C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform.

abstract：SIGNIFICANCE:The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins that accumulate oxidative post-translational modifications only if these detected modifications are co...

journal_title：Antioxidants & redox signaling

authors： Feeney MB,Schöneich C

更新日期：2012-12-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, complications of pregnancy, cognitive impairment, and osteoporosis. That elevated homocysteine leads to vascular dysfunction may be the linking factor between these apparently unrelated pathologies. Although a growing body of evidence sugge...

journal_title：Antioxidants & redox signaling

authors： Glushchenko AV,Jacobsen DW

更新日期：2007-11-01 00:00:00

abstract：:Anthracyclines are widely used in anticancer protocols, but can induce cardiotoxicity by mechanisms that mainly involve oxidative damage and mitochondrial dysfunction. Radiotherapy (RT) can also impair cardiac function by promoting myocardial fibrosis, microvascular damage, and decreased density of myocardial capillar...

journal_title：Antioxidants & redox signaling

authors： Mercurio V,Cuomo A,Della Pepa R,Ciervo D,Cella L,Pirozzi F,Parrella P,Campi G,Franco R,Varricchi G,Abete P,Marone G,Petretta M,Bonaduce D,Pacelli R,Picardi M,Tocchetti CG

更新日期：2019-11-20 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00

abstract：:Disruption of the oxidant/antioxidant balance in the lung is thought to be a key step in the development of many airway pathologies. Hence, antioxidant enzymes play key roles in controlling or preventing pulmonary diseases related to oxidative stress. The superoxide dismutases (SOD) are a family of enzymes that play a...

journal_title：Antioxidants & redox signaling

authors： Gao F,Kinnula VL,Myllärniemi M,Oury TD

更新日期：2008-02-01 00:00:00

abstract：: Significance: Streptococcus pneumoniae (Spn), a facultative anaerobic Gram-positive human pathogen with increasing rates of penicillin and macrolide resistance, is a major cause of lower respiratory tract infections worldwide. Pneumococci are a primary agent of severe pneum...

journal_title：Antioxidants & redox signaling

authors： Mraheil MA,Toque HA,La Pietra L,Hamacher J,Phanthok T,Verin A,Gonzales J,Su Y,Fulton D,Eaton DC,Chakraborty T,Lucas R

更新日期：2020-08-14 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seems to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, which are composed of several genes termed "vitagenes," among these, the heat shock system, a highly co...

journal_title：Antioxidants & redox signaling

authors： Calabrese V,Stella AM,Butterfield DA,Scapagnini G

更新日期：2004-10-01 00:00:00

abstract：AIMS:Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) are sufficient to increase ...

journal_title：Antioxidants & redox signaling

authors： Leuner K,Schütt T,Kurz C,Eckert SH,Schiller C,Occhipinti A,Mai S,Jendrach M,Eckert GP,Kruse SE,Palmiter RD,Brandt U,Dröse S,Wittig I,Willem M,Haass C,Reichert AS,Müller WE

更新日期：2012-06-15 00:00:00

abstract：:Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•-) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aortic endothelial cells, ...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Jen N,Ai L,Hamilton R,Wang S,Holmes K,Dharbandi F,Khalsa B,Bressler S,Barr ML,Li R,Hsiai TK

更新日期：2011-09-01 00:00:00

abstract：SIGNIFICANCE:Development of donor-specific antibodies (DSA) after kidney transplantation is associated with reduced allograft survival. A few strategies have been tested in controlled clinical trials for the treatment of antibody-mediated rejection (AMR), and no therapies are approved by regulatory authorities. Thus de...

journal_title：Antioxidants & redox signaling

authors： Ejaz NS,Alloway RR,Halleck F,Dürr M,Budde K,Woodle ES

更新日期：2014-12-10 00:00:00

abstract：:Extensive literature exists supporting a role for mitochondrial dysfunction and oxidative damage in the pathogenesis of Alzheimer's disease. Mitochondria are a major source of intracellular reactive oxygen species and are particularly vulnerable to oxidative stress. This review discusses evidence supporting the notion...

