Cell cycle regulators guide mitochondrial activity in radiation-induced adaptive response.

abstract：:Although much is known about how TNF-alpha induces apoptosis in the presence of inhibitors of protein synthesis, little is known about how it induces apoptosis without these inhibitors. In this report we investigated temporal sequence of events induced by TNF-alpha in the absence of protein synthesis. Regardless of wh...

journal_title：Antioxidants & redox signaling

authors： Shakibaei M,Sung B,Sethi G,Aggarwal BB

更新日期：2010-09-15 00:00:00

abstract：SIGNIFICANCE:Mitochondrial dynamics is a complex process that impacts on mitochondrial biology. RECENT ADVANCES:Recent evidence indicates that proteins participating in mitochondrial dynamics have additional cellular roles. Mitofusin 2 (Mfn2) is a potent modulator of mitochondrial metabolism with an impact on energy m...

journal_title：Antioxidants & redox signaling

authors： Zorzano A,Hernández-Alvarez MI,Sebastián D,Muñoz JP

更新日期：2015-04-20 00:00:00

abstract：:BLNK (B cell linker protein) represents a central linker protein that bridges the B cell receptor-associated kinases with a multitude of signaling pathways. In this study, we have investigated the role of BLNK in oxidative stress signaling in B cells. H2O2 treatment of B cells induced a rapid tyrosine phosphorylation ...

journal_title：Antioxidants & redox signaling

authors： Han W,Takano T,He J,Ding J,Gao S,Noda C,Yanagi S,Yamamura H

更新日期：2001-12-01 00:00:00

abstract：:The redox status of tumors inoculated into the footpads of mice was investigated by using an in vivo ESR/spin-probe technique. A single-cell suspension of a metastatic subclone of colon carcinoma NL-17 was inoculated into the footpads of Balb/c mice. At 12, 24, 48, and 96 h after the inoculation, a spin probe, either ...

journal_title：Antioxidants & redox signaling

authors： Ichikawa K,Sakabe E,Kuninobu K,Yamori T,Tsuruo T,Yao T,Tsuneyoshi M,Utsumi H

更新日期：2007-10-01 00:00:00

abstract：:Aging is associated not only with oxidant stress, but also with increased interleukin-6 (IL-6) levels. To determine if oxidative stress could contribute to the age-associated increase IL-6 expression, we exposed LNCaP prostate carcinoma cells and HeLa cervical carcinoma cells to H2O2 as an oxidant challenge. We found ...

journal_title：Antioxidants & redox signaling

authors： Zhang J,Johnston G,Stebler B,Keller ET

更新日期：2001-06-01 00:00:00

abstract：:Aging is the accumulation of changes that increase the risk of death. Aging changes can be attributed to development, genetic defects, the environment, disease, and an inborn process: the aging process. The latter is the major risk factor for disease and death after age 28 in the developed countries. In these countrie...

journal_title：Antioxidants & redox signaling

authors： Harman D

更新日期：2003-10-01 00:00:00

abstract：:Nox family NADPH oxidases serve a variety of functions requiring reactive oxygen species (ROS) generation, including antimicrobial defense, biosynthetic processes, oxygen sensing, and redox-based cellular signaling. We explored targeting, assembly, and activation of several Nox family oxidases, since ROS production ap...

journal_title：Antioxidants & redox signaling

authors： Leto TL,Morand S,Hurt D,Ueyama T

更新日期：2009-10-01 00:00:00

abstract：AIMS:Excitotoxicity triggered by extrasynaptic N-methyl-d-aspartate-type glutamate receptors has been implicated in many neurodegenerative conditions, including Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke. Mitochondrial calcium overload leading to mitochondrial dysfunction repre...

journal_title：Antioxidants & redox signaling

authors： Depp C,Bas-Orth C,Schroeder L,Hellwig A,Bading H

更新日期：2018-10-20 00:00:00

abstract：:In striated muscle, the sarcoplasmic reticulum (SR) is the major storage compartment of intracellular Ca2+ that controls cytosolic free Ca2+ (Cai) and developed force by sequestering and releasing Ca2+ during each contraction. Ca2+ release from the SR occurs through high-conductance Ca2+ release channels or ryanodine ...

journal_title：Antioxidants & redox signaling

authors： Salama G,Menshikova EV,Abramson JJ

更新日期：2000-04-01 00:00:00

abstract：:Cells oxidize molecules to generate energy and to make the materials to build and support the structures and functions needed for life. However, unwanted oxidations can damage these same structures and impair function. Lipids (the lipids in membranes and lipoproteins) are targets of unwanted oxidations. The primary me...

