SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.

abstract：: Significance: Heme oxygenase-1 (HO-1) is a ubiquitous 32-kDa protein expressed in many tissues and highly inducible. They catalyze the degradation of the heme group and the release of free iron, carbon monoxide, and biliverdin; the latter converted to bilirubin by biliverd...

journal_title：Antioxidants & redox signaling

authors： Medina MV,Sapochnik D,Garcia Solá M,Coso O

更新日期：2020-05-10 00:00:00

abstract：:Increased oxidative stress and impaired heat shock protein (HSP) synthesis may contribute to diabetic nephropathy. The question of whether 8-week thiol antioxidant alpha-lipoic acid (LA) supplementation modulates HSP response and oxidative stress was studied in the kidney of streptozotocin-induced diabetic (SID) and n...

journal_title：Antioxidants & redox signaling

authors： Oksala NK,Lappalainen J,Laaksonen DE,Khanna S,Kaarniranta K,Sen CK,Atalay M

更新日期：2007-04-01 00:00:00

abstract：SIGNIFICANCE:There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated a...

journal_title：Antioxidants & redox signaling

authors： Alexandrou AT,Li JJ

更新日期：2014-03-20 00:00:00

abstract：:In the brain, the mu-opioid receptor (MOR) activates neural nitric oxide synthase (nNOS) through the PI3K/Akt pathway. The resulting nitric oxide (NO) enhances the function of the glutamate N-methyl-d-aspartate receptor (NMDAR)/calcium and calmodulin-dependent serine/threonine kinase (CaMKII), which subsequently dimin...

journal_title：Antioxidants & redox signaling

authors： Rodríguez-Muñoz M,de la Torre-Madrid E,Sánchez-Blázquez P,Garzón J

更新日期：2011-06-15 00:00:00

abstract：:Loss of redox homeostasis and formation of excessive free radicals play an important role in the pathogenesis of kidney disease and hypertension. Free radicals such as reactive oxygen species (ROS) are necessary in physiologic processes. However, loss of redox homeostasis contributes to proinflammatory and profibrotic...

journal_title：Antioxidants & redox signaling

authors： Nistala R,Whaley-Connell A,Sowers JR

更新日期：2008-12-01 00:00:00

abstract：:Scholarly peer review represents the linchpin of academic publishing. Recognized benefits of the peer review system are manifold. Critics raise several valid concerns that deserve attention. Several studies show that the current peer review system lacks robustness and is subject to bias in favor of well-established re...

journal_title：Antioxidants & redox signaling

authors： Sen CK

更新日期：2012-02-15 00:00:00

abstract：SIGNIFICANCE:In bacteria, transcriptional responses to reactive oxygen and nitrogen species (ROS and RNS, respectively) are typically coordinated by regulatory proteins that employ metal centers or reactive thiols to detect the presence of those species. This review is focused on the structure, function and mechanism o...

journal_title：Antioxidants & redox signaling

authors： Spiro S,D'Autréaux B

更新日期：2012-11-01 00:00:00

abstract：SIGNIFICANCE:The accepted effects of aging in mammalian skeletal muscle are progressive atrophy and weakening, or sarcopenia. Canonical hallmarks of aging in skeletal muscle include a reduction in muscle fiber cross-sectional area, a loss in muscle fibers through apoptosis and denervation, and infiltration of connectiv...

journal_title：Antioxidants & redox signaling

authors： Lawler JM,Hindle A

更新日期：2011-11-01 00:00:00

abstract：:The signaling for activation of protein tyrosine kinases (PTKs) is usually started by binding of ligands to cell-surface receptors. However, recent evidence suggests the presence of ligand binding-independent signaling pathways that are mediated by oxidative stress. Oxidation and reduction of protein cysteine sulfhydr...

journal_title：Antioxidants & redox signaling

authors： Nakashima I,Kato M,Akhand AA,Suzuki H,Takeda K,Hossain K,Kawamoto Y

更新日期：2002-06-01 00:00:00

abstract：:Cellular compartments differ dramatically in their redox potentials. This translates directly into variations in the extent of disulfide bond formation within proteins, depending on their cellular localization. It has long been assumed that proteins that are present in the reducing environment of the cytosol do not po...

