Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad.

abstract：AIMS:While much data exist for the effects of flavonoid-rich foods on spatial memory in rodents, there are no such data for foods/beverages predominantly containing hydroxycinnamates and phenolic acids. To address this, we investigated the effects of moderate Champagne wine intake, which is rich in these components, on...

journal_title：Antioxidants & redox signaling

authors： Corona G,Vauzour D,Hercelin J,Williams CM,Spencer JP

更新日期：2013-11-10 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, maintains alveolar integrity and participates in the control of host defense and inflammation in the lung. Surfactant proteins A, B, C, and D are important components of surfactant that play diverse roles in the surface tension reducing as well as host defense an...

journal_title：Antioxidants & redox signaling

authors： Boggaram V

更新日期：2004-02-01 00:00:00

abstract：SIGNIFICANCE:Protein degradation has been identified as being deregulated in numerous human diseases. Hence, proteins involved in proteasomal as well as lysosomal degradation are regarded as interesting potential drug targets and are thoroughly investigated in clinical studies. RECENT ADVANCES:Technical advances in th...

journal_title：Antioxidants & redox signaling

authors： Engelke R,Becker AC,Dengjel J

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:The paracellular cleft within epithelia/endothelia is sealed by tight junction (TJ) proteins. Their extracellular loops (ECLs) are assumed to control paracellular permeability and are targets of pathogenes. We demonstrated that claudin-1 is crucial for paracellular tightening. Its ECL1 is essential for the s...

journal_title：Antioxidants & redox signaling

authors： Dabrowski S,Staat C,Zwanziger D,Sauer RS,Bellmann C,Günther R,Krause E,Haseloff RF,Rittner H,Blasig IE

更新日期：2015-01-01 00:00:00

abstract：AIMS:To evaluate mechanisms underlying modulation of inflammatory chemokines in primary human keratinocytes (normal human epidermal keratinocytes) and repair-related processes in wound models by plant polyphenols (PPs) with antioxidant and superoxide scavenging properties (verbascoside [Vb], resveratrol [Rv], polydatin...

journal_title：Antioxidants & redox signaling

authors： Pastore S,Lulli D,Fidanza P,Potapovich AI,Kostyuk VA,De Luca C,Mikhal'chik E,Korkina LG

更新日期：2012-02-15 00:00:00

abstract：SIGNIFICANCE:Heart disease is the primary cause of death in the industrialized world. Cardiac failure is dictated by an uncompensated reduction in the number of viable and fully functional cardiomyocytes. While current pharmacological therapies alleviate the symptoms associated with cardiac deterioration, heart transpl...

journal_title：Antioxidants & redox signaling

authors： Goichberg P,Chang J,Liao R,Leri A

更新日期：2014-11-10 00:00:00

abstract：AIM:Antrodia Camphorate (AC) is a mushroom that is widely used in Asian countries to prevent and treat various diseases, including liver diseases. However, the active ingredients that contribute to the biological functions remain elusive. The purpose of the present study is to test the hepatoprotective effect of Antcin...

journal_title：Antioxidants & redox signaling

authors： Huo Y,Win S,Than TA,Yin S,Ye M,Hu H,Kaplowitz N

更新日期：2017-02-10 00:00:00

abstract：AIMS:Psychosocial stress alters the hypothalamic-pituitary-adrenal axis (HPA-axis). Increasing evidence shows a link between these alterations and oxidant elevation. Oxidative stress is implicated in the stress response and in the pathogenesis of neurologic and psychiatric diseases. NADPH oxidases (NOXs) are a major so...

journal_title：Antioxidants & redox signaling

authors： Colaianna M,Schiavone S,Zotti M,Tucci P,Morgese MG,Bäckdahl L,Holmdahl R,Krause KH,Cuomo V,Trabace L

更新日期：2013-04-20 00:00:00

abstract：:Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthe...

journal_title：Antioxidants & redox signaling

authors： Bendall JK,Douglas G,McNeill E,Channon KM,Crabtree MJ

更新日期：2014-06-20 00:00:00

abstract：SIGNIFICANCE:Mitochondria are complex dynamic organelles pivotal for cellular physiology and human health. Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders. Furthermore, a decline in mitochondrial health is prevalent with...

journal_title：Antioxidants & redox signaling

authors： Bohovych I,Chan SS,Khalimonchuk O

更新日期：2015-04-20 00:00:00

abstract：SIGNIFICANCE:The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. R...

