Transgenic Organisms Meet Redox Bioimaging: One Step Closer to Physiology.

abstract：AIMS:Emerging lines of evidence indicate that oxidants such as hydrogen peroxide exert specific signaling functions during the processing of chronic pain. However, the mechanisms by which oxidants regulate pain processing in vivo remain poorly understood. Here, we investigated whether cyclic guanosine monophosphate (cG...

journal_title：Antioxidants & redox signaling

authors： Lorenz JE,Kallenborn-Gerhardt W,Lu R,Syhr KM,Eaton P,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to regulate a variety of physiological functions, including vascular tone. The inhibition of NO synthase by N(omega)-nitro-L-arginine methyl ester (L-NAME) has been reported to increase arterial blood pressure. The present studies were undertaken to investigate if the increased blood p...

journal_title：Antioxidants & redox signaling

authors： Anand-Srivastava MB,Di Fusco F

更新日期：2004-04-01 00:00:00

abstract：:Thiol peroxidases comprise glutathione peroxidases (GPx) and peroxiredoxins (Prx). The enzymes of both families reduce hydroperoxides with thiols by enzyme-substitution mechanisms. H(2)O(2) and organic hydroperoxides are reduced by all thiol peroxidases, most efficiently by SecGPxs, whereas fast peroxynitrite reductio...

journal_title：Antioxidants & redox signaling

authors： Flohé L,Toppo S,Cozza G,Ursini F

更新日期：2011-08-01 00:00:00

abstract：:Cells oxidize molecules to generate energy and to make the materials to build and support the structures and functions needed for life. However, unwanted oxidations can damage these same structures and impair function. Lipids (the lipids in membranes and lipoproteins) are targets of unwanted oxidations. The primary me...

journal_title：Antioxidants & redox signaling

authors： Venkataraman S,Schafer FQ,Buettner GR

更新日期：2004-06-01 00:00:00

abstract：:The aim of the present study is to examine the effects of dietary saturated fatty acids on liver adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) in ethanol-administered animals and in ethanol-exposed cultured hepatic cells, and to explore the underlying molecular mechanisms. The mRNA and protein ...

journal_title：Antioxidants & redox signaling

authors： Liang X,Hu M,Rogers CQ,Shen Z,You M

更新日期：2011-07-15 00:00:00

abstract：:Methionine residues are susceptible to oxidation, but this damage may be reversed by methionine sulfoxide reductases MsrA and MsrB. Mammals contain one MsrA and three MsrBs, including a selenoprotein MsrB1. Here, we show that MsrB1 is the major methionine sulfoxide reductase in liver of mice and it is among the protei...

journal_title：Antioxidants & redox signaling

authors： Novoselov SV,Kim HY,Hua D,Lee BC,Astle CM,Harrison DE,Friguet B,Moustafa ME,Carlson BA,Hatfield DL,Gladyshev VN

更新日期：2010-04-01 00:00:00

abstract：:Protein and amine halogenation is a type of oxidative stress induced by phagocytic overstimulation, and its role in Parkinson's disease (PD) has not been discerned. We have detected that advanced oxidized protein products, markers of protein halogenation, are reliably enhanced in serum of patients with PD (n=60) relat...

journal_title：Antioxidants & redox signaling

authors： García-Moreno JM,Martín de Pablos A,García-Sánchez MI,Méndez-Lucena C,Damas-Hermoso F,Rus M,Chacón J,Fernández E

更新日期：2013-04-10 00:00:00

abstract：: Aims: Autophagy is a catabolic process required for the maintenance of cardiac health. Insulin and insulin-like growth factor 1 (IGF-1) are potent inhibitors of autophagy and as such, one would predict that autophagy will be increased in the insulin-resistant/diabetic hear...

journal_title：Antioxidants & redox signaling

authors： Pires KM,Torres NS,Buffolo M,Gunville R,Schaaf C,Davis K,Selzman CH,Gottlieb RA,Boudina S

更新日期：2019-08-20 00:00:00

abstract：AIMS:The risk factors promoting acute kidney injury (AKI) to chronic kidney disease (CKD) progression remain largely unknown. The aim of the present study was to investigate whether hyperhomocysteinemia (Hhcy) accelerates the development of renal fibrosis after AKI. RESULTS:Hhcy aggravated ischemia-reperfusion-induced...

journal_title：Antioxidants & redox signaling

authors： Li S,Qiu B,Lu H,Lai Y,Liu J,Luo J,Zhu F,Hu Z,Zhou M,Tian J,Zhou Z,Yu S,Yi F,Nie J

