Free radical scavenging activity in the nonenzymatic fraction of human saliva: a simple DPPH assay showing the effect of physical exercise.

abstract：SIGNIFICANCE:Autophagy is a fundamental cellular process that functions in the turnover of subcellular organelles and protein. Activation of autophagy may represent a cellular defense against oxidative stress, or related conditions that cause accumulation of damaged proteins or organelles. Selective forms of autophagy ...

journal_title：Antioxidants & redox signaling

authors： Nakahira K,Cloonan SM,Mizumura K,Choi AM,Ryter SW

更新日期：2014-01-20 00:00:00

abstract：:Post-ischemic reperfusion may result in reactive oxygen species (ROS) generation, reduced availability of nitric oxide (NO•), Ca(2+)overload, prolonged opening of mitochondrial permeability transition pore, and other processes contributing to cell death, myocardial infarction, stunning, and arrhythmias. With the disco...

journal_title：Antioxidants & redox signaling

authors： Pagliaro P,Moro F,Tullio F,Perrelli MG,Penna C

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:Glycating stress can occur together with oxidative stress during neurodegeneration and contribute to the pathogenic mechanism. Nerve growth factor (NGF) accumulates in several neurodegenerative diseases. Besides promoting survival, NGF can paradoxically induce cell death by signaling through the p75 neurot...

journal_title：Antioxidants & redox signaling

authors： Kim MJ,Vargas MR,Harlan BA,Killoy KM,Ball LE,Comte-Walters S,Gooz M,Yamamoto Y,Beckman JS,Barbeito L,Pehar M

更新日期：2018-06-20 00:00:00

abstract：SIGNIFICANCE:Glutathione is the most abundant antioxidant molecule in living organisms and has multiple functions. Intracellular glutathione homeostasis, through its synthesis, consumption, and degradation, is an intricately balanced process. Glutathione levels are often high in tumor cells before treatment, and there ...

journal_title：Antioxidants & redox signaling

authors： Hatem E,El Banna N,Huang ME

更新日期：2017-11-20 00:00:00

abstract：:Although much is known about how TNF-alpha induces apoptosis in the presence of inhibitors of protein synthesis, little is known about how it induces apoptosis without these inhibitors. In this report we investigated temporal sequence of events induced by TNF-alpha in the absence of protein synthesis. Regardless of wh...

journal_title：Antioxidants & redox signaling

authors： Shakibaei M,Sung B,Sethi G,Aggarwal BB

更新日期：2010-09-15 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, maintains alveolar integrity and participates in the control of host defense and inflammation in the lung. Surfactant proteins A, B, C, and D are important components of surfactant that play diverse roles in the surface tension reducing as well as host defense an...

journal_title：Antioxidants & redox signaling

authors： Boggaram V

更新日期：2004-02-01 00:00:00

abstract：:Integrin-mediated phagocytosis in fibroblasts is associated to collagenase 1 induction when the particles are coated with high-affinity binding ligands. This study shows that the high density of ligand coating on the particle elicits RhoA-dependent particle uptake coupled to signal transduction. Integrin clustering in...

journal_title：Antioxidants & redox signaling

authors： Werner E

更新日期：2005-03-01 00:00:00

abstract：AIMS:Heart failure (HF) is characterized by regionalized contractile alterations resulting in loss of the transmural contractile gradient across the left ventricular free wall. We tested whether a regional alteration in mitochondrial oxidative metabolism during HF could affect myofilament function through protein kinas...

journal_title：Antioxidants & redox signaling

authors： Andre L,Fauconnier J,Reboul C,Feillet-Coudray C,Meschin P,Farah C,Fouret G,Richard S,Lacampagne A,Cazorla O

更新日期：2013-03-20 00:00:00

abstract：SIGNIFICANCE:Reactive oxygen and nitrogen species contributing to homeostatic regulation and the pathogenesis of various cardiovascular diseases, including atherosclerosis, hypertension, endothelial dysfunction, and cardiac hypertrophy, is well established. The ability of oxidant species to mediate such effects is in p...

journal_title：Antioxidants & redox signaling

authors： Pimentel D,Haeussler DJ,Matsui R,Burgoyne JR,Cohen RA,Bachschmid MM

更新日期：2012-03-15 00:00:00

abstract：AIM:Our previous studies have shown that NOD-like receptor protein (NALP3) inflammasome activation is importantly involved in podocyte dysfunction and glomerular sclerosis induced by hyperhomocysteinemia (hHcys). The present study was designed to test whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-...