journal_title：Antioxidants & redox signaling

authors： Linke K,Jakob U

更新日期：2003-08-01 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：:Free-radicals and other reactive oxygen species (ROS) have been implicated as being major damaging species in pathology and they have been widely investigated. Using 1,1'-diphenyl-2-picrylhydrazyl (DPPH), we estimated total free radical scavenging activity in the low-molecular-weight nonenzymatic fraction (LMNEF) of h...

journal_title：Antioxidants & redox signaling

authors： Atsumi T,Iwakura I,Kashiwagi Y,Fujisawa S,Ueha T

更新日期：1999-01-01 00:00:00

abstract：:The signaling networks that mediate activation, proliferation, or programmed cell death of T lymphocytes are dependent on complex redox and metabolic pathways. T lymphocytes are primarily activated through the T-cell receptor and co-stimulatory molecules. Although activation results in lymphokine production, prolifera...

journal_title：Antioxidants & redox signaling

authors： Perl A,Gergely P Jr,Puskas F,Banki K

更新日期：2002-06-01 00:00:00

abstract：:Chronic inflammatory processes induce oxidative stress and lipid peroxidation (LPO), hereby generating DNA-reactive aldehydes such as trans-4-hydroxy-2-nonenal (HNE). Etheno-modified DNA bases are inter alia generated by reaction of DNA with HNE. Using an immunoaffinity-(32)P-postlabeling method, the authors have inve...

journal_title：Antioxidants & redox signaling

authors： Nair J,Gansauge F,Beger H,Dolara P,Winde G,Bartsch H

更新日期：2006-05-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：:Through hypoxia-inducible factor 1 (HIF-1), hypoxia regulates the expression of numerous genes and is a potent inducer of angiogenesis. However, interleukin-8 (IL-8), an important angiogenic mediator, has been reported to be downregulated by HIF-1, although the mechanisms have not been elucidated. HIF-1 was induced in...

journal_title：Antioxidants & redox signaling

authors： Loboda A,Stachurska A,Florczyk U,Rudnicka D,Jazwa A,Wegrzyn J,Kozakowska M,Stalinska K,Poellinger L,Levonen AL,Yla-Herttuala S,Jozkowicz A,Dulak J

更新日期：2009-07-01 00:00:00

abstract：SIGNIFICANCE:The protein tyrosine phosphatases (PTPs) are a family of proteins that play critical roles in cellular signaling and influence many aspects of human health and disease. Although a wealth of information has been collected about PTPs since their discovery, many questions regarding their regulation and functi...

journal_title：Antioxidants & redox signaling

authors： Stanford SM,Ahmed V,Barrios AM,Bottini N

更新日期：2014-05-10 00:00:00

abstract：:Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/beta-catenin pathway, which itself regulates cell fate and earl...

journal_title：Antioxidants & redox signaling

authors： Funato Y,Miki H

更新日期：2007-08-01 00:00:00

abstract：:The herbicide paraquat (PQ) has been implicated as a potential risk factor for the development of Parkinson's disease. In this study, PQ (0.5-1 microM) was shown to be selectively toxic to dopaminergic (DA) neurons through the activation of microglial NADPH oxidase and the generation of superoxide. Neuron-glia culture...

journal_title：Antioxidants & redox signaling

authors： Wu XF,Block ML,Zhang W,Qin L,Wilson B,Zhang WQ,Veronesi B,Hong JS

更新日期：2005-05-01 00:00:00

abstract：:Molecular chaperones play key roles in protein quality control, signal transduction, proliferation, and cell death, and confer cytoprotection and assure survival after environmental stress. The heat-shock response is implicated in a variety of conditions including ischemic diseases, infection and immunity, neurodegene...

