Hypoxia and carbon monoxide in the vasculature.


:Hypoxia is sensed by all mammalian cells and elicits a variety of adaptive and pathophysiological responses at the molecular and cellular level. For the pulmonary vasculature, hypoxia causes increased vasoconstriction and vessel-wall remodeling. These responses are mediated by complex intracellular cascades leading to altered gene expression and cell-cell interaction. Hypoxia transiently increases the transcriptional rate of the heme oxygenase-1 (HO-1) gene, resulting in increased production of carbon monoxide (CO) and bilirubin. CO has vasodilatory and antiinflammatory properties in the vasculature, whereas bilirubin is an antioxidant. Both enzymatic products could thus modulate the hypoxic cellular response. Accumulating data suggest that CO inhibits the hypoxic induction of genes encoding vasoconstrictors and smooth muscle cell mitogens in the early hypoxic phase. During chronic hypoxia, low CO levels tilt the balance toward increased production of growth factors and vasoconstrictors that promote vessel-wall remodeling. Mice null in the HO-1 gene manifest decreased tolerance to hypoxia with right ventricular dilatation and infarction, whereas targeted lung overexpression of HO-1 prevents hypoxia-induced inflammatory responses and protects against the development of pulmonary hypertension. Such observations point to CO as a critical modulator of the body's adaptive responses to hypoxia.


Antioxid Redox Signal


Kourembanas S





Has Abstract


2002-04-01 00:00:00












  • Mitochondrial plasticity in obesity and diabetes mellitus.

    abstract:SIGNIFICANCE:Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of mitochondria in the development of insulin resistance. RECENT ADVANCES:Refined methodology of ex vivo high-resolution respirometry and...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Jelenik T,Roden M

    更新日期:2013-07-20 00:00:00

  • The A640G and C242T p22(phox) polymorphisms in patients with coronary artery disease.

    abstract::Oxidative stress plays a significant role in the pathogenesis of coronary artery disease (CAD). A p22(phox)-based NAD(P)H oxidase acts as a potent superoxide-generating system in the vasculature. We studied the association of the A640G and the C242T polymorphisms with clinical risk factors, endothelial function, and s...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Zafari AM,Davidoff MN,Austin H,Valppu L,Cotsonis G,Lassègue B,Griendling KK

    更新日期:2002-08-01 00:00:00

  • Dissecting the oxidative folding of circular cystine knot miniproteins.

    abstract::Cyclotides are plant proteins with exceptional stability owing to the presence of a cyclic backbone and three disulfide bonds arranged in a cystine knot motif. Accordingly, they have been proposed as templates to stabilize bioactive epitopes in drug-design applications. The two main subfamilies, referred to as the Möb...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Gunasekera S,Daly NL,Clark RJ,Craik DJ

    更新日期:2009-05-01 00:00:00

  • NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle.

    abstract::The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood. In this study, we investigated the effect of AngII on aortic smooth muscle from wild-type and NOX1-deficient mice. NOX1-deficient cells sho...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Basset O,Deffert C,Foti M,Bedard K,Jaquet V,Ogier-Denis E,Krause KH

    更新日期:2009-10-01 00:00:00

  • Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities.

    abstract::The development of multidrug resistance to cancer chemotherapy is a major obstacle to the effective treatment of human malignancies. It has been established that membrane proteins, notably multidrug resistance (MDR), multidrug resistance protein (MRP), and breast cancer resistance protein (BCRP) of the ATP binding cas...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Kuo MT

    更新日期:2009-01-01 00:00:00

  • Peroxiredoxin6, a Multitask Antioxidant Enzyme Involved in the Pathophysiology of Chronic Noncommunicable Diseases.

    abstract:SIGNIFICANCE:Chronic noncommunicable diseases (NCDs) are the leading causes of disability and death worldwide. NCDs mainly comprise diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and neurological degenerative diseases, which kill more than 80% of population, especially the el...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Pacifici F,Della Morte D,Capuani B,Pastore D,Bellia A,Sbraccia P,Di Daniele N,Lauro R,Lauro D

    更新日期:2019-01-20 00:00:00

  • Hyperglycemia and glycation in diabetic complications.

    abstract::Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is considered a major health concern,as its incidence is increasing at an alarming rate, and the high invalidating effects of its l...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Negre-Salvayre A,Salvayre R,Augé N,Pamplona R,Portero-Otín M

    更新日期:2009-12-01 00:00:00

  • What is the significance of perioperative release of macrophage migration inhibitory factor in cardiac surgery?

    abstract::Cardiac surgery is associated with release of the pleiotropic cytokine macrophage migration inhibitory factor (MIF). The trigger for MIF release has not yet been elucidated. Owing to its intrinsic antioxidative activity, MIF might reduce oxidative stress and protect from myocardial ischemia and reperfusion (I/R) injur...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,随机对照试验


    authors: Stoppe C,Werker T,Rossaint R,Dollo F,Lue H,Wonisch W,Menon A,Goetzenich A,Bruells CS,Coburn M,Kopp R,Bucala R,Bernhagen J,Rex S

