Mitochondrial quality control and dynamics in Parkinson's disease.

abstract：SIGNIFICANCE:Glutaredoxins are ubiquitous small thiol proteins of the thioredoxin-fold superfamily. Two major groups are distinguished based on their active sites: the dithiol (2-C-Grxs) and the monothiol (1-C-Grxs) glutaredoxins with a CXXC and a CXXS active site motif, respectively. Glutaredoxins are involved in cell...

journal_title：Antioxidants & redox signaling

authors： Comini MA,Krauth-Siegel RL,Bellanda M

更新日期：2013-09-01 00:00:00

abstract：:The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood. In this study, we investigated the effect of AngII on aortic smooth muscle from wild-type and NOX1-deficient mice. NOX1-deficient cells sho...

journal_title：Antioxidants & redox signaling

authors： Basset O,Deffert C,Foti M,Bedard K,Jaquet V,Ogier-Denis E,Krause KH

更新日期：2009-10-01 00:00:00

abstract：:To study early subcellular pathologic changes of tumorigenesis in mouse skin and possible modulation by overexpression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD), skin keratinocytes from nontransgenic (Ntg) and transgenic (TgH) mice overexpressing MnSOD topically treated with one do...

journal_title：Antioxidants & redox signaling

authors： Oberley TD,Xue Y,Zhao Y,Kiningham K,Szweda LI,St Clair DK

更新日期：2004-06-01 00:00:00

abstract：: Aims: Lifelong pain is a hallmark feature of sickle cell disease (SCD). How sickle pathobiology evokes pain remains unknown. We hypothesize that increased cell-free heme due to ongoing hemolysis activates toll-like receptor 4 (TLR4), leading to the formation of reactive ox...

journal_title：Antioxidants & redox signaling

authors： Lei J,Paul J,Wang Y,Gupta M,Vang D,Thompson S,Jha R,Nguyen J,Valverde Y,Lamarre Y,Jones MK,Gupta K

更新日期：2021-02-01 00:00:00

abstract：:Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents. After phosphorylation and dissociation from the cytoplasmic inhibitor, Kelch-...

journal_title：Antioxidants & redox signaling

authors： Cho HY,Reddy SP,Kleeberger SR

更新日期：2006-01-01 00:00:00

abstract：:Methionine residues are susceptible to oxidation, but this damage may be reversed by methionine sulfoxide reductases MsrA and MsrB. Mammals contain one MsrA and three MsrBs, including a selenoprotein MsrB1. Here, we show that MsrB1 is the major methionine sulfoxide reductase in liver of mice and it is among the protei...

journal_title：Antioxidants & redox signaling

authors： Novoselov SV,Kim HY,Hua D,Lee BC,Astle CM,Harrison DE,Friguet B,Moustafa ME,Carlson BA,Hatfield DL,Gladyshev VN

更新日期：2010-04-01 00:00:00

abstract：:Epidemiological studies have shown that advancing age is associated with an increased prevalence of cardiovascular disease (CVD). Vascular smooth muscle cells (VSMC) comprise the major arterial cell population, and changes in VSMC behavior, function, and redox status with age contribute to alterations in vascular remo...

journal_title：Antioxidants & redox signaling

authors： Li M,Fukagawa NK

更新日期：2010-03-01 00:00:00

abstract：:Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifac...

journal_title：Antioxidants & redox signaling

authors： Okouchi M,Ekshyyan O,Maracine M,Aw TY

更新日期：2007-08-01 00:00:00

abstract：SIGNIFICANCE:The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins that accumulate oxidative post-translational modifications only if these detected modifications are co...

journal_title：Antioxidants & redox signaling

authors： Feeney MB,Schöneich C

更新日期：2012-12-01 00:00:00

abstract：:Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle of an individual mitochondrion reveals several points where fusion, fission, and mitophagy interact. Mitochondrial fission can produce an...

journal_title：Antioxidants & redox signaling

authors： Twig G,Shirihai OS

更新日期：2011-05-15 00:00:00

abstract：:Through hypoxia-inducible factor 1 (HIF-1), hypoxia regulates the expression of numerous genes and is a potent inducer of angiogenesis. However, interleukin-8 (IL-8), an important angiogenic mediator, has been reported to be downregulated by HIF-1, although the mechanisms have not been elucidated. HIF-1 was induced in...

