The multidomain thioredoxin-monothiol glutaredoxins represent a distinct functional group.

abstract：: Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway essential for generation of energy and biosynthetic intermediates. Alterations of the TCA cycle play a pivotal role in oncogenesis and inflammation. As such, some metabolic vulnerabilities...

journal_title：Antioxidants & redox signaling

authors： Scagliola A,Mainini F,Cardaci S

更新日期：2020-04-20 00:00:00

abstract：SIGNIFICANCE:Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor radioresistance. RECENT ADVANCES:Two main types of hypoxia exist in the tumor microenvironment: chronic and cycling hypoxia. Chronic hypoxia re...

journal_title：Antioxidants & redox signaling

authors： Lee CT,Boss MK,Dewhirst MW

更新日期：2014-07-10 00:00:00

abstract：SIGNIFICANCE:Abnormal lung development in the perinatal period can result in severe neonatal complications, including persistent pulmonary hypertension (PH) of the newborn and bronchopulmonary dysplasia. Reactive oxygen species (ROS) play a substantive role in the development of PH associated with these diseases. ROS i...

journal_title：Antioxidants & redox signaling

authors： Wedgwood S,Steinhorn RH

更新日期：2014-11-01 00:00:00

abstract：:In response to tissue damage and inflammation induced by a variety of xenobiotics including acetaminophen, carbon tetrachloride, ethanol, galactosamine, and endotoxin, as well as disease states such as viral hepatitis, and postischemic and regenerative injury, the liver produces large quantities of nitric oxide. Indee...

journal_title：Antioxidants & redox signaling

authors： Laskin JD,Heck DE,Gardner CR,Laskin DL

更新日期：2001-04-01 00:00:00

abstract：SIGNIFICANCE:Protein degradation has been identified as being deregulated in numerous human diseases. Hence, proteins involved in proteasomal as well as lysosomal degradation are regarded as interesting potential drug targets and are thoroughly investigated in clinical studies. RECENT ADVANCES:Technical advances in th...

journal_title：Antioxidants & redox signaling

authors： Engelke R,Becker AC,Dengjel J

更新日期：2012-09-01 00:00:00

abstract：SIGNIFICANCE:Fetal lung development takes place in hypoxia meaning that premature birth is hyperoxia for the prematurely born infant. The most common respiratory morbidity afflicting premature infants is bronchopulmonary dysplasia (BPD). Pathophysiologically, BPD represents the impact of injury, including O2 toxicity, ...

journal_title：Antioxidants & redox signaling

authors： Tipple TE

更新日期：2014-11-01 00:00:00

abstract：:We previously reported a spontaneous development of type 2 diabetes-like phenotypes in glutathione peroxidase-1 (GPX1)-overexpressing (OE) mice. Diet restriction of these mice rescued all their phenotypes, except for hyperinsulinemia and hypersecretion of insulin. This study was to determine whether dietary Se deficie...

journal_title：Antioxidants & redox signaling

authors： Pepper MP,Vatamaniuk MZ,Yan X,Roneker CA,Lei XG

更新日期：2011-02-01 00:00:00

abstract：SIGNIFICANCE:The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins that accumulate oxidative post-translational modifications only if these detected modifications are co...

journal_title：Antioxidants & redox signaling

authors： Feeney MB,Schöneich C

更新日期：2012-12-01 00:00:00

abstract：SIGNIFICANCE:Cystic fibrosis (CF) is the most common lethal genetic disorder in the Caucasian people. It is due to the mutation of cystic fibrosis transmembrane conductance regulator (CFTR) gene located on the long arm of the chromosome 7, which encodes for CFTR protein. The latter, an adenosine triphosphate binding ca...

journal_title：Antioxidants & redox signaling

authors： Kleme ML,Levy E

更新日期：2015-03-01 00:00:00

abstract：:Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents. After phosphorylation and dissociation from the cytoplasmic inhibitor, Kelch-...

journal_title：Antioxidants & redox signaling

authors： Cho HY,Reddy SP,Kleeberger SR

更新日期：2006-01-01 00:00:00

abstract：:Liver fibrosis is the consequence of chronic liver injury of any etiology. When advanced, fibrosis causes portal hypertension and liver insufficiency, and is a risk factor for developing hepatocellular carcinoma. In the last decade, there have been major advances in the knowledge of the pathogenesis of hepatic fibrosi...

