Dissecting the oxidative folding of circular cystine knot miniproteins.

abstract：: Aims: Autophagy is a catabolic process required for the maintenance of cardiac health. Insulin and insulin-like growth factor 1 (IGF-1) are potent inhibitors of autophagy and as such, one would predict that autophagy will be increased in the insulin-resistant/diabetic hear...

journal_title：Antioxidants & redox signaling

authors： Pires KM,Torres NS,Buffolo M,Gunville R,Schaaf C,Davis K,Selzman CH,Gottlieb RA,Boudina S

更新日期：2019-08-20 00:00:00

abstract：:Gamma-interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in most antigen presenting cells and is interferon γ inducible in other cell types via signal transducer and activator of transcription 1. Normally, N- and C-terminal propeptides are cleaved in the early endosome, and the mature pr...

journal_title：Antioxidants & redox signaling

authors： Hastings KT,Cresswell P

更新日期：2011-08-01 00:00:00

abstract：:The protein kinase C (PKC) isozyme family plays key roles in cell growth regulation and influences neoplastic disease development and progression. For example, PKCepsilon is oncogenic, and PKCdelta tumor-suppressive. PKC isozymes are characterized by distinct activation mechanisms entailing phosphatidylserine-dependen...

journal_title：Antioxidants & redox signaling

authors： Chu F,O'Brian CA

更新日期：2005-07-01 00:00:00

abstract：:The aim of the present study is to examine the effects of dietary saturated fatty acids on liver adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2) in ethanol-administered animals and in ethanol-exposed cultured hepatic cells, and to explore the underlying molecular mechanisms. The mRNA and protein ...

journal_title：Antioxidants & redox signaling

authors： Liang X,Hu M,Rogers CQ,Shen Z,You M

更新日期：2011-07-15 00:00:00

abstract：:Transforming growth factor-betas (TGF-beta) regulate a wide variety of cellular functions in normal development and are involved in both tissue homeostasis and disease pathogenesis. The regulation of the TGF-beta family of growth factors is unique because they are targeted to the extracellular matrix in a biologically...

journal_title：Antioxidants & redox signaling

authors： Koli K,Myllärniemi M,Keski-Oja J,Kinnula VL

更新日期：2008-02-01 00:00:00

abstract：:Exposure of neonatal rat cardiac myocytes to palmitate and glucose produces apoptosis as seen by cytochrome c release, caspase 3-like activation, DNA laddering, and poly(ADP-ribose) polymerase cleavage. The purpose of this study was to understand the role of reactive oxygen species in the initiation of programmed cell...

journal_title：Antioxidants & redox signaling

authors： Sparagna GC,Hickson-Bick DL,Buja LM,McMillin JB

更新日期：2001-02-01 00:00:00

abstract：:Prospective epidemiological studies have shown that the incidence of numerous cardiovascular pathologies is correlated with body selenium status. However, it remains unclear whether selenium status also influences the outcome of myocardial infarction. The aim of the present study was to test whether dietary selenium i...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Morel S,Berthonneche C,Toufektsian MC,de Lorgeril M,Ducros V,Tosaki A,de Leiris J,Boucher F

更新日期：2004-08-01 00:00:00

abstract：:5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a key sensor of cellular energy status. AMPK signaling regulates energy balance at the cellular, organ, and whole-body level. More recently, it has become apparent that AMPK plays also an important role in long-term decisions that determine cell fate,...

journal_title：Antioxidants & redox signaling

authors： Weisová P,Dávila D,Tuffy LP,Ward MW,Concannon CG,Prehn JH

更新日期：2011-05-15 00:00:00

abstract：SIGNIFICANCE:Currently, calcific aortic valve disease (CAVD) is only treatable through surgical intervention because the specific mechanisms leading to the disease remain unclear. In this review, we explore the forces and structure of the valve, as well as the mechanosensors and downstream signaling in the valve endoth...

journal_title：Antioxidants & redox signaling

authors： Fernández Esmerats J,Heath J,Jo H

更新日期：2016-09-01 00:00:00

abstract：SIGNIFICANCE:Disturbance of glutathione (GSH) metabolism is a hallmark of numerous diseases, yet GSH functions are poorly understood. One key to this question is to consider its functional compartmentation. GSH is present in the endoplasmic reticulum (ER), where it competes with substrates for oxidation by the oxidativ...

