory poison and gaseous signaling molecule. Although CO-releasing molecules (CORMs) deliver CO with temporal and spatial specificity in mammals, and are proven antimicrobial agents, we do not understand the modes of CO toxicity. Our aim was to explore the impact of CO gas per se, withou...

journal_title：Antioxidants & redox signaling

authors： Wareham LK,Begg R,Jesse HE,Van Beilen JW,Ali S,Svistunenko D,McLean S,Hellingwerf KJ,Sanguinetti G,Poole RK

更新日期：2016-06-10 00:00:00

abstract：:Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glyco...

journal_title：Antioxidants & redox signaling

authors： Abdel-Fatah T,Arora A,Gorguc I,Abbotts R,Beebeejaun S,Storr S,Mohan V,Hawkes C,Soomro I,Lobo DN,Parsons SL,Madhusudan S

更新日期：2013-06-20 00:00:00

abstract：: Aims: Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolism of reactive oxygen species (ROS). Increased oxidative stress in adipose tissue contributes to the development of insulin resistance and metabolic syndrome in obesity. This study aimed to...

journal_title：Antioxidants & redox signaling

authors： Piao L,Dorotea D,Jiang S,Koh EH,Oh GT,Ha H

更新日期：2019-12-20 00:00:00

abstract：:The signaling networks that mediate activation, proliferation, or programmed cell death of T lymphocytes are dependent on complex redox and metabolic pathways. T lymphocytes are primarily activated through the T-cell receptor and co-stimulatory molecules. Although activation results in lymphokine production, prolifera...

journal_title：Antioxidants & redox signaling

authors： Perl A,Gergely P Jr,Puskas F,Banki K

更新日期：2002-06-01 00:00:00

abstract：:Disruption of the oxidant/antioxidant balance in the lung is thought to be a key step in the development of many airway pathologies. Hence, antioxidant enzymes play key roles in controlling or preventing pulmonary diseases related to oxidative stress. The superoxide dismutases (SOD) are a family of enzymes that play a...

journal_title：Antioxidants & redox signaling

authors： Gao F,Kinnula VL,Myllärniemi M,Oury TD

更新日期：2008-02-01 00:00:00

abstract：:Liver fibrosis is the consequence of chronic liver injury of any etiology. When advanced, fibrosis causes portal hypertension and liver insufficiency, and is a risk factor for developing hepatocellular carcinoma. In the last decade, there have been major advances in the knowledge of the pathogenesis of hepatic fibrosi...

journal_title：Antioxidants & redox signaling

authors： Bataller R,Sancho-Bru P,Ginès P,Brenner DA

更新日期：2005-09-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, maintains alveolar integrity and participates in the control of host defense and inflammation in the lung. Surfactant proteins A, B, C, and D are important components of surfactant that play diverse roles in the surface tension reducing as well as host defense an...

journal_title：Antioxidants & redox signaling

authors： Boggaram V

更新日期：2004-02-01 00:00:00

abstract：: Aims: In this study, we investigate the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune diseases. We focus on oxidative regulation at the interaction between antigen-presenting cells (APCs) and T cells, and consequent effect of ROS a...

journal_title：Antioxidants & redox signaling

authors： Zhong J,Yau ACY,Holmdahl R

更新日期：2020-01-20 00:00:00

abstract：SIGNIFICANCE:There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated a...

journal_title：Antioxidants & redox signaling

authors： Alexandrou AT,Li JJ

更新日期：2014-03-20 00:00:00

abstract：:Although there is an abundance of evidence suggesting that insulin resistance plays a significant role in the vasculature, the precise mechanistic role involved still remains unclear. In this review, we discuss the current background of insulin resistance in the context of insulin signaling and action in the vasculatu...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S,Motley ED

更新日期：2005-07-01 00:00:00

abstract：:Junctional adhesion molecules are transmembrane proteins that belong to the immunoglobulin superfamily. In addition to their localization in close proximity to the tight junctions in endothelial and epithelial cells, junctional adhesion molecules are also expressed in circulating cells that do not form junctions, such...

