NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat.

abstract：AIM:TNF (tumor necrosis factor)-related apoptosis-inducing ligand (TRAIL), is a selective killer of tumor cells, although its potential is limited by the development of resistance. In this article, we investigated whether the polyherbal preparation Zyflamend(®) can sensitize tumor cells to TRAIL. RESULTS:We found that...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Park B,Gupta SC,Kannappan R,Sung B,Aggarwal BB

更新日期：2012-03-01 00:00:00

abstract：:Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifac...

journal_title：Antioxidants & redox signaling

authors： Okouchi M,Ekshyyan O,Maracine M,Aw TY

更新日期：2007-08-01 00:00:00

abstract：AIMS:Carbon monoxide (CO)-releasing molecules (CORMs) are candidates for animal and antimicrobial therapeutics. We aimed to probe the antimicrobial potential of a novel manganese CORM. RESULTS:[Mn(CO)4S2CNMe(CH2CO2H)], CORM-401, inhibits growth of Escherichia coli and several antibiotic-resistant clinical pathogens. C...

journal_title：Antioxidants & redox signaling

authors： Wareham LK,McLean S,Begg R,Rana N,Ali S,Kendall JJ,Sanguinetti G,Mann BE,Poole RK

更新日期：2018-05-10 00:00:00

abstract：:Aging is the accumulation of changes that increase the risk of death. Aging changes can be attributed to development, genetic defects, the environment, disease, and an inborn process: the aging process. The latter is the major risk factor for disease and death after age 28 in the developed countries. In these countrie...

journal_title：Antioxidants & redox signaling

authors： Harman D

更新日期：2003-10-01 00:00:00

abstract：:Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins. Whereas optimal levels of Se in the diet have important health benefits, a recent clinical trial has suggested that supplemental intake of Se above the adequate level potentially may raise the risk ...

journal_title：Antioxidants & redox signaling

authors： Labunskyy VM,Lee BC,Handy DE,Loscalzo J,Hatfield DL,Gladyshev VN

更新日期：2011-06-15 00:00:00

abstract：:Tumor necrosis factor (TNF) induces a caspase-independent but mitochondria-dependent cell death process in the mouse fibrosarcoma cell line L929. Mitochondria actively participate in this TNF-induced necrotic cell death by the generation of mitochondrial reactive oxygen species (ROS). The aim of this study was to iden...

journal_title：Antioxidants & redox signaling

authors： Goossens V,Stangé G,Moens K,Pipeleers D,Grooten J

更新日期：1999-10-01 00:00:00

abstract：: Significance: Excessive and prolonged proinflammatory responses are associated with oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such condition favors tissue destruction and consequently bacterial spread. A tissue remodeling program is als...

journal_title：Antioxidants & redox signaling

authors： Amaral EP,Vinhaes CL,Oliveira-de-Souza D,Nogueira B,Akrami KM,Andrade BB

更新日期：2021-02-20 00:00:00

abstract：SIGNIFICANCE:There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated a...

journal_title：Antioxidants & redox signaling

authors： Alexandrou AT,Li JJ

更新日期：2014-03-20 00:00:00

abstract：: Aims: Lifelong pain is a hallmark feature of sickle cell disease (SCD). How sickle pathobiology evokes pain remains unknown. We hypothesize that increased cell-free heme due to ongoing hemolysis activates toll-like receptor 4 (TLR4), leading to the formation of reactive ox...

journal_title：Antioxidants & redox signaling

authors： Lei J,Paul J,Wang Y,Gupta M,Vang D,Thompson S,Jha R,Nguyen J,Valverde Y,Lamarre Y,Jones MK,Gupta K

更新日期：2021-02-01 00:00:00

abstract：AIMS:Abnormal accumulation of α-synuclein aggregates is one of the key pathological features of many neurodegenerative movement disorders and dementias. These pathological aggregates propagate into larger brain regions as the disease progresses, with the associated clinical symptoms becoming increasingly severe and com...

journal_title：Antioxidants & redox signaling

authors： Bae EJ,Ho DH,Park E,Jung JW,Cho K,Hong JH,Lee HJ,Kim KP,Lee SJ

更新日期：2013-03-01 00:00:00

abstract：: Significance: Since the discovery of vascular stem cells, there has been considerable advancement in comprehending the nature and functions of these cells. Due to their differentiation potential to repair endothelial cells and to participate in lesion formation during vasc...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Sun X,Deng J,Hu Y,Xu Q