journal_title：Antioxidants & redox signaling

authors： Moreira PI,Santos MS,Oliveira CR

更新日期：2007-10-01 00:00:00

abstract：:In striated muscle, the sarcoplasmic reticulum (SR) is the major storage compartment of intracellular Ca2+ that controls cytosolic free Ca2+ (Cai) and developed force by sequestering and releasing Ca2+ during each contraction. Ca2+ release from the SR occurs through high-conductance Ca2+ release channels or ryanodine ...

journal_title：Antioxidants & redox signaling

authors： Salama G,Menshikova EV,Abramson JJ

更新日期：2000-04-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress induces an adaptive program called the unfolded protein response (UPR), which affects activity of an array of kinases and transcription factors. Previous reports provided evidence for activation of nuclear factor-kappaB (NF-kappaB), the major transcription factor regulating inflammato...

journal_title：Antioxidants & redox signaling

authors： Kitamura M

更新日期：2009-09-01 00:00:00

abstract：: Significance: Metabolic syndrome (MetS) represents a cluster of cardiometabolic disorders, which accelerate the risk of developing diabetes, nonalcoholic fatty liver disease, and cardiovascular disorders such as atherosclerosis. Oxidative stress (OxS) and inflammation cont...

journal_title：Antioxidants & redox signaling

authors： Foisy Sauvé M,Spahis S,Delvin E,Levy E

更新日期：2021-01-20 00:00:00

abstract：:Mitochondrial ferritin (MtFt) is a newly identified H-ferritin-like protein expressed only in mitochondria. Previous studies have shown that its overexpression markedly affects intracellular iron homeostasis and rescues defects caused by frataxin deficiency. To assess how MtFt exerts its function under oxidative stres...

journal_title：Antioxidants & redox signaling

authors： Lu Z,Nie G,Li Y,Soe-Lin S,Tao Y,Cao Y,Zhang Z,Liu N,Ponka P,Zhao B

更新日期：2009-08-01 00:00:00

abstract：:Dr. Gregg L. Semenza is recognized here as a Redox Pioneer because he has published three articles that have been cited more than 1,000 times, and 74 articles that have each been cited more than 100 times. Dr. Semenza is known for his seminal discovery of hypoxia-inducible factor-1 (HIF-1) and for identifying molecula...

journal_title：Antioxidants & redox signaling

authors： Prabhakar NR

更新日期：2010-08-15 00:00:00

abstract：: Aims: Clinical use of cisplatin (Cisp), one of the most widely used, common, and effective chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Previous studies suggest that hydrogen sulfide (H2S) alleviates Cisp-i...

journal_title：Antioxidants & redox signaling

authors： Yuan Y,Zhu L,Li L,Liu J,Chen Y,Cheng J,Peng T,Lu Y

更新日期：2019-12-01 00:00:00

abstract：:The endothelium is essential for the maintenance of vascular homeostasis. Central to this role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the endothelial isoform of nitric oxide synthase (eNOS). Endothelial dysfunction, manifested as impaired EDNO bioactivity, is an important early ev...

journal_title：Antioxidants & redox signaling

authors： Thomas SR,Witting PK,Drummond GR

更新日期：2008-10-01 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：AIMS:The risk factors promoting acute kidney injury (AKI) to chronic kidney disease (CKD) progression remain largely unknown. The aim of the present study was to investigate whether hyperhomocysteinemia (Hhcy) accelerates the development of renal fibrosis after AKI. RESULTS:Hhcy aggravated ischemia-reperfusion-induced...

journal_title：Antioxidants & redox signaling

authors： Li S,Qiu B,Lu H,Lai Y,Liu J,Luo J,Zhu F,Hu Z,Zhou M,Tian J,Zhou Z,Yu S,Yi F,Nie J