journal_title：Antioxidants & redox signaling

authors： Loboda A,Stachurska A,Florczyk U,Rudnicka D,Jazwa A,Wegrzyn J,Kozakowska M,Stalinska K,Poellinger L,Levonen AL,Yla-Herttuala S,Jozkowicz A,Dulak J

更新日期：2009-07-01 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. The pathogenesis of PD remains incompletely understood. Environmental factors, oxidative damage, misfolded protein aggregates, ubiquitin-proteasome syste...

journal_title：Antioxidants & redox signaling

authors： Wang HQ,Takahashi R

更新日期：2007-05-01 00:00:00

abstract：AIMS:Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the impact of targeted disruption of Txnrd2 on tumor growth. RESULTS:Tumor...

journal_title：Antioxidants & redox signaling

authors： Hellfritsch J,Kirsch J,Schneider M,Fluege T,Wortmann M,Frijhoff J,Dagnell M,Fey T,Esposito I,Kölle P,Pogoda K,Angeli JP,Ingold I,Kuhlencordt P,Östman A,Pohl U,Conrad M,Beck H

更新日期：2015-04-10 00:00:00

abstract：SIGNIFICANCE:Worldwide demand has driven the development of hemoglobin (Hb)-based oxygen carriers (HBOCs) as potential acellular oxygen therapeutics. HBOCs have the potential to provide an oxygen bridge to patients and minimize current problems associated with supply and storage of donated blood. However, to date, safe...

journal_title：Antioxidants & redox signaling

authors： Strader MB,Alayash AI

更新日期：2017-05-10 00:00:00

abstract：SIGNIFICANCE:Decrypting the cellular response to oxidative stress relies on a comprehensive understanding of the redox signaling pathways stimulated under oxidizing conditions. Redox signaling events can be divided into upstream sensing of oxidants, midstream redox signaling of protein function, and downstream transcri...

journal_title：Antioxidants & redox signaling

authors： Young D,Pedre B,Ezeriņa D,De Smet B,Lewandowska A,Tossounian MA,Bodra N,Huang J,Astolfi Rosado L,Van Breusegem F,Messens J

更新日期：2019-04-01 00:00:00

abstract：SIGNIFICANCE:Evidence is emerging that parenteral administration of high-dose vitamin C may warrant development as an adjuvant therapy for patients with sepsis. RECENT ADVANCES:Sepsis increases risk of death and disability, but its treatment consists only of supportive therapies because no specific therapy is availabl...

journal_title：Antioxidants & redox signaling

authors： Wilson JX

更新日期：2013-12-10 00:00:00

abstract：: Aims: Normal mitochondrial function and integrity are crucial for cellular physiology. Given the paramount role of mitochondrial quality control proteases in these processes, our study focused on investigating mechanisms by which the activity of a key quality control prote...

journal_title：Antioxidants & redox signaling

authors： Bohovych I,Dietz JV,Swenson S,Zahayko N,Khalimonchuk O

更新日期：2019-08-20 00:00:00

abstract：:Trisulfides and other oligosulfides are widely distributed in the biological world. In plants, for example, garlic, trisulfides are associated with potentially beneficial properties. However, an extra neutral sulfur atom covalently bound between the two sulfur atoms of a pair of cysteines is not a common post-translat...

journal_title：Antioxidants & redox signaling

authors： Nielsen RW,Tachibana C,Hansen NE,Winther JR

更新日期：2011-07-01 00:00:00

abstract：AIMS:Cardiovascular interventions continue to fail as a result of arterial restenosis secondary to neointimal hyperplasia. We sought to develop and evaluate a systemically delivered nanostructure targeted to the site of arterial injury to prevent neointimal hyperplasia. Nanostructures were based on self-assembling biod...

journal_title：Antioxidants & redox signaling

authors： Bahnson ES,Kassam HA,Moyer TJ,Jiang W,Morgan CE,Vercammen JM,Jiang Q,Flynn ME,Stupp SI,Kibbe MR

更新日期：2016-03-10 00:00:00

abstract：:Cellular compartments differ dramatically in their redox potentials. This translates directly into variations in the extent of disulfide bond formation within proteins, depending on their cellular localization. It has long been assumed that proteins that are present in the reducing environment of the cytosol do not po...