journal_title：Antioxidants & redox signaling

authors： Abais JM,Zhang C,Xia M,Liu Q,Gehr TW,Boini KM,Li PL

更新日期：2013-05-01 00:00:00

abstract：AIM:To evaluate the role of matrix metalloproteinase (MMP)-9 deletion on citrate synthase (CS) activity postmyocardial infarction (MI). RESULTS:We fractionated left ventricle (LV) samples using a differential solubility-based approach. The insoluble protein fraction was analyzed by mass spectrometry, and we identified...

journal_title：Antioxidants & redox signaling

authors： de Castro Brás LE,Cates CA,DeLeon-Pennell KY,Ma Y,Iyer RP,Halade GV,Yabluchanskiy A,Fields GB,Weintraub ST,Lindsey ML

更新日期：2014-11-10 00:00:00

abstract：SIGNIFICANCE:Ascorbic acid and sodium-dependent vitamin C transporters (SVCT) have been shown to have important functions in the peripheral nervous system (PNS). Ascorbic acid is known to promote myelination in vitro in Schwann cell/dorsal root ganglion co-cultures by the formation of a collagen- and laminin-containing...

journal_title：Antioxidants & redox signaling

authors： Gess B,Röhr D,Young P

更新日期：2013-12-10 00:00:00

abstract：SIGNIFICANCE:Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eicosanoids, steroids,...

journal_title：Antioxidants & redox signaling

authors： Deponte M

更新日期：2017-11-20 00:00:00

abstract：:Aging is the accumulation of changes that increase the risk of death. Aging changes can be attributed to development, genetic defects, the environment, disease, and an inborn process: the aging process. The latter is the major risk factor for disease and death after age 28 in the developed countries. In these countrie...

journal_title：Antioxidants & redox signaling

authors： Harman D

更新日期：2003-10-01 00:00:00

abstract：AIMS:Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)-mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that UCP2-mediated uncoupl...

journal_title：Antioxidants & redox signaling

authors： Ježek J,Dlasková A,Zelenka J,Jabůrek M,Ježek P

更新日期：2015-10-20 00:00:00

abstract：:Previous studies identified NADPH oxidases (Nox) and mitochondrial electron transport chain at complex I as major cellular sources of reactive oxygen species (ROS) mediating systemic and cellular responses to intermittent hypoxia (IH). In the present study, we investigated potential interactions between Nox and the mi...

journal_title：Antioxidants & redox signaling

authors： Khan SA,Nanduri J,Yuan G,Kinsman B,Kumar GK,Joseph J,Kalyanaraman B,Prabhakar NR

更新日期：2011-02-15 00:00:00

abstract：AIMS:Cardiovascular interventions continue to fail as a result of arterial restenosis secondary to neointimal hyperplasia. We sought to develop and evaluate a systemically delivered nanostructure targeted to the site of arterial injury to prevent neointimal hyperplasia. Nanostructures were based on self-assembling biod...

journal_title：Antioxidants & redox signaling

authors： Bahnson ES,Kassam HA,Moyer TJ,Jiang W,Morgan CE,Vercammen JM,Jiang Q,Flynn ME,Stupp SI,Kibbe MR

更新日期：2016-03-10 00:00:00

abstract：SIGNIFICANCE:The successful adaptation of microorganisms to ever-changing environments depends, to a great extent, on their ability to maintain redox homeostasis. To effectively maintain the redox balance, cells have developed a variety of strategies mainly coordinated by a battery of transcriptional regulators through...

journal_title：Antioxidants & redox signaling

authors： Sevilla E,Bes MT,González A,Peleato ML,Fillat MF

更新日期：2019-05-01 00:00:00

abstract：:Cell division requires the coordinated assembly of cyclins and cyclin-dependent kinases that promote cell-cycle progression through S phase and mitosis. Two families of cyclin-dependent kinase inhibitors prevent abnormal or premature proliferation by blocking cyclin kinase activity. Expression of the cyclin-dependent ...