journal_title：Antioxidants & redox signaling

authors： Venkataraman S,Schafer FQ,Buettner GR

更新日期：2004-06-01 00:00:00

abstract：SIGNIFICANCE:Mitochondrial function is central to a wide range of biological processes in health and disease and there is considerable interest in developing small molecules that are taken up by mitochondria and act as either probes of mitochondrial function or therapeutics in vivo. RECENT ADVANCES:Various strategies ...

journal_title：Antioxidants & redox signaling

authors： Smith RA,Hartley RC,Murphy MP

更新日期：2011-12-15 00:00:00

abstract：SIGNIFICANCE:Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to posttranslational modifications of proteins or the production of second messengers. Either as a primary cause or as a secondary component of the pat...

journal_title：Antioxidants & redox signaling

authors： Pehar M,Harlan BA,Killoy KM,Vargas MR

更新日期：2018-06-20 00:00:00

abstract：SIGNIFICANCE:Evidence is emerging that parenteral administration of high-dose vitamin C may warrant development as an adjuvant therapy for patients with sepsis. RECENT ADVANCES:Sepsis increases risk of death and disability, but its treatment consists only of supportive therapies because no specific therapy is availabl...

journal_title：Antioxidants & redox signaling

authors： Wilson JX

更新日期：2013-12-10 00:00:00

abstract：:Mitochondrial ferritin (MtFt) is a newly identified H-ferritin-like protein expressed only in mitochondria. Previous studies have shown that its overexpression markedly affects intracellular iron homeostasis and rescues defects caused by frataxin deficiency. To assess how MtFt exerts its function under oxidative stres...

journal_title：Antioxidants & redox signaling

authors： Lu Z,Nie G,Li Y,Soe-Lin S,Tao Y,Cao Y,Zhang Z,Liu N,Ponka P,Zhao B

更新日期：2009-08-01 00:00:00

abstract：SIGNIFICANCE:Heart disease is the primary cause of death in the industrialized world. Cardiac failure is dictated by an uncompensated reduction in the number of viable and fully functional cardiomyocytes. While current pharmacological therapies alleviate the symptoms associated with cardiac deterioration, heart transpl...

journal_title：Antioxidants & redox signaling

authors： Goichberg P,Chang J,Liao R,Leri A

更新日期：2014-11-10 00:00:00

abstract：:Tumor necrosis factor (TNF) induces a caspase-independent but mitochondria-dependent cell death process in the mouse fibrosarcoma cell line L929. Mitochondria actively participate in this TNF-induced necrotic cell death by the generation of mitochondrial reactive oxygen species (ROS). The aim of this study was to iden...

journal_title：Antioxidants & redox signaling

authors： Goossens V,Stangé G,Moens K,Pipeleers D,Grooten J

更新日期：1999-10-01 00:00:00

abstract：:Discovery of the F2-isoprostanes, a group of prostaglandin F2-like compounds biosynthesized from arachidonic acid nonenzymatically, has uncovered a new and novel facet of free radical biology. Some of these compounds are bioactive and thus may mediate adverse effects associated with oxidant stress. F2-Isoprostanes hav...

journal_title：Antioxidants & redox signaling

authors： Basu S,Helmersson J

更新日期：2005-01-01 00:00:00

abstract：:Nitric oxide (NO) has been shown to regulate a variety of physiological functions, including vascular tone. The inhibition of NO synthase by N(omega)-nitro-L-arginine methyl ester (L-NAME) has been reported to increase arterial blood pressure. The present studies were undertaken to investigate if the increased blood p...

journal_title：Antioxidants & redox signaling

authors： Anand-Srivastava MB,Di Fusco F

更新日期：2004-04-01 00:00:00

abstract：:Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression. We used MAO A knock-out (KO) mice as a model to study the effect of ginkgo biloba (EGb) on aggression. When EGb was administered to MAO A KO mice, their aggressive behavior in ...

journal_title：Antioxidants & redox signaling

authors： Shih JC,Chen K,Ridd MJ,Seif I

更新日期：2000-10-01 00:00:00

abstract：AIMS:The immune system is critical for protection against infections and cancer, but requires scrupulous regulation to limit self-reactivity and autoimmunity. Our group has utilized a manganese porphyrin catalytic antioxidant (MnTE-2-PyP(5+), MnP) as a potential immunoregulatory therapy for type 1 diabetes. MnP has pre...

