Evaluation of vitamin C for adjuvant sepsis therapy.

abstract：SIGNIFICANCE:Mitochondrial function is central to a wide range of biological processes in health and disease and there is considerable interest in developing small molecules that are taken up by mitochondria and act as either probes of mitochondrial function or therapeutics in vivo. RECENT ADVANCES:Various strategies ...

journal_title：Antioxidants & redox signaling

authors： Smith RA,Hartley RC,Murphy MP

更新日期：2011-12-15 00:00:00

abstract：:The phagocytic NADPH oxidase is recognized as a critical component of innate immunity, responsible for generation of microbicidal reactive oxygen species (ROS). This enzyme is one representative of the Nox family of oxidases (Nox1-Nox5, Duox1, and Duox2) that exhibit diverse expression patterns and appear to serve a v...

journal_title：Antioxidants & redox signaling

authors： Leto TL,Geiszt M

更新日期：2006-09-01 00:00:00

abstract：: Aims: To ascertain if human pericytes produce SPARC (acronym for Secreted Protein Acidic and Cysteine Rich), a matricellular protein implicated in the regulation of cell proliferation, migration, and cell-matrix interactions; clarify if SPARC expression in cardiac pericyte...

journal_title：Antioxidants & redox signaling

authors： Avolio E,Mangialardi G,Slater SC,Alvino VV,Gu Y,Cathery W,Beltrami AP,Katare R,Heesom K,Caputo M,Madeddu P

更新日期：2020-11-23 00:00:00

abstract：AIMS:Myocardial ischemia/reperfusion (I/R) is associated with mitochondrial dysfunction and subsequent cardiomyocyte death. The generation of excessive quantities of reactive oxygen species (ROS) and resultant damage to mitochondrial enzymes is considered an important mechanism underlying reperfusion injury. Mitochondr...

journal_title：Antioxidants & redox signaling

authors： Gorenkova N,Robinson E,Grieve DJ,Galkin A

更新日期：2013-11-01 00:00:00

abstract：SIGNIFICANCE:Protein degradation has been identified as being deregulated in numerous human diseases. Hence, proteins involved in proteasomal as well as lysosomal degradation are regarded as interesting potential drug targets and are thoroughly investigated in clinical studies. RECENT ADVANCES:Technical advances in th...

journal_title：Antioxidants & redox signaling

authors： Engelke R,Becker AC,Dengjel J

更新日期：2012-09-01 00:00:00

abstract：:Cyclotides are plant proteins with exceptional stability owing to the presence of a cyclic backbone and three disulfide bonds arranged in a cystine knot motif. Accordingly, they have been proposed as templates to stabilize bioactive epitopes in drug-design applications. The two main subfamilies, referred to as the Möb...

journal_title：Antioxidants & redox signaling

authors： Gunasekera S,Daly NL,Clark RJ,Craik DJ

更新日期：2009-05-01 00:00:00

abstract：:DJ-1 is a member of the large and functionally diverse DJ-1/PfpI superfamily and has homologs in nearly all organisms. Because of its connection to parkinsonism and cancer, human DJ-1 has been intensely studied for over a decade. The current view is that DJ-1 is a multifunctional oxidative stress response protein that...

journal_title：Antioxidants & redox signaling

authors： Wilson MA

更新日期：2011-07-01 00:00:00

abstract：AIMS:An abnormal generation of reactive oxygen species (ROS) is thought to contribute to systemic sclerosis (SSc), fostering autoimmunity, fibrosis, and vascular inflammation. The function of the prototypic damage-associated molecular pattern, high mobility group box 1 (HMGB1), depends on its redox status. Here we inve...

journal_title：Antioxidants & redox signaling

authors： Maugeri N,Rovere-Querini P,Baldini M,Baldissera E,Sabbadini MG,Bianchi ME,Manfredi AA

更新日期：2014-03-01 00:00:00

abstract：:Secretory and transmembrane proteins are correctly folded or processed in the endoplasmic reticulum (ER). Various stresses disturb ER function and provoke the accumulation of unfolded proteins in the ER lumen. This condition is termed ER stress. Recently, ER stress has been linked to neuronal death in various neurodeg...

