Lysosomal function and dysfunction: mechanism and disease.

abstract：:Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifac...

journal_title：Antioxidants & redox signaling

authors： Okouchi M,Ekshyyan O,Maracine M,Aw TY

更新日期：2007-08-01 00:00:00

abstract：SIGNIFICANCE:A wealth of fluorescent reporters and imaging systems are now available to characterize dynamic physiological processes in living cells with high spatiotemporal resolution. The most reliable probes for quantitative measurements show shifts in their excitation or emission spectrum, rather than just a change...

journal_title：Antioxidants & redox signaling

authors： Fricker MD

更新日期：2016-05-01 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：:Homocysteine is a thiol-containing amino acid that has gained notoriety because its elevation in the plasma is correlated with complex and multifactorial diseases, including cardiovascular diseases, neurodegenerative diseases, and neural tube defects. Homocysteine is redox-active, and its toxic effects have been frequ...

journal_title：Antioxidants & redox signaling

authors： Zou CG,Banerjee R

更新日期：2005-05-01 00:00:00

abstract：SIGNIFICANCE:Synaptic degeneration, an early pathological feature in Alzheimer's disease (AD), is closely correlated to impaired cognitive function and memory loss. Recent studies suggest that involvement of amyloid-beta peptide (Aβ) in synaptic mitochondrial alteration underlies these synaptic lesions. Thus, to unders...

journal_title：Antioxidants & redox signaling

authors： Du H,Guo L,Yan SS

更新日期：2012-06-15 00:00:00

abstract：:Aging of somatic cells can be defined as the gradual loss of the information embedded in the global and local properties of complex macromolecular networks. This loss of information may reflect the dynamic interplay between stochastic factors, such as the accumulation of unrepaired somatic damage, and gene-encoded pro...

journal_title：Antioxidants & redox signaling

authors： Suh Y,Vijg J

更新日期：2006-03-01 00:00:00

abstract：AIMS:While much data exist for the effects of flavonoid-rich foods on spatial memory in rodents, there are no such data for foods/beverages predominantly containing hydroxycinnamates and phenolic acids. To address this, we investigated the effects of moderate Champagne wine intake, which is rich in these components, on...

journal_title：Antioxidants & redox signaling

authors： Corona G,Vauzour D,Hercelin J,Williams CM,Spencer JP

更新日期：2013-11-10 00:00:00

abstract：SIGNIFICANCE:Insulin resistance and its related diseases, obesity and type 2 diabetes mellitus (T2DM), have been linked to changes in aerobic metabolism, pointing to a possible role of mitochondria in the development of insulin resistance. RECENT ADVANCES:Refined methodology of ex vivo high-resolution respirometry and...

journal_title：Antioxidants & redox signaling

authors： Jelenik T,Roden M

更新日期：2013-07-20 00:00:00

abstract：:This work rests on our previous report (J Cereb Blood Flow Metab 30: 1275-1287, 2010) recognizing that glutamate (Glu) oxaloacetate transaminase (GOT) is induced when brain tissue hypoxia is corrected during acute ischemic stroke (AIS). GOT can metabolize Glu into tricarboxylic acid cycle intermediates and may therefo...

journal_title：Antioxidants & redox signaling

authors： Rink C,Gnyawali S,Peterson L,Khanna S

更新日期：2011-05-15 00:00:00

abstract：:Studies from many laboratories have shown that overexpression of manganese superoxide dismutase (MnSOD) inhibits the growth of numerous tumor cell types. The inhibition of tumor cell growth can be attributed to the increase in the steady-state levels of H2O2 as a result of the increased dismuting activity of MnSOD. He...

journal_title：Antioxidants & redox signaling

authors： Kim KH,Rodriguez AM,Carrico PM,Melendez JA

更新日期：2001-06-01 00:00:00

abstract：AIMS:Cigarette smoke (CS)-mediated acquired cystic fibrosis transmembrane conductance regulator (CFTR)-dysfunction, autophagy-impairment, and resulting inflammatory-oxidative/nitrosative stress leads to chronic obstructive pulmonary disease (COPD)-emphysema pathogenesis. Moreover, nitric oxide (NO) signaling regulates ...

