Abstract:
:It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides through their Se-independent glutathione peroxidase activity and that these enzymes can also detoxify lipid peroxidation end products such as 4-hydroxynonenal (4-HNE). In this article, recent studies suggesting that the Alpha class GSTs provide a formidable defense against oxidative stress are critically evaluated and the role of these enzymes in the regulation of oxidative stress-mediated signaling is reviewed. Available evidence from earlier studies together with results of recent studies in our laboratories strongly suggests that lipid peroxidation products, particularly hydroperoxides and 4-HNE, are involved in the mechanisms of stress-mediated signaling and that it can be modulated by the Alpha class GSTs through the regulation of the intracellular concentrations of 4-HNE.
journal_name
Antioxid Redox Signaljournal_title
Antioxidants & redox signalingauthors
Sharma R,Yang Y,Sharma A,Awasthi S,Awasthi YCdoi
10.1089/152308604322899350keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
289-300issue
2eissn
1523-0864issn
1557-7716journal_volume
6pub_type
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