Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy.

abstract：SIGNIFICANCE:Development of donor-specific antibodies (DSA) after kidney transplantation is associated with reduced allograft survival. A few strategies have been tested in controlled clinical trials for the treatment of antibody-mediated rejection (AMR), and no therapies are approved by regulatory authorities. Thus de...

journal_title：Antioxidants & redox signaling

authors： Ejaz NS,Alloway RR,Halleck F,Dürr M,Budde K,Woodle ES

更新日期：2014-12-10 00:00:00

abstract：:Oxidative stress due to increased epidermal levels of H(2)O(2) with consequent inhibition of catalase activity is generally accepted as a leading cytotoxic mechanism of melanocyte loss in vitiligo. Keratinocyte-derived cytokines are considered key factors in the maintenance of melanocyte structure and functions. We hy...

journal_title：Antioxidants & redox signaling

authors： Kostyuk VA,Potapovich AI,Cesareo E,Brescia S,Guerra L,Valacchi G,Pecorelli A,Deeva IB,Raskovic D,De Luca C,Pastore S,Korkina LG

更新日期：2010-09-01 00:00:00

abstract：:Methamphetamine (METH) increases the oxidative DNA lesion 8-oxoguanine (8-oxoG) in fetal mouse brain, and causes postnatal motor coordination deficits after in utero exposure. Like oxoguanine glycosylase 1 (OGG1), the Cockayne syndrome B (CSB) protein is involved in the repair of oxidatively damaged DNA, although its ...

journal_title：Antioxidants & redox signaling

authors： McCallum GP,Wong AW,Wells PG

更新日期：2011-03-01 00:00:00

abstract：: Significance: Hypertension is characterized as the imbalance of vasoconstriction and vasodilatation. Hypertension is influenced by genetic variation and environmental risk factors, such as unhealthy diet. Clinical trial results suggest that increasing intake of foods rich ...

journal_title：Antioxidants & redox signaling

authors： Wang H,Li Q,Zhu Y,Zhang X

更新日期：2020-06-12 00:00:00

abstract：: Significance: Type 2 diabetes development involves multiple changes in β-cells, related to the oxidative stress and impaired redox signaling, beginning frequently by sustained overfeeding due to the resulting lipotoxicity and glucotoxicity. Uncovering relationships among t...

journal_title：Antioxidants & redox signaling

authors： Ježek P,Jabůrek M,Plecitá-Hlavatá L

更新日期：2019-10-01 00:00:00

abstract：:Neutrophils have a short half-life and high tendency to undergo apoptosis. One feature that may influence these characteristics is the antioxidant/oxidant balance of these cells. There are few studies on the levels of antioxidant enzymes in human neutrophils. We have analyzed by immunohistochemistry of paraffin-embedd...

journal_title：Antioxidants & redox signaling

authors： Kinnula VL,Soini Y,Kvist-Mäkelä K,Savolainen ER,Koistinen P

更新日期：2002-02-01 00:00:00

abstract：:Toxic renal failure induced by gentamicin, glycerol, or cisplatin, as well as ischemic renal failure in vivo and hypoxia/reoxygenation of tubular epithelial cells in vitro, induces the production of reactive oxygen metabolites (ROM). Generation of ROM is responsible for the induction of tubular epithelial cell death, ...

journal_title：Antioxidants & redox signaling

authors： Basnakian AG,Kaushal GP,Shah SV

更新日期：2002-12-01 00:00:00

abstract：:Nitric oxide (NO) mediates cellular signaling pathways that regulate a plethora of physiological processes. One of the signaling mechanisms mediated by NO is through S-nitrosylation of cysteine residues in target proteins, which is now regarded as an important redox-based physiological action. Deregulation of the prot...

journal_title：Antioxidants & redox signaling

authors： Shahani N,Sawa A

更新日期：2011-04-15 00:00:00

abstract：AIM:Antrodia Camphorate (AC) is a mushroom that is widely used in Asian countries to prevent and treat various diseases, including liver diseases. However, the active ingredients that contribute to the biological functions remain elusive. The purpose of the present study is to test the hepatoprotective effect of Antcin...