journal_title：Antioxidants & redox signaling

authors： Bodas M,Silverberg D,Walworth K,Brucia K,Vij N

更新日期：2017-09-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, maintains alveolar integrity and participates in the control of host defense and inflammation in the lung. Surfactant proteins A, B, C, and D are important components of surfactant that play diverse roles in the surface tension reducing as well as host defense an...

journal_title：Antioxidants & redox signaling

authors： Boggaram V

更新日期：2004-02-01 00:00:00

abstract：:Secretory and transmembrane proteins are correctly folded or processed in the endoplasmic reticulum (ER). Various stresses disturb ER function and provoke the accumulation of unfolded proteins in the ER lumen. This condition is termed ER stress. Recently, ER stress has been linked to neuronal death in various neurodeg...

journal_title：Antioxidants & redox signaling

authors： Saito A,Hino S,Murakami T,Kondo S,Imaizumi K

更新日期：2007-05-01 00:00:00

abstract：:The mitogen-activated protein kinases (MAPKs) play a central role in mediating the activation and transcriptional responses of diverse cells, including glia. c-Jun N-terminal kinase (JNK), a member of the MAPK family, is activated by a variety of stress and proinflammatory signals and in turn phosphorylates its downst...

journal_title：Antioxidants & redox signaling

authors： Pawate S,Bhat NR

更新日期：2006-05-01 00:00:00

abstract：AIMS:We have tested the hypothesis that selenium (Se)-containing antioxidative enzymes protect thyroid epithelial cells from oxidative damage associated with enzymatic production of hydrogen peroxide required for thyroid hormone biosynthesis. Thyroid epithelial cells therefore express antioxidative enzymes, including c...

journal_title：Antioxidants & redox signaling

authors： Chiu-Ugalde J,Wirth EK,Klein MO,Sapin R,Fradejas-Villar N,Renko K,Schomburg L,Köhrle J,Schweizer U

更新日期：2012-09-15 00:00:00

abstract：:In the CNS, the heme oxygenase (HO) system has been reported to be active and to operate as a fundamental defensive mechanism for neurons exposed to an oxidant challenge. We have recently shown that both curcumin and caffeic acid phenethyl ester, two phenolic natural compounds, potently induce HO-1 expression and acti...

journal_title：Antioxidants & redox signaling

authors： Scapagnini G,Butterfield DA,Colombrita C,Sultana R,Pascale A,Calabrese V

更新日期：2004-10-01 00:00:00

abstract：SIGNIFICANCE:Cardiac function is energetically demanding, reliant on efficient well-coupled mitochondria to generate adenosine triphosphate and fulfill the cardiac demand. Predictably then, mitochondrial dysfunction is associated with cardiac pathologies, often related to metabolic disease, most commonly diabetes. Diab...

journal_title：Antioxidants & redox signaling

authors： Galloway CA,Yoon Y

更新日期：2015-06-10 00:00:00

abstract：:Zinc/cysteine coordination environments in proteins are redox-active. Oxidation of the sulfur ligands mobilizes zinc, while reduction of the oxidized ligands enhances zinc binding, providing redox control over the availability of zinc ions. Some zinc proteins are redox sensors, in which zinc release is coupled to conf...

journal_title：Antioxidants & redox signaling

authors： Maret W

更新日期：2006-09-01 00:00:00

abstract：SIGNIFICANCE:The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through...

journal_title：Antioxidants & redox signaling

authors： Sevilla E,Bes MT,González A,Peleato ML,Fillat MF

更新日期：2019-05-01 00:00:00

abstract：:Vitamin K epoxide, a by-product of the carboxylation of blood coagulation factors, is reduced to vitamin K by an enzymatic system possessing vitamin K epoxide reductase (VKOR) activity. This system is the target of coumarin-derived drugs widely used in thrombosis therapy and prophylaxis. Recently, the key protein of t...

