Britanin Ameliorates Cerebral Ischemia-Reperfusion Injury by Inducing the Nrf2 Protective Pathway.

abstract：SIGNIFICANCE:Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor radioresistance. RECENT ADVANCES:Two main types of hypoxia exist in the tumor microenvironment: chronic and cycling hypoxia. Chronic hypoxia re...

journal_title：Antioxidants & redox signaling

authors： Lee CT,Boss MK,Dewhirst MW

更新日期：2014-07-10 00:00:00

abstract：: Significance: T lymphocytes, as part of the adaptive immune system, possess the ability to activate and function in extreme cellular microenvironments, which requires these cells to remain highly malleable. One mechanism in which T lymphocytes achieve this adaptability is ...

journal_title：Antioxidants & redox signaling

authors： Moshfegh CM,Case AJ

更新日期：2020-04-30 00:00:00

abstract：:Coenzyme Q10 (CoQ) has long been utilized as a cardioprotective agent in various heart diseases. One of the most important mechanisms by which CoQ exerts cardioprotection is aerobic ATP production as a mobile electron carrier in the mitochondrial electron transfer chain. The ability of CoQ to afford myocardial protect...

journal_title：Antioxidants & redox signaling

authors： Yamamura T,Otani H,Nakao Y,Hattori R,Osako M,Imamura H,Das DK

更新日期：2001-02-01 00:00:00

abstract：AIMS:Recent studies suggest that the molybdenum enzymes xanthine oxidase, aldehyde oxidase, and mARC exhibit nitrite reductase activity at low oxygen pressures. However, inhibition studies of xanthine oxidase in humans have failed to block nitrite-dependent changes in blood flow, leading to continued exploration for ot...

journal_title：Antioxidants & redox signaling

authors： Wang J,Krizowski S,Fischer-Schrader K,Niks D,Tejero J,Sparacino-Watkins C,Wang L,Ragireddy V,Frizzell S,Kelley EE,Zhang Y,Basu P,Hille R,Schwarz G,Gladwin MT

更新日期：2015-08-01 00:00:00

abstract：SIGNIFICANCE:Redox signaling is a common mechanism in the cellular response toward a variety of stimuli. For analyzing redox-dependent specific alterations in a cell, genetically encoded biosensors were highly instrumental in the past. To advance the knowledge about the importance of this signaling mechanism in vivo, m...

journal_title：Antioxidants & redox signaling

authors： Swain L,Nanadikar MS,Borowik S,Zieseniss A,Katschinski DM

更新日期：2018-08-20 00:00:00

abstract：AIMS:Macrophages are of key importance for tissue repair after myocardial infarction (MI). Hydrogen sulfide (H2S) has been shown to exert cardioprotective effects in MI. However, the mechanisms by which H2S modulates cardiac remodeling and repair post-MI remain to be clarified. RESULTS:In our current study, we showed ...

journal_title：Antioxidants & redox signaling

authors： Miao L,Shen X,Whiteman M,Xin H,Shen Y,Xin X,Moore PK,Zhu YZ

更新日期：2016-08-10 00:00:00

abstract：:Although the essential role of selenium for cellular immune responses is obvious, delineation of the functions is lacking because selenium can either promote or inhibit cell growth, cytokine production, and activation of transcription factor nuclear factor-kappaB (NF-kappaB). Studies with human thioredoxin-1 (Trx-1)-t...

journal_title：Antioxidants & redox signaling

authors： Ueno H,Kajihara H,Nakamura H,Yodoi J,Nakamuro K

更新日期：2007-01-01 00:00:00

abstract：:Secretory and transmembrane proteins are correctly folded or processed in the endoplasmic reticulum (ER). Various stresses disturb ER function and provoke the accumulation of unfolded proteins in the ER lumen. This condition is termed ER stress. Recently, ER stress has been linked to neuronal death in various neurodeg...

journal_title：Antioxidants & redox signaling

authors： Saito A,Hino S,Murakami T,Kondo S,Imaizumi K

更新日期：2007-05-01 00:00:00

abstract：:Nox family NADPH oxidases serve a variety of functions requiring reactive oxygen species (ROS) generation, including antimicrobial defense, biosynthetic processes, oxygen sensing, and redox-based cellular signaling. We explored targeting, assembly, and activation of several Nox family oxidases, since ROS production ap...

