Biphasic, bidirectional regulation of NF-kappaB by endoplasmic reticulum stress.

abstract：SIGNIFICANCE:Mitochondria are complex dynamic organelles pivotal for cellular physiology and human health. Failure to maintain mitochondrial health leads to numerous maladies that include late-onset neurodegenerative diseases and cardiovascular disorders. Furthermore, a decline in mitochondrial health is prevalent with...

journal_title：Antioxidants & redox signaling

authors： Bohovych I,Chan SS,Khalimonchuk O

更新日期：2015-04-20 00:00:00

abstract：AIMS:Emerging lines of evidence indicate that oxidants such as hydrogen peroxide exert specific signaling functions during the processing of chronic pain. However, the mechanisms by which oxidants regulate pain processing in vivo remain poorly understood. Here, we investigated whether cyclic guanosine monophosphate (cG...

journal_title：Antioxidants & redox signaling

authors： Lorenz JE,Kallenborn-Gerhardt W,Lu R,Syhr KM,Eaton P,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：AIMS:Pulmonary infections with Pseudomonas aeruginosa are a serious clinical problem and are often lethal. Because many strains of P. aeruginosa are resistant to antibiotics, therapeutic options are limited. Neutrophils play an important role in the host's early acute defense against pulmonary P. aeruginosa. Therefore,...

journal_title：Antioxidants & redox signaling

authors： Managò A,Becker KA,Carpinteiro A,Wilker B,Soddemann M,Seitz AP,Edwards MJ,Grassmé H,Szabò I,Gulbins E

更新日期：2015-05-01 00:00:00

abstract：:The RING (really interesting new gene) finger proteins containing a characteristic C3HC4 or C3H2C3 motif appear to act as E3 ubiquitin ligase and play important roles in many processes, including cell-cycle progression, oncogenesis, signal transduction, and development. This review is focused on SAG/ROC/Rbx/Hrt (sensi...

journal_title：Antioxidants & redox signaling

authors： Sun Y,Tan M,Duan H,Swaroop M

更新日期：2001-08-01 00:00:00

abstract：: Significance: Excessive and prolonged proinflammatory responses are associated with oxidative stress, which is commonly observed during chronic tuberculosis (TB). Such condition favors tissue destruction and consequently bacterial spread. A tissue remodeling program is als...

journal_title：Antioxidants & redox signaling

authors： Amaral EP,Vinhaes CL,Oliveira-de-Souza D,Nogueira B,Akrami KM,Andrade BB

更新日期：2021-02-20 00:00:00

abstract：:The production of reactive oxygen and reactive nitrogen intermediates is an important host defense mechanism mediated in response to infection by bacterial pathogens. Not surprisingly, intracellular pathogens have evolved numerous defense strategies to protect themselves against the damaging effects of these agents. I...

journal_title：Antioxidants & redox signaling

authors： Zahrt TC,Deretic V

更新日期：2002-02-01 00:00:00

abstract：AIMS:Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to eliminate Her2high disease. RESULTS:We demonstrate that Her2high cells and t...

journal_title：Antioxidants & redox signaling

authors： Rohlenova K,Sachaphibulkij K,Stursa J,Bezawork-Geleta A,Blecha J,Endaya B,Werner L,Cerny J,Zobalova R,Goodwin J,Spacek T,Alizadeh Pesdar E,Yan B,Nguyen MN,Vondrusova M,Sobol M,Jezek P,Hozak P,Truksa J,Rohlena J,Do

更新日期：2017-01-10 00:00:00

abstract：:The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood. In this study, we investigated the effect of AngII on aortic smooth muscle from wild-type and NOX1-deficient mice. NOX1-deficient cells sho...

journal_title：Antioxidants & redox signaling

authors： Basset O,Deffert C,Foti M,Bedard K,Jaquet V,Ogier-Denis E,Krause KH

更新日期：2009-10-01 00:00:00

abstract：:Dr. Gregg L. Semenza is recognized here as a Redox Pioneer because he has published three articles that have been cited more than 1,000 times, and 74 articles that have each been cited more than 100 times. Dr. Semenza is known for his seminal discovery of hypoxia-inducible factor-1 (HIF-1) and for identifying molecula...

journal_title：Antioxidants & redox signaling

authors： Prabhakar NR

更新日期：2010-08-15 00:00:00

abstract：:The nuclear factor-kappaB (NF-kappaB) is a transcription factor that plays a pivotal role in the induction of genes involved in physiological processes, as well as in the response to inflammation. In this study, we used a selective nonpeptidyl superoxide dismutase mimetic, M40403, to investigate the role of superoxide...