journal_title：Antioxidants & redox signaling

authors： O'Reilly MA

更新日期：2005-01-01 00:00:00

abstract：:Protein and amine halogenation is a type of oxidative stress induced by phagocytic overstimulation, and its role in Parkinson's disease (PD) has not been discerned. We have detected that advanced oxidized protein products, markers of protein halogenation, are reliably enhanced in serum of patients with PD (n=60) relat...

journal_title：Antioxidants & redox signaling

authors： García-Moreno JM,Martín de Pablos A,García-Sánchez MI,Méndez-Lucena C,Damas-Hermoso F,Rus M,Chacón J,Fernández E

更新日期：2013-04-10 00:00:00

abstract：AIMS:Emerging lines of evidence indicate that oxidants such as hydrogen peroxide exert specific signaling functions during the processing of chronic pain. However, the mechanisms by which oxidants regulate pain processing in vivo remain poorly understood. Here, we investigated whether cyclic guanosine monophosphate (cG...

journal_title：Antioxidants & redox signaling

authors： Lorenz JE,Kallenborn-Gerhardt W,Lu R,Syhr KM,Eaton P,Geisslinger G,Schmidtko A

更新日期：2014-10-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthe...

journal_title：Antioxidants & redox signaling

authors： Bendall JK,Douglas G,McNeill E,Channon KM,Crabtree MJ

更新日期：2014-06-20 00:00:00

abstract：AIMS:Cigarette smoke (CS)-mediated acquired cystic fibrosis transmembrane conductance regulator (CFTR)-dysfunction, autophagy-impairment, and resulting inflammatory-oxidative/nitrosative stress leads to chronic obstructive pulmonary disease (COPD)-emphysema pathogenesis. Moreover, nitric oxide (NO) signaling regulates ...

journal_title：Antioxidants & redox signaling

authors： Bodas M,Silverberg D,Walworth K,Brucia K,Vij N

更新日期：2017-09-01 00:00:00

abstract：:In the brain, the mu-opioid receptor (MOR) activates neural nitric oxide synthase (nNOS) through the PI3K/Akt pathway. The resulting nitric oxide (NO) enhances the function of the glutamate N-methyl-d-aspartate receptor (NMDAR)/calcium and calmodulin-dependent serine/threonine kinase (CaMKII), which subsequently dimin...

journal_title：Antioxidants & redox signaling

authors： Rodríguez-Muñoz M,de la Torre-Madrid E,Sánchez-Blázquez P,Garzón J

更新日期：2011-06-15 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has recently been viewed as an inflammation-dependent systemic disease. Oxidative modifications in the pulmonary microenvironment can result in a number of functional changes in pulmonary tissue as well as in the blood. Studies have been carried out to detect whether oxidat...

journal_title：Antioxidants & redox signaling

authors： Minetti M,Leto TL,Malorni W

更新日期：2008-04-01 00:00:00

abstract：:Junctional adhesion molecules are transmembrane proteins that belong to the immunoglobulin superfamily. In addition to their localization in close proximity to the tight junctions in endothelial and epithelial cells, junctional adhesion molecules are also expressed in circulating cells that do not form junctions, such...

journal_title：Antioxidants & redox signaling

authors： Bazzoni G

更新日期：2011-09-01 00:00:00

abstract：:Mitochondrial uncoupling proteins (UCPs), a subfamily of the mitochondrial transporter family, are related by sequence homology to UCP1. This protein, which is located in the inner mitochondrial membrane, dissipates the proton gradient between the intermembrane space and the mitochondrial matrix to uncouple electron t...

journal_title：Antioxidants & redox signaling

authors： Kim-Han JS,Dugan LL

更新日期：2005-09-01 00:00:00

abstract：:Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents. After phosphorylation and dissociation from the cytoplasmic inhibitor, Kelch-...

journal_title：Antioxidants & redox signaling

authors： Cho HY,Reddy SP,Kleeberger SR

更新日期：2006-01-01 00:00:00

abstract：:To study early subcellular pathologic changes of tumorigenesis in mouse skin and possible modulation by overexpression of the mitochondrial antioxidant enzyme manganese superoxide dismutase (MnSOD), skin keratinocytes from nontransgenic (Ntg) and transgenic (TgH) mice overexpressing MnSOD topically treated with one do...

journal_title：Antioxidants & redox signaling

authors： Oberley TD,Xue Y,Zhao Y,Kiningham K,Szweda LI,St Clair DK

更新日期：2004-06-01 00:00:00