Radical generation and alterations of erythrocyte integrity as bioindicators of diagnostic or prognostic value in COPD?


:Chronic obstructive pulmonary disease (COPD) has recently been viewed as an inflammation-dependent systemic disease. Oxidative modifications in the pulmonary microenvironment can result in a number of functional changes in pulmonary tissue as well as in the blood. Studies have been carried out to detect whether oxidatively modified molecules or cells could be considered possible markers of the disease. We hypothesize here that new insights into COPD could come from enzymes involved in deliberate radical generation (i.e., Nox and NOS family enzymes) as well as from alterations of erythrocyte integrity and function, which could become bioindicators of diagnostic or prognostic value in the near future.


Antioxid Redox Signal


Minetti M,Leto TL,Malorni W




Has Abstract


2008-04-01 00:00:00












  • Does the Cerebrospinal Fluid Reflect Altered Redox State But Not Neurotrophic Support Loss in Parkinson's Disease?

    abstract::Alteration in neurotrophic factors support and antioxidant defenses in the central nervous system (CNS) along with deficit of ferritin have been associated with idiopathic Parkinson's disease (PD). The objectives were to analyze in the cerebrospinal fluid (CSF) of patients with PD and controls the following: (i) the l...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Martín de Pablos A,García-Moreno JM,Fernández E

    更新日期:2015-10-10 00:00:00

  • Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice.

    abstract::Reactive oxygen species (ROS) can directly induce or enhance tumor necrosis factor (TNF)-mediated apoptosis in a number of different cell lines. To test the relevance of intracellular ROS in modulating apoptotic signaling in vivo, we evaluated hepatocellular apoptosis mediated by the TNF or Fas receptor in wild-type a...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Bajt ML,Ho YS,Vonderfecht SL,Jaeschke H

    更新日期:2002-10-01 00:00:00

  • Factors regulating isoprostane formation in vivo.

    abstract::Discovery of the F2-isoprostanes, a group of prostaglandin F2-like compounds biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel facet of free radical biology. Some of these compounds are bioactive and thus may mediate adverse effects associated with oxidant stress. F2-Isoprostanes hav...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Basu S,Helmersson J

    更新日期:2005-01-01 00:00:00

  • Physiological Significance of Plant Peroxiredoxins and the Structure-Related and Multifunctional Biochemistry of Peroxiredoxin 1.

    abstract:SIGNIFICANCE:Sessile plants respond to oxidative stress caused by internal and external stimuli by producing diverse forms of enzymatic and nonenzymatic antioxidant molecules. Peroxiredoxins (Prxs) in plants, including the Prx1, Prx5, Prx6, and PrxQ isoforms, constitute a family of antioxidant enzymes and play importan...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Lee ES,Kang CH,Park JH,Lee SY

    更新日期:2018-03-01 00:00:00

  • Antiatherogenic effect of bisvanillyl-hydralazone, a new hydralazine derivative with antioxidant, carbonyl scavenger, and antiapoptotic properties.

    abstract::Reactive oxygen species (ROS) generated within the vascular wall trigger low-density lipoprotein (LDL) oxidation, lipid peroxidation, and carbonyl stress that are involved in atherogenesis. We recently reported that the antihypertensive drug, hydralazine, exhibits carbonyl scavenger and antiatherogenic properties, but...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Bouguerne B,Belkheiri N,Bedos-Belval F,Vindis C,Uchida K,Duran H,Grazide MH,Baltas M,Salvayre R,Nègre-Salvayre A

    更新日期:2011-06-01 00:00:00

  • Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in mammals.

    abstract:SIGNIFICANCE:Mitochondria are double membrane-bound organelles with tubular network structures that are essential for oxidative ATP production and play pivotal roles in regulating calcium homeostasis and apoptosis. Furthermore, mitochondria produce large amounts of reactive oxygen species that are fatal to cellular fun...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Ishihara N,Otera H,Oka T,Mihara K

    更新日期:2013-08-01 00:00:00

  • Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.

