Role of poly(ADP-ribose) polymerase-1 activation in the pathogenesis of diabetic complications: endothelial dysfunction, as a common underlying theme.

abstract：:Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is considered a major health concern,as its incidence is increasing at an alarming rate, and the high invalidating effects of its l...

journal_title：Antioxidants & redox signaling

authors： Negre-Salvayre A,Salvayre R,Augé N,Pamplona R,Portero-Otín M

更新日期：2009-12-01 00:00:00

abstract：:Aging of somatic cells can be defined as the gradual loss of the information embedded in the global and local properties of complex macromolecular networks. This loss of information may reflect the dynamic interplay between stochastic factors, such as the accumulation of unrepaired somatic damage, and gene-encoded pro...

journal_title：Antioxidants & redox signaling

authors： Suh Y,Vijg J

更新日期：2006-03-01 00:00:00

abstract：AIMS:Cardiovascular interventions continue to fail as a result of arterial restenosis secondary to neointimal hyperplasia. We sought to develop and evaluate a systemically delivered nanostructure targeted to the site of arterial injury to prevent neointimal hyperplasia. Nanostructures were based on self-assembling biod...

journal_title：Antioxidants & redox signaling

authors： Bahnson ES,Kassam HA,Moyer TJ,Jiang W,Morgan CE,Vercammen JM,Jiang Q,Flynn ME,Stupp SI,Kibbe MR

更新日期：2016-03-10 00:00:00

abstract：AIMS:Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to investigate hypoxia-induced miR-210 regulation ...

journal_title：Antioxidants & redox signaling

authors： Zaccagnini G,Maimone B,Di Stefano V,Fasanaro P,Greco S,Perfetti A,Capogrossi MC,Gaetano C,Martelli F

更新日期：2014-09-10 00:00:00

abstract：SIGNIFICANCE:Pyridine dinucleotides, nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), were discovered more than 100 years ago as necessary cofactors for fermentation in yeast extracts. Since that time, these molecules have been recognized as fundamental players in a variet...

journal_title：Antioxidants & redox signaling

authors： Fessel JP,Oldham WM

更新日期：2018-01-20 00:00:00

abstract：:Monothiol glutaredoxins (Grxs) with a noncanonical CGFS active site are found in all kingdoms of life. They include members with a single domain and thioredoxin-Grx fusion proteins. In Saccharomyces cerevisiae, the multidomain Grx3 and Grx4 play an essential role in intracellular iron trafficking. This crucial task is...

journal_title：Antioxidants & redox signaling

authors： Hoffmann B,Uzarska MA,Berndt C,Godoy JR,Haunhorst P,Lillig CH,Lill R,Mühlenhoff U

更新日期：2011-07-01 00:00:00

abstract：SIGNIFICANCE:Once considered to be mere by-products of metabolism, reactive oxygen, nitrogen and sulfur species are now recognized to play important roles in diverse cellular processes such as response to pathogens and regulation of cellular differentiation. It is becoming increasingly evident that redox imbalance can ...

journal_title：Antioxidants & redox signaling

authors： Sbodio JI,Snyder SH,Paul BD

更新日期：2019-04-10 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：:Intestinal detection of nutrients is a crucial step to inform the whole body of the nutritional status. In this paradigm, peripheral information generated by nutrients is transferred to the brain, which in turn controls physiological functions, including glucose metabolism. Here, we investigated the effect of enteric ...

journal_title：Antioxidants & redox signaling

authors： Duparc T,Naslain D,Colom A,Muccioli GG,Massaly N,Delzenne NM,Valet P,Cani PD,Knauf C

更新日期：2011-02-01 00:00:00

abstract：:The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calor...

journal_title：Antioxidants & redox signaling

authors： Redman LM,Ravussin E

更新日期：2011-01-15 00:00:00

abstract：AIMS:Cystathionine β-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of three major enzymes responsible for the biogenesis of H2S, a signaling molecule. We have previously demonstrated that CBS is activated in cel...

journal_title：Antioxidants & redox signaling

authors： Niu WN,Yadav PK,Adamec J,Banerjee R

更新日期：2015-02-10 00:00:00

abstract：:Through hypoxia-inducible factor 1 (HIF-1), hypoxia regulates the expression of numerous genes and is a potent inducer of angiogenesis. However, interleukin-8 (IL-8), an important angiogenic mediator, has been reported to be downregulated by HIF-1, although the mechanisms have not been elucidated. HIF-1 was induced in...

