Reactive Oxygen Species and Mitochondrial Homeostasis as Regulators of Stem Cell Fate and Function.

abstract：:Intraorgan communication in the cardiovascular system is exerted not only by direct cell-cell contacts but also by locally released factors, which modulate neighboring cells by paracrine signals (e.g., NO, vascular endothelial growth factor, adenosine, reactive oxygen species). Moreover, cells in close proximity to th...

journal_title：Antioxidants & redox signaling

authors： Gödecke A,Haendeler J

更新日期：2017-04-20 00:00:00

abstract：AIMS:Emerging lines of evidence indicate that oxidants such as hydrogen peroxide exert specific signaling functions during the processing of chronic pain. However, the mechanisms by which oxidants regulate pain processing in vivo remain poorly understood. Here, we investigated whether cyclic guanosine monophosphate (cG...

journal_title：Antioxidants & redox signaling

authors： Lorenz JE,Kallenborn-Gerhardt W,Lu R,Syhr KM,Eaton P,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：:The diabetogenic agent alloxan is a triketone that selectively destroys pancreatic beta cells. To investigate the importance of the triketone structure of alloxan for its cytotoxic potency, alloxan was compared with ninhydrin, also a triketone, and the amino derivative of alloxan uramil, which is not a triketone, beca...

journal_title：Antioxidants & redox signaling

authors： Elsner M,Gurgul-Convey E,Lenzen S

更新日期：2008-04-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00

abstract：AIMS:The potential receptor for hydrogen sulfide (H2S) remains unknown. RESULTS:H2S could directly activate vascular endothelial growth factor receptor 2 (VEGFR2) and that a small interfering RNA (siRNA)-mediated knockdown of VEGFR2 inhibited H2S-induced migration of human vascular endothelial cells. H2S promoted angi...

journal_title：Antioxidants & redox signaling

authors： Tao BB,Liu SY,Zhang CC,Fu W,Cai WJ,Wang Y,Shen Q,Wang MJ,Chen Y,Zhang LJ,Zhu YZ,Zhu YC

更新日期：2013-08-10 00:00:00

abstract：AIMS:Nuclear factor-erythroid-related factor 2 (Nrf2) is a critical transcriptional factor that is used in regulating cellular defense against oxidative stress. This study is aimed at investigating new interacting protein partners of Nrf2 using One-strep tag pull-down coupled with LTQ Orbitrap LC/MS/MS, and at examinin...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Xu EY,Sacks DB,Lee J,Shu L,Xia B,Kong AN

更新日期：2013-07-10 00:00:00

abstract：: Aims: Severe acute pancreatitis (AP) is a serious condition without specific treatment. Mitochondrial dysfunction plays a crucial role in the pathogenesis of AP. Irisin, a novel exercise-induced hormone, contributes to many health benefits of physical activity. We and othe...

journal_title：Antioxidants & redox signaling

authors： Ren Y,Qiu M,Zhang J,Bi J,Wang M,Hu L,Du Z,Li T,Zhang L,Wang Y,Lv Y,Wu Z,Wu R

更新日期：2019-10-10 00:00:00

abstract：:From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemis...

journal_title：Antioxidants & redox signaling

authors： San Martin A,Griendling KK

更新日期：2014-06-10 00:00:00

abstract：:Since the initial report of nitric oxide (NO) activity, enormous progress has been made over the last two decades in the field of NO research. Whereas most physiological responses triggered by moderate concentrations of NO are mediated by soluble guanylate cyclase activation and the subsequent production of cyclic GMP...

journal_title：Antioxidants & redox signaling

authors： Donnini S,Ziche M

更新日期：2002-10-01 00:00:00

abstract：:Reductions in brain glucose metabolism and increased oxidative stress invariably occur in Alzheimer's disease (AD) and thiamine (vitamin B1) deficiency. Both conditions cause irreversible cognitive impairment; their behavioral consequences overlap but are not identical. Thiamine-dependent processes are critical in glu...

journal_title：Antioxidants & redox signaling

authors： Gibson GE,Blass JP

更新日期：2007-10-01 00:00:00

abstract：: Aims: Oxidative stress is causally linked to male reproductive pathologies, driven primarily by lipid peroxidation and an attendant production of highly reactive lipid aldehydes, such as 4-hydroxynonenal (4HNE) within the male germ line. In somatic cells, 4HNE dysregulates...