    abstract::We studied the subcellular distribution of mitochondria and superoxide dismutase-1 (SOD1) in whole mounts of microdissected motor axons of rats expressing the ALS-linked SOD1-G93A mutation. The rationale was to determine whether physical interactions between the enzyme and mitochondria were linked to the axonopathy of...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Sotelo-Silveira JR,Lepanto P,Elizondo V,Horjales S,Palacios F,Martinez-Palma L,Marin M,Beckman JS,Barbeito L

    更新日期:2009-07-01 00:00:00

  • Redox-Based Transcriptional Regulation in Prokaryotes: Revisiting Model Mechanisms.

    abstract:SIGNIFICANCE:The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Sevilla E,Bes MT,González A,Peleato ML,Fillat MF

    更新日期:2019-05-01 00:00:00

  • Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.

    abstract:AIMS:Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the impact of targeted disruption of Txnrd2 on tumor growth. RESULTS:Tumor...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Hellfritsch J,Kirsch J,Schneider M,Fluege T,Wortmann M,Frijhoff J,Dagnell M,Fey T,Esposito I,Kölle P,Pogoda K,Angeli JP,Ingold I,Kuhlencordt P,Östman A,Pohl U,Conrad M,Beck H

    更新日期:2015-04-10 00:00:00

  • SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.

    abstract:AIMS:Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases mitochondrial ATP levels. Here, we investigate the mechanistic connection between SIRT3 and energy homeost...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Vassilopoulos A,Pennington JD,Andresson T,Rees DM,Bosley AD,Fearnley IM,Ham A,Flynn CR,Hill S,Rose KL,Kim HS,Deng CX,Walker JE,Gius D

    更新日期:2014-08-01 00:00:00

  • Nox NADPH oxidases and the endoplasmic reticulum.

    abstract:SIGNIFICANCE:Understanding isoform- and context-specific subcellular Nox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase compartmentalization allows relevant functional inferences. This review addresses the interplay between Nox NADPH oxidases and the endoplasmic reticulum (ER), an increasingly evid...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Laurindo FR,Araujo TL,Abrahão TB

    更新日期:2014-06-10 00:00:00

  • Isletopathy in Type 2 diabetes mellitus: implications of islet RAS, islet fibrosis, islet amyloid, remodeling, and oxidative stress.

    abstract::This review focuses primarily on islet structural and functional changes related to an activated islet renin- angiotensin system (RAS), islet oxidative-redox imbalance, the concurrence of islet fibrosis (pericapillary, intra- and peri-islet), and islet amyloid deposition (pericapillary, intra- and peri-islet). The isl...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Hayden MR,Sowers JR

    更新日期:2007-07-01 00:00:00

  • The role of reactive oxygen species in insulin signaling in the vasculature.

    abstract::Although there is an abundance of evidence suggesting that insulin resistance plays a significant role in the vasculature, the precise mechanistic role involved still remains unclear. In this review, we discuss the current background of insulin resistance in the context of insulin signaling and action in the vasculatu...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Frank GD,Eguchi S,Motley ED

    更新日期:2005-07-01 00:00:00

  • Plant polyphenols regulate chemokine expression and tissue repair in human keratinocytes through interaction with cytoplasmic and nuclear components of epidermal growth factor receptor system.

    abstract:AIMS:To evaluate mechanisms underlying modulation of inflammatory chemokines in primary human keratinocytes (normal human epidermal keratinocytes) and repair-related processes in wound models by plant polyphenols (PPs) with antioxidant and superoxide scavenging properties (verbascoside [Vb], resveratrol [Rv], polydatin...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Pastore S,Lulli D,Fidanza P,Potapovich AI,Kostyuk VA,De Luca C,Mikhal'chik E,Korkina LG

    更新日期:2012-02-15 00:00:00

  • Contribution of thioredoxin reductase to T-cell mitogenesis and NF-kappaB DNA-binding promoted by selenite.

