Abstract:
:Oxidative stresses are largely mediated by intracellular protein oxidations by reactive oxygen species (ROS). Host cells are equipped with antioxidants that scavenge ROS. The cellular reduction/oxidation (redox) balance is maintained by ROS and antioxidants. Accumulating evidence suggests that the redox balance plays an important role in cellular signaling through the redox modification of cysteine residues in various important components of the signal transduction pathway. Thioredoxin (TRX) is a small protein playing important roles in cellular responses, including cell growth, cell cycle, gene expression, and apoptosis, to maintain the redox circumstance. Moreover, many recent papers have shown that the redox regulation by TRX is deeply involved in the pathogenesis of various oxidative stress-associated disorders. This review focuses on TRX and its related molecules, and discusses the role of TRX-dependent redox regulation in oxidative stress-induced signal transduction.
journal_name
Antioxid Redox Signaljournal_title
Antioxidants & redox signalingauthors
Kondo N,Nakamura H,Masutani H,Yodoi Jdoi
10.1089/ars.2006.8.1881subject
Has Abstractpub_date
2006-09-01 00:00:00pages
1881-90issue
9-10eissn
1523-0864issn
1557-7716journal_volume
8pub_type
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-07-20 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2013-12-10 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Antioxidants & redox signaling
pub_type: 杂志文章
doi:10.1089/ars.2018.7721
更新日期:2020-04-10 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2013-09-01 00:00:00
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更新日期:2019-04-01 00:00:00
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更新日期:2011-11-15 00:00:00