journal_title：Antioxidants & redox signaling

authors： Huo Y,Win S,Than TA,Yin S,Ye M,Hu H,Kaplowitz N

更新日期：2017-02-10 00:00:00

abstract：SIGNIFICANCE:Synaptic degeneration, an early pathological feature in Alzheimer's disease (AD), is closely correlated to impaired cognitive function and memory loss. Recent studies suggest that involvement of amyloid-beta peptide (Aβ) in synaptic mitochondrial alteration underlies these synaptic lesions. Thus, to unders...

journal_title：Antioxidants & redox signaling

authors： Du H,Guo L,Yan SS

更新日期：2012-06-15 00:00:00

abstract：:Extensive literature exists supporting a role for mitochondrial dysfunction and oxidative damage in the pathogenesis of Alzheimer's disease. Mitochondria are a major source of intracellular reactive oxygen species and are particularly vulnerable to oxidative stress. This review discusses evidence supporting the notion...

journal_title：Antioxidants & redox signaling

authors： Moreira PI,Santos MS,Oliveira CR

更新日期：2007-10-01 00:00:00

abstract：SIGNIFICANCE:A wealth of fluorescent reporters and imaging systems are now available to characterize dynamic physiological processes in living cells with high spatiotemporal resolution. The most reliable probes for quantitative measurements show shifts in their excitation or emission spectrum, rather than just a change...

journal_title：Antioxidants & redox signaling

authors： Fricker MD

更新日期：2016-05-01 00:00:00

abstract：AIMS:Cystathionine β-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of three major enzymes responsible for the biogenesis of H2S, a signaling molecule. We have previously demonstrated that CBS is activated in cel...

journal_title：Antioxidants & redox signaling

authors： Niu WN,Yadav PK,Adamec J,Banerjee R

更新日期：2015-02-10 00:00:00

abstract：:Thioredoxin (TRX) family proteins are involved in various biologic processes by regulating the response to oxidative stress. Nucleoredoxin (NRX), a relatively uncharacterized member of the TRX family protein, has recently been reported to regulate the Wnt/beta-catenin pathway, which itself regulates cell fate and earl...

journal_title：Antioxidants & redox signaling

authors： Funato Y,Miki H

更新日期：2007-08-01 00:00:00

abstract：SIGNIFICANCE:Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there ...

journal_title：Antioxidants & redox signaling

authors： Hatem E,El Banna N,Huang ME

更新日期：2017-11-20 00:00:00

abstract：:Transforming growth factor-betas (TGF-beta) regulate a wide variety of cellular functions in normal development and are involved in both tissue homeostasis and disease pathogenesis. The regulation of the TGF-beta family of growth factors is unique because they are targeted to the extracellular matrix in a biologically...

journal_title：Antioxidants & redox signaling

authors： Koli K,Myllärniemi M,Keski-Oja J,Kinnula VL

更新日期：2008-02-01 00:00:00

abstract：:Nitrite, previously considered physiologically irrelevant and a simple end product of endogenous nitric oxide (NO) metabolism, is now envisaged as a reservoir of NO to be activated in response to oxygen (O(2)) depletion. In the first part of this review, we summarize and compare the mechanisms of nitrite-dependent pro...

journal_title：Antioxidants & redox signaling

authors： Castiglione N,Rinaldo S,Giardina G,Stelitano V,Cutruzzolà F

更新日期：2012-08-15 00:00:00

abstract：SIGNIFICANCE:Extranuclear sirtuins in cytosol (SIRT2) and mitochondria (SIRT3, SIRT4, and SIRT5) are key regulators of metabolic enzymes and the antioxidative defense mechanisms. They play an important role in the adjustment of metabolic pathways in alterations of the nutritional status. Recent Advances: Recent studies...

journal_title：Antioxidants & redox signaling

authors： Elkhwanky MS,Hakkola J

更新日期：2018-03-10 00:00:00

abstract：AIM:TNF (tumor necrosis factor)-related apoptosis-inducing ligand (TRAIL), is a selective killer of tumor cells, although its potential is limited by the development of resistance. In this article, we investigated whether the polyherbal preparation Zyflamend(®) can sensitize tumor cells to TRAIL. RESULTS:We found that...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Park B,Gupta SC,Kannappan R,Sung B,Aggarwal BB

更新日期：2012-03-01 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：SIGNIFICANCE:Oxidative stress and damage are well-established components of neurodegenerative diseases, contributing to neuronal death during disease progression. Here, we consider key K(+) channels as target proteins that can undergo oxidative modulation, describe what is understood about how this influences disease p...