journal_title：Antioxidants & redox signaling

authors： Linke K,Jakob U

更新日期：2003-08-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a gasotransmitter with multifaceted physiological functions, including the regulation of glucose metabolism. Methylglyoxal (MG) is an intermediate of glucose metabolism and plays an important role in the pathogenesis of insulin resistance syndromes. In the present study, we investigated the...

journal_title：Antioxidants & redox signaling

authors： Chang T,Untereiner A,Liu J,Wu L

更新日期：2010-05-01 00:00:00

abstract：:Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins. Whereas optimal levels of Se in the diet have important health benefits, a recent clinical trial has suggested that supplemental intake of Se above the adequate level potentially may raise the risk ...

journal_title：Antioxidants & redox signaling

authors： Labunskyy VM,Lee BC,Handy DE,Loscalzo J,Hatfield DL,Gladyshev VN

更新日期：2011-06-15 00:00:00

abstract：:This Forum issue "Heme Oxygenase" (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual rol...

journal_title：Antioxidants & redox signaling

authors： Facchinetti MM

更新日期：2020-06-10 00:00:00

abstract：:We previously reported a spontaneous development of type 2 diabetes-like phenotypes in glutathione peroxidase-1 (GPX1)-overexpressing (OE) mice. Diet restriction of these mice rescued all their phenotypes, except for hyperinsulinemia and hypersecretion of insulin. This study was to determine whether dietary Se deficie...

journal_title：Antioxidants & redox signaling

authors： Pepper MP,Vatamaniuk MZ,Yan X,Roneker CA,Lei XG

更新日期：2011-02-01 00:00:00

abstract：SIGNIFICANCE:A wealth of fluorescent reporters and imaging systems are now available to characterize dynamic physiological processes in living cells with high spatiotemporal resolution. The most reliable probes for quantitative measurements show shifts in their excitation or emission spectrum, rather than just a change...

journal_title：Antioxidants & redox signaling

authors： Fricker MD

更新日期：2016-05-01 00:00:00

abstract：: Aims: Nuclear factor (erythroid-derived 2)-like-2 factor (NRF-2) is a transcription factor well known to provide an advantage for cancer growth and survival regulating the cellular redox pathway. In breast cancer cells, we recently identified the monomeric heme-globin neur...

journal_title：Antioxidants & redox signaling

authors： Solar Fernandez V,Cipolletti M,Ascenzi P,Marino M,Fiocchetti M

更新日期：2020-02-01 00:00:00

abstract：:Intraorgan communication in the cardiovascular system is exerted not only by direct cell-cell contacts but also by locally released factors, which modulate neighboring cells by paracrine signals (e.g., NO, vascular endothelial growth factor, adenosine, reactive oxygen species). Moreover, cells in close proximity to th...

journal_title：Antioxidants & redox signaling

authors： Gödecke A,Haendeler J

更新日期：2017-04-20 00:00:00

abstract：AIMS:Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known safety in humans using a hippocampal neuroblast line expressing a reporter...

journal_title：Antioxidants & redox signaling

authors： Aleyasin H,Karuppagounder SS,Kumar A,Sleiman S,Basso M,Ma T,Siddiq A,Chinta SJ,Brochier C,Langley B,Haskew-Layton R,Bane SL,Riggins GJ,Gazaryan I,Starkov AA,Andersen JK,Ratan RR

更新日期：2015-01-10 00:00:00

abstract：SIGNIFICANCE:Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to posttranslational modifications of proteins or the production of second messengers. Either as a primary cause or as a secondary component of the pat...

journal_title：Antioxidants & redox signaling

authors： Pehar M,Harlan BA,Killoy KM,Vargas MR

更新日期：2018-06-20 00:00:00

abstract：:Post-ischemic reperfusion may result in reactive oxygen species (ROS) generation, reduced availability of nitric oxide (NO•), Ca(2+)overload, prolonged opening of mitochondrial permeability transition pore, and other processes contributing to cell death, myocardial infarction, stunning, and arrhythmias. With the disco...

journal_title：Antioxidants & redox signaling

authors： Pagliaro P,Moro F,Tullio F,Perrelli MG,Penna C

更新日期：2011-03-01 00:00:00