journal_title：Antioxidants & redox signaling

authors： Saito A,Hino S,Murakami T,Kondo S,Imaizumi K

更新日期：2007-05-01 00:00:00

abstract：SIGNIFICANCE:Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling mechanism triggered by Ca2+ depletion of the endoplasmic reticulum (ER) and by a variety of cellular stresses. Reactive oxygen species (ROS) are often concomitantly produced in response to these stresses, however, the relationship between redo...

journal_title：Antioxidants & redox signaling

authors： Nunes P,Demaurex N

更新日期：2014-08-20 00:00:00

abstract：:An increase of mitochondrial-derived reactive oxygen species (ROS) occurs in nerve growth factor (NGF)-deprived sympathetic neurons undergoing apoptotic death. It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen-activated protein kinase kinase (MEK)/mi...

journal_title：Antioxidants & redox signaling

authors： Kirkland RA,Franklin JL

更新日期：2003-10-01 00:00:00

abstract：:The cellular redox state is associated with major cellular processes including differentiation, transformation, and apoptosis. Glutaredoxin 2 (Grx2) is a mitochondrial oxidoreductase suggested to play a critical role in protection against apoptotic stimuli. An alternative Grx2 transcript variant encoding a nonmitochon...

journal_title：Antioxidants & redox signaling

authors： Lönn ME,Hudemann C,Berndt C,Cherkasov V,Capani F,Holmgren A,Lillig CH

更新日期：2008-03-01 00:00:00

abstract：:The possibility of a plasma oxygen diffusion barrier implies a significant resistance to oxygen diffusion and the existence of capillary erythrocyte-associated transients of oxygen. This effect was analyzed by measuring intracapillary blood and tissue pO(2) in the hamster chamber window model using a noninvasive intra...

journal_title：Antioxidants & redox signaling

authors： Cabrales P,Intaglietta M

更新日期：2007-07-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a gasotransmitter with multifaceted physiological functions, including the regulation of glucose metabolism. Methylglyoxal (MG) is an intermediate of glucose metabolism and plays an important role in the pathogenesis of insulin resistance syndromes. In the present study, we investigated the...

journal_title：Antioxidants & redox signaling

authors： Chang T,Untereiner A,Liu J,Wu L

更新日期：2010-05-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to regulate a variety of physiological functions, including vascular tone. The inhibition of NO synthase by N(omega)-nitro-L-arginine methyl ester (L-NAME) has been reported to increase arterial blood pressure. The present studies were undertaken to investigate if the increased blood p...

journal_title：Antioxidants & redox signaling

authors： Anand-Srivastava MB,Di Fusco F

更新日期：2004-04-01 00:00:00

abstract：AIMS:Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its monomeric form to its solubl...

journal_title：Antioxidants & redox signaling

authors： Deas E,Cremades N,Angelova PR,Ludtmann MH,Yao Z,Chen S,Horrocks MH,Banushi B,Little D,Devine MJ,Gissen P,Klenerman D,Dobson CM,Wood NW,Gandhi S,Abramov AY

更新日期：2016-03-01 00:00:00

abstract：SIGNIFICANCE:Reactive oxygen and nitrogen species contributing to homeostatic regulation and the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, endothelial dysfunction, and cardiac hypertrophy, is well established. The ability of oxidant species to mediate such effects is in p...

journal_title：Antioxidants & redox signaling

authors： Pimentel D,Haeussler DJ,Matsui R,Burgoyne JR,Cohen RA,Bachschmid MM

更新日期：2012-03-15 00:00:00

abstract：:Vitamin K epoxide, a by-product of the carboxylation of blood coagulation factors, is reduced to vitamin K by an enzymatic system possessing vitamin K epoxide reductase (VKOR) activity. This system is the target of coumarin-derived drugs widely used in thrombosis therapy and prophylaxis. Recently, the key protein of t...