    abstract::Although the essential role of selenium for cellular immune responses is obvious, delineation of the functions is lacking because selenium can either promote or inhibit cell growth, cytokine production, and activation of transcription factor nuclear factor-kappaB (NF-kappaB). Studies with human thioredoxin-1 (Trx-1)-t...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Ueno H,Kajihara H,Nakamura H,Yodoi J,Nakamuro K

    更新日期:2007-01-01 00:00:00

  • Hyperglycemia and glycation in diabetic complications.

    abstract::Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is considered a major health concern,as its incidence is increasing at an alarming rate, and the high invalidating effects of its l...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Negre-Salvayre A,Salvayre R,Augé N,Pamplona R,Portero-Otín M

    更新日期:2009-12-01 00:00:00

  • Harnessing Genomic Stress for Antitumor Immunity.

    abstract:: Significance: Genomic instability, a hallmark of cancer, renders cancer cells susceptible to genomic stress from both endogenous and exogenous origins, resulting in the increased tendency to accrue DNA damage, chromosomal instability, or aberrant DNA localization. Apart fr...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Pu C,Tao S,Xu J,Huang M

    更新日期:2020-12-04 00:00:00

  • Integrin clustering drives phagocytosis coupled to collagenase 1 induction through RhoA GTPase and superoxide production.

    abstract::Integrin-mediated phagocytosis in fibroblasts is associated to collagenase 1 induction when the particles are coated with high-affinity binding ligands. This study shows that the high density of ligand coating on the particle elicits RhoA-dependent particle uptake coupled to signal transduction. Integrin clustering in...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Werner E

    更新日期:2005-03-01 00:00:00

  • Redox regulation of cell-cycle re-entry: cyclin D1 as a primary target for the mitogenic effects of reactive oxygen and nitrogen species.

    abstract::Reactive oxygen and nitrogen species inhibit or promote cell proliferation by modulating the cell signaling pathways that dictate decisions between cell survival, proliferation, and death. In the growth factor-dependent pathways that regulate mitogenesis, numerous positive and negative effectors of signaling are influ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Burch PM,Heintz NH

    更新日期:2005-05-01 00:00:00

  • Mitochondrial quality control and dynamics in Parkinson's disease.

    abstract:SIGNIFICANCE:Studies of sporadic cases, toxin models, and genetic causes of Parkinson's disease suggest that mitochondrial dysfunction may be an early feature of pathogenesis. RECENT ADVANCES:Compelling evidence of a causal relationship between mitochondrial function and disease was found with the identification of se...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: McCoy MK,Cookson MR

    更新日期:2012-05-01 00:00:00

  • Histone h3 glutathionylation in proliferating mammalian cells destabilizes nucleosomal structure.

    abstract:AIMS:Here we report that chromatin, the complex and dynamic eukaryotic DNA packaging structure, is able to sense cellular redox changes. Histone H3, the only nucleosomal protein that possesses cysteine(s), can be modified by glutathione (GSH). RESULTS:Using Biotin labeled glutathione ethyl ester (BioGEE) treatment of ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: García-Giménez JL,Òlaso G,Hake SB,Bönisch C,Wiedemann SM,Markovic J,Dasí F,Gimeno A,Pérez-Quilis C,Palacios O,Capdevila M,Viña J,Pallardó FV

    更新日期:2013-10-20 00:00:00

  • Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

    abstract::Lipoic acid (LA) and its reduced product dihydrolipoic acid (DHLA) are potent antioxidants with capacity to scavenge reactive oxygen species (ROS) and recycle endogenous antioxidants. LA may increase cellular glutathione (GSH), an antioxidant lacking in the lung's epithelial lining fluid in lung disorders such as idio...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: O'Neill HC,Rancourt RC,White CW

    更新日期:2008-02-01 00:00:00

  • The thioredoxin system in neonatal lung disease.

    abstract:SIGNIFICANCE:Fetal lung development takes place in hypoxia meaning that premature birth is hyperoxia for the prematurely born infant. The most common respiratory morbidity afflicting premature infants is bronchopulmonary dysplasia (BPD). Pathophysiologically, BPD represents the impact of injury, including O2 toxicity, ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Tipple TE