journal_title：Antioxidants & redox signaling

authors： Cuzzocrea S,Pisano B,Dugo L,Ianaro A,Ndengele M,Salvemini D

更新日期：2004-08-01 00:00:00

abstract：:Coenzyme Q10 (CoQ) has long been utilized as a cardioprotective agent in various heart diseases. One of the most important mechanisms by which CoQ exerts cardioprotection is aerobic ATP production as a mobile electron carrier in the mitochondrial electron transfer chain. The ability of CoQ to afford myocardial protect...

journal_title：Antioxidants & redox signaling

authors： Yamamura T,Otani H,Nakao Y,Hattori R,Osako M,Imamura H,Das DK

更新日期：2001-02-01 00:00:00

abstract：:Epidemiological studies have shown that advancing age is associated with an increased prevalence of cardiovascular disease (CVD). Vascular smooth muscle cells (VSMC) comprise the major arterial cell population, and changes in VSMC behavior, function, and redox status with age contribute to alterations in vascular remo...

journal_title：Antioxidants & redox signaling

authors： Li M,Fukagawa NK

更新日期：2010-03-01 00:00:00

abstract：:Our aim is to deliver an authoritative and challenging perspective of current concepts in plant redox signaling, focusing particularly on the complex interface between the redox and hormone-signaling pathways that allow precise control of plant growth and defense in response to metabolic triggers and environmental con...

journal_title：Antioxidants & redox signaling

authors： Foyer CH,Noctor G

更新日期：2013-06-01 00:00:00

abstract：: Aims: Hemangioendothelioma (HE) may be benign or malignant. Mouse hemangioendothelioma endothelial (EOMA) cells are validated to study mechanisms in HE. This work demonstrates that EOMA cells heavily rely on mitochondria to thrive. Thus, a combination therapy, including we...

journal_title：Antioxidants & redox signaling

authors： Gordillo GM,Biswas A,Singh K,Sen A,Guda PR,Miller C,Pan X,Khanna S,Cadenas E,Sen CK

更新日期：2021-01-10 00:00:00

abstract：:Changes in the hemodynamic environment (e.g., hypertension, increased blood flow/shear stress) are known to lead to vascular remodeling; however, the underlying mechanisms by which hemodynamic forces control gene expression in vascular cells are not yet completely understood. This review considers how mechanosensitive...

journal_title：Antioxidants & redox signaling

authors： Ungvari Z,Wolin MS,Csiszar A

更新日期：2006-07-01 00:00:00

abstract：AIMS:Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases mitochondrial ATP levels. Here, we investigate the mechanistic connection between SIRT3 and energy homeost...

journal_title：Antioxidants & redox signaling

authors： Vassilopoulos A,Pennington JD,Andresson T,Rees DM,Bosley AD,Fearnley IM,Ham A,Flynn CR,Hill S,Rose KL,Kim HS,Deng CX,Walker JE,Gius D

更新日期：2014-08-01 00:00:00

abstract：:Efficient extracellular hemoglobin (Hb) clearance is essential to prevent oxidative- and nitrosative-mediated toxicity. CD163 belongs to group B of the scavenger receptor cysteine-rich (SRCR) protein family found on the surface of monocytes and macrophages and is responsible for Hb-haptoglobin (Hp) complex uptake. Hb ...

journal_title：Antioxidants & redox signaling

authors： Schaer DJ,Alayash AI,Buehler PW

更新日期：2007-07-01 00:00:00

abstract：:Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle of an individual mitochondrion reveals several points where fusion, fission, and mitophagy interact. Mitochondrial fission can produce an...

journal_title：Antioxidants & redox signaling

authors： Twig G,Shirihai OS

更新日期：2011-05-15 00:00:00

abstract：SIGNIFICANCE:Synaptic degeneration, an early pathological feature in Alzheimer's disease (AD), is closely correlated to impaired cognitive function and memory loss. Recent studies suggest that involvement of amyloid-beta peptide (Aβ) in synaptic mitochondrial alteration underlies these synaptic lesions. Thus, to unders...

journal_title：Antioxidants & redox signaling

authors： Du H,Guo L,Yan SS

更新日期：2012-06-15 00:00:00

abstract：AIMS:Large doses of intraperitoneally injected basic amino acids, L-arginine, or L-ornithine, induce acute pancreatitis in rodents, although the mechanisms mediating pancreatic toxicity remain unknown. Another basic amino acid, L-lysine, was also shown to cause pancreatic acinar cell injury. The aim of the study was to...

journal_title：Antioxidants & redox signaling

authors： Biczó G,Hegyi P,Dósa S,Shalbuyeva N,Berczi S,Sinervirta R,Hracskó Z,Siska A,Kukor Z,Jármay K,Venglovecz V,Varga IS,Iványi B,Alhonen L,Wittmann T,Gukovskaya A,Takács T,Rakonczay Z Jr

