Liver fibrogenesis: a new role for the renin-angiotensin system.

abstract：: Significance: Since the discovery of vascular stem cells, there has been considerable advancement in comprehending the nature and functions of these cells. Due to their differentiation potential to repair endothelial cells and to participate in lesion formation during vasc...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Sun X,Deng J,Hu Y,Xu Q

更新日期：2021-01-19 00:00:00

abstract：SIGNIFICANCE:The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through...

journal_title：Antioxidants & redox signaling

authors： Sevilla E,Bes MT,González A,Peleato ML,Fillat MF

更新日期：2019-05-01 00:00:00

abstract：:Reductions in brain glucose metabolism and increased oxidative stress invariably occur in Alzheimer's disease (AD) and thiamine (vitamin B1) deficiency. Both conditions cause irreversible cognitive impairment; their behavioral consequences overlap but are not identical. Thiamine-dependent processes are critical in glu...

journal_title：Antioxidants & redox signaling

authors： Gibson GE,Blass JP

更新日期：2007-10-01 00:00:00

abstract：:Ischemia followed by reperfusion is the primary cause of tissue injury and infarction during heart attack and stroke. The initiating stimulus is believed to involve reactive oxygen species that are produced during reperfusion when electron transport resumes in the mitochondria after suppression by ischemia. Programmed...

journal_title：Antioxidants & redox signaling

authors： Webster KA,Graham RM,Thompson JW,Spiga MG,Frazier DP,Wilson A,Bishopric NH

更新日期：2006-09-01 00:00:00

abstract：:Although oxygen is essential for promoting energy metabolism and for enhancing cell proliferation, early mouse embryos are very sensitive to high oxygen concentration. Because the tissue-specificity and sequential changes of the expression of antioxidative enzymes in rodent embryos have not been investigated systemati...

journal_title：Antioxidants & redox signaling

authors： Kobayashi M,Nakamura H,Yodoi J,Shiota K

更新日期：2000-01-01 00:00:00

abstract：AIMS:Recent studies suggest that the molybdenum enzymes xanthine oxidase, aldehyde oxidase, and mARC exhibit nitrite reductase activity at low oxygen pressures. However, inhibition studies of xanthine oxidase in humans have failed to block nitrite-dependent changes in blood flow, leading to continued exploration for ot...

journal_title：Antioxidants & redox signaling

authors： Wang J,Krizowski S,Fischer-Schrader K,Niks D,Tejero J,Sparacino-Watkins C,Wang L,Ragireddy V,Frizzell S,Kelley EE,Zhang Y,Basu P,Hille R,Schwarz G,Gladwin MT

更新日期：2015-08-01 00:00:00

abstract：: Significance: Hypertension is characterized as the imbalance of vasoconstriction and vasodilatation. Hypertension is influenced by genetic variation and environmental risk factors, such as unhealthy diet. Clinical trial results suggest that increasing intake of foods rich ...

journal_title：Antioxidants & redox signaling

authors： Wang H,Li Q,Zhu Y,Zhang X

更新日期：2020-06-12 00:00:00

abstract：SIGNIFICANCE:Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling mechanism triggered by Ca2+ depletion of the endoplasmic reticulum (ER) and by a variety of cellular stresses. Reactive oxygen species (ROS) are often concomitantly produced in response to these stresses, however, the relationship between redo...

journal_title：Antioxidants & redox signaling

authors： Nunes P,Demaurex N

更新日期：2014-08-20 00:00:00

abstract：:Anthracyclines are widely used in anticancer protocols, but can induce cardiotoxicity by mechanisms that mainly involve oxidative damage and mitochondrial dysfunction. Radiotherapy (RT) can also impair cardiac function by promoting myocardial fibrosis, microvascular damage, and decreased density of myocardial capillar...

journal_title：Antioxidants & redox signaling

authors： Mercurio V,Cuomo A,Della Pepa R,Ciervo D,Cella L,Pirozzi F,Parrella P,Campi G,Franco R,Varricchi G,Abete P,Marone G,Petretta M,Bonaduce D,Pacelli R,Picardi M,Tocchetti CG