    更新日期:2013-07-20 00:00:00

  • Flow shear stress and atherosclerosis: a matter of site specificity.

    abstract::It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch points where disturbed blood flow (d-flow) predisposes to the development of plaques. Investigations both in vivo and in vitro have shown that d-flow is pro-atherogenic by promoting oxidative and inflammatory states in the a...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Nigro P,Abe J,Berk BC

    更新日期:2011-09-01 00:00:00

  • Regulation of Transcription Factors by Reactive Oxygen Species and Nitric Oxide in Vascular Physiology and Pathology.

    abstract:SIGNIFICANCE:Cardiovascular diseases are the main cause of death worldwide and pose an immense economical burden. In most cases, the underlying problem is vascular occlusion by atherosclerotic plaques. Importantly, different cell types of the vascular wall and the immune system play crucial roles in atherosclerosis at ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Kohlgrüber S,Upadhye A,Dyballa-Rukes N,McNamara CA,Altschmied J

    更新日期:2017-05-01 00:00:00

  • Genome-Scale Modeling of NADPH-Driven β-Lapachone Sensitization in Head and Neck Squamous Cell Carcinoma.

    abstract:AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

    更新日期:2018-10-01 00:00:00

  • Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia.

    abstract:AIMS:Myocardial ischemia/reperfusion (I/R) is associated with mitochondrial dysfunction and subsequent cardiomyocyte death. The generation of excessive quantities of reactive oxygen species (ROS) and resultant damage to mitochondrial enzymes is considered an important mechanism underlying reperfusion injury. Mitochondr...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Gorenkova N,Robinson E,Grieve DJ,Galkin A

    更新日期:2013-11-01 00:00:00

  • Interaction of methylglyoxal and hydrogen sulfide in rat vascular smooth muscle cells.

    abstract::Hydrogen sulfide (H(2)S) is a gasotransmitter with multifaceted physiological functions, including the regulation of glucose metabolism. Methylglyoxal (MG) is an intermediate of glucose metabolism and plays an important role in the pathogenesis of insulin resistance syndromes. In the present study, we investigated the...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Chang T,Untereiner A,Liu J,Wu L

    更新日期:2010-05-01 00:00:00

  • Prooxidant and antioxidant functions of nitric oxide in liver toxicity.

    abstract::In response to tissue damage and inflammation induced by a variety of xenobiotics including acetaminophen, carbon tetrachloride, ethanol, galactosamine, and endotoxin, as well as disease states such as viral hepatitis, and postischemic and regenerative injury, the liver produces large quantities of nitric oxide. Indee...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Laskin JD,Heck DE,Gardner CR,Laskin DL

    更新日期:2001-04-01 00:00:00

  • Review of bortezomib treatment of antibody-mediated rejection in renal transplantation.

    abstract:SIGNIFICANCE:Development of donor-specific antibodies (DSA) after kidney transplantation is associated with reduced allograft survival. A few strategies have been tested in controlled clinical trials for the treatment of antibody-mediated rejection (AMR), and no therapies are approved by regulatory authorities. Thus de...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Ejaz NS,Alloway RR,Halleck F,Dürr M,Budde K,Woodle ES

    更新日期:2014-12-10 00:00:00

  • Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad.

    abstract::The redox status of tumors inoculated into the footpads of mice was investigated by using an in vivo ESR/spin-probe technique. A single-cell suspension of a metastatic subclone of colon carcinoma NL-17 was inoculated into the footpads of Balb/c mice. At 12, 24, 48, and 96 h after the inoculation, a spin probe, either ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Ichikawa K,Sakabe E,Kuninobu K,Yamori T,Tsuruo T,Yao T,Tsuneyoshi M,Utsumi H

    更新日期:2007-10-01 00:00:00

  • The contribution of the DNA damage response to neuronal viability.

    abstract::Neurons are extremely active cells and metabolize up to 20% of the oxygen that was consumed by the organism. Despite their highly oxygenic metabolism, neuronal cells have a lower capacity to neutralize the reactive oxygen species (ROS) that they generate or to which they are exposed. High levels of ROS can lead to acc...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Barzilai A

    更新日期:2007-02-01 00:00:00

  • F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications.

    abstract::Oxidative stress is implicated as one of the major underlying mechanisms behind many acute and chronic diseases, and involved in normal aging. However, the measurement of free radicals or their end products is complicated. Thus, proof of association of free radicals in pathologic conditions has been absent. Isoprostan...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Basu S

    更新日期:2008-08-01 00:00:00

  • Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts Through Modulation of Macrophages via Activation of Signal Transducer and Activator of Transcription 6.

    abstract:: Aims: Human embryonic stem cell derived-cardiovascular progenitor cells (hESC-CVPCs) are a promising cell source for cardiac repair, while the underlying mechanisms need to be elucidated. We recently observed cardioprotective effects of human pluripotent stem cell (hPSC)-C...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Wang J,Liu M,Wu Q,Li Q,Gao L,Jiang Y,Deng B,Huang W,Bi W,Chen Z,Chin YE,Paul C,Wang Y,Yang HT

    更新日期:2019-08-10 00:00:00

  • Forkhead box o as a sensor, mediator, and regulator of redox signaling.

