Does the Cerebrospinal Fluid Reflect Altered Redox State But Not Neurotrophic Support Loss in Parkinson's Disease?

abstract：:Apoptosis is a highly regulated process essential for the development and homeostasis of multicellular organisms. Whereas caspases, a large family of intracellular cysteine proteases, play central roles in the execution of apoptosis, other proapoptotic and antiapoptotic regulators such as the members of the Bcl-2 fami...

journal_title：Antioxidants & redox signaling

authors： Takeda K,Naguro I,Nishitoh H,Matsuzawa A,Ichijo H

更新日期：2011-08-01 00:00:00

abstract：SIGNIFICANCE:Stiffness of endothelial cells is closely linked to the function of the vasculature as it regulates the release of vasoactive substances such as nitric oxide (NO) and reactive oxygen species. The outer layer of endothelial cells, consisting of the glycocalyx above and the cortical zone beneath the plasma m...

journal_title：Antioxidants & redox signaling

authors： Fels J,Kusche-Vihrog K

更新日期：2019-03-01 00:00:00

abstract：SIGNIFICANCE:Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific comm...

journal_title：Antioxidants & redox signaling

authors： Parrow NL,Leshin JA,Levine M

更新日期：2013-12-10 00:00:00

abstract：:Dr. Gregg L. Semenza is recognized here as a Redox Pioneer because he has published three articles that have been cited more than 1,000 times, and 74 articles that have each been cited more than 100 times. Dr. Semenza is known for his seminal discovery of hypoxia-inducible factor-1 (HIF-1) and for identifying molecula...

journal_title：Antioxidants & redox signaling

authors： Prabhakar NR

更新日期：2010-08-15 00:00:00

abstract：SIGNIFICANCE:Chronic myeloid leukemia (CML) involves the malignant transformation of hematopoietic stem cells, defined largely by the Philadelphia chromosome and expression of the breakpoint cluster region-Abelson (BCR-ABL) oncoprotein. Pharmacological tyrosine kinase inhibitors (TKIs), including imatinib mesylate, hav...

journal_title：Antioxidants & redox signaling

authors： Tortorella SM,Hung A,Karagiannis TC

更新日期：2015-06-01 00:00:00

abstract：:Peroxisomes are multifunctional organelles with an important role in the generation and decomposition of reactive oxygen species (ROS). In this review, the ROS-producing enzymes, as well as the antioxidative defense system in mammalian peroxisomes, are described. In addition, various conditions leading to disturbances...

journal_title：Antioxidants & redox signaling

authors： Antonenkov VD,Grunau S,Ohlmeier S,Hiltunen JK

更新日期：2010-08-15 00:00:00

abstract：:The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calor...

journal_title：Antioxidants & redox signaling

authors： Redman LM,Ravussin E

更新日期：2011-01-15 00:00:00

abstract：:Integrin-mediated phagocytosis in fibroblasts is associated to collagenase 1 induction when the particles are coated with high-affinity binding ligands. This study shows that the high density of ligand coating on the particle elicits RhoA-dependent particle uptake coupled to signal transduction. Integrin clustering in...

journal_title：Antioxidants & redox signaling

authors： Werner E

更新日期：2005-03-01 00:00:00

abstract：AIMS:The immune system is critical for protection against infections and cancer, but requires scrupulous regulation to limit self-reactivity and autoimmunity. Our group has utilized a manganese porphyrin catalytic antioxidant (MnTE-2-PyP(5+), MnP) as a potential immunoregulatory therapy for type 1 diabetes. MnP has pre...

journal_title：Antioxidants & redox signaling

authors： Delmastro-Greenwood MM,Votyakova T,Goetzman E,Marre ML,Previte DM,Tovmasyan A,Batinic-Haberle I,Trucco MM,Piganelli JD

更新日期：2013-12-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：: Significance: Since the discovery of vascular stem cells, there has been considerable advancement in comprehending the nature and functions of these cells. Due to their differentiation potential to repair endothelial cells and to participate in lesion formation during vasc...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Sun X,Deng J,Hu Y,Xu Q