journal_title：Antioxidants & redox signaling

authors： Cafe SL,Nixon B,Dun MD,Roman SD,Bernstein IR,Bromfield EG

更新日期：2020-03-10 00:00:00

abstract：SIGNIFICANCE:The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. R...

journal_title：Antioxidants & redox signaling

authors： Nussbaum C,Klinke A,Adam M,Baldus S,Sperandio M

更新日期：2013-02-20 00:00:00

abstract：:Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into ancient archaea species. During evolution, mitochondria lost most of the prokaryotic bacterial genes and only conserved a small fraction including those encoding 13 proteins of the respiratory chain. In this process, many functions ...

journal_title：Antioxidants & redox signaling

authors： Antico Arciuch VG,Elguero ME,Poderoso JJ,Carreras MC

更新日期：2012-05-15 00:00:00

abstract：AIM:Skeletal muscle nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity. However, GC function and the consequences of reduced GC activity in skeletal muscle are unknown. In this ...

journal_title：Antioxidants & redox signaling

authors： Moon Y,Balke JE,Madorma D,Siegel MP,Knowels G,Brouckaert P,Buys ES,Marcinek DJ,Percival JM

更新日期：2017-06-10 00:00:00

abstract：:Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport chain triggers several pathways of injury involved in the pathogenesis of diabetic complications [protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product (AGE) formation] by inhibiting glyceralde...

journal_title：Antioxidants & redox signaling

authors： Pacher P,Szabó C

更新日期：2005-11-01 00:00:00

abstract：:Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression. We used MAO A knock-out (KO) mice as a model to study the effect of ginkgo biloba (EGb) on aggression. When EGb was administered to MAO A KO mice, their aggressive behavior in ...

journal_title：Antioxidants & redox signaling

authors： Shih JC,Chen K,Ridd MJ,Seif I

更新日期：2000-10-01 00:00:00

abstract：:Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•-) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aortic endothelial cells, ...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Jen N,Ai L,Hamilton R,Wang S,Holmes K,Dharbandi F,Khalsa B,Bressler S,Barr ML,Li R,Hsiai TK

更新日期：2011-09-01 00:00:00

abstract：: Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway essential for generation of energy and biosynthetic intermediates. Alterations of the TCA cycle play a pivotal role in oncogenesis and inflammation. As such, some metabolic vulnerabilities...

journal_title：Antioxidants & redox signaling

authors： Scagliola A,Mainini F,Cardaci S

更新日期：2020-04-20 00:00:00

abstract：AIMS:Recent studies have shown that cigarette smoke (CS)-induced oxidative stress impairs autophagy, resulting in aggresome-formation that correlates with severity of chronic obstructive pulmonary disease (COPD)-emphysema, although the specific step in autophagy pathway that is impaired is unknown. Hence, in this study...

journal_title：Antioxidants & redox signaling

authors： Bodas M,Patel N,Silverberg D,Walworth K,Vij N

更新日期：2017-07-20 00:00:00

abstract：:This brief review first touches on the origins of the earth's oxygen. It then identifies and locates the principal oxygen sensor in vertebrates, the carotid body (CB). The CB is unique in that in human subjects, it is the only sensor of lower than normal levels in the partial pressure of oxygen (hypoxia, HH). Another ...

journal_title：Antioxidants & redox signaling

authors： Fitzgerald RS,Shirahata M,Balbir A,Grossman CE

更新日期：2007-06-01 00:00:00

abstract：:The mechanism for regeneration of the active-site "peroxidatic" cysteine in 1-Cys peroxiredoxins is a matter of debate. Saccharomyces cerevisiae Prx1 is a mitochondrial enzyme belonging to the 1-Cys Prx, whereas Grx2 is involved in antioxidant defense and localizes at the mitochondria, so we hypothesized that it could...

journal_title：Antioxidants & redox signaling

authors： Pedrajas JR,Padilla CA,McDonagh B,Bárcena JA

更新日期：2010-08-01 00:00:00

abstract：:Increasing evidence indicates that disequilibrium of the alveolar oxidant-antioxidant balance may play a role in the pathogenesis of chronic fibrosing lung diseases. Excessive production of oxidants and a differential regulation of antioxidant enzymes have been described under these conditions. We characterized for th...