journal_title：Antioxidants & redox signaling

authors： Bataller R,Sancho-Bru P,Ginès P,Brenner DA

更新日期：2005-09-01 00:00:00

abstract：:Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium i...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Morel S,Berthonneche C,Toufektsian MC,de Lorgeril M,Ducros V,Tosaki A,de Leiris J,Boucher F

更新日期：2004-08-01 00:00:00

abstract：:Zinc/cysteine coordination environments in proteins are redox-active. Oxidation of the sulfur ligands mobilizes zinc, while reduction of the oxidized ligands enhances zinc binding, providing redox control over the availability of zinc ions. Some zinc proteins are redox sensors, in which zinc release is coupled to conf...

journal_title：Antioxidants & redox signaling

authors： Maret W

更新日期：2006-09-01 00:00:00

abstract：AIMS:An abnormal generation of reactive oxygen species (ROS) is thought to contribute to systemic sclerosis (SSc), fostering autoimmunity, fibrosis, and vascular inflammation. The function of the prototypic damage-associated molecular pattern, high mobility group box 1 (HMGB1), depends on its redox status. Here we inve...

journal_title：Antioxidants & redox signaling

authors： Maugeri N,Rovere-Querini P,Baldini M,Baldissera E,Sabbadini MG,Bianchi ME,Manfredi AA

更新日期：2014-03-01 00:00:00

abstract：SIGNIFICANCE:Oxidative (reactive oxygen species [ROS]) and nitrosative (reactive nitrogen species [RNS]) stress affects many physiological processes, including survival and death. Although high levels of ROS/RNS mainly causes cell death, low levels of free radicals directly modulate the activities of transcriptional fa...

journal_title：Antioxidants & redox signaling

authors： Kaminskyy VO,Zhivotovsky B

更新日期：2014-07-01 00:00:00

abstract：:Chronic inflammatory processes induce oxidative stress and lipid peroxidation (LPO), hereby generating DNA-reactive aldehydes such as trans-4-hydroxy-2-nonenal (HNE). Etheno-modified DNA bases are inter alia generated by reaction of DNA with HNE. Using an immunoaffinity-(32)P-postlabeling method, the authors have inve...

journal_title：Antioxidants & redox signaling

authors： Nair J,Gansauge F,Beger H,Dolara P,Winde G,Bartsch H

更新日期：2006-05-01 00:00:00

abstract：:Reactive oxygen species (ROS) generated within the vascular wall trigger low-density lipoprotein (LDL) oxidation, lipid peroxidation, and carbonyl stress that are involved in atherogenesis. We recently reported that the antihypertensive drug, hydralazine, exhibits carbonyl scavenger and antiatherogenic properties, but...

journal_title：Antioxidants & redox signaling

authors： Bouguerne B,Belkheiri N,Bedos-Belval F,Vindis C,Uchida K,Duran H,Grazide MH,Baltas M,Salvayre R,Nègre-Salvayre A

更新日期：2011-06-01 00:00:00

abstract：AIMS:Recent studies have revealed that autophagy is induced under various disease conditions; however, the role of autophagy in pathological states is controversial. NAD(P)H:quinone oxidoreductase 1 (NQO1) is a highly inducible cytoprotective gene that regulates reactive oxygen species (ROS) generation. In this study,...

journal_title：Antioxidants & redox signaling

authors： Kim TW,Kim YJ,Kim HT,Park SR,Lee MY,Park YD,Lee CH,Jung JY

更新日期：2016-05-20 00:00:00

abstract：AIMS:Oxidative stress is considered the major cause of tissue injury after cerebral ischemia. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is one of the most important defensive mechanisms against oxidative stresses and has been confirmed as a target for stroke treatment. Thus, we desired to find new ...

journal_title：Antioxidants & redox signaling

authors： Wu G,Zhu L,Yuan X,Chen H,Xiong R,Zhang S,Cheng H,Shen Y,An H,Li T,Li H,Zhang W

更新日期：2017-10-10 00:00:00

abstract：AIMS:Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro us...

journal_title：Antioxidants & redox signaling

authors： Manta B,Pavan C,Sturlese M,Medeiros A,Crispo M,Berndt C,Krauth-Siegel RL,Bellanda M,Comini MA

