Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy.

abstract：:Cardiac surgery is associated with release of the pleiotropic cytokine macrophage migration inhibitory factor (MIF). The trigger for MIF release has not yet been elucidated. Owing to its intrinsic antioxidative activity, MIF might reduce oxidative stress and protect from myocardial ischemia and reperfusion (I/R) injur...

journal_title：Antioxidants & redox signaling

authors： Stoppe C,Werker T,Rossaint R,Dollo F,Lue H,Wonisch W,Menon A,Goetzenich A,Bruells CS,Coburn M,Kopp R,Bucala R,Bernhagen J,Rex S

更新日期：2013-07-20 00:00:00

abstract：:The cellular redox state is associated with major cellular processes including differentiation, transformation, and apoptosis. Glutaredoxin 2 (Grx2) is a mitochondrial oxidoreductase suggested to play a critical role in protection against apoptotic stimuli. An alternative Grx2 transcript variant encoding a nonmitochon...

journal_title：Antioxidants & redox signaling

authors： Lönn ME,Hudemann C,Berndt C,Cherkasov V,Capani F,Holmgren A,Lillig CH

更新日期：2008-03-01 00:00:00

abstract：SIGNIFICANCE:Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific comm...

journal_title：Antioxidants & redox signaling

authors： Parrow NL,Leshin JA,Levine M

更新日期：2013-12-10 00:00:00

abstract：:In striated muscle, the sarcoplasmic reticulum (SR) is the major storage compartment of intracellular Ca2+ that controls cytosolic free Ca2+ (Cai) and developed force by sequestering and releasing Ca2+ during each contraction. Ca2+ release from the SR occurs through high-conductance Ca2+ release channels or ryanodine ...

journal_title：Antioxidants & redox signaling

authors： Salama G,Menshikova EV,Abramson JJ

更新日期：2000-04-01 00:00:00

abstract：:The decision to remove or refold oxidized, denatured, or misfolded proteins by heat shock protein 70 and its binding partners is critical to determine cell fate under pathophysiological conditions. Overexpression of the ubiquitin ligase C-terminus of HSC70 interacting protein (CHIP) can compensate for failure of other...

journal_title：Antioxidants & redox signaling

authors： Stankowski JN,Zeiger SL,Cohen EL,DeFranco DB,Cai J,McLaughlin B

更新日期：2011-05-15 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. The pathogenesis of PD remains incompletely understood. Environmental factors, oxidative damage, misfolded protein aggregates, ubiquitin-proteasome syste...

journal_title：Antioxidants & redox signaling

authors： Wang HQ,Takahashi R

更新日期：2007-05-01 00:00:00

abstract：:Scholarly peer review represents the linchpin of academic publishing. Recognized benefits of the peer review system are manifold. Critics raise several valid concerns that deserve attention. Several studies show that the current peer review system lacks robustness and is subject to bias in favor of well-established re...

journal_title：Antioxidants & redox signaling

authors： Sen CK

更新日期：2012-02-15 00:00:00

abstract：:Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/beta-catenin pathway, which itself regulates cell fate and earl...

journal_title：Antioxidants & redox signaling

authors： Funato Y,Miki H

更新日期：2007-08-01 00:00:00

abstract：SIGNIFICANCE:The therapeutic effects of current micellar and vesicular drug formulations are restricted by slow and inefficient drug release at the pathological site. The development of smart polymeric nanocarriers that release drugs upon arriving at the target site has received a tremendous amount of attention for can...

journal_title：Antioxidants & redox signaling

authors： Sun H,Meng F,Cheng R,Deng C,Zhong Z

更新日期：2014-08-10 00:00:00

abstract：SIGNIFICANCE:Mitochondrial function is central to a wide range of biological processes in health and disease and there is considerable interest in developing small molecules that are taken up by mitochondria and act as either probes of mitochondrial function or therapeutics in vivo. RECENT ADVANCES:Various strategies ...

journal_title：Antioxidants & redox signaling

authors： Smith RA,Hartley RC,Murphy MP

更新日期：2011-12-15 00:00:00

abstract：:Oxidative stress is implicated as one of the major underlying mechanisms behind many acute and chronic diseases, and involved in normal aging. However, the measurement of free radicals or their end products is complicated. Thus, proof of association of free radicals in pathologic conditions has been absent. Isoprostan...