journal_title：Antioxidants & redox signaling

authors： Bazzoni G

更新日期：2011-09-01 00:00:00

abstract：SIGNIFICANCE:Currently, calcific aortic valve disease (CAVD) is only treatable through surgical intervention because the specific mechanisms leading to the disease remain unclear. In this review, we explore the forces and structure of the valve, as well as the mechanosensors and downstream signaling in the valve endoth...

journal_title：Antioxidants & redox signaling

authors： Fernández Esmerats J,Heath J,Jo H

更新日期：2016-09-01 00:00:00

abstract：AIMS:Abnormal accumulation of α-synuclein aggregates is one of the key pathological features of many neurodegenerative movement disorders and dementias. These pathological aggregates propagate into larger brain regions as the disease progresses, with the associated clinical symptoms becoming increasingly severe and com...

journal_title：Antioxidants & redox signaling

authors： Bae EJ,Ho DH,Park E,Jung JW,Cho K,Hong JH,Lee HJ,Kim KP,Lee SJ

更新日期：2013-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) generated within the vascular wall trigger low-density lipoprotein (LDL) oxidation, lipid peroxidation, and carbonyl stress that are involved in atherogenesis. We recently reported that the antihypertensive drug, hydralazine, exhibits carbonyl scavenger and antiatherogenic properties, but...

journal_title：Antioxidants & redox signaling

authors： Bouguerne B,Belkheiri N,Bedos-Belval F,Vindis C,Uchida K,Duran H,Grazide MH,Baltas M,Salvayre R,Nègre-Salvayre A

更新日期：2011-06-01 00:00:00

abstract：:Oxidative stress due to increased epidermal levels of H(2)O(2) with consequent inhibition of catalase activity is generally accepted as a leading cytotoxic mechanism of melanocyte loss in vitiligo. Keratinocyte-derived cytokines are considered key factors in the maintenance of melanocyte structure and functions. We hy...

journal_title：Antioxidants & redox signaling

authors： Kostyuk VA,Potapovich AI,Cesareo E,Brescia S,Guerra L,Valacchi G,Pecorelli A,Deeva IB,Raskovic D,De Luca C,Pastore S,Korkina LG

更新日期：2010-09-01 00:00:00

abstract：:The herbicide paraquat (PQ) has been implicated as a potential risk factor for the development of Parkinson's disease. In this study, PQ (0.5-1 microM) was shown to be selectively toxic to dopaminergic (DA) neurons through the activation of microglial NADPH oxidase and the generation of superoxide. Neuron-glia culture...

journal_title：Antioxidants & redox signaling

authors： Wu XF,Block ML,Zhang W,Qin L,Wilson B,Zhang WQ,Veronesi B,Hong JS

更新日期：2005-05-01 00:00:00

abstract：AIMS:Large doses of intraperitoneally injected basic amino acids, L-arginine, or L-ornithine, induce acute pancreatitis in rodents, although the mechanisms mediating pancreatic toxicity remain unknown. Another basic amino acid, L-lysine, was also shown to cause pancreatic acinar cell injury. The aim of the study was to...

journal_title：Antioxidants & redox signaling

authors： Biczó G,Hegyi P,Dósa S,Shalbuyeva N,Berczi S,Sinervirta R,Hracskó Z,Siska A,Kukor Z,Jármay K,Venglovecz V,Varga IS,Iványi B,Alhonen L,Wittmann T,Gukovskaya A,Takács T,Rakonczay Z Jr

更新日期：2011-11-15 00:00:00

abstract：AIMS:Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is mainly degraded by dimethylarginine dimethylaminohydrolase (DDAH). Emerging evidence suggests that plasma ADMA accumulation and DDAH1 activity/expression reduction are linked to chronic kidney disease (CKD) pathology, but the ...

