The Redox-Metabolic Couple of T Lymphocytes: Potential Consequences for Hypertension.

abstract：:Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium i...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Morel S,Berthonneche C,Toufektsian MC,de Lorgeril M,Ducros V,Tosaki A,de Leiris J,Boucher F

更新日期：2004-08-01 00:00:00

abstract：:Efficient extracellular hemoglobin (Hb) clearance is essential to prevent oxidative- and nitrosative-mediated toxicity. CD163 belongs to group B of the scavenger receptor cysteine-rich (SRCR) protein family found on the surface of monocytes and macrophages and is responsible for Hb-haptoglobin (Hp) complex uptake. Hb ...

journal_title：Antioxidants & redox signaling

authors： Schaer DJ,Alayash AI,Buehler PW

更新日期：2007-07-01 00:00:00

abstract：:Post-ischemic reperfusion may result in reactive oxygen species (ROS) generation, reduced availability of nitric oxide (NO•), Ca(2+)overload, prolonged opening of mitochondrial permeability transition pore, and other processes contributing to cell death, myocardial infarction, stunning, and arrhythmias. With the disco...

journal_title：Antioxidants & redox signaling

authors： Pagliaro P,Moro F,Tullio F,Perrelli MG,Penna C

更新日期：2011-03-01 00:00:00

abstract：:Reactive oxygen species (ROS) have multifaceted roles in the orchestration of plant gene expression and gene-product regulation. Cellular redox homeostasis is considered to be an "integrator" of information from metabolism and the environment controlling plant growth and acclimation responses, as well as cell suicide ...

journal_title：Antioxidants & redox signaling

authors： Foyer CH,Noctor G

更新日期：2009-04-01 00:00:00

abstract：AIM:Skeletal muscle nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity. However, GC function and the consequences of reduced GC activity in skeletal muscle are unknown. In this ...

journal_title：Antioxidants & redox signaling

authors： Moon Y,Balke JE,Madorma D,Siegel MP,Knowels G,Brouckaert P,Buys ES,Marcinek DJ,Percival JM

更新日期：2017-06-10 00:00:00

abstract：: Significance: Genomic instability, a hallmark of cancer, renders cancer cells susceptible to genomic stress from both endogenous and exogenous origins, resulting in the increased tendency to accrue DNA damage, chromosomal instability, or aberrant DNA localization. Apart fr...

journal_title：Antioxidants & redox signaling

authors： Pu C,Tao S,Xu J,Huang M

更新日期：2020-12-04 00:00:00

abstract：AIMS:Cyclic adenosine 3'5'-monophosphate (cAMP) is a universal second messenger that plays an important role in intracellular signal transduction. cAMP is synthesized by adenylate cyclases from adenosine triphosphate and terminated by the phosphodiesterases (PDEs). In the present study, we investigated the role of the ...

journal_title：Antioxidants & redox signaling

authors： Ding H,Bai F,Cao H,Xu J,Fang L,Wu J,Yuan Q,Zhou Y,Sun Q,He W,Dai C,Zen K,Jiang L,Yang J

更新日期：2018-09-01 00:00:00

abstract：:Reactive oxygen and nitrogen species inhibit or promote cell proliferation by modulating the cell signaling pathways that dictate decisions between cell survival, proliferation, and death. In the growth factor-dependent pathways that regulate mitogenesis, numerous positive and negative effectors of signaling are influ...

journal_title：Antioxidants & redox signaling

authors： Burch PM,Heintz NH

更新日期：2005-05-01 00:00:00

abstract：AIMS:Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the impact of targeted disruption of Txnrd2 on tumor growth. RESULTS:Tumor...

journal_title：Antioxidants & redox signaling

authors： Hellfritsch J,Kirsch J,Schneider M,Fluege T,Wortmann M,Frijhoff J,Dagnell M,Fey T,Esposito I,Kölle P,Pogoda K,Angeli JP,Ingold I,Kuhlencordt P,Östman A,Pohl U,Conrad M,Beck H

更新日期：2015-04-10 00:00:00

abstract：:Molecular chaperones play key roles in protein quality control, signal transduction, proliferation, and cell death, and confer cytoprotection and assure survival after environmental stress. The heat-shock response is implicated in a variety of conditions including ischemic diseases, infection and immunity, neurodegene...