journal_title：Antioxidants & redox signaling

authors： Peers C,Boyle JP

更新日期：2015-02-20 00:00:00

abstract：:The dual or biphasic responses of cancer to nitric oxide (NO) arise from its concentration dependent ability to regulate tumor growth, migration, invasion, survival, angiogenesis, and metastasis. The outcome of these various NO-dependent processes is dictated by several factors including NO flux, the chemical redox en...

journal_title：Antioxidants & redox signaling

authors： Ridnour LA,Thomas DD,Donzelli S,Espey MG,Roberts DD,Wink DA,Isenberg JS

更新日期：2006-07-01 00:00:00

abstract：: Aims: Nuclear factor (erythroid-derived 2)-like-2 factor (NRF-2) is a transcription factor well known to provide an advantage for cancer growth and survival regulating the cellular redox pathway. In breast cancer cells, we recently identified the monomeric heme-globin neur...

journal_title：Antioxidants & redox signaling

authors： Solar Fernandez V,Cipolletti M,Ascenzi P,Marino M,Fiocchetti M

更新日期：2020-02-01 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：:Aging is associated not only with oxidant stress, but also with increased interleukin-6 (IL-6) levels. To determine if oxidative stress could contribute to the age-associated increase IL-6 expression, we exposed LNCaP prostate carcinoma cells and HeLa cervical carcinoma cells to H2O2 as an oxidant challenge. We found ...

journal_title：Antioxidants & redox signaling

authors： Zhang J,Johnston G,Stebler B,Keller ET

更新日期：2001-06-01 00:00:00

abstract：SIGNIFICANCE:Accumulating evidence indicates that the success of some anticancer treatments (select chemotherapies or radiotherapy or trastuzumab) could be related to the stimulation of an anticancer immune response through the induction of an immunogenic tumor cell death (ICD). RECENT ADVANCES:Preclinical data reveal...

journal_title：Antioxidants & redox signaling

authors： Ladoire S,Hannani D,Vetizou M,Locher C,Aymeric L,Apetoh L,Kepp O,Kroemer G,Ghiringhelli F,Zitvogel L

更新日期：2014-03-01 00:00:00

abstract：AIMS:S-glutathionylation of cysteine residues, catalyzed by glutathione S-transferase Pi (GSTP), alters structure/function characteristics of certain targeted proteins. Our goal is to characterize how S-glutathionylation of proteins within the endoplasmic reticulum (ER) impact cell sensitivity to ER-stress inducing dru...

journal_title：Antioxidants & redox signaling

authors： Ye ZW,Zhang J,Ancrum T,Manevich Y,Townsend DM,Tew KD

更新日期：2017-02-20 00:00:00

abstract：:Thiol peroxidases comprise glutathione peroxidases (GPx) and peroxiredoxins (Prx). The enzymes of both families reduce hydroperoxides with thiols by enzyme-substitution mechanisms. H(2)O(2) and organic hydroperoxides are reduced by all thiol peroxidases, most efficiently by SecGPxs, whereas fast peroxynitrite reductio...

journal_title：Antioxidants & redox signaling

authors： Flohé L,Toppo S,Cozza G,Ursini F

更新日期：2011-08-01 00:00:00

abstract：:The role of free radicals in aging has been a long-standing theory that has now been extended to include both reactive oxygen and nitrogen species. The original concepts that overwhelming oxidative stress depleted antioxidants and thus damaged intracellular targets is being supplanted by the hypothesis that the reacti...

journal_title：Antioxidants & redox signaling

authors： Darley-Usmar V,Starke-Reed PE

更新日期：2000-10-01 00:00:00

abstract：AIMS:Large doses of intraperitoneally injected basic amino acids, L-arginine, or L-ornithine, induce acute pancreatitis in rodents, although the mechanisms mediating pancreatic toxicity remain unknown. Another basic amino acid, L-lysine, was also shown to cause pancreatic acinar cell injury. The aim of the study was to...

journal_title：Antioxidants & redox signaling

authors： Biczó G,Hegyi P,Dósa S,Shalbuyeva N,Berczi S,Sinervirta R,Hracskó Z,Siska A,Kukor Z,Jármay K,Venglovecz V,Varga IS,Iványi B,Alhonen L,Wittmann T,Gukovskaya A,Takács T,Rakonczay Z Jr

更新日期：2011-11-15 00:00:00