journal_title：Antioxidants & redox signaling

authors： Loboda A,Stachurska A,Florczyk U,Rudnicka D,Jazwa A,Wegrzyn J,Kozakowska M,Stalinska K,Poellinger L,Levonen AL,Yla-Herttuala S,Jozkowicz A,Dulak J

更新日期：2009-07-01 00:00:00

abstract：UNLABELLED:In living systems, the mechanisms of inheritance involving gene expression are operated by (i) the traditional model of genetics where the deoxyribonucleic acid (DNA) transcription and messenger ribonucleic acid stability are influenced by the DNA sequences and any aberrations in the primary DNA sequences an...

journal_title：Antioxidants & redox signaling

authors： Malireddy S,Kotha SR,Secor JD,Gurney TO,Abbott JL,Maulik G,Maddipati KR,Parinandi NL

更新日期：2012-07-15 00:00:00

abstract：SIGNIFICANCE:The rising global prevalence of diabetes and its debilitating complications give rise to significant disability and premature mortality. Due to the silent nature of diabetes and its vascular complications, and limitations in current methods for detection, there is a need for novel biomarkers for early dete...

journal_title：Antioxidants & redox signaling

authors： Fan B,Luk AOY,Chan JCN,Ma RCW

更新日期：2018-10-10 00:00:00

abstract：SIGNIFICANCE:Cardiac function is energetically demanding, reliant on efficient well-coupled mitochondria to generate adenosine triphosphate and fulfill the cardiac demand. Predictably then, mitochondrial dysfunction is associated with cardiac pathologies, often related to metabolic disease, most commonly diabetes. Diab...

journal_title：Antioxidants & redox signaling

authors： Galloway CA,Yoon Y

更新日期：2015-06-10 00:00:00

abstract：:In this study, we sought to investigate the putative association of the oxidized metabolites derived from linoleic acid (OXFAs) with pediatric nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). We studied 80 obese adolescents (age 13.3 ± 3.31 years; body mass index 33.0 ± 6.79 kg/m(2)), who underwent ...

journal_title：Antioxidants & redox signaling

authors： Santoro N,Caprio S,Giannini C,Kim G,Kursawe R,Pierpont B,Shaw MM,Feldstein AE

更新日期：2014-01-10 00:00:00

abstract：SIGNIFICANCE:Reactive oxygen and nitrogen species contributing to homeostatic regulation and the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, endothelial dysfunction, and cardiac hypertrophy, is well established. The ability of oxidant species to mediate such effects is in p...

journal_title：Antioxidants & redox signaling

authors： Pimentel D,Haeussler DJ,Matsui R,Burgoyne JR,Cohen RA,Bachschmid MM

更新日期：2012-03-15 00:00:00

abstract：AIMS:Astrocytes have been revealed as a controller of synaptic plasticity and memory via releasing gliotransmitters. Our recent findings showed that reactive sulfur species (RSS), including hydrogen sulfide (H2S) and polysulfide (H2Sn), regulated the availability of d-serine, which is a well-known gliotransmitter that ...

journal_title：Antioxidants & redox signaling

authors： Luo H,Wu PF,Han QQ,Cao Y,Deng SL,Wang J,Deng Q,Wang F,Chen JG

更新日期：2019-06-01 00:00:00

abstract：:In striated muscle, the sarcoplasmic reticulum (SR) is the major storage compartment of intracellular Ca2+ that controls cytosolic free Ca2+ (Cai) and developed force by sequestering and releasing Ca2+ during each contraction. Ca2+ release from the SR occurs through high-conductance Ca2+ release channels or ryanodine ...

journal_title：Antioxidants & redox signaling

authors： Salama G,Menshikova EV,Abramson JJ

更新日期：2000-04-01 00:00:00

abstract：: Significance: Genomic instability, a hallmark of cancer, renders cancer cells susceptible to genomic stress from both endogenous and exogenous origins, resulting in the increased tendency to accrue DNA damage, chromosomal instability, or aberrant DNA localization. Apart fr...

journal_title：Antioxidants & redox signaling

authors： Pu C,Tao S,Xu J,Huang M

更新日期：2020-12-04 00:00:00

abstract：SIGNIFICANCE:There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated a...