journal_title：Antioxidants & redox signaling

authors： Nussbaum C,Klinke A,Adam M,Baldus S,Sperandio M

更新日期：2013-02-20 00:00:00

abstract：:The forkhead box O (FOXO) family of transcription factors regulates a variety of cellular programs, including cell cycle arrest, reactive oxygen species (ROS) scavenging, and apoptosis, and are of key importance in the decision over cell fate. In animal model systems it has been shown that FOXO is involved in the regu...

journal_title：Antioxidants & redox signaling

authors： de Keizer PL,Burgering BM,Dansen TB

更新日期：2011-03-15 00:00:00

abstract：:Since the initial report of nitric oxide (NO) activity, enormous progress has been made over the last two decades in the field of NO research. Whereas most physiological responses triggered by moderate concentrations of NO are mediated by soluble guanylate cyclase activation and the subsequent production of cyclic GMP...

journal_title：Antioxidants & redox signaling

authors： Donnini S,Ziche M

更新日期：2002-10-01 00:00:00

abstract：: Aims: Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolism of reactive oxygen species (ROS). Increased oxidative stress in adipose tissue contributes to the development of insulin resistance and metabolic syndrome in obesity. This study aimed to...

journal_title：Antioxidants & redox signaling

authors： Piao L,Dorotea D,Jiang S,Koh EH,Oh GT,Ha H

更新日期：2019-12-20 00:00:00

abstract：: Aims: In this study, we investigate the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune diseases. We focus on oxidative regulation at the interaction between antigen-presenting cells (APCs) and T cells, and consequent effect of ROS a...

journal_title：Antioxidants & redox signaling

authors： Zhong J,Yau ACY,Holmdahl R

更新日期：2020-01-20 00:00:00

abstract：:Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently. Proteins that share the similar active-site sequence, -Cys-Xxx-Yyy-Cys-, are called the Trx family, and the number of Trx family members is increasing. Trx reductase, which reduces oxidized Trx in cooperation with NADPH, has th...

journal_title：Antioxidants & redox signaling

authors： Nakamura H

更新日期：2005-05-01 00:00:00

abstract：AIM:The present study was designed to explore the effects of hydrogen sulfide (H2S) on Ca(2+) homeostasis in rat pancreatic acini. RESULTS:Sodium hydrosulfide (NaHS; an H2S donor) induced a biphasic increase in the intracellular Ca(2+) concentration ([Ca(2+)]i) in a dose-dependent manner. The NaHS-induced [Ca(2+)]i el...

journal_title：Antioxidants & redox signaling

authors： Moustafa A,Habara Y

更新日期：2014-02-10 00:00:00

abstract：AIMS:Large doses of intraperitoneally injected basic amino acids, L-arginine, or L-ornithine, induce acute pancreatitis in rodents, although the mechanisms mediating pancreatic toxicity remain unknown. Another basic amino acid, L-lysine, was also shown to cause pancreatic acinar cell injury. The aim of the study was to...

journal_title：Antioxidants & redox signaling

authors： Biczó G,Hegyi P,Dósa S,Shalbuyeva N,Berczi S,Sinervirta R,Hracskó Z,Siska A,Kukor Z,Jármay K,Venglovecz V,Varga IS,Iványi B,Alhonen L,Wittmann T,Gukovskaya A,Takács T,Rakonczay Z Jr

更新日期：2011-11-15 00:00:00

abstract：:Homocysteine is a thiol-containing amino acid that has gained notoriety because its elevation in the plasma is correlated with complex and multifactorial diseases, including cardiovascular diseases, neurodegenerative diseases, and neural tube defects. Homocysteine is redox-active, and its toxic effects have been frequ...

journal_title：Antioxidants & redox signaling

authors： Zou CG,Banerjee R

更新日期：2005-05-01 00:00:00

abstract：:In response to tissue damage and inflammation induced by a variety of xenobiotics including acetaminophen, carbon tetrachloride, ethanol, galactosamine, and endotoxin, as well as disease states such as viral hepatitis, and postischemic and regenerative injury, the liver produces large quantities of nitric oxide. Indee...