journal_title：Antioxidants & redox signaling

authors： Leto TL,Morand S,Hurt D,Ueyama T

更新日期：2009-10-01 00:00:00

abstract：:Studies from many laboratories have shown that overexpression of manganese superoxide dismutase (MnSOD) inhibits the growth of numerous tumor cell types. The inhibition of tumor cell growth can be attributed to the increase in the steady-state levels of H2O2 as a result of the increased dismuting activity of MnSOD. He...

journal_title：Antioxidants & redox signaling

authors： Kim KH,Rodriguez AM,Carrico PM,Melendez JA

更新日期：2001-06-01 00:00:00

abstract：: Aims: Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolism of reactive oxygen species (ROS). Increased oxidative stress in adipose tissue contributes to the development of insulin resistance and metabolic syndrome in obesity. This study aimed to...

journal_title：Antioxidants & redox signaling

authors： Piao L,Dorotea D,Jiang S,Koh EH,Oh GT,Ha H

更新日期：2019-12-20 00:00:00

abstract：: Aims: Human embryonic stem cell derived-cardiovascular progenitor cells (hESC-CVPCs) are a promising cell source for cardiac repair, while the underlying mechanisms need to be elucidated. We recently observed cardioprotective effects of human pluripotent stem cell (hPSC)-C...

journal_title：Antioxidants & redox signaling

authors： Wang J,Liu M,Wu Q,Li Q,Gao L,Jiang Y,Deng B,Huang W,Bi W,Chen Z,Chin YE,Paul C,Wang Y,Yang HT

更新日期：2019-08-10 00:00:00

abstract：SIGNIFICANCE:Lysosomes are organelles in which cellular degradation occurs in a controlled manner, separated from other cellular components. As several pathways terminate in the lysosome, lysosomal dysfunction has a profound impact on cell homeostasis, resulting in manifold pathological situations, including infectious...

journal_title：Antioxidants & redox signaling

authors： Boya P

更新日期：2012-09-01 00:00:00

abstract：:Accumulating evidence suggests that oxidative stress associated with impaired metabolism of the antioxidant glutathione (GSH) plays a key role in the pathophysiology of schizophrenia. Magnetic resonance spectroscopy (MRS) is one of the brain-imaging techniques that can quantitatively measure bioactive substances such ...

journal_title：Antioxidants & redox signaling

authors： Matsuzawa D,Hashimoto K

更新日期：2011-10-01 00:00:00

abstract：:The Arc two-component system is a complex signal transduction system that plays a key role in regulating energy metabolism at the level of transcription in bacteria. This system comprises the ArcB protein, a tripartite membrane-associated sensor kinase, and the ArcA protein, a typical response regulator. Under anoxic ...

journal_title：Antioxidants & redox signaling

authors： Malpica R,Sandoval GR,Rodríguez C,Franco B,Georgellis D

更新日期：2006-05-01 00:00:00

abstract：SIGNIFICANCE:The accepted effects of aging in mammalian skeletal muscle are progressive atrophy and weakening, or sarcopenia. Canonical hallmarks of aging in skeletal muscle include a reduction in muscle fiber cross-sectional area, a loss in muscle fibers through apoptosis and denervation, and infiltration of connectiv...

journal_title：Antioxidants & redox signaling

authors： Lawler JM,Hindle A

更新日期：2011-11-01 00:00:00

abstract：:Efficient extracellular hemoglobin (Hb) clearance is essential to prevent oxidative- and nitrosative-mediated toxicity. CD163 belongs to group B of the scavenger receptor cysteine-rich (SRCR) protein family found on the surface of monocytes and macrophages and is responsible for Hb-haptoglobin (Hp) complex uptake. Hb ...

journal_title：Antioxidants & redox signaling

authors： Schaer DJ,Alayash AI,Buehler PW

更新日期：2007-07-01 00:00:00

abstract：SIGNIFICANCE:Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of mitochondria in the development of insulin resistance. RECENT ADVANCES:Refined methodology of ex vivo high-resolution respirometry and...

journal_title：Antioxidants & redox signaling

authors： Jelenik T,Roden M

更新日期：2013-07-20 00:00:00

abstract：:Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by redox chemotherapeutics. This review will present an update on drug discovery, target ...