更新日期：2011-11-15 00:00:00

abstract：AIMS:Carbon monoxide is a respiratory poison and gaseous signaling molecule. Although CO-releasing molecules (CORMs) deliver CO with temporal and spatial specificity in mammals, and are proven antimicrobial agents, we do not understand the modes of CO toxicity. Our aim was to explore the impact of CO gas per se, withou...

journal_title：Antioxidants & redox signaling

authors： Wareham LK,Begg R,Jesse HE,Van Beilen JW,Ali S,Svistunenko D,McLean S,Hellingwerf KJ,Sanguinetti G,Poole RK

更新日期：2016-06-10 00:00:00

abstract：:Signal transduction via PI 3-kinases plays an important role in regulating the cellular processes of cell growth, survival, proliferation, and motility. The stimulated generation of reactive oxygen species is a necessary component of the signal transduction mechanisms by which many growth factors and cytokines activat...

journal_title：Antioxidants & redox signaling

authors： Leslie NR

更新日期：2006-09-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：:The tumor suppressor p53 protects organisms from most types of cancer through multiple mechanisms. The p53 gene encodes a stress-activated transcriptional factor that transcriptionally regulates a large set of genes with versatile functions. These p53-activated genes mitigate consequences of stress regulating cell via...

journal_title：Antioxidants & redox signaling

authors： Budanov AV

更新日期：2011-09-15 00:00:00

abstract：:An overview is provided of the use of cyclic voltammetry and electrochemical detectors for HPLC to characterize antioxidants that are active as reducing agents at inert electrodes. Results are presented for cyclic voltammetry at a glassy carbon electrode in 50% methanol, 50% 0.1 M HClO4, a solution typically used in H...

journal_title：Antioxidants & redox signaling

authors： Kilmartin PA

更新日期：2001-12-01 00:00:00

abstract：AIMS:Intracellular amyloid beta (Aβ) oligomers and extracellular Aβ plaques are key players in the progression of sporadic Alzheimer's disease (AD). Still, the molecular signals triggering Aβ production are largely unclear. We asked whether mitochondrion-derived reactive oxygen species (ROS) are sufficient to increase ...

journal_title：Antioxidants & redox signaling

authors： Leuner K,Schütt T,Kurz C,Eckert SH,Schiller C,Occhipinti A,Mai S,Jendrach M,Eckert GP,Kruse SE,Palmiter RD,Brandt U,Dröse S,Wittig I,Willem M,Haass C,Reichert AS,Müller WE

更新日期：2012-06-15 00:00:00

abstract：:Cardiac surgery is associated with release of the pleiotropic cytokine macrophage migration inhibitory factor (MIF). The trigger for MIF release has not yet been elucidated. Owing to its intrinsic antioxidative activity, MIF might reduce oxidative stress and protect from myocardial ischemia and reperfusion (I/R) injur...

journal_title：Antioxidants & redox signaling

authors： Stoppe C,Werker T,Rossaint R,Dollo F,Lue H,Wonisch W,Menon A,Goetzenich A,Bruells CS,Coburn M,Kopp R,Bucala R,Bernhagen J,Rex S

更新日期：2013-07-20 00:00:00

abstract：:Free-radicals and other reactive oxygen species (ROS) have been implicated as being major damaging species in pathology and they have been widely investigated. Using 1,1'-diphenyl-2-picrylhydrazyl (DPPH), we estimated total free radical scavenging activity in the low-molecular-weight nonenzymatic fraction (LMNEF) of h...

journal_title：Antioxidants & redox signaling

authors： Atsumi T,Iwakura I,Kashiwagi Y,Fujisawa S,Ueha T

更新日期：1999-01-01 00:00:00

abstract：:Hyperglycemia-induced overproduction of superoxide by mitochondrial electron-transport chain triggers several pathways of injury involved in the pathogenesis of diabetic complications [protein kinase C (PKC), hexosamine and polyol pathway fluxes, advanced glycation end product (AGE) formation] by inhibiting glyceralde...

journal_title：Antioxidants & redox signaling

authors： Pacher P,Szabó C

更新日期：2005-11-01 00:00:00

abstract：SIGNIFICANCE:Understanding isoform- and context-specific subcellular Nox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase compartmentalization allows relevant functional inferences. This review addresses the interplay between Nox NADPH oxidases and the endoplasmic reticulum (ER), an increasingly evid...

journal_title：Antioxidants & redox signaling

authors： Laurindo FR,Araujo TL,Abrahão TB

更新日期：2014-06-10 00:00:00