journal_title：Antioxidants & redox signaling

authors： Basu S

更新日期：2008-08-01 00:00:00

abstract：:Fluid shear stress plays a critical role in the regulation of vascular biology and its pathology, such as atherosclerosis, via modulation of redox balance. Both pro-atherogenic (either oscillatory or turbulent, nonunidirectional) shear stress and anti-atherogenic (either steady or pulsatile, unidirectional laminar) sh...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Warabi E,Noguchi N

更新日期：2011-09-01 00:00:00

abstract：:The phagocytic NADPH oxidase is recognized as a critical component of innate immunity, responsible for generation of microbicidal reactive oxygen species (ROS). This enzyme is one representative of the Nox family of oxidases (Nox1-Nox5, Duox1, and Duox2) that exhibit diverse expression patterns and appear to serve a v...

journal_title：Antioxidants & redox signaling

authors： Leto TL,Geiszt M

更新日期：2006-09-01 00:00:00

abstract：:Parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra zona compacta, and in other subcortical nuclei associated with a widespread occurrence of Lewy bodies. The causes of cell death in Parkinson's disease are still poorly understood, but a defect in mitochondrial ox...

journal_title：Antioxidants & redox signaling

authors： Sharma SK,Ebadi M

更新日期：2003-06-01 00:00:00

abstract：:Discovery of the F2-isoprostanes, a group of prostaglandin F2-like compounds biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel facet of free radical biology. Some of these compounds are bioactive and thus may mediate adverse effects associated with oxidant stress. F2-Isoprostanes hav...

journal_title：Antioxidants & redox signaling

authors： Basu S,Helmersson J

更新日期：2005-01-01 00:00:00

abstract：AIMS:Nuclear factor-erythroid-related factor 2 (Nrf2) is a critical transcriptional factor that is used in regulating cellular defense against oxidative stress. This study is aimed at investigating new interacting protein partners of Nrf2 using One-strep tag pull-down coupled with LTQ Orbitrap LC/MS/MS, and at examinin...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Xu EY,Sacks DB,Lee J,Shu L,Xia B,Kong AN

更新日期：2013-07-10 00:00:00

abstract：:In the CNS, the heme oxygenase (HO) system has been reported to be active and to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge. We have recently shown that both curcumin and caffeic acid phenethyl ester, two phenolic natural compounds, potently induce HO-1 expression and acti...

journal_title：Antioxidants & redox signaling

authors： Scapagnini G,Butterfield DA,Colombrita C,Sultana R,Pascale A,Calabrese V

更新日期：2004-10-01 00:00:00

abstract：:Signal transduction via PI 3-kinases plays an important role in regulating the cellular processes of cell growth, survival, proliferation, and motility. The stimulated generation of reactive oxygen species is a necessary component of the signal transduction mechanisms by which many growth factors and cytokines activat...

journal_title：Antioxidants & redox signaling

authors： Leslie NR

更新日期：2006-09-01 00:00:00

abstract：SIGNIFICANCE:Oxidative (reactive oxygen species [ROS]) and nitrosative (reactive nitrogen species [RNS]) stress affects many physiological processes, including survival and death. Although high levels of ROS/RNS mainly causes cell death, low levels of free radicals directly modulate the activities of transcriptional fa...

journal_title：Antioxidants & redox signaling

authors： Kaminskyy VO,Zhivotovsky B

更新日期：2014-07-01 00:00:00

abstract：:It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch points where disturbed blood flow (d-flow) predisposes to the development of plaques. Investigations both in vivo and in vitro have shown that d-flow is pro-atherogenic by promoting oxidative and inflammatory states in the a...

journal_title：Antioxidants & redox signaling

authors： Nigro P,Abe J,Berk BC

更新日期：2011-09-01 00:00:00

abstract：:Hypoxia is sensed by all mammalian cells and elicits a variety of adaptive and pathophysiological responses at the molecular and cellular level. For the pulmonary vasculature, hypoxia causes increased vasoconstriction and vessel-wall remodeling. These responses are mediated by complex intracellular cascades leading to...

journal_title：Antioxidants & redox signaling

authors： Kourembanas S

更新日期：2002-04-01 00:00:00

abstract：AIMS:Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known safety in humans using a hippocampal neuroblast line expressing a reporter...