journal_title：Antioxidants & redox signaling

authors： Wondrak GT

更新日期：2009-12-01 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：:The redox status of tumors inoculated into the footpads of mice was investigated by using an in vivo ESR/spin-probe technique. A single-cell suspension of a metastatic subclone of colon carcinoma NL-17 was inoculated into the footpads of Balb/c mice. At 12, 24, 48, and 96 h after the inoculation, a spin probe, either ...

journal_title：Antioxidants & redox signaling

authors： Ichikawa K,Sakabe E,Kuninobu K,Yamori T,Tsuruo T,Yao T,Tsuneyoshi M,Utsumi H

更新日期：2007-10-01 00:00:00

abstract：:Cardiac hypertrophy and heart failure are major causes of morbidity and mortality in Western societies. Many factors have been implicated in cardiac remodeling, including alterations in gene expression in myocytes, cardiomyocytes apoptosis, cytokines and growth factors that influence cardiac dynamics, and deficits in ...

journal_title：Antioxidants & redox signaling

authors： Gupta S,Das B,Sen S

更新日期：2007-06-01 00:00:00

abstract：SIGNIFICANCE:Half a century of research provided unambiguous proof that superoxide and species derived from it-reactive oxygen species (ROS)-play a central role in many diseases and degenerative processes. This stimulated the search for pharmaceutical agents that are capable of preventing oxidative damage, and methods ...

journal_title：Antioxidants & redox signaling

authors： Tovmasyan A,Reboucas JS,Benov L

更新日期：2014-05-20 00:00:00

abstract：SIGNIFICANCE:The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through...

journal_title：Antioxidants & redox signaling

authors： Sevilla E,Bes MT,González A,Peleato ML,Fillat MF

更新日期：2019-05-01 00:00:00

abstract：:BLNK (B cell linker protein) represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways. In this study, we have investigated the role of BLNK in oxidative stress signaling in B cells. H2O2 treatment of B cells induced a rapid tyrosine phosphorylation ...

journal_title：Antioxidants & redox signaling

authors： Han W,Takano T,He J,Ding J,Gao S,Noda C,Yanagi S,Yamamura H

更新日期：2001-12-01 00:00:00

abstract：:Enhanced production of reactive oxygen species (ROS) such as H(2)O(2) and a failure in ROS removal by scavenging systems are hallmarks of several cardiovascular diseases such as atherosclerosis and hypertension. ROS act as second messengers that play a prominent role in intracellular signaling and cellular function. I...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S

更新日期：2003-12-01 00:00:00

abstract：AIMS:Nuclear factor-erythroid-related factor 2 (Nrf2) is a critical transcriptional factor that is used in regulating cellular defense against oxidative stress. This study is aimed at investigating new interacting protein partners of Nrf2 using One-strep tag pull-down coupled with LTQ Orbitrap LC/MS/MS, and at examinin...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Xu EY,Sacks DB,Lee J,Shu L,Xia B,Kong AN

更新日期：2013-07-10 00:00:00

abstract：AIMS:Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro us...

journal_title：Antioxidants & redox signaling

authors： Manta B,Pavan C,Sturlese M,Medeiros A,Crispo M,Berndt C,Krauth-Siegel RL,Bellanda M,Comini MA

更新日期：2013-09-01 00:00:00

abstract：AIMS:Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases mitochondrial ATP levels. Here, we investigate the mechanistic connection between SIRT3 and energy homeost...

journal_title：Antioxidants & redox signaling

authors： Vassilopoulos A,Pennington JD,Andresson T,Rees DM,Bosley AD,Fearnley IM,Ham A,Flynn CR,Hill S,Rose KL,Kim HS,Deng CX,Walker JE,Gius D

更新日期：2014-08-01 00:00:00

abstract：:Autophagy is a bulk degradation process in which cytosolic proteins and organelles are degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we generated adenovirus and cardiac-specific transgenic mice harboring tandem fluorescent mRFP-GFP-LC3. Starvation significantly increased the number of mR...

journal_title：Antioxidants & redox signaling

authors： Hariharan N,Zhai P,Sadoshima J

更新日期：2011-06-01 00:00:00