journal_title：Antioxidants & redox signaling

authors： Putics A,Végh EM,Csermely P,Soti C

更新日期：2008-01-01 00:00:00

abstract：:In the CNS, the heme oxygenase (HO) system has been reported to be active and to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge. We have recently shown that both curcumin and caffeic acid phenethyl ester, two phenolic natural compounds, potently induce HO-1 expression and acti...

journal_title：Antioxidants & redox signaling

authors： Scapagnini G,Butterfield DA,Colombrita C,Sultana R,Pascale A,Calabrese V

更新日期：2004-10-01 00:00:00

abstract：AIMS:Endothelium-dependent vasorelaxation is mediated by endothelium-derived relaxing factor and endothelium-derived hyperpolarizing factor (EDHF). However, the molecular entity of EDHF remains unclear. The present study examined whether hydrogen sulfide (H₂S) acts as EDHF and how H₂S mediates EDHF pathways from endoth...

journal_title：Antioxidants & redox signaling

authors： Tang G,Yang G,Jiang B,Ju Y,Wu L,Wang R

更新日期：2013-11-10 00:00:00

abstract：:The ability of iron to accept or donate electrons, coupled with the ability of oxygen to act as an electron acceptor, renders both elements essential to normal cellular biology. However, these same chemical properties allow free iron in solution to generate toxic free radicals, particularly in combination with oxygen....

journal_title：Antioxidants & redox signaling

authors： Mole DR

更新日期：2010-04-01 00:00:00

abstract：AIMS:Mesenchymal stromal cells (MSCs) are heterogeneous cells from adult tissues that are able to differentiate in vitro into adipocytes, osteoblasts, or chondrocytes. Such cells are widely studied in regenerative medicine. However, the success of cellular therapy depends on the cell survival. Heme oxygenase-1 (HO-1, e...

journal_title：Antioxidants & redox signaling

authors： Nowak WN,Taha H,Kachamakova-Trojanowska N,Stępniewski J,Markiewicz JA,Kusienicka A,Szade K,Szade A,Bukowska-Strakova K,Hajduk K,Klóska D,Kopacz A,Grochot-Przęczek A,Barthenheier K,Cauvin C,Dulak J,Józkowicz A

更新日期：2018-07-10 00:00:00

abstract：:To test the hypothesis that the inducible nitric oxide synthase (iNOS) is involved in mediating the toll-like receptor 4-dependent effects on the liver in the onset of fructose-induced steatosis, wild-type and iNOS knockout (iNOS(-/-)) mice were either fed tap water or 30% fructose solution for 8 weeks. Chronic consum...

journal_title：Antioxidants & redox signaling

authors： Spruss A,Kanuri G,Uebel K,Bischoff SC,Bergheim I

更新日期：2011-06-01 00:00:00

abstract：:Heme oxygenase (HO)-1, involved in the heme degradation process, is an important antioxidant enzyme. The induction of HO-1 gene expression, in response to diverse oxidative stimuli, represents a critical event in adaptive cellular response. Experimental models of various diseases, including acute inflammation, atheros...

journal_title：Antioxidants & redox signaling

authors： Prawan A,Kundu JK,Surh YJ

更新日期：2005-11-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00

abstract：SIGNIFICANCE:Studies of sporadic cases, toxin models, and genetic causes of Parkinson's disease suggest that mitochondrial dysfunction may be an early feature of pathogenesis. RECENT ADVANCES:Compelling evidence of a causal relationship between mitochondrial function and disease was found with the identification of se...

journal_title：Antioxidants & redox signaling

authors： McCoy MK,Cookson MR

更新日期：2012-05-01 00:00:00

abstract：:Intestinal detection of nutrients is a crucial step to inform the whole body of the nutritional status. In this paradigm, peripheral information generated by nutrients is transferred to the brain, which in turn controls physiological functions, including glucose metabolism. Here, we investigated the effect of enteric ...

journal_title：Antioxidants & redox signaling

authors： Duparc T,Naslain D,Colom A,Muccioli GG,Massaly N,Delzenne NM,Valet P,Cani PD,Knauf C

更新日期：2011-02-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a fundamental process, paradigmatic of the concept of cell plasticity, that leads epithelial cells to lose their polarization and specialized junctional structures, to undergo cytoskeleton reorganization, and to acquire morphological and functional features of mesenchymal-...