journal_title：Antioxidants & redox signaling

authors： Delaunay-Moisan A,Ponsero A,Toledano MB

更新日期：2017-11-20 00:00:00

abstract：:The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calor...

journal_title：Antioxidants & redox signaling

authors： Redman LM,Ravussin E

更新日期：2011-01-15 00:00:00

abstract：SIGNIFICANCE:Atrial fibrillation (AF) is a burgeoning health-care problem, and the currently available therapeutic armamentarium is barely efficient. Experimental and clinical evidence implicates inflammation and myocardial oxidative stress in the pathogenesis of AF. RECENT ADVANCES:Local and systemic inflammation has...

journal_title：Antioxidants & redox signaling

authors： Pinho-Gomes AC,Reilly S,Brandes RP,Casadei B

更新日期：2014-03-10 00:00:00

abstract：:Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently. Proteins that share the similar active-site sequence, -Cys-Xxx-Yyy-Cys-, are called the Trx family, and the number of Trx family members is increasing. Trx reductase, which reduces oxidized Trx in cooperation with NADPH, has th...

journal_title：Antioxidants & redox signaling

authors： Nakamura H

更新日期：2005-05-01 00:00:00

abstract：:Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glyco...

journal_title：Antioxidants & redox signaling

authors： Abdel-Fatah T,Arora A,Gorguc I,Abbotts R,Beebeejaun S,Storr S,Mohan V,Hawkes C,Soomro I,Lobo DN,Parsons SL,Madhusudan S

更新日期：2013-06-20 00:00:00

abstract：:Glycerophospholipids represent a common class of lipids critically important for integrity of cellular membranes. Oxidation of esterified unsaturated fatty acids dramatically changes biological activities of phospholipids. Apart from impairment of their structural function, oxidation makes oxidized phospholipids (OxPL...

journal_title：Antioxidants & redox signaling

authors： Bochkov VN,Oskolkova OV,Birukov KG,Levonen AL,Binder CJ,Stöckl J

更新日期：2010-04-15 00:00:00

abstract：:Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•-) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aortic endothelial cells, ...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Jen N,Ai L,Hamilton R,Wang S,Holmes K,Dharbandi F,Khalsa B,Bressler S,Barr ML,Li R,Hsiai TK

更新日期：2011-09-01 00:00:00

abstract：:Hemoglobin is considered a potentially toxic molecule when released from erythrocytes during hemolysis, inflammation, or tissue injury. The mechanisms of toxicity involve reduced nitric oxide bioavailability and oxidative processes both occurring at the heme prosthetic groups. When the endogenous oxidant H(2)O(2) reac...

journal_title：Antioxidants & redox signaling

authors： Widmer CC,Pereira CP,Gehrig P,Vallelian F,Schoedon G,Buehler PW,Schaer DJ

更新日期：2010-02-01 00:00:00

abstract：:Dr. Gregg L. Semenza is recognized here as a Redox Pioneer because he has published three articles that have been cited more than 1,000 times, and 74 articles that have each been cited more than 100 times. Dr. Semenza is known for his seminal discovery of hypoxia-inducible factor-1 (HIF-1) and for identifying molecula...

journal_title：Antioxidants & redox signaling

authors： Prabhakar NR

更新日期：2010-08-15 00:00:00

abstract：:It was recently found that age-related changes in SMP30 expression can be modulated by antioxidative action. In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter...

journal_title：Antioxidants & redox signaling

authors： Jung KJ,Maruyama N,Ishigami A,Yu BP,Chung HY

更新日期：2006-03-01 00:00:00

abstract：:Junctional adhesion molecules are transmembrane proteins that belong to the immunoglobulin superfamily. In addition to their localization in close proximity to the tight junctions in endothelial and epithelial cells, junctional adhesion molecules are also expressed in circulating cells that do not form junctions, such...

journal_title：Antioxidants & redox signaling

authors： Bazzoni G

更新日期：2011-09-01 00:00:00

abstract：:Alteration in neurotrophic factors support and antioxidant defenses in the central nervous system (CNS) along with deficit of ferritin have been associated with idiopathic Parkinson's disease (PD). The objectives were to analyze in the cerebrospinal fluid (CSF) of patients with PD and controls the following: (i) the l...