更新日期：2021-01-19 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：SIGNIFICANCE:Calcium (Ca2+) hypothesis of Alzheimer's disease (AD) gains popularity. It points to new signaling pathways that may underlie AD pathogenesis. Based on calcium hypothesis, novel targets for the development of potential AD therapies are identified. Recent Advances: Recently, the key role of neuronal store-o...

journal_title：Antioxidants & redox signaling

authors： Popugaeva E,Pchitskaya E,Bezprozvanny I

更新日期：2018-10-20 00:00:00

abstract：SIGNIFICANCE:In bacteria, transcriptional responses to reactive oxygen and nitrogen species (ROS and RNS, respectively) are typically coordinated by regulatory proteins that employ metal centers or reactive thiols to detect the presence of those species. This review is focused on the structure, function and mechanism o...

journal_title：Antioxidants & redox signaling

authors： Spiro S,D'Autréaux B

更新日期：2012-11-01 00:00:00

abstract：:Cardiac hypertrophy and heart failure are major causes of morbidity and mortality in Western societies. Many factors have been implicated in cardiac remodeling, including alterations in gene expression in myocytes, cardiomyocytes apoptosis, cytokines and growth factors that influence cardiac dynamics, and deficits in ...

journal_title：Antioxidants & redox signaling

authors： Gupta S,Das B,Sen S

更新日期：2007-06-01 00:00:00

abstract：SIGNIFICANCE:Mitochondria are complex dynamic organelles pivotal for cellular physiology and human health. Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders. Furthermore, a decline in mitochondrial health is prevalent with...

journal_title：Antioxidants & redox signaling

authors： Bohovych I,Chan SS,Khalimonchuk O

更新日期：2015-04-20 00:00:00

abstract：AIM:Skeletal muscle nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity. However, GC function and the consequences of reduced GC activity in skeletal muscle are unknown. In this ...

journal_title：Antioxidants & redox signaling

authors： Moon Y,Balke JE,Madorma D,Siegel MP,Knowels G,Brouckaert P,Buys ES,Marcinek DJ,Percival JM

更新日期：2017-06-10 00:00:00

abstract：:The signaling for activation of protein tyrosine kinases (PTKs) is usually started by binding of ligands to cell-surface receptors. However, recent evidence suggests the presence of ligand binding-independent signaling pathways that are mediated by oxidative stress. Oxidation and reduction of protein cysteine sulfhydr...

journal_title：Antioxidants & redox signaling

authors： Nakashima I,Kato M,Akhand AA,Suzuki H,Takeda K,Hossain K,Kawamoto Y

更新日期：2002-06-01 00:00:00

abstract：: Aims: Normal mitochondrial function and integrity are crucial for cellular physiology. Given the paramount role of mitochondrial quality control proteases in these processes, our study focused on investigating mechanisms by which the activity of a key quality control prote...

journal_title：Antioxidants & redox signaling

authors： Bohovych I,Dietz JV,Swenson S,Zahayko N,Khalimonchuk O

更新日期：2019-08-20 00:00:00

abstract：:Oxidative stress due to increased epidermal levels of H(2)O(2) with consequent inhibition of catalase activity is generally accepted as a leading cytotoxic mechanism of melanocyte loss in vitiligo. Keratinocyte-derived cytokines are considered key factors in the maintenance of melanocyte structure and functions. We hy...

journal_title：Antioxidants & redox signaling

authors： Kostyuk VA,Potapovich AI,Cesareo E,Brescia S,Guerra L,Valacchi G,Pecorelli A,Deeva IB,Raskovic D,De Luca C,Pastore S,Korkina LG

更新日期：2010-09-01 00:00:00

abstract：:Junctional adhesion molecules are transmembrane proteins that belong to the immunoglobulin superfamily. In addition to their localization in close proximity to the tight junctions in endothelial and epithelial cells, junctional adhesion molecules are also expressed in circulating cells that do not form junctions, such...

journal_title：Antioxidants & redox signaling

authors： Bazzoni G

更新日期：2011-09-01 00:00:00

abstract：:The redox status of tumors inoculated into the footpads of mice was investigated by using an in vivo ESR/spin-probe technique. A single-cell suspension of a metastatic subclone of colon carcinoma NL-17 was inoculated into the footpads of Balb/c mice. At 12, 24, 48, and 96 h after the inoculation, a spin probe, either ...