journal_title：Antioxidants & redox signaling

authors： Oldenburg J,Bevans CG,Müller CR,Watzka M

更新日期：2006-03-01 00:00:00

abstract：:Scholarly peer review represents the linchpin of academic publishing. Recognized benefits of the peer review system are manifold. Critics raise several valid concerns that deserve attention. Several studies show that the current peer review system lacks robustness and is subject to bias in favor of well-established re...

journal_title：Antioxidants & redox signaling

authors： Sen CK

更新日期：2012-02-15 00:00:00

abstract：:Methamphetamine (METH) increases the oxidative DNA lesion 8-oxoguanine (8-oxoG) in fetal mouse brain, and causes postnatal motor coordination deficits after in utero exposure. Like oxoguanine glycosylase 1 (OGG1), the Cockayne syndrome B (CSB) protein is involved in the repair of oxidatively damaged DNA, although its ...

journal_title：Antioxidants & redox signaling

authors： McCallum GP,Wong AW,Wells PG

更新日期：2011-03-01 00:00:00

abstract：:Homeostasis within the central nervous system (CNS) is a prerequisite to elicit proper neuronal function. The CNS is tightly sealed from the changeable milieu of the blood stream by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). Whereas the BBB is established by specialized endo...

journal_title：Antioxidants & redox signaling

authors： Coisne C,Engelhardt B

更新日期：2011-09-01 00:00:00

abstract：:Free-radicals and other reactive oxygen species (ROS) have been implicated as being major damaging species in pathology and they have been widely investigated. Using 1,1'-diphenyl-2-picrylhydrazyl (DPPH), we estimated total free radical scavenging activity in the low-molecular-weight nonenzymatic fraction (LMNEF) of h...

journal_title：Antioxidants & redox signaling

authors： Atsumi T,Iwakura I,Kashiwagi Y,Fujisawa S,Ueha T

更新日期：1999-01-01 00:00:00

abstract：:Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides. Peroxides oxidize the peroxidatic Cys-SH to Cys-SOH, which then reacts with another cysteine residue (typically the resolving Cys [C(R)]) to fo...

journal_title：Antioxidants & redox signaling

authors： Rhee SG,Woo HA

更新日期：2011-08-01 00:00:00

abstract：SIGNIFICANCE:Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis. Recent Advances: The aim of this review is to...

journal_title：Antioxidants & redox signaling

authors： Feliers D,Lee HJ,Kasinath BS

更新日期：2016-11-01 00:00:00

abstract：AIMS:Astrocytes have been revealed as a controller of synaptic plasticity and memory via releasing gliotransmitters. Our recent findings showed that reactive sulfur species (RSS), including hydrogen sulfide (H2S) and polysulfide (H2Sn), regulated the availability of d-serine, which is a well-known gliotransmitter that ...

journal_title：Antioxidants & redox signaling

authors： Luo H,Wu PF,Han QQ,Cao Y,Deng SL,Wang J,Deng Q,Wang F,Chen JG

更新日期：2019-06-01 00:00:00

abstract：AIMS:Myocardial ischemia/reperfusion (I/R) is associated with mitochondrial dysfunction and subsequent cardiomyocyte death. The generation of excessive quantities of reactive oxygen species (ROS) and resultant damage to mitochondrial enzymes is considered an important mechanism underlying reperfusion injury. Mitochondr...

journal_title：Antioxidants & redox signaling

authors： Gorenkova N,Robinson E,Grieve DJ,Galkin A

更新日期：2013-11-01 00:00:00

abstract：SIGNIFICANCE:The precise role and impact of reactive oxygen species (ROS) in stem cells, which are essential for lifelong tissue homeostasis and regeneration, remain of significant interest to the field. The long-term regenerative potential of a stem cell compartment is determined by the delicate balance between quiesc...

journal_title：Antioxidants & redox signaling

authors： Tan DQ,Suda T

更新日期：2018-07-10 00:00:00

abstract：SIGNIFICANCE:Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eicosanoids, steroids,...

journal_title：Antioxidants & redox signaling

authors： Deponte M

更新日期：2017-11-20 00:00:00