Role of the inducible nitric oxide synthase in the onset of fructose-induced steatosis in mice.

abstract：AIM:Epithelial-mesenchymal transition (EMT) is characterized by the acquisition of invasive fibroblast-like morphology by epithelial cells that are highly polarized. EMT is recognized as a crucial mechanism in cancer progression and metastasis. In this study, we sought to assess the involvement of manganese superoxide ...

journal_title：Antioxidants & redox signaling

authors： Loo SY,Hirpara JL,Pandey V,Tan TZ,Yap CT,Lobie PE,Thiery JP,Goh BC,Pervaiz S,Clément MV,Kumar AP

更新日期：2016-08-20 00:00:00

abstract：:Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins. Whereas optimal levels of Se in the diet have important health benefits, a recent clinical trial has suggested that supplemental intake of Se above the adequate level potentially may raise the risk ...

journal_title：Antioxidants & redox signaling

authors： Labunskyy VM,Lee BC,Handy DE,Loscalzo J,Hatfield DL,Gladyshev VN

更新日期：2011-06-15 00:00:00

abstract：:Oxidative stress is implicated as one of the major underlying mechanisms behind many acute and chronic diseases, and involved in normal aging. However, the measurement of free radicals or their end products is complicated. Thus, proof of association of free radicals in pathologic conditions has been absent. Isoprostan...

journal_title：Antioxidants & redox signaling

authors： Basu S

更新日期：2008-08-01 00:00:00

abstract：:Extensive literature exists supporting a role for mitochondrial dysfunction and oxidative damage in the pathogenesis of Alzheimer's disease. Mitochondria are a major source of intracellular reactive oxygen species and are particularly vulnerable to oxidative stress. This review discusses evidence supporting the notion...

journal_title：Antioxidants & redox signaling

authors： Moreira PI,Santos MS,Oliveira CR

更新日期：2007-10-01 00:00:00

abstract：:Previous reports have shown that the human immunodeficiency virus (HIV) regulatory protein Tat has both pro-oxidant and pro-inflammatory properties, suggesting that Tat might contribute to the neurological complications of HIV. However, the intracellular mechanisms whereby Tat triggers free radical production and infl...

journal_title：Antioxidants & redox signaling

authors： Turchan-Cholewo J,Dimayuga VM,Gupta S,Gorospe RM,Keller JN,Bruce-Keller AJ

更新日期：2009-02-01 00:00:00

abstract：SIGNIFICANCE:Currently, calcific aortic valve disease (CAVD) is only treatable through surgical intervention because the specific mechanisms leading to the disease remain unclear. In this review, we explore the forces and structure of the valve, as well as the mechanosensors and downstream signaling in the valve endoth...

journal_title：Antioxidants & redox signaling

authors： Fernández Esmerats J,Heath J,Jo H

更新日期：2016-09-01 00:00:00

abstract：:Protection of ischemic myocardium is an important unmet need in reperfusion therapy of acute myocardial infarction. Myocardial ischemia and reperfusion induce necrosis and apoptosis in cardiomyocytes. Caspase processing and activation are critical steps in most receptor and nonreceptor pathways of apoptosis. Caspase i...

journal_title：Antioxidants & redox signaling

authors： Li HL,Karwatowska-Prokopczuk E,Mutomba M,Wu J,Karanewsky D,Valentino K,Engler RL,Gottlieb RA

更新日期：2001-02-01 00:00:00

abstract：: Aims: Hemangioendothelioma (HE) may be benign or malignant. Mouse hemangioendothelioma endothelial (EOMA) cells are validated to study mechanisms in HE. This work demonstrates that EOMA cells heavily rely on mitochondria to thrive. Thus, a combination therapy, including we...

journal_title：Antioxidants & redox signaling

authors： Gordillo GM,Biswas A,Singh K,Sen A,Guda PR,Miller C,Pan X,Khanna S,Cadenas E,Sen CK

更新日期：2021-01-10 00:00:00

abstract：AIMS:Oxidative stress is thought to be involved in Friedreich's ataxia (FRDA), yet it has not been demonstrated in the target neurons that are first to degenerate. Using the YG8R mouse model of FRDA, microarray and neuritic growth experiments were carried out in the dorsal root ganglion (DRG), the primary site of neuro...

journal_title：Antioxidants & redox signaling

authors： Shan Y,Schoenfeld RA,Hayashi G,Napoli E,Akiyama T,Iodi Carstens M,Carstens EE,Pook MA,Cortopassi GA

更新日期：2013-11-01 00:00:00

abstract：:Apoptosis is a highly regulated process essential for the development and homeostasis of multicellular organisms. Whereas caspases, a large family of intracellular cysteine proteases, play central roles in the execution of apoptosis, other proapoptotic and antiapoptotic regulators such as the members of the Bcl-2 fami...