journal_title：Antioxidants & redox signaling

authors： Alexandrou AT,Li JJ

更新日期：2014-03-20 00:00:00

abstract：:Cells oxidize molecules to generate energy and to make the materials to build and support the structures and functions needed for life. However, unwanted oxidations can damage these same structures and impair function. Lipids (the lipids in membranes and lipoproteins) are targets of unwanted oxidations. The primary me...

journal_title：Antioxidants & redox signaling

authors： Venkataraman S,Schafer FQ,Buettner GR

更新日期：2004-06-01 00:00:00

abstract：: Significance: Unique to the branched-chain aminotransferase (BCAT) proteins is their redox-active CXXC motif. Subjected to post-translational modification by reactive oxygen species and reactive nitrogen species, these proteins have the potential to adopt numerous cellular...

journal_title：Antioxidants & redox signaling

authors： Conway ME

更新日期：2020-08-03 00:00:00

abstract：SIGNIFICANCE:Selenoprotein K (SelK) is an endoplasmic reticulum (ER) membrane protein, and its expression is sensitive to dietary selenium levels. A recently described role for SelK as a cofactor in catalyzing protein palmitoylation reactions provides an important link between low dietary selenium intake and suboptimal...

journal_title：Antioxidants & redox signaling

authors： Fredericks GJ,Hoffmann PR

更新日期：2015-10-01 00:00:00

abstract：:Homocysteine is a thiol-containing amino acid that has gained notoriety because its elevation in the plasma is correlated with complex and multifactorial diseases, including cardiovascular diseases, neurodegenerative diseases, and neural tube defects. Homocysteine is redox-active, and its toxic effects have been frequ...

journal_title：Antioxidants & redox signaling

authors： Zou CG,Banerjee R

更新日期：2005-05-01 00:00:00

abstract：:Protein thiolation is elicited by oxidation by different mechanisms and is involved in a variety of biological processes. Thiols, protein SH (PSH) and non-protein SH groups (NPSH, namely GSH), are in competition in all biological environments in the regulation of oxidant homeostasis because oxidants thiolate proteins,...

journal_title：Antioxidants & redox signaling

authors： Di Simplicio P,Frosali S,Priora R,Summa D,Cherubini Di Simplicio F,Di Giuseppe D,Di Stefano A

更新日期：2005-07-01 00:00:00

abstract：AIM:Our previous studies have shown that NOD-like receptor protein (NALP3) inflammasome activation is importantly involved in podocyte dysfunction and glomerular sclerosis induced by hyperhomocysteinemia (hHcys). The present study was designed to test whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-...

journal_title：Antioxidants & redox signaling

authors： Abais JM,Zhang C,Xia M,Liu Q,Gehr TW,Boini KM,Li PL

更新日期：2013-05-01 00:00:00

abstract：:Increased free radical generation and decreased efficiency of the reparative/degradative mechanisms both primarily contribute to age-related elevation in the level of oxidative stress and brain damage. Excess formation of reactive oxygen and nitrogen species can cause proteasomal dysfunction and protein overloading. T...

journal_title：Antioxidants & redox signaling

authors： Calabrese V,Butterfield DA,Scapagnini G,Stella AM,Maines MD

更新日期：2006-03-01 00:00:00

abstract：:Protein and amine halogenation is a type of oxidative stress induced by phagocytic overstimulation, and its role in Parkinson's disease (PD) has not been discerned. We have detected that advanced oxidized protein products, markers of protein halogenation, are reliably enhanced in serum of patients with PD (n=60) relat...

journal_title：Antioxidants & redox signaling

authors： García-Moreno JM,Martín de Pablos A,García-Sánchez MI,Méndez-Lucena C,Damas-Hermoso F,Rus M,Chacón J,Fernández E

更新日期：2013-04-10 00:00:00

abstract：:Lipoic acid (LA) and its reduced product dihydrolipoic acid (DHLA) are potent antioxidants with capacity to scavenge reactive oxygen species (ROS) and recycle endogenous antioxidants. LA may increase cellular glutathione (GSH), an antioxidant lacking in the lung's epithelial lining fluid in lung disorders such as idio...

journal_title：Antioxidants & redox signaling

authors： O'Neill HC,Rancourt RC,White CW

更新日期：2008-02-01 00:00:00