journal_title：Antioxidants & redox signaling

authors： Laskin JD,Heck DE,Gardner CR,Laskin DL

更新日期：2001-04-01 00:00:00

abstract：SIGNIFICANCE:Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of mitochondria in the development of insulin resistance. RECENT ADVANCES:Refined methodology of ex vivo high-resolution respirometry and...

journal_title：Antioxidants & redox signaling

authors： Jelenik T,Roden M

更新日期：2013-07-20 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. The pathogenesis of PD remains incompletely understood. Environmental factors, oxidative damage, misfolded protein aggregates, ubiquitin-proteasome syste...

journal_title：Antioxidants & redox signaling

authors： Wang HQ,Takahashi R

更新日期：2007-05-01 00:00:00

abstract：AIMS:Astrocytes have been revealed as a controller of synaptic plasticity and memory via releasing gliotransmitters. Our recent findings showed that reactive sulfur species (RSS), including hydrogen sulfide (H2S) and polysulfide (H2Sn), regulated the availability of d-serine, which is a well-known gliotransmitter that ...

journal_title：Antioxidants & redox signaling

authors： Luo H,Wu PF,Han QQ,Cao Y,Deng SL,Wang J,Deng Q,Wang F,Chen JG

更新日期：2019-06-01 00:00:00

abstract：SIGNIFICANCE:Selenoprotein K (SelK) is an endoplasmic reticulum (ER) membrane protein, and its expression is sensitive to dietary selenium levels. A recently described role for SelK as a cofactor in catalyzing protein palmitoylation reactions provides an important link between low dietary selenium intake and suboptimal...

journal_title：Antioxidants & redox signaling

authors： Fredericks GJ,Hoffmann PR

更新日期：2015-10-01 00:00:00

abstract：:Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by redox chemotherapeutics. This review will present an update on drug discovery, target ...

journal_title：Antioxidants & redox signaling

authors： Wondrak GT

更新日期：2009-12-01 00:00:00

abstract：:Proteasome-mediated protein degradation is responsible for a large percentage of bulk protein turnover, particularly the degradation of short-lived and oxidized proteins. Increasing evidence suggests that proteasome inhibition occurs during the aging of the central nervous system (CNS), and in a variety of age-related...

journal_title：Antioxidants & redox signaling

authors： Ding Q,Dimayuga E,Keller JN

更新日期：2006-01-01 00:00:00

abstract：:Monothiol glutaredoxins (Grxs) with a noncanonical CGFS active site are found in all kingdoms of life. They include members with a single domain and thioredoxin-Grx fusion proteins. In Saccharomyces cerevisiae, the multidomain Grx3 and Grx4 play an essential role in intracellular iron trafficking. This crucial task is...

journal_title：Antioxidants & redox signaling

authors： Hoffmann B,Uzarska MA,Berndt C,Godoy JR,Haunhorst P,Lillig CH,Lill R,Mühlenhoff U

更新日期：2011-07-01 00:00:00

abstract：:We previously reported a spontaneous development of type 2 diabetes-like phenotypes in glutathione peroxidase-1 (GPX1)-overexpressing (OE) mice. Diet restriction of these mice rescued all their phenotypes, except for hyperinsulinemia and hypersecretion of insulin. This study was to determine whether dietary Se deficie...

journal_title：Antioxidants & redox signaling

authors： Pepper MP,Vatamaniuk MZ,Yan X,Roneker CA,Lei XG

更新日期：2011-02-01 00:00:00

abstract：SIGNIFICANCE:Worldwide demand has driven the development of hemoglobin (Hb)-based oxygen carriers (HBOCs) as potential acellular oxygen therapeutics. HBOCs have the potential to provide an oxygen bridge to patients and minimize current problems associated with supply and storage of donated blood. However, to date, safe...

journal_title：Antioxidants & redox signaling

authors： Strader MB,Alayash AI

更新日期：2017-05-10 00:00:00

abstract：SIGNIFICANCE:Therapeutic hypothermia is commonly applied to limit ischemic injury in organ transplantation, during cardiac and brain surgery and after cardiopulmonary resuscitation. In these procedures, the kidneys are particularly at risk for ischemia/reperfusion injury (IRI), likely due to their high rate of metaboli...

journal_title：Antioxidants & redox signaling

authors： Dugbartey GJ,Hardenberg MC,Kok WF,Boerema AS,Carey HV,Staples JF,Henning RH,Bouma HR

更新日期：2017-09-20 00:00:00