更新日期：2019-05-01 00:00:00

abstract：:Eukaryotic mitochondria resulted from symbiotic incorporation of α-proteobacteria into ancient archaea species. During evolution, mitochondria lost most of the prokaryotic bacterial genes and only conserved a small fraction including those encoding 13 proteins of the respiratory chain. In this process, many functions ...

journal_title：Antioxidants & redox signaling

authors： Antico Arciuch VG,Elguero ME,Poderoso JJ,Carreras MC

更新日期：2012-05-15 00:00:00

abstract：:Intracellular Ca(2+) signaling, and related mechanisms involving inositol 1,4,5-trisphosphate (IP(3)), nitric oxide, and the excitatory neurotransmitter glutamate, play a major role in the regulation of cellular function in the brain. Due to the complex morphology of central neurons, the correct spatiotemporal distrib...

journal_title：Antioxidants & redox signaling

authors： Okubo Y,Kanemaru K,Iino M

更新日期：2011-04-01 00:00:00

abstract：:The forkhead box O (FOXO) family of transcription factors regulates a variety of cellular programs, including cell cycle arrest, reactive oxygen species (ROS) scavenging, and apoptosis, and are of key importance in the decision over cell fate. In animal model systems it has been shown that FOXO is involved in the regu...

journal_title：Antioxidants & redox signaling

authors： de Keizer PL,Burgering BM,Dansen TB

更新日期：2011-03-15 00:00:00

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. The pathogenesis of PD remains incompletely understood. Environmental factors, oxidative damage, misfolded protein aggregates, ubiquitin-proteasome syste...

journal_title：Antioxidants & redox signaling

authors： Wang HQ,Takahashi R

更新日期：2007-05-01 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：:Hypoxia and its corollaries pose both negative and positive pressures to multicellular eukaryotes. Evolutionarily, life developed under hypoxia, and the building blocks were established under conditions close to anaerobiosis; therefore, reason exists to expect that certain biologic processes may perform preferentially...

journal_title：Antioxidants & redox signaling

authors： Webster KA

更新日期：2007-09-01 00:00:00

abstract：:Through hypoxia-inducible factor 1 (HIF-1), hypoxia regulates the expression of numerous genes and is a potent inducer of angiogenesis. However, interleukin-8 (IL-8), an important angiogenic mediator, has been reported to be downregulated by HIF-1, although the mechanisms have not been elucidated. HIF-1 was induced in...

journal_title：Antioxidants & redox signaling

authors： Loboda A,Stachurska A,Florczyk U,Rudnicka D,Jazwa A,Wegrzyn J,Kozakowska M,Stalinska K,Poellinger L,Levonen AL,Yla-Herttuala S,Jozkowicz A,Dulak J

更新日期：2009-07-01 00:00:00

abstract：: Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and they constitute an ever-growing global burden that has a c...

journal_title：Antioxidants & redox signaling

authors： Gianazza E,Brioschi M,Martinez Fernandez A,Casalnuovo F,Altomare A,Aldini G,Banfi C

更新日期：2021-01-01 00:00:00

abstract：:Our aim is to deliver an authoritative and challenging perspective of current concepts in plant redox signaling, focusing particularly on the complex interface between the redox and hormone-signaling pathways that allow precise control of plant growth and defense in response to metabolic triggers and environmental con...

journal_title：Antioxidants & redox signaling

authors： Foyer CH,Noctor G

更新日期：2013-06-01 00:00:00

abstract：: Aims: The management of myocardial ischemia has been challenged by reperfusion injury. Reactive oxygen species (ROS) production is the critical cause of reperfusion injury, but antioxidant treatment failed to gain satisfactory effects. We hypothesized that improvement of r...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Zeng H,Ni L,Qi L,Xu Y,Xia L,Yu Y,Liu B,Yang H,Hao H,Li P

更新日期：2019-07-20 00:00:00