journal_title：Antioxidants & redox signaling

authors： Cannito S,Novo E,di Bonzo LV,Busletta C,Colombatto S,Parola M

更新日期：2010-06-15 00:00:00

abstract：SIGNIFICANCE:Stiffness of endothelial cells is closely linked to the function of the vasculature as it regulates the release of vasoactive substances such as nitric oxide (NO) and reactive oxygen species. The outer layer of endothelial cells, consisting of the glycocalyx above and the cortical zone beneath the plasma m...

journal_title：Antioxidants & redox signaling

authors： Fels J,Kusche-Vihrog K

更新日期：2019-03-01 00:00:00

abstract：:The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood. In this study, we investigated the effect of AngII on aortic smooth muscle from wild-type and NOX1-deficient mice. NOX1-deficient cells sho...

journal_title：Antioxidants & redox signaling

authors： Basset O,Deffert C,Foti M,Bedard K,Jaquet V,Ogier-Denis E,Krause KH

更新日期：2009-10-01 00:00:00

abstract：: Aims: Lifelong pain is a hallmark feature of sickle cell disease (SCD). How sickle pathobiology evokes pain remains unknown. We hypothesize that increased cell-free heme due to ongoing hemolysis activates toll-like receptor 4 (TLR4), leading to the formation of reactive ox...

journal_title：Antioxidants & redox signaling

authors： Lei J,Paul J,Wang Y,Gupta M,Vang D,Thompson S,Jha R,Nguyen J,Valverde Y,Lamarre Y,Jones MK,Gupta K

更新日期：2021-02-01 00:00:00

abstract：:The diabetogenic agent alloxan is a triketone that selectively destroys pancreatic beta cells. To investigate the importance of the triketone structure of alloxan for its cytotoxic potency, alloxan was compared with ninhydrin, also a triketone, and the amino derivative of alloxan uramil, which is not a triketone, beca...

journal_title：Antioxidants & redox signaling

authors： Elsner M,Gurgul-Convey E,Lenzen S

更新日期：2008-04-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has recently been viewed as an inflammation-dependent systemic disease. Oxidative modifications in the pulmonary microenvironment can result in a number of functional changes in pulmonary tissue as well as in the blood. Studies have been carried out to detect whether oxidat...

journal_title：Antioxidants & redox signaling

authors： Minetti M,Leto TL,Malorni W

更新日期：2008-04-01 00:00:00

abstract：:It was recently found that age-related changes in SMP30 expression can be modulated by antioxidative action. In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter...

journal_title：Antioxidants & redox signaling

authors： Jung KJ,Maruyama N,Ishigami A,Yu BP,Chung HY

更新日期：2006-03-01 00:00:00

abstract：AIMS:Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) are sufficient to increase ...

journal_title：Antioxidants & redox signaling

authors： Leuner K,Schütt T,Kurz C,Eckert SH,Schiller C,Occhipinti A,Mai S,Jendrach M,Eckert GP,Kruse SE,Palmiter RD,Brandt U,Dröse S,Wittig I,Willem M,Haass C,Reichert AS,Müller WE

更新日期：2012-06-15 00:00:00

abstract：:Reactive oxygen species (ROS) such as superoxide anion (O2-*) and hydrogen peroxide (H2O2) can be produced by vascular endothelium and smooth muscle cells under diverse physiological and pathophysiological situations. These species are known to exert various deleterious effects by which they might induce changes in va...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Boucher F,Toufektsian MC,Besse S,de Leiris J

更新日期：2000-07-01 00:00:00

abstract：AIMS:The usefulness of estrogen replacement therapy (ERT) in preventing oxidative stress associated with menopause is controversial. We aimed to study if there is a critical time window for effective treatment of the effects of ovariectomy with estrogens at the molecular, metabolic, and cellular level. RESULTS:Our mai...

journal_title：Antioxidants & redox signaling

authors： López-Grueso R,Gambini J,Abdelaziz KM,Monleón D,Díaz A,El Alami M,Bonet-Costa V,Borrás C,Viña J

更新日期：2014-01-10 00:00:00

abstract：:Cell division requires the coordinated assembly of cyclins and cyclin-dependent kinases that promote cell-cycle progression through S phase and mitosis. Two families of cyclin-dependent kinase inhibitors prevent abnormal or premature proliferation by blocking cyclin kinase activity. Expression of the cyclin-dependent ...

journal_title：Antioxidants & redox signaling

authors： O'Reilly MA

更新日期：2005-01-01 00:00:00