更新日期：2013-09-01 00:00:00

abstract：AIMS:Abnormal accumulation of α-synuclein aggregates is one of the key pathological features of many neurodegenerative movement disorders and dementias. These pathological aggregates propagate into larger brain regions as the disease progresses, with the associated clinical symptoms becoming increasingly severe and com...

journal_title：Antioxidants & redox signaling

authors： Bae EJ,Ho DH,Park E,Jung JW,Cho K,Hong JH,Lee HJ,Kim KP,Lee SJ

更新日期：2013-03-01 00:00:00

abstract：: Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and they constitute an ever-growing global burden that has a c...

journal_title：Antioxidants & redox signaling

authors： Gianazza E,Brioschi M,Martinez Fernandez A,Casalnuovo F,Altomare A,Aldini G,Banfi C

更新日期：2021-01-01 00:00:00

abstract：:The redox status of tumors inoculated into the footpads of mice was investigated by using an in vivo ESR/spin-probe technique. A single-cell suspension of a metastatic subclone of colon carcinoma NL-17 was inoculated into the footpads of Balb/c mice. At 12, 24, 48, and 96 h after the inoculation, a spin probe, either ...

journal_title：Antioxidants & redox signaling

authors： Ichikawa K,Sakabe E,Kuninobu K,Yamori T,Tsuruo T,Yao T,Tsuneyoshi M,Utsumi H

更新日期：2007-10-01 00:00:00

abstract：SIGNIFICANCE:Stiffness of endothelial cells is closely linked to the function of the vasculature as it regulates the release of vasoactive substances such as nitric oxide (NO) and reactive oxygen species. The outer layer of endothelial cells, consisting of the glycocalyx above and the cortical zone beneath the plasma m...

journal_title：Antioxidants & redox signaling

authors： Fels J,Kusche-Vihrog K

更新日期：2019-03-01 00:00:00

abstract：AIMS:Recent studies have shown that cigarette smoke (CS)-induced oxidative stress impairs autophagy, resulting in aggresome-formation that correlates with severity of chronic obstructive pulmonary disease (COPD)-emphysema, although the specific step in autophagy pathway that is impaired is unknown. Hence, in this study...

journal_title：Antioxidants & redox signaling

authors： Bodas M,Patel N,Silverberg D,Walworth K,Vij N

更新日期：2017-07-20 00:00:00

abstract：:Ceramide has been shown by many studies to induce apoptosis. Therefore, upregulation of ceramide is discussed as a novel approach for tumor treatment. However, it is unknown whether overexpression of acid sphingomyelinase releasing ceramide from sphingomyelin sensitizes cells to chemotherapy and, thus, serves as a pot...

journal_title：Antioxidants & redox signaling

authors： Grammatikos G,Teichgräber V,Carpinteiro A,Trarbach T,Weller M,Hengge UR,Gulbins E

更新日期：2007-09-01 00:00:00

abstract：:The tumor suppressor p53 protects organisms from most types of cancer through multiple mechanisms. The p53 gene encodes a stress-activated transcriptional factor that transcriptionally regulates a large set of genes with versatile functions. These p53-activated genes mitigate consequences of stress regulating cell via...

journal_title：Antioxidants & redox signaling

authors： Budanov AV

更新日期：2011-09-15 00:00:00

abstract：:Myocardial infarction triggers an inflammatory cascade that results in healing and replacement of the damaged tissue with scar. Cardiomyocyte necrosis triggers innate immune mechanisms eliciting Toll-like receptor- mediated responses, activating the complement cascade and generating reactive oxygen species. Subsequent...

journal_title：Antioxidants & redox signaling

authors： Frangogiannis NG

更新日期：2006-11-01 00:00:00

abstract：:Oxidative stresses are largely mediated by intracellular protein oxidations by reactive oxygen species (ROS). Host cells are equipped with antioxidants that scavenge ROS. The cellular reduction/oxidation (redox) balance is maintained by ROS and antioxidants. Accumulating evidence suggests that the redox balance plays ...

journal_title：Antioxidants & redox signaling

authors： Kondo N,Nakamura H,Masutani H,Yodoi J

更新日期：2006-09-01 00:00:00

abstract：:DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has homologs in nearly all organisms. Because of its connection to parkinsonism and cancer, human DJ-1 has been intensely studied for over a decade. The current view is that DJ-1 is a multifunctional oxidative stress response protein that...

journal_title：Antioxidants & redox signaling

authors： Wilson MA

更新日期：2011-07-01 00:00:00