journal_title：Antioxidants & redox signaling

authors： Delmastro-Greenwood MM,Votyakova T,Goetzman E,Marre ML,Previte DM,Tovmasyan A,Batinic-Haberle I,Trucco MM,Piganelli JD

更新日期：2013-12-01 00:00:00

abstract：SIGNIFICANCE:Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects ∼8% of the adult population worldwide. Pancreatic beta-cell dysfunction and loss are central to the disease process, although understanding of the underlying molecular mechanisms is still fragment...

journal_title：Antioxidants & redox signaling

authors： Gerber PA,Rutter GA

更新日期：2017-04-01 00:00:00

abstract：AIM:Skeletal muscle nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity. However, GC function and the consequences of reduced GC activity in skeletal muscle are unknown. In this ...

journal_title：Antioxidants & redox signaling

authors： Moon Y,Balke JE,Madorma D,Siegel MP,Knowels G,Brouckaert P,Buys ES,Marcinek DJ,Percival JM

更新日期：2017-06-10 00:00:00

abstract：:Homeostasis within the central nervous system (CNS) is a prerequisite to elicit proper neuronal function. The CNS is tightly sealed from the changeable milieu of the blood stream by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (BCSFB). Whereas the BBB is established by specialized endo...

journal_title：Antioxidants & redox signaling

authors： Coisne C,Engelhardt B

更新日期：2011-09-01 00:00:00

abstract：AIMS:Monothiol glutaredoxins (1-C-Grxs) are small proteins linked to the cellular iron and redox metabolism. Trypanosoma brucei brucei, model organism for human African trypanosomiasis, expresses three 1-C-Grxs. 1-C-Grx1 is a highly abundant mitochondrial protein capable to bind an iron-sulfur cluster (ISC) in vitro us...

journal_title：Antioxidants & redox signaling

authors： Manta B,Pavan C,Sturlese M,Medeiros A,Crispo M,Berndt C,Krauth-Siegel RL,Bellanda M,Comini MA

更新日期：2013-09-01 00:00:00

abstract：:The mechanism for regeneration of the active-site "peroxidatic" cysteine in 1-Cys peroxiredoxins is a matter of debate. Saccharomyces cerevisiae Prx1 is a mitochondrial enzyme belonging to the 1-Cys Prx, whereas Grx2 is involved in antioxidant defense and localizes at the mitochondria, so we hypothesized that it could...

journal_title：Antioxidants & redox signaling

authors： Pedrajas JR,Padilla CA,McDonagh B,Bárcena JA

更新日期：2010-08-01 00:00:00

abstract：:Although there is an abundance of evidence suggesting that insulin resistance plays a significant role in the vasculature, the precise mechanistic role involved still remains unclear. In this review, we discuss the current background of insulin resistance in the context of insulin signaling and action in the vasculatu...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S,Motley ED

更新日期：2005-07-01 00:00:00

abstract：: Significance: Metabolic syndrome (MetS) represents a cluster of cardiometabolic disorders, which accelerate the risk of developing diabetes, nonalcoholic fatty liver disease, and cardiovascular disorders such as atherosclerosis. Oxidative stress (OxS) and inflammation cont...

journal_title：Antioxidants & redox signaling

authors： Foisy Sauvé M,Spahis S,Delvin E,Levy E

更新日期：2021-01-20 00:00:00

abstract：:Previous reports have shown that the human immunodeficiency virus (HIV) regulatory protein Tat has both pro-oxidant and pro-inflammatory properties, suggesting that Tat might contribute to the neurological complications of HIV. However, the intracellular mechanisms whereby Tat triggers free radical production and infl...

journal_title：Antioxidants & redox signaling

authors： Turchan-Cholewo J,Dimayuga VM,Gupta S,Gorospe RM,Keller JN,Bruce-Keller AJ

更新日期：2009-02-01 00:00:00

abstract：:This Forum issue "Heme Oxygenase" (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual rol...

journal_title：Antioxidants & redox signaling

authors： Facchinetti MM

更新日期：2020-06-10 00:00:00

abstract：:Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport chain triggers several pathways of injury involved in the pathogenesis of diabetic complications [protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product (AGE) formation] by inhibiting glyceralde...

journal_title：Antioxidants & redox signaling

authors： Pacher P,Szabó C

更新日期：2005-11-01 00:00:00