journal_title：Antioxidants & redox signaling

authors： Markart P,Luboeinski T,Korfei M,Schmidt R,Wygrecka M,Mahavadi P,Mayer K,Wilhelm J,Seeger W,Guenther A,Ruppert C

更新日期：2009-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) generated within the vascular wall trigger low-density lipoprotein (LDL) oxidation, lipid peroxidation, and carbonyl stress that are involved in atherogenesis. We recently reported that the antihypertensive drug, hydralazine, exhibits carbonyl scavenger and antiatherogenic properties, but...

journal_title：Antioxidants & redox signaling

authors： Bouguerne B,Belkheiri N,Bedos-Belval F,Vindis C,Uchida K,Duran H,Grazide MH,Baltas M,Salvayre R,Nègre-Salvayre A

更新日期：2011-06-01 00:00:00

abstract：:Nitrite, previously considered physiologically irrelevant and a simple end product of endogenous nitric oxide (NO) metabolism, is now envisaged as a reservoir of NO to be activated in response to oxygen (O(2)) depletion. In the first part of this review, we summarize and compare the mechanisms of nitrite-dependent pro...

journal_title：Antioxidants & redox signaling

authors： Castiglione N,Rinaldo S,Giardina G,Stelitano V,Cutruzzolà F

更新日期：2012-08-15 00:00:00

abstract：SIGNIFICANCE:Heart disease is the primary cause of death in the industrialized world. Cardiac failure is dictated by an uncompensated reduction in the number of viable and fully functional cardiomyocytes. While current pharmacological therapies alleviate the symptoms associated with cardiac deterioration, heart transpl...

journal_title：Antioxidants & redox signaling

authors： Goichberg P,Chang J,Liao R,Leri A

更新日期：2014-11-10 00:00:00

abstract：:Our aim is to deliver an authoritative and challenging perspective of current concepts in plant redox signaling, focusing particularly on the complex interface between the redox and hormone-signaling pathways that allow precise control of plant growth and defense in response to metabolic triggers and environmental con...

journal_title：Antioxidants & redox signaling

authors： Foyer CH,Noctor G

更新日期：2013-06-01 00:00:00

abstract：:Gamma-interferon-inducible lysosomal thiol reductase (GILT) is constitutively expressed in most antigen presenting cells and is interferon γ inducible in other cell types via signal transducer and activator of transcription 1. Normally, N- and C-terminal propeptides are cleaved in the early endosome, and the mature pr...

journal_title：Antioxidants & redox signaling

authors： Hastings KT,Cresswell P

更新日期：2011-08-01 00:00:00

abstract：AIMS:Astrocytes have been revealed as a controller of synaptic plasticity and memory via releasing gliotransmitters. Our recent findings showed that reactive sulfur species (RSS), including hydrogen sulfide (H2S) and polysulfide (H2Sn), regulated the availability of d-serine, which is a well-known gliotransmitter that ...

journal_title：Antioxidants & redox signaling

authors： Luo H,Wu PF,Han QQ,Cao Y,Deng SL,Wang J,Deng Q,Wang F,Chen JG

更新日期：2019-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) can directly induce or enhance tumor necrosis factor (TNF)-mediated apoptosis in a number of different cell lines. To test the relevance of intracellular ROS in modulating apoptotic signaling in vivo, we evaluated hepatocellular apoptosis mediated by the TNF or Fas receptor in wild-type a...

journal_title：Antioxidants & redox signaling

authors： Bajt ML,Ho YS,Vonderfecht SL,Jaeschke H

更新日期：2002-10-01 00:00:00

abstract：SIGNIFICANCE:Ewan Cameron reported that ascorbate, given orally and intravenously at doses of up to 10 g/day, was effective in the treatment of cancer. Double-blind placebo-controlled clinical trials showed no survival advantage when the same doses of ascorbate were given orally, leading the medical and scientific comm...

journal_title：Antioxidants & redox signaling

authors： Parrow NL,Leshin JA,Levine M

更新日期：2013-12-10 00:00:00