更新日期：2021-01-19 00:00:00

abstract：:Discovery of the F2-isoprostanes, a group of prostaglandin F2-like compounds biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel facet of free radical biology. Some of these compounds are bioactive and thus may mediate adverse effects associated with oxidant stress. F2-Isoprostanes hav...

journal_title：Antioxidants & redox signaling

authors： Basu S,Helmersson J

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Glycating stress can occur together with oxidative stress during neurodegeneration and contribute to the pathogenic mechanism. Nerve growth factor (NGF) accumulates in several neurodegenerative diseases. Besides promoting survival, NGF can paradoxically induce cell death by signaling through the p75 neurot...

journal_title：Antioxidants & redox signaling

authors： Kim MJ,Vargas MR,Harlan BA,Killoy KM,Ball LE,Comte-Walters S,Gooz M,Yamamoto Y,Beckman JS,Barbeito L,Pehar M

更新日期：2018-06-20 00:00:00

abstract：:Homocysteine is a thiol-containing amino acid that has gained notoriety because its elevation in the plasma is correlated with complex and multifactorial diseases, including cardiovascular diseases, neurodegenerative diseases, and neural tube defects. Homocysteine is redox-active, and its toxic effects have been frequ...

journal_title：Antioxidants & redox signaling

authors： Zou CG,Banerjee R

更新日期：2005-05-01 00:00:00

abstract：SIGNIFICANCE:A mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow--hypoxic vasodilation--occur in an attempt to restore oxygen supply. Nitric oxide (NO) is a major signaling...

journal_title：Antioxidants & redox signaling

authors： Umbrello M,Dyson A,Feelisch M,Singer M

更新日期：2013-11-10 00:00:00

abstract：:We previously reported a spontaneous development of type 2 diabetes-like phenotypes in glutathione peroxidase-1 (GPX1)-overexpressing (OE) mice. Diet restriction of these mice rescued all their phenotypes, except for hyperinsulinemia and hypersecretion of insulin. This study was to determine whether dietary Se deficie...

journal_title：Antioxidants & redox signaling

authors： Pepper MP,Vatamaniuk MZ,Yan X,Roneker CA,Lei XG

更新日期：2011-02-01 00:00:00

abstract：: Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays a significant role in the control of redox balance, which is crucial in cancer cells. NRF2 a...

journal_title：Antioxidants & redox signaling

authors： Smolková K,Mikó E,Kovács T,Leguina-Ruzzi A,Sipos A,Bai P

更新日期：2020-11-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthe...

journal_title：Antioxidants & redox signaling

authors： Bendall JK,Douglas G,McNeill E,Channon KM,Crabtree MJ

更新日期：2014-06-20 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. The pathogenesis of PD remains incompletely understood. Environmental factors, oxidative damage, misfolded protein aggregates, ubiquitin-proteasome syste...

journal_title：Antioxidants & redox signaling

authors： Wang HQ,Takahashi R

更新日期：2007-05-01 00:00:00

abstract：:In the brain, the mu-opioid receptor (MOR) activates neural nitric oxide synthase (nNOS) through the PI3K/Akt pathway. The resulting nitric oxide (NO) enhances the function of the glutamate N-methyl-d-aspartate receptor (NMDAR)/calcium and calmodulin-dependent serine/threonine kinase (CaMKII), which subsequently dimin...

journal_title：Antioxidants & redox signaling

authors： Rodríguez-Muñoz M,de la Torre-Madrid E,Sánchez-Blázquez P,Garzón J

更新日期：2011-06-15 00:00:00

abstract：:Previous reports have shown that the human immunodeficiency virus (HIV) regulatory protein Tat has both pro-oxidant and pro-inflammatory properties, suggesting that Tat might contribute to the neurological complications of HIV. However, the intracellular mechanisms whereby Tat triggers free radical production and infl...

journal_title：Antioxidants & redox signaling

authors： Turchan-Cholewo J,Dimayuga VM,Gupta S,Gorospe RM,Keller JN,Bruce-Keller AJ