更新日期：2019-05-01 00:00:00

abstract：:Homeostasis within the central nervous system (CNS) is a prerequisite to elicit proper neuronal function. The CNS is tightly sealed from the changeable milieu of the blood stream by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). Whereas the BBB is established by specialized endo...

journal_title：Antioxidants & redox signaling

authors： Coisne C,Engelhardt B

更新日期：2011-09-01 00:00:00

abstract：SIGNIFICANCE:Lysosomes are organelles in which cellular degradation occurs in a controlled manner, separated from other cellular components. As several pathways terminate in the lysosome, lysosomal dysfunction has a profound impact on cell homeostasis, resulting in manifold pathological situations, including infectious...

journal_title：Antioxidants & redox signaling

authors： Boya P

更新日期：2012-09-01 00:00:00

abstract：:Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently. Proteins that share the similar active-site sequence, -Cys-Xxx-Yyy-Cys-, are called the Trx family, and the number of Trx family members is increasing. Trx reductase, which reduces oxidized Trx in cooperation with NADPH, has th...

journal_title：Antioxidants & redox signaling

authors： Nakamura H

更新日期：2005-05-01 00:00:00

abstract：AIM:Skeletal muscle nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity. However, GC function and the consequences of reduced GC activity in skeletal muscle are unknown. In this ...

journal_title：Antioxidants & redox signaling

authors： Moon Y,Balke JE,Madorma D,Siegel MP,Knowels G,Brouckaert P,Buys ES,Marcinek DJ,Percival JM

更新日期：2017-06-10 00:00:00

abstract：:Heme oxygenase-1 is the rate-limiting enzyme for the degradation of the prooxidant heme. Previously, we showed that an E-box within the HO-1 promoter is crucial for the regulation of HO-1 expression in primary hepatocytes. Further to investigate the importance of this E-box, we determined the regulatory capacity of th...

journal_title：Antioxidants & redox signaling

authors： Samoylenko A,Dimova EY,Horbach T,Teplyuk N,Immenschuh S,Kietzmann T

更新日期：2008-07-01 00:00:00

abstract：:Alteration in neurotrophic factors support and antioxidant defenses in the central nervous system (CNS) along with deficit of ferritin have been associated with idiopathic Parkinson's disease (PD). The objectives were to analyze in the cerebrospinal fluid (CSF) of patients with PD and controls the following: (i) the l...

journal_title：Antioxidants & redox signaling

authors： Martín de Pablos A,García-Moreno JM,Fernández E

更新日期：2015-10-10 00:00:00

abstract：SIGNIFICANCE:The discovery of the oxidoreductase disulfide bond protein A (DsbA) in 1991 opened the way to the unraveling of the pathways of disulfide bond formation in the periplasm of Escherichia coli and other Gram-negative bacteria. Correct oxidative protein folding in the E. coli envelope depends on both the DsbA/...

journal_title：Antioxidants & redox signaling

authors： Denoncin K,Collet JF

更新日期：2013-07-01 00:00:00

abstract：:Intracellular Ca(2+) signaling, and related mechanisms involving inositol 1,4,5-trisphosphate (IP(3)), nitric oxide, and the excitatory neurotransmitter glutamate, play a major role in the regulation of cellular function in the brain. Due to the complex morphology of central neurons, the correct spatiotemporal distrib...

journal_title：Antioxidants & redox signaling

authors： Okubo Y,Kanemaru K,Iino M

更新日期：2011-04-01 00:00:00

abstract：:In this study, we sought to investigate the putative association of the oxidized metabolites derived from linoleic acid (OXFAs) with pediatric nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). We studied 80 obese adolescents (age 13.3 ± 3.31 years; body mass index 33.0 ± 6.79 kg/m(2)), who underwent ...

journal_title：Antioxidants & redox signaling

authors： Santoro N,Caprio S,Giannini C,Kim G,Kursawe R,Pierpont B,Shaw MM,Feldstein AE

更新日期：2014-01-10 00:00:00

abstract：:Anthracyclines are widely used in anticancer protocols, but can induce cardiotoxicity by mechanisms that mainly involve oxidative damage and mitochondrial dysfunction. Radiotherapy (RT) can also impair cardiac function by promoting myocardial fibrosis, microvascular damage, and decreased density of myocardial capillar...

journal_title：Antioxidants & redox signaling

authors： Mercurio V,Cuomo A,Della Pepa R,Ciervo D,Cella L,Pirozzi F,Parrella P,Campi G,Franco R,Varricchi G,Abete P,Marone G,Petretta M,Bonaduce D,Pacelli R,Picardi M,Tocchetti CG