更新日期：2019-11-20 00:00:00

abstract：SIGNIFICANCE:Many cardiovascular disorders are accompanied by a deregulated cellular redox balance resulting in elevated levels of intracellular reactive oxygen species (ROS). One major antioxidative cellular molecule is thioredoxin-1 (Trx-1). Its indispensability is demonstrated by the embryonic lethality of Trx-1 def...

journal_title：Antioxidants & redox signaling

authors： Zschauer TC,Matsushima S,Altschmied J,Shao D,Sadoshima J,Haendeler J

更新日期：2013-03-20 00:00:00

abstract：SIGNIFICANCE:Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there ...

journal_title：Antioxidants & redox signaling

authors： Hatem E,El Banna N,Huang ME

更新日期：2017-11-20 00:00:00

abstract：:Fluid shear stress plays a critical role in the regulation of vascular biology and its pathology, such as atherosclerosis, via modulation of redox balance. Both pro-atherogenic (either oscillatory or turbulent, nonunidirectional) shear stress and anti-atherogenic (either steady or pulsatile, unidirectional laminar) sh...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Warabi E,Noguchi N

更新日期：2011-09-01 00:00:00

abstract：AIMS:To evaluate mechanisms underlying modulation of inflammatory chemokines in primary human keratinocytes (normal human epidermal keratinocytes) and repair-related processes in wound models by plant polyphenols (PPs) with antioxidant and superoxide scavenging properties (verbascoside [Vb], resveratrol [Rv], polydatin...

journal_title：Antioxidants & redox signaling

authors： Pastore S,Lulli D,Fidanza P,Potapovich AI,Kostyuk VA,De Luca C,Mikhal'chik E,Korkina LG

更新日期：2012-02-15 00:00:00

abstract：AIM:Antrodia Camphorate (AC) is a mushroom that is widely used in Asian countries to prevent and treat various diseases, including liver diseases. However, the active ingredients that contribute to the biological functions remain elusive. The purpose of the present study is to test the hepatoprotective effect of Antcin...

journal_title：Antioxidants & redox signaling

authors： Huo Y,Win S,Than TA,Yin S,Ye M,Hu H,Kaplowitz N

更新日期：2017-02-10 00:00:00

abstract：:DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has homologs in nearly all organisms. Because of its connection to parkinsonism and cancer, human DJ-1 has been intensely studied for over a decade. The current view is that DJ-1 is a multifunctional oxidative stress response protein that...

journal_title：Antioxidants & redox signaling

authors： Wilson MA

更新日期：2011-07-01 00:00:00

abstract：AIMS:Pulmonary infections with Pseudomonas aeruginosa are a serious clinical problem and are often lethal. Because many strains of P. aeruginosa are resistant to antibiotics, therapeutic options are limited. Neutrophils play an important role in the host's early acute defense against pulmonary P. aeruginosa. Therefore,...

journal_title：Antioxidants & redox signaling

authors： Managò A,Becker KA,Carpinteiro A,Wilker B,Soddemann M,Seitz AP,Edwards MJ,Grassmé H,Szabò I,Gulbins E

更新日期：2015-05-01 00:00:00

abstract：:Exposure of neonatal rat cardiac myocytes to palmitate and glucose produces apoptosis as seen by cytochrome c release, caspase 3-like activation, DNA laddering, and poly(ADP-ribose) polymerase cleavage. The purpose of this study was to understand the role of reactive oxygen species in the initiation of programmed cell...

journal_title：Antioxidants & redox signaling

authors： Sparagna GC,Hickson-Bick DL,Buja LM,McMillin JB

更新日期：2001-02-01 00:00:00

abstract：SIGNIFICANCE:Atrial fibrillation (AF) is a burgeoning health-care problem, and the currently available therapeutic armamentarium is barely efficient. Experimental and clinical evidence implicates inflammation and myocardial oxidative stress in the pathogenesis of AF. RECENT ADVANCES:Local and systemic inflammation has...

journal_title：Antioxidants & redox signaling

authors： Pinho-Gomes AC,Reilly S,Brandes RP,Casadei B

更新日期：2014-03-10 00:00:00

abstract：AIMS:Cystathionine β-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of three major enzymes responsible for the biogenesis of H2S, a signaling molecule. We have previously demonstrated that CBS is activated in cel...