journal_title：Antioxidants & redox signaling

authors： Oldenburg J,Bevans CG,Müller CR,Watzka M

更新日期：2006-03-01 00:00:00

abstract：:This brief review first touches on the origins of the earth's oxygen. It then identifies and locates the principal oxygen sensor in vertebrates, the carotid body (CB). The CB is unique in that in human subjects, it is the only sensor of lower than normal levels in the partial pressure of oxygen (hypoxia, HH). Another ...

journal_title：Antioxidants & redox signaling

authors： Fitzgerald RS,Shirahata M,Balbir A,Grossman CE

更新日期：2007-06-01 00:00:00

abstract：:Neurons are extremely active cells and metabolize up to 20% of the oxygen that was consumed by the organism. Despite their highly oxygenic metabolism, neuronal cells have a lower capacity to neutralize the reactive oxygen species (ROS) that they generate or to which they are exposed. High levels of ROS can lead to acc...

journal_title：Antioxidants & redox signaling

authors： Barzilai A

更新日期：2007-02-01 00:00:00

abstract：SIGNIFICANCE:Ionizing radiation is a vital component in the oncologist's arsenal for the treatment of cancer. Approximately 50% of all cancer patients will receive some form of radiation therapy as part of their treatment regimen. DNA is considered the major cellular target of ionizing radiation and can be damaged dire...

journal_title：Antioxidants & redox signaling

authors： Holley AK,Miao L,St Clair DK,St Clair WH

更新日期：2014-04-01 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：:The signaling networks that mediate activation, proliferation, or programmed cell death of T lymphocytes are dependent on complex redox and metabolic pathways. T lymphocytes are primarily activated through the T-cell receptor and co-stimulatory molecules. Although activation results in lymphokine production, prolifera...

journal_title：Antioxidants & redox signaling

authors： Perl A,Gergely P Jr,Puskas F,Banki K

更新日期：2002-06-01 00:00:00

abstract：SIGNIFICANCE:Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific comm...

journal_title：Antioxidants & redox signaling

authors： Parrow NL,Leshin JA,Levine M

更新日期：2013-12-10 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：SIGNIFICANCE:Synaptic degeneration, an early pathological feature in Alzheimer's disease (AD), is closely correlated to impaired cognitive function and memory loss. Recent studies suggest that involvement of amyloid-beta peptide (Aβ) in synaptic mitochondrial alteration underlies these synaptic lesions. Thus, to unders...

journal_title：Antioxidants & redox signaling

authors： Du H,Guo L,Yan SS

更新日期：2012-06-15 00:00:00

abstract：:Protein and amine halogenation is a type of oxidative stress induced by phagocytic overstimulation, and its role in Parkinson's disease (PD) has not been discerned. We have detected that advanced oxidized protein products, markers of protein halogenation, are reliably enhanced in serum of patients with PD (n=60) relat...

journal_title：Antioxidants & redox signaling

authors： García-Moreno JM,Martín de Pablos A,García-Sánchez MI,Méndez-Lucena C,Damas-Hermoso F,Rus M,Chacón J,Fernández E

更新日期：2013-04-10 00:00:00

abstract：AIMS:Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that UCP2-mediated uncoupl...

journal_title：Antioxidants & redox signaling

authors： Ježek J,Dlasková A,Zelenka J,Jabůrek M,Ježek P

更新日期：2015-10-20 00:00:00

abstract：:The mechanism for regeneration of the active-site "peroxidatic" cysteine in 1-Cys peroxiredoxins is a matter of debate. Saccharomyces cerevisiae Prx1 is a mitochondrial enzyme belonging to the 1-Cys Prx, whereas Grx2 is involved in antioxidant defense and localizes at the mitochondria, so we hypothesized that it could...

journal_title：Antioxidants & redox signaling

authors： Pedrajas JR,Padilla CA,McDonagh B,Bárcena JA

更新日期：2010-08-01 00:00:00

abstract：:From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemis...

journal_title：Antioxidants & redox signaling

authors： San Martin A,Griendling KK

更新日期：2014-06-10 00:00:00