    abstract::The forkhead box O (FOXO) family of transcription factors regulates a variety of cellular programs, including cell cycle arrest, reactive oxygen species (ROS) scavenging, and apoptosis, and are of key importance in the decision over cell fate. In animal model systems it has been shown that FOXO is involved in the regu...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: de Keizer PL,Burgering BM,Dansen TB

    更新日期:2011-03-15 00:00:00

  • Integrin clustering drives phagocytosis coupled to collagenase 1 induction through RhoA GTPase and superoxide production.

    abstract::Integrin-mediated phagocytosis in fibroblasts is associated to collagenase 1 induction when the particles are coated with high-affinity binding ligands. This study shows that the high density of ligand coating on the particle elicits RhoA-dependent particle uptake coupled to signal transduction. Integrin clustering in...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Werner E

    更新日期:2005-03-01 00:00:00

  • Oxidative stress stimulates autophagic flux during ischemia/reperfusion.

    abstract::Autophagy is a bulk degradation process in which cytosolic proteins and organelles are degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we generated adenovirus and cardiac-specific transgenic mice harboring tandem fluorescent mRFP-GFP-LC3. Starvation significantly increased the number of mR...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Hariharan N,Zhai P,Sadoshima J

    更新日期:2011-06-01 00:00:00

  • Mitochondria as Target for Tumor Management of Hemangioendothelioma.

    abstract:: Aims: Hemangioendothelioma (HE) may be benign or malignant. Mouse hemangioendothelioma endothelial (EOMA) cells are validated to study mechanisms in HE. This work demonstrates that EOMA cells heavily rely on mitochondria to thrive. Thus, a combination therapy, including we...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Gordillo GM,Biswas A,Singh K,Sen A,Guda PR,Miller C,Pan X,Khanna S,Cadenas E,Sen CK

    更新日期:2021-01-10 00:00:00

  • Free radicals in cross talk between autophagy and apoptosis.

    abstract:SIGNIFICANCE:Oxidative (reactive oxygen species [ROS]) and nitrosative (reactive nitrogen species [RNS]) stress affects many physiological processes, including survival and death. Although high levels of ROS/RNS mainly causes cell death, low levels of free radicals directly modulate the activities of transcriptional fa...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Kaminskyy VO,Zhivotovsky B

    更新日期:2014-07-01 00:00:00

  • Lipid Peroxidation in Atherosclerotic Cardiovascular Diseases.

    abstract:: Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and they constitute an ever-growing global burden that has a c...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Gianazza E,Brioschi M,Martinez Fernandez A,Casalnuovo F,Altomare A,Aldini G,Banfi C

    更新日期:2021-01-01 00:00:00

  • Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.

    abstract::Increased free radical generation and decreased efficiency of the reparative/degradative mechanisms both primarily contribute to age-related elevation in the level of oxidative stress and brain damage. Excess formation of reactive oxygen and nitrogen species can cause proteasomal dysfunction and protein overloading. T...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Calabrese V,Butterfield DA,Scapagnini G,Stella AM,Maines MD

    更新日期:2006-03-01 00:00:00

  • Redox sensing by proteins: oxidative modifications on cysteines and the consequent events.

    abstract:SIGNIFICANCE:Reactive oxygen species (ROS) are not only essential for the cell's normal functions, but also mediate many pathological effects. When cells experience oxidative stress, proteins are modulated by redox changes and ultimately generate novel signaling patterns. It remains elusive how proteins are modulated, ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Wang Y,Yang J,Yi J

    更新日期:2012-04-01 00:00:00

  • Expanding insights on the involvement of endoplasmic reticulum stress in Parkinson's disease.

    abstract::Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. The pathogenesis of PD remains incompletely understood. Environmental factors, oxidative damage, misfolded protein aggregates, ubiquitin-proteasome syste...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Wang HQ,Takahashi R

    更新日期:2007-05-01 00:00:00

  • C-terminus of heat shock cognate 70 interacting protein increases following stroke and impairs survival against acute oxidative stress.

    abstract::The decision to remove or refold oxidized, denatured, or misfolded proteins by heat shock protein 70 and its binding partners is critical to determine cell fate under pathophysiological conditions. Overexpression of the ubiquitin ligase C-terminus of HSC70 interacting protein (CHIP) can compensate for failure of other...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Stankowski JN,Zeiger SL,Cohen EL,DeFranco DB,Cai J,McLaughlin B

    更新日期:2011-05-15 00:00:00

  • Augmentation of S-Nitrosoglutathione Controls Cigarette Smoke-Induced Inflammatory-Oxidative Stress and Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis by Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function.

    abstract:AIMS:Cigarette smoke (CS)-mediated acquired cystic fibrosis transmembrane conductance regulator (CFTR)-dysfunction, autophagy-impairment, and resulting inflammatory-oxidative/nitrosative stress leads to chronic obstructive pulmonary disease (COPD)-emphysema pathogenesis. Moreover, nitric oxide (NO) signaling regulates ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Bodas M,Silverberg D,Walworth K,Brucia K,Vij N

    更新日期:2017-09-01 00:00:00