journal_title：Antioxidants & redox signaling

authors： Niu WN,Yadav PK,Adamec J,Banerjee R

更新日期：2015-02-10 00:00:00

abstract：:Heme oxygenase-1 is the rate-limiting enzyme for the degradation of the prooxidant heme. Previously, we showed that an E-box within the HO-1 promoter is crucial for the regulation of HO-1 expression in primary hepatocytes. Further to investigate the importance of this E-box, we determined the regulatory capacity of th...

journal_title：Antioxidants & redox signaling

authors： Samoylenko A,Dimova EY,Horbach T,Teplyuk N,Immenschuh S,Kietzmann T

更新日期：2008-07-01 00:00:00

abstract：:Hypoxia and its corollaries pose both negative and positive pressures to multicellular eukaryotes. Evolutionarily, life developed under hypoxia, and the building blocks were established under conditions close to anaerobiosis; therefore, reason exists to expect that certain biologic processes may perform preferentially...

journal_title：Antioxidants & redox signaling

authors： Webster KA

更新日期：2007-09-01 00:00:00

abstract：SIGNIFICANCE:The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. R...

journal_title：Antioxidants & redox signaling

authors： Nussbaum C,Klinke A,Adam M,Baldus S,Sperandio M

更新日期：2013-02-20 00:00:00

abstract：:Nitrite, previously considered physiologically irrelevant and a simple end product of endogenous nitric oxide (NO) metabolism, is now envisaged as a reservoir of NO to be activated in response to oxygen (O(2)) depletion. In the first part of this review, we summarize and compare the mechanisms of nitrite-dependent pro...

journal_title：Antioxidants & redox signaling

authors： Castiglione N,Rinaldo S,Giardina G,Stelitano V,Cutruzzolà F

更新日期：2012-08-15 00:00:00

abstract：: Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway essential for generation of energy and biosynthetic intermediates. Alterations of the TCA cycle play a pivotal role in oncogenesis and inflammation. As such, some metabolic vulnerabilities...

journal_title：Antioxidants & redox signaling

authors： Scagliola A,Mainini F,Cardaci S

更新日期：2020-04-20 00:00:00

abstract：SIGNIFICANCE:Alzheimer's disease is a neurodegenerative disorder that is projected to exceed more than 100 million cases worldwide by 2050. Aging is considered the primary risk factor for some 90% of Alzheimer's cases but a significant 10% of patients suffer from aggressive, early-onset forms of the disease. There is c...

journal_title：Antioxidants & redox signaling

authors： Bonet-Costa V,Pomatto LC,Davies KJ

更新日期：2016-12-01 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：SIGNIFICANCE:Studies of sporadic cases, toxin models, and genetic causes of Parkinson's disease suggest that mitochondrial dysfunction may be an early feature of pathogenesis. RECENT ADVANCES:Compelling evidence of a causal relationship between mitochondrial function and disease was found with the identification of se...

journal_title：Antioxidants & redox signaling

authors： McCoy MK,Cookson MR

更新日期：2012-05-01 00:00:00

abstract：:Carica papaya Linn is widely known as a medicinal fruit. We sought to study a standardized fermented papaya preparation (FPP) for its effects on wound healing in adult obese diabetic (db/db) mice. FPP blunted the gain in blood glucose and improved the lipid profile after 8 weeks of oral supplementation. However, FPP d...

journal_title：Antioxidants & redox signaling

authors： Collard E,Roy S

更新日期：2010-09-01 00:00:00

abstract：AIMS:Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases mitochondrial ATP levels. Here, we investigate the mechanistic connection between SIRT3 and energy homeost...

journal_title：Antioxidants & redox signaling

authors： Vassilopoulos A,Pennington JD,Andresson T,Rees DM,Bosley AD,Fearnley IM,Ham A,Flynn CR,Hill S,Rose KL,Kim HS,Deng CX,Walker JE,Gius D

更新日期：2014-08-01 00:00:00

abstract：:Gamma-interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in most antigen presenting cells and is interferon γ inducible in other cell types via signal transducer and activator of transcription 1. Normally, N- and C-terminal propeptides are cleaved in the early endosome, and the mature pr...

journal_title：Antioxidants & redox signaling

authors： Hastings KT,Cresswell P

更新日期：2011-08-01 00:00:00