journal_title：Antioxidants & redox signaling

authors： Takeda K,Naguro I,Nishitoh H,Matsuzawa A,Ichijo H

更新日期：2011-08-01 00:00:00

abstract：AIMS:Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases mitochondrial ATP levels. Here, we investigate the mechanistic connection between SIRT3 and energy homeost...

journal_title：Antioxidants & redox signaling

authors： Vassilopoulos A,Pennington JD,Andresson T,Rees DM,Bosley AD,Fearnley IM,Ham A,Flynn CR,Hill S,Rose KL,Kim HS,Deng CX,Walker JE,Gius D

更新日期：2014-08-01 00:00:00

abstract：AIMS:Cigarette smoke (CS)-mediated acquired cystic fibrosis transmembrane conductance regulator (CFTR)-dysfunction, autophagy-impairment, and resulting inflammatory-oxidative/nitrosative stress leads to chronic obstructive pulmonary disease (COPD)-emphysema pathogenesis. Moreover, nitric oxide (NO) signaling regulates ...

journal_title：Antioxidants & redox signaling

authors： Bodas M,Silverberg D,Walworth K,Brucia K,Vij N

更新日期：2017-09-01 00:00:00

abstract：:Glycerophospholipids represent a common class of lipids critically important for integrity of cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes biological activities of phospholipids. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPL...

journal_title：Antioxidants & redox signaling

authors： Bochkov VN,Oskolkova OV,Birukov KG,Levonen AL,Binder CJ,Stöckl J

更新日期：2010-04-15 00:00:00

abstract：: Significance: Hydrogen sulfide (H2S), the "new entry" in the series of endogenous gasotransmitters, plays a fundamental role in regulating the biological functions of various organs and systems. Consequently, the lack of adequate levels of H2S may represent the etiopathoge...

journal_title：Antioxidants & redox signaling

authors： Martelli A,Citi V,Testai L,Brogi S,Calderone V

更新日期：2020-01-10 00:00:00

abstract：:Since the initial report of nitric oxide (NO) activity, enormous progress has been made over the last two decades in the field of NO research. Whereas most physiological responses triggered by moderate concentrations of NO are mediated by soluble guanylate cyclase activation and the subsequent production of cyclic GMP...

journal_title：Antioxidants & redox signaling

authors： Donnini S,Ziche M

更新日期：2002-10-01 00:00:00

abstract：:Heme oxygenase-1 is the rate-limiting enzyme for the degradation of the prooxidant heme. Previously, we showed that an E-box within the HO-1 promoter is crucial for the regulation of HO-1 expression in primary hepatocytes. Further to investigate the importance of this E-box, we determined the regulatory capacity of th...

journal_title：Antioxidants & redox signaling

authors： Samoylenko A,Dimova EY,Horbach T,Teplyuk N,Immenschuh S,Kietzmann T

更新日期：2008-07-01 00:00:00

abstract：:Hypoxia and its corollaries pose both negative and positive pressures to multicellular eukaryotes. Evolutionarily, life developed under hypoxia, and the building blocks were established under conditions close to anaerobiosis; therefore, reason exists to expect that certain biologic processes may perform preferentially...

journal_title：Antioxidants & redox signaling

authors： Webster KA

更新日期：2007-09-01 00:00:00

abstract：SIGNIFICANCE:Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific comm...

journal_title：Antioxidants & redox signaling

authors： Parrow NL,Leshin JA,Levine M

更新日期：2013-12-10 00:00:00

abstract：SIGNIFICANCE:Sessile plants respond to oxidative stress caused by internal and external stimuli by producing diverse forms of enzymatic and nonenzymatic antioxidant molecules. Peroxiredoxins (Prxs) in plants, including the Prx1, Prx5, Prx6, and PrxQ isoforms, constitute a family of antioxidant enzymes and play importan...

journal_title：Antioxidants & redox signaling

authors： Lee ES,Kang CH,Park JH,Lee SY

更新日期：2018-03-01 00:00:00

abstract：:Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/beta-catenin pathway, which itself regulates cell fate and earl...

journal_title：Antioxidants & redox signaling

authors： Funato Y,Miki H

更新日期：2007-08-01 00:00:00

abstract：SIGNIFICANCE:Half a century of research provided unambiguous proof that superoxide and species derived from it-reactive oxygen species (ROS)-play a central role in many diseases and degenerative processes. This stimulated the search for pharmaceutical agents that are capable of preventing oxidative damage, and methods ...