更新日期：2019-11-20 00:00:00

abstract：:The Arc two-component system is a complex signal transduction system that plays a key role in regulating energy metabolism at the level of transcription in bacteria. This system comprises the ArcB protein, a tripartite membrane-associated sensor kinase, and the ArcA protein, a typical response regulator. Under anoxic ...

journal_title：Antioxidants & redox signaling

authors： Malpica R,Sandoval GR,Rodríguez C,Franco B,Georgellis D

更新日期：2006-05-01 00:00:00

abstract：:Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium i...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Morel S,Berthonneche C,Toufektsian MC,de Lorgeril M,Ducros V,Tosaki A,de Leiris J,Boucher F

更新日期：2004-08-01 00:00:00

abstract：:Increased free radical generation and decreased efficiency of the reparative/degradative mechanisms both primarily contribute to age-related elevation in the level of oxidative stress and brain damage. Excess formation of reactive oxygen and nitrogen species can cause proteasomal dysfunction and protein overloading. T...

journal_title：Antioxidants & redox signaling

authors： Calabrese V,Butterfield DA,Scapagnini G,Stella AM,Maines MD

更新日期：2006-03-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a fundamental process, paradigmatic of the concept of cell plasticity, that leads epithelial cells to lose their polarization and specialized junctional structures, to undergo cytoskeleton reorganization, and to acquire morphological and functional features of mesenchymal-...

journal_title：Antioxidants & redox signaling

authors： Cannito S,Novo E,di Bonzo LV,Busletta C,Colombatto S,Parola M

更新日期：2010-06-15 00:00:00

abstract：: Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway essential for generation of energy and biosynthetic intermediates. Alterations of the TCA cycle play a pivotal role in oncogenesis and inflammation. As such, some metabolic vulnerabilities...

journal_title：Antioxidants & redox signaling

authors： Scagliola A,Mainini F,Cardaci S

更新日期：2020-04-20 00:00:00

abstract：:Homocysteine is a thiol-containing amino acid that has gained notoriety because its elevation in the plasma is correlated with complex and multifactorial diseases, including cardiovascular diseases, neurodegenerative diseases, and neural tube defects. Homocysteine is redox-active, and its toxic effects have been frequ...

journal_title：Antioxidants & redox signaling

authors： Zou CG,Banerjee R

更新日期：2005-05-01 00:00:00

abstract：:This review focuses primarily on islet structural and functional changes related to an activated islet renin- angiotensin system (RAS), islet oxidative-redox imbalance, the concurrence of islet fibrosis (pericapillary, intra- and peri-islet), and islet amyloid deposition (pericapillary, intra- and peri-islet). The isl...

journal_title：Antioxidants & redox signaling

authors： Hayden MR,Sowers JR

更新日期：2007-07-01 00:00:00

abstract：:Loss of redox homeostasis and formation of excessive free radicals play an important role in the pathogenesis of kidney disease and hypertension. Free radicals such as reactive oxygen species (ROS) are necessary in physiologic processes. However, loss of redox homeostasis contributes to proinflammatory and profibrotic...

journal_title：Antioxidants & redox signaling

authors： Nistala R,Whaley-Connell A,Sowers JR

更新日期：2008-12-01 00:00:00

abstract：:Tissue oxygen plays a crucial role in maintaining tissue viability and in various diseases, including responses to therapy. Useful knowledge has been gained by methods that can give limited snapshots of tissue oxygen (e.g., oxygen electrodes) or evidence of a history of tissue hypoxia (e.g., EF5) or even indirect evid...

journal_title：Antioxidants & redox signaling

authors： Khan N,Williams BB,Hou H,Li H,Swartz HM

更新日期：2007-08-01 00:00:00

abstract：SIGNIFICANCE:Decrypting the cellular response to oxidative stress relies on a comprehensive understanding of the redox signaling pathways stimulated under oxidizing conditions. Redox signaling events can be divided into upstream sensing of oxidants, midstream redox signaling of protein function, and downstream transcri...

journal_title：Antioxidants & redox signaling

authors： Young D,Pedre B,Ezeriņa D,De Smet B,Lewandowska A,Tossounian MA,Bodra N,Huang J,Astolfi Rosado L,Van Breusegem F,Messens J

更新日期：2019-04-01 00:00:00

abstract：SIGNIFICANCE:Half a century of research provided unambiguous proof that superoxide and species derived from it-reactive oxygen species (ROS)-play a central role in many diseases and degenerative processes. This stimulated the search for pharmaceutical agents that are capable of preventing oxidative damage, and methods ...

journal_title：Antioxidants & redox signaling

authors： Tovmasyan A,Reboucas JS,Benov L

更新日期：2014-05-20 00:00:00