journal_title：Antioxidants & redox signaling

authors： Aleyasin H,Karuppagounder SS,Kumar A,Sleiman S,Basso M,Ma T,Siddiq A,Chinta SJ,Brochier C,Langley B,Haskew-Layton R,Bane SL,Riggins GJ,Gazaryan I,Starkov AA,Andersen JK,Ratan RR

更新日期：2015-01-10 00:00:00

abstract：: Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and they constitute an ever-growing global burden that has a c...

journal_title：Antioxidants & redox signaling

authors： Gianazza E,Brioschi M,Martinez Fernandez A,Casalnuovo F,Altomare A,Aldini G,Banfi C

更新日期：2021-01-01 00:00:00

abstract：: Aims: Hemangioendothelioma (HE) may be benign or malignant. Mouse hemangioendothelioma endothelial (EOMA) cells are validated to study mechanisms in HE. This work demonstrates that EOMA cells heavily rely on mitochondria to thrive. Thus, a combination therapy, including we...

journal_title：Antioxidants & redox signaling

authors： Gordillo GM,Biswas A,Singh K,Sen A,Guda PR,Miller C,Pan X,Khanna S,Cadenas E,Sen CK

更新日期：2021-01-10 00:00:00

abstract：:Extensive literature exists supporting a role for mitochondrial dysfunction and oxidative damage in the pathogenesis of Alzheimer's disease. Mitochondria are a major source of intracellular reactive oxygen species and are particularly vulnerable to oxidative stress. This review discusses evidence supporting the notion...

journal_title：Antioxidants & redox signaling

authors： Moreira PI,Santos MS,Oliveira CR

更新日期：2007-10-01 00:00:00

abstract：:The 6(th) COSTAM/SFRR (ASEAN/Malaysia) workshop, "Micronutrients, Oxidative Stress, and the Environment," was held from June 29 to July 2 at Holiday Inn Damai Beach Resort in Kuching, Sarawak. Two hundred twenty participants from 17 countries presented recent advances on natural antioxidants in the area of oxidative s...

journal_title：Antioxidants & redox signaling

authors： Nesaretnam K,Sies H

更新日期：2006-11-01 00:00:00

abstract：:Monothiol glutaredoxins (Grxs) with a noncanonical CGFS active site are found in all kingdoms of life. They include members with a single domain and thioredoxin-Grx fusion proteins. In Saccharomyces cerevisiae, the multidomain Grx3 and Grx4 play an essential role in intracellular iron trafficking. This crucial task is...

journal_title：Antioxidants & redox signaling

authors： Hoffmann B,Uzarska MA,Berndt C,Godoy JR,Haunhorst P,Lillig CH,Lill R,Mühlenhoff U

更新日期：2011-07-01 00:00:00

abstract：AIMS:Aberrant Cdk5 (cyclin-dependent kinase 5) and oxidative stress are crucial components of diverse neurodegenerative disorders, including Alzheimer's disease (AD). We previously reported that a change in peroxiredoxin (Prx) expression is associated with protection from neuronal death. The aim of the current study wa...

journal_title：Antioxidants & redox signaling

authors： Park J,Kim B,Chae U,Lee DG,Kam MK,Lee SR,Lee S,Lee HS,Park JW,Lee DS

更新日期：2017-10-10 00:00:00

abstract：AIMS:Recent studies have revealed that autophagy is induced under various disease conditions; however, the role of autophagy in pathological states is controversial. NAD(P)H:quinone oxidoreductase 1 (NQO1) is a highly inducible cytoprotective gene that regulates reactive oxygen species (ROS) generation. In this study,...

journal_title：Antioxidants & redox signaling

authors： Kim TW,Kim YJ,Kim HT,Park SR,Lee MY,Park YD,Lee CH,Jung JY

更新日期：2016-05-20 00:00:00

abstract：AIMS:Recent studies suggest that the molybdenum enzymes xanthine oxidase, aldehyde oxidase, and mARC exhibit nitrite reductase activity at low oxygen pressures. However, inhibition studies of xanthine oxidase in humans have failed to block nitrite-dependent changes in blood flow, leading to continued exploration for ot...

journal_title：Antioxidants & redox signaling

authors： Wang J,Krizowski S,Fischer-Schrader K,Niks D,Tejero J,Sparacino-Watkins C,Wang L,Ragireddy V,Frizzell S,Kelley EE,Zhang Y,Basu P,Hille R,Schwarz G,Gladwin MT

更新日期：2015-08-01 00:00:00