journal_title：Antioxidants & redox signaling

authors： Putics A,Végh EM,Csermely P,Soti C

更新日期：2008-01-01 00:00:00

abstract：:Cardiac hypertrophy and heart failure are major causes of morbidity and mortality in Western societies. Many factors have been implicated in cardiac remodeling, including alterations in gene expression in myocytes, cardiomyocytes apoptosis, cytokines and growth factors that influence cardiac dynamics, and deficits in ...

journal_title：Antioxidants & redox signaling

authors： Gupta S,Das B,Sen S

更新日期：2007-06-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00

abstract：: Aims: Lifelong pain is a hallmark feature of sickle cell disease (SCD). How sickle pathobiology evokes pain remains unknown. We hypothesize that increased cell-free heme due to ongoing hemolysis activates toll-like receptor 4 (TLR4), leading to the formation of reactive ox...

journal_title：Antioxidants & redox signaling

authors： Lei J,Paul J,Wang Y,Gupta M,Vang D,Thompson S,Jha R,Nguyen J,Valverde Y,Lamarre Y,Jones MK,Gupta K

更新日期：2021-02-01 00:00:00

abstract：:DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has homologs in nearly all organisms. Because of its connection to parkinsonism and cancer, human DJ-1 has been intensely studied for over a decade. The current view is that DJ-1 is a multifunctional oxidative stress response protein that...

journal_title：Antioxidants & redox signaling

authors： Wilson MA

更新日期：2011-07-01 00:00:00

abstract：:Lipoic acid (LA) and its reduced product dihydrolipoic acid (DHLA) are potent antioxidants with capacity to scavenge reactive oxygen species (ROS) and recycle endogenous antioxidants. LA may increase cellular glutathione (GSH), an antioxidant lacking in the lung's epithelial lining fluid in lung disorders such as idio...

journal_title：Antioxidants & redox signaling

authors： O'Neill HC,Rancourt RC,White CW

更新日期：2008-02-01 00:00:00

abstract：SIGNIFICANCE:Redox signaling is a common mechanism in the cellular response toward a variety of stimuli. For analyzing redox-dependent specific alterations in a cell, genetically encoded biosensors were highly instrumental in the past. To advance the knowledge about the importance of this signaling mechanism in vivo, m...

journal_title：Antioxidants & redox signaling

authors： Swain L,Nanadikar MS,Borowik S,Zieseniss A,Katschinski DM

更新日期：2018-08-20 00:00:00

abstract：:Trisulfides and other oligosulfides are widely distributed in the biological world. In plants, for example, garlic, trisulfides are associated with potentially beneficial properties. However, an extra neutral sulfur atom covalently bound between the two sulfur atoms of a pair of cysteines is not a common post-translat...

journal_title：Antioxidants & redox signaling

authors： Nielsen RW,Tachibana C,Hansen NE,Winther JR

更新日期：2011-07-01 00:00:00

abstract：AIM:Epithelial-mesenchymal transition (EMT) is characterized by the acquisition of invasive fibroblast-like morphology by epithelial cells that are highly polarized. EMT is recognized as a crucial mechanism in cancer progression and metastasis. In this study, we sought to assess the involvement of manganese superoxide ...

journal_title：Antioxidants & redox signaling

authors： Loo SY,Hirpara JL,Pandey V,Tan TZ,Yap CT,Lobie PE,Thiery JP,Goh BC,Pervaiz S,Clément MV,Kumar AP

更新日期：2016-08-20 00:00:00

abstract：:It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch points where disturbed blood flow (d-flow) predisposes to the development of plaques. Investigations both in vivo and in vitro have shown that d-flow is pro-atherogenic by promoting oxidative and inflammatory states in the a...

journal_title：Antioxidants & redox signaling

authors： Nigro P,Abe J,Berk BC

更新日期：2011-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) can directly induce or enhance tumor necrosis factor (TNF)-mediated apoptosis in a number of different cell lines. To test the relevance of intracellular ROS in modulating apoptotic signaling in vivo, we evaluated hepatocellular apoptosis mediated by the TNF or Fas receptor in wild-type a...

journal_title：Antioxidants & redox signaling

authors： Bajt ML,Ho YS,Vonderfecht SL,Jaeschke H

更新日期：2002-10-01 00:00:00