journal_title：Antioxidants & redox signaling

authors： Martín de Pablos A,García-Moreno JM,Fernández E

更新日期：2015-10-10 00:00:00

abstract：:Reactive oxygen and nitrogen species inhibit or promote cell proliferation by modulating the cell signaling pathways that dictate decisions between cell survival, proliferation, and death. In the growth factor-dependent pathways that regulate mitogenesis, numerous positive and negative effectors of signaling are influ...

journal_title：Antioxidants & redox signaling

authors： Burch PM,Heintz NH

更新日期：2005-05-01 00:00:00

abstract：AIMS:Mitochondrial thioredoxin reductase (Txnrd2) is a central player in the control of mitochondrial hydrogen peroxide (H2O2) abundance by serving as a direct electron donor to the thioredoxin-peroxiredoxin axis. In this study, we investigated the impact of targeted disruption of Txnrd2 on tumor growth. RESULTS:Tumor...

journal_title：Antioxidants & redox signaling

authors： Hellfritsch J,Kirsch J,Schneider M,Fluege T,Wortmann M,Frijhoff J,Dagnell M,Fey T,Esposito I,Kölle P,Pogoda K,Angeli JP,Ingold I,Kuhlencordt P,Östman A,Pohl U,Conrad M,Beck H

更新日期：2015-04-10 00:00:00

abstract：:Although the essential role of selenium for cellular immune responses is obvious, delineation of the functions is lacking because selenium can either promote or inhibit cell growth, cytokine production, and activation of transcription factor nuclear factor-kappaB (NF-kappaB). Studies with human thioredoxin-1 (Trx-1)-t...

journal_title：Antioxidants & redox signaling

authors： Ueno H,Kajihara H,Nakamura H,Yodoi J,Nakamuro K

更新日期：2007-01-01 00:00:00

abstract：SIGNIFICANCE:Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of mitochondria in the development of insulin resistance. RECENT ADVANCES:Refined methodology of ex vivo high-resolution respirometry and...

journal_title：Antioxidants & redox signaling

authors： Jelenik T,Roden M

更新日期：2013-07-20 00:00:00

abstract：:Protection of ischemic myocardium is an important unmet need in reperfusion therapy of acute myocardial infarction. Myocardial ischemia and reperfusion induce necrosis and apoptosis in cardiomyocytes. Caspase processing and activation are critical steps in most receptor and nonreceptor pathways of apoptosis. Caspase i...

journal_title：Antioxidants & redox signaling

authors： Li HL,Karwatowska-Prokopczuk E,Mutomba M,Wu J,Karanewsky D,Valentino K,Engler RL,Gottlieb RA

更新日期：2001-02-01 00:00:00

abstract：:Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into ancient archaea species. During evolution, mitochondria lost most of the prokaryotic bacterial genes and only conserved a small fraction including those encoding 13 proteins of the respiratory chain. In this process, many functions ...

journal_title：Antioxidants & redox signaling

authors： Antico Arciuch VG,Elguero ME,Poderoso JJ,Carreras MC

更新日期：2012-05-15 00:00:00

abstract：: Significance: Mitochondria undergo constant morphological changes through fusion, fission, and mitophagy. As the key organelle in cells, mitochondria are responsible for numerous essential cellular functions such as metabolism, regulation of calcium (Ca2+), generation of r...

journal_title：Antioxidants & redox signaling

authors： Chiu HY,Tay EXY,Ong DST,Taneja R

更新日期：2020-02-10 00:00:00

abstract：SIGNIFICANCE:Mitochondrial dynamics is a complex process that impacts on mitochondrial biology. RECENT ADVANCES:Recent evidence indicates that proteins participating in mitochondrial dynamics have additional cellular roles. Mitofusin 2 (Mfn2) is a potent modulator of mitochondrial metabolism with an impact on energy m...

journal_title：Antioxidants & redox signaling

authors： Zorzano A,Hernández-Alvarez MI,Sebastián D,Muñoz JP

更新日期：2015-04-20 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and a progressive neurodegeneration that appears to result from multiple pathogenic mechanisms (including protein misfolding/aggregation, involved in both amyloid β-dependent senile plaques and tau-dependent neurofibrillary tangles), metabolic and mitochond...

journal_title：Antioxidants & redox signaling

authors： von Bernhardi R,Eugenín J

更新日期：2012-05-01 00:00:00