journal_title：Antioxidants & redox signaling

authors： Tovmasyan A,Reboucas JS,Benov L

更新日期：2014-05-20 00:00:00

abstract：SIGNIFICANCE:Extranuclear sirtuins in cytosol (SIRT2) and mitochondria (SIRT3, SIRT4, and SIRT5) are key regulators of metabolic enzymes and the antioxidative defense mechanisms. They play an important role in the adjustment of metabolic pathways in alterations of the nutritional status. Recent Advances: Recent studies...

journal_title：Antioxidants & redox signaling

authors： Elkhwanky MS,Hakkola J

更新日期：2018-03-10 00:00:00

abstract：SIGNIFICANCE:The accepted effects of aging in mammalian skeletal muscle are progressive atrophy and weakening, or sarcopenia. Canonical hallmarks of aging in skeletal muscle include a reduction in muscle fiber cross-sectional area, a loss in muscle fibers through apoptosis and denervation, and infiltration of connectiv...

journal_title：Antioxidants & redox signaling

authors： Lawler JM,Hindle A

更新日期：2011-11-01 00:00:00

abstract：:Oxidative stress plays a significant role in the pathogenesis of coronary artery disease (CAD). A p22(phox)-based NAD(P)H oxidase acts as a potent superoxide-generating system in the vasculature. We studied the association of the A640G and the C242T polymorphisms with clinical risk factors, endothelial function, and s...

journal_title：Antioxidants & redox signaling

authors： Zafari AM,Davidoff MN,Austin H,Valppu L,Cotsonis G,Lassègue B,Griendling KK

更新日期：2002-08-01 00:00:00

abstract：: Aims: Clinical use of cisplatin (Cisp), one of the most widely used, common, and effective chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Previous studies suggest that hydrogen sulfide (H2S) alleviates Cisp-i...

journal_title：Antioxidants & redox signaling

authors： Yuan Y,Zhu L,Li L,Liu J,Chen Y,Cheng J,Peng T,Lu Y

更新日期：2019-12-01 00:00:00

abstract：AIMS:Oxidative stress is considered the major cause of tissue injury after cerebral ischemia. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway is one of the most important defensive mechanisms against oxidative stresses and has been confirmed as a target for stroke treatment. Thus, we desired to find new ...

journal_title：Antioxidants & redox signaling

authors： Wu G,Zhu L,Yuan X,Chen H,Xiong R,Zhang S,Cheng H,Shen Y,An H,Li T,Li H,Zhang W

更新日期：2017-10-10 00:00:00

abstract：AIM:To evaluate the role of matrix metalloproteinase (MMP)-9 deletion on citrate synthase (CS) activity postmyocardial infarction (MI). RESULTS:We fractionated left ventricle (LV) samples using a differential solubility-based approach. The insoluble protein fraction was analyzed by mass spectrometry, and we identified...

journal_title：Antioxidants & redox signaling

authors： de Castro Brás LE,Cates CA,DeLeon-Pennell KY,Ma Y,Iyer RP,Halade GV,Yabluchanskiy A,Fields GB,Weintraub ST,Lindsey ML

更新日期：2014-11-10 00:00:00

abstract：SIGNIFICANCE:Reactive oxygen species (ROS) are not only essential for the cell's normal functions, but also mediate many pathological effects. When cells experience oxidative stress, proteins are modulated by redox changes and ultimately generate novel signaling patterns. It remains elusive how proteins are modulated, ...

journal_title：Antioxidants & redox signaling

authors： Wang Y,Yang J,Yi J

更新日期：2012-04-01 00:00:00

abstract：AIMS:Chronic metabolic impairment and oxidative stress are associated with the pathogenesis of axonal dysfunction in a growing number of neurodegenerative conditions. To investigate the intertwining of both noxious factors, we have chosen the mouse model of adrenoleukodystrophy (X-ALD), which exhibits axonal degenerati...

journal_title：Antioxidants & redox signaling

authors： Galino J,Ruiz M,Fourcade S,Schlüter A,López-Erauskin J,Guilera C,Jove M,Naudi A,García-Arumí E,Andreu AL,Starkov AA,Pamplona R,Ferrer I,Portero-Otin M,Pujol A

更新日期：2011-10-15 00:00:00

abstract：:Our laboratory demonstrated that hyperhomocysteinemia accelerates atherosclerosis in mouse models through ER stress and activation of the unfolded protein response (UPR). In this study, we tested the hypothesis that homocysteine-induced ER stress may arise from ER-Ca(2+) disequilibria. We found that homocysteine-induc...

journal_title：Antioxidants & redox signaling

authors： Dickhout JG,Sood SK,Austin RC

更新日期：2007-11-01 00:00:00