journal_title：Antioxidants & redox signaling

authors： Shi L,Zhao C,Wang H,Lei T,Liu S,Cao J,Lu Z

更新日期：2017-12-01 00:00:00

abstract：:Homeostasis within the central nervous system (CNS) is a prerequisite to elicit proper neuronal function. The CNS is tightly sealed from the changeable milieu of the blood stream by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). Whereas the BBB is established by specialized endo...

journal_title：Antioxidants & redox signaling

authors： Coisne C,Engelhardt B

更新日期：2011-09-01 00:00:00

abstract：AIMS:Heart failure (HF) is characterized by regionalized contractile alterations resulting in loss of the transmural contractile gradient across the left ventricular free wall. We tested whether a regional alteration in mitochondrial oxidative metabolism during HF could affect myofilament function through protein kinas...

journal_title：Antioxidants & redox signaling

authors： Andre L,Fauconnier J,Reboul C,Feillet-Coudray C,Meschin P,Farah C,Fouret G,Richard S,Lacampagne A,Cazorla O

更新日期：2013-03-20 00:00:00

abstract：:The possibility of a plasma oxygen diffusion barrier implies a significant resistance to oxygen diffusion and the existence of capillary erythrocyte-associated transients of oxygen. This effect was analyzed by measuring intracapillary blood and tissue pO(2) in the hamster chamber window model using a noninvasive intra...

journal_title：Antioxidants & redox signaling

authors： Cabrales P,Intaglietta M

更新日期：2007-07-01 00:00:00

abstract：:Despite the significance of redox post-translational modifications (PTMs) in regulating diverse signal transduction pathways, the enzymatic systems that catalyze reversible and specific oxidative or reductive modifications have yet to be firmly established. Thioredoxin 1 (Trx1) is a conserved antioxidant protein that ...

journal_title：Antioxidants & redox signaling

authors： Wu C,Parrott AM,Fu C,Liu T,Marino SM,Gladyshev VN,Jain MR,Baykal AT,Li Q,Oka S,Sadoshima J,Beuve A,Simmons WJ,Li H

更新日期：2011-11-01 00:00:00

abstract：:Glycerophospholipids represent a common class of lipids critically important for integrity of cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes biological activities of phospholipids. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPL...

journal_title：Antioxidants & redox signaling

authors： Bochkov VN,Oskolkova OV,Birukov KG,Levonen AL,Binder CJ,Stöckl J

更新日期：2010-04-15 00:00:00

abstract：:The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calor...

journal_title：Antioxidants & redox signaling

authors： Redman LM,Ravussin E

更新日期：2011-01-15 00:00:00

abstract：:Through hypoxia-inducible factor 1 (HIF-1), hypoxia regulates the expression of numerous genes and is a potent inducer of angiogenesis. However, interleukin-8 (IL-8), an important angiogenic mediator, has been reported to be downregulated by HIF-1, although the mechanisms have not been elucidated. HIF-1 was induced in...

journal_title：Antioxidants & redox signaling

authors： Loboda A,Stachurska A,Florczyk U,Rudnicka D,Jazwa A,Wegrzyn J,Kozakowska M,Stalinska K,Poellinger L,Levonen AL,Yla-Herttuala S,Jozkowicz A,Dulak J

更新日期：2009-07-01 00:00:00

abstract：:Membrane (lipid) rafts and caveolae, a subset of rafts, are cellular domains that concentrate plasma membrane proteins and lipids involved in the regulation of cell function. In addition to providing signaling platforms for G-protein-coupled receptors and certain tyrosine kinase receptors, rafts/caveolae can influence...

journal_title：Antioxidants & redox signaling

authors： Patel HH,Insel PA

更新日期：2009-06-01 00:00:00

abstract：SIGNIFICANCE:A mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow--hypoxic vasodilation--occur in an attempt to restore oxygen supply. Nitric oxide (NO) is a major signaling...

journal_title：Antioxidants & redox signaling

authors： Umbrello M,Dyson A,Feelisch M,Singer M

更新日期：2013-11-10 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00