    更新日期:2014-11-01 00:00:00

  • In situ reduction of oxidative damage, increased cell turnover, and delay of mitochondrial injury by overexpression of manganese superoxide dismutase in a multistage skin carcinogenesis model.

    abstract::To study early subcellular pathologic changes of tumorigenesis in mouse skin and possible modulation by overexpression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD), skin keratinocytes from nontransgenic (Ntg) and transgenic (TgH) mice overexpressing MnSOD topically treated with one do...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Oberley TD,Xue Y,Zhao Y,Kiningham K,Szweda LI,St Clair DK

    更新日期:2004-06-01 00:00:00

  • Regulation of the Expression of Heme Oxygenase-1: Signal Transduction, Gene Promoter Activation, and Beyond.

    abstract:: Significance: Heme oxygenase-1 (HO-1) is a ubiquitous 32-kDa protein expressed in many tissues and highly inducible. They catalyze the degradation of the heme group and the release of free iron, carbon monoxide, and biliverdin; the latter converted to bilirubin by biliverd...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Medina MV,Sapochnik D,Garcia Solá M,Coso O

    更新日期:2020-05-10 00:00:00

  • Early, but not late onset estrogen replacement therapy prevents oxidative stress and metabolic alterations caused by ovariectomy.

    abstract:AIMS:The usefulness of estrogen replacement therapy (ERT) in preventing oxidative stress associated with menopause is controversial. We aimed to study if there is a critical time window for effective treatment of the effects of ovariectomy with estrogens at the molecular, metabolic, and cellular level. RESULTS:Our mai...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: López-Grueso R,Gambini J,Abdelaziz KM,Monleón D,Díaz A,El Alami M,Bonet-Costa V,Borrás C,Viña J

    更新日期:2014-01-10 00:00:00

  • Redox modulation of Gi protein expression and adenylyl cyclase signaling: role of nitric oxide.

    abstract::Nitric oxide (NO) has been shown to regulate a variety of physiological functions, including vascular tone. The inhibition of NO synthase by N(omega)-nitro-L-arginine methyl ester (L-NAME) has been reported to increase arterial blood pressure. The present studies were undertaken to investigate if the increased blood p...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Anand-Srivastava MB,Di Fusco F

    更新日期:2004-04-01 00:00:00

  • 6th COSTAM/SFRR (ASEAN/Malaysia) International Workshop on Micronutrients, Oxidative Stress, and the Environment.

    abstract::The 6(th) COSTAM/SFRR (ASEAN/Malaysia) workshop, "Micronutrients, Oxidative Stress, and the Environment," was held from June 29 to July 2 at Holiday Inn Damai Beach Resort in Kuching, Sarawak. Two hundred twenty participants from 17 countries presented recent advances on natural antioxidants in the area of oxidative s...

    journal_title:Antioxidants & redox signaling



    authors: Nesaretnam K,Sies H

    更新日期:2006-11-01 00:00:00

  • Mitochondria as Target for Tumor Management of Hemangioendothelioma.

    abstract:: Aims: Hemangioendothelioma (HE) may be benign or malignant. Mouse hemangioendothelioma endothelial (EOMA) cells are validated to study mechanisms in HE. This work demonstrates that EOMA cells heavily rely on mitochondria to thrive. Thus, a combination therapy, including we...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章


    authors: Gordillo GM,Biswas A,Singh K,Sen A,Guda PR,Miller C,Pan X,Khanna S,Cadenas E,Sen CK

    更新日期:2021-01-10 00:00:00

  • Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities.

    abstract:SIGNIFICANCE:Once considered to be mere by-products of metabolism, reactive oxygen, nitrogen and sulfur species are now recognized to play important roles in diverse cellular processes such as response to pathogens and regulation of cellular differentiation. It is becoming increasingly evident that redox imbalance can ...

    journal_title:Antioxidants & redox signaling

    pub_type: 杂志文章,评审


    authors: Sbodio JI,Snyder SH,Paul BD

    更新日期:2019-04-10 00:00:00