更新日期：2009-02-01 00:00:00

abstract：:Ischemia followed by reperfusion is the primary cause of tissue injury and infarction during heart attack and stroke. The initiating stimulus is believed to involve reactive oxygen species that are produced during reperfusion when electron transport resumes in the mitochondria after suppression by ischemia. Programmed...

journal_title：Antioxidants & redox signaling

authors： Webster KA,Graham RM,Thompson JW,Spiga MG,Frazier DP,Wilson A,Bishopric NH

更新日期：2006-09-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, complications of pregnancy, cognitive impairment, and osteoporosis. That elevated homocysteine leads to vascular dysfunction may be the linking factor between these apparently unrelated pathologies. Although a growing body of evidence sugge...

journal_title：Antioxidants & redox signaling

authors： Glushchenko AV,Jacobsen DW

更新日期：2007-11-01 00:00:00

abstract：SIGNIFICANCE:Once considered to be mere by-products of metabolism, reactive oxygen, nitrogen and sulfur species are now recognized to play important roles in diverse cellular processes such as response to pathogens and regulation of cellular differentiation. It is becoming increasingly evident that redox imbalance can ...

journal_title：Antioxidants & redox signaling

authors： Sbodio JI,Snyder SH,Paul BD

更新日期：2019-04-10 00:00:00

abstract：:The herbicide paraquat (PQ) has been implicated as a potential risk factor for the development of Parkinson's disease. In this study, PQ (0.5-1 microM) was shown to be selectively toxic to dopaminergic (DA) neurons through the activation of microglial NADPH oxidase and the generation of superoxide. Neuron-glia culture...

journal_title：Antioxidants & redox signaling

authors： Wu XF,Block ML,Zhang W,Qin L,Wilson B,Zhang WQ,Veronesi B,Hong JS

更新日期：2005-05-01 00:00:00

abstract：:Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glyco...

journal_title：Antioxidants & redox signaling

authors： Abdel-Fatah T,Arora A,Gorguc I,Abbotts R,Beebeejaun S,Storr S,Mohan V,Hawkes C,Soomro I,Lobo DN,Parsons SL,Madhusudan S

更新日期：2013-06-20 00:00:00

abstract：SIGNIFICANCE:A wealth of fluorescent reporters and imaging systems are now available to characterize dynamic physiological processes in living cells with high spatiotemporal resolution. The most reliable probes for quantitative measurements show shifts in their excitation or emission spectrum, rather than just a change...

journal_title：Antioxidants & redox signaling

authors： Fricker MD

更新日期：2016-05-01 00:00:00

abstract：SIGNIFICANCE:Calcium (Ca2+) hypothesis of Alzheimer's disease (AD) gains popularity. It points to new signaling pathways that may underlie AD pathogenesis. Based on calcium hypothesis, novel targets for the development of potential AD therapies are identified. Recent Advances: Recently, the key role of neuronal store-o...

journal_title：Antioxidants & redox signaling

authors： Popugaeva E,Pchitskaya E,Bezprozvanny I

更新日期：2018-10-20 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a fundamental process, paradigmatic of the concept of cell plasticity, that leads epithelial cells to lose their polarization and specialized junctional structures, to undergo cytoskeleton reorganization, and to acquire morphological and functional features of mesenchymal-...

journal_title：Antioxidants & redox signaling

authors： Cannito S,Novo E,di Bonzo LV,Busletta C,Colombatto S,Parola M

更新日期：2010-06-15 00:00:00

abstract：:Thiol peroxidases comprise glutathione peroxidases (GPx) and peroxiredoxins (Prx). The enzymes of both families reduce hydroperoxides with thiols by enzyme-substitution mechanisms. H(2)O(2) and organic hydroperoxides are reduced by all thiol peroxidases, most efficiently by SecGPxs, whereas fast peroxynitrite reductio...

journal_title：Antioxidants & redox signaling

authors： Flohé L,Toppo S,Cozza G,Ursini F

更新日期：2011-08-01 00:00:00