journal_title：Antioxidants & redox signaling

authors： Ichikawa K,Sakabe E,Kuninobu K,Yamori T,Tsuruo T,Yao T,Tsuneyoshi M,Utsumi H

更新日期：2007-10-01 00:00:00

abstract：:The 6(th) COSTAM/SFRR (ASEAN/Malaysia) workshop, "Micronutrients, Oxidative Stress, and the Environment," was held from June 29 to July 2 at Holiday Inn Damai Beach Resort in Kuching, Sarawak. Two hundred twenty participants from 17 countries presented recent advances on natural antioxidants in the area of oxidative s...

journal_title：Antioxidants & redox signaling

authors： Nesaretnam K,Sies H

更新日期：2006-11-01 00:00:00

abstract：:It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides through their Se-independent glutathione peroxidase activity and that these enzymes can also detoxify lipid peroxidation end products such as 4-hydroxynonenal (4-HNE). In this article, recent studies suggesting that the Alpha clas...

journal_title：Antioxidants & redox signaling

authors： Sharma R,Yang Y,Sharma A,Awasthi S,Awasthi YC

更新日期：2004-04-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to regulate a variety of physiological functions, including vascular tone. The inhibition of NO synthase by N(omega)-nitro-L-arginine methyl ester (L-NAME) has been reported to increase arterial blood pressure. The present studies were undertaken to investigate if the increased blood p...

journal_title：Antioxidants & redox signaling

authors： Anand-Srivastava MB,Di Fusco F

更新日期：2004-04-01 00:00:00

abstract：AIM:The present study was designed to explore the effects of hydrogen sulfide (H2S) on Ca(2+) homeostasis in rat pancreatic acini. RESULTS:Sodium hydrosulfide (NaHS; an H2S donor) induced a biphasic increase in the intracellular Ca(2+) concentration ([Ca(2+)]i) in a dose-dependent manner. The NaHS-induced [Ca(2+)]i el...

journal_title：Antioxidants & redox signaling

authors： Moustafa A,Habara Y

更新日期：2014-02-10 00:00:00

abstract：:Post-ischemic reperfusion may result in reactive oxygen species (ROS) generation, reduced availability of nitric oxide (NO•), Ca(2+)overload, prolonged opening of mitochondrial permeability transition pore, and other processes contributing to cell death, myocardial infarction, stunning, and arrhythmias. With the disco...

journal_title：Antioxidants & redox signaling

authors： Pagliaro P,Moro F,Tullio F,Perrelli MG,Penna C

更新日期：2011-03-01 00:00:00

abstract：AIMS:Aberrant Cdk5 (cyclin-dependent kinase 5) and oxidative stress are crucial components of diverse neurodegenerative disorders, including Alzheimer's disease (AD). We previously reported that a change in peroxiredoxin (Prx) expression is associated with protection from neuronal death. The aim of the current study wa...

journal_title：Antioxidants & redox signaling

authors： Park J,Kim B,Chae U,Lee DG,Kam MK,Lee SR,Lee S,Lee HS,Park JW,Lee DS

更新日期：2017-10-10 00:00:00

abstract：AIMS:Recent studies suggest that the molybdenum enzymes xanthine oxidase, aldehyde oxidase, and mARC exhibit nitrite reductase activity at low oxygen pressures. However, inhibition studies of xanthine oxidase in humans have failed to block nitrite-dependent changes in blood flow, leading to continued exploration for ot...

journal_title：Antioxidants & redox signaling

authors： Wang J,Krizowski S,Fischer-Schrader K,Niks D,Tejero J,Sparacino-Watkins C,Wang L,Ragireddy V,Frizzell S,Kelley EE,Zhang Y,Basu P,Hille R,Schwarz G,Gladwin MT

更新日期：2015-08-01 00:00:00

abstract：:Increasing evidence indicates that disequilibrium of the alveolar oxidant-antioxidant balance may play a role in the pathogenesis of chronic fibrosing lung diseases. Excessive production of oxidants and a differential regulation of antioxidant enzymes have been described under these conditions. We characterized for th...

journal_title：Antioxidants & redox signaling

authors： Markart P,Luboeinski T,Korfei M,Schmidt R,Wygrecka M,Mahavadi P,Mayer K,Wilhelm J,Seeger W,Guenther A,Ruppert C

更新日期：2009-02-01 00:00:00