The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?

abstract：: Aims: The management of myocardial ischemia has been challenged by reperfusion injury. Reactive oxygen species (ROS) production is the critical cause of reperfusion injury, but antioxidant treatment failed to gain satisfactory effects. We hypothesized that improvement of r...

journal_title：Antioxidants & redox signaling

authors： Jiang L,Zeng H,Ni L,Qi L,Xu Y,Xia L,Yu Y,Liu B,Yang H,Hao H,Li P

更新日期：2019-07-20 00:00:00

abstract：AIMS:Excitotoxicity triggered by extrasynaptic N-methyl-d-aspartate-type glutamate receptors has been implicated in many neurodegenerative conditions, including Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, and stroke. Mitochondrial calcium overload leading to mitochondrial dysfunction repre...

journal_title：Antioxidants & redox signaling

authors： Depp C,Bas-Orth C,Schroeder L,Hellwig A,Bading H

更新日期：2018-10-20 00:00:00

abstract：:Fluid shear stress is intimately linked with vascular oxidative stress and atherosclerosis. We posited that atherogenic oscillatory shear stress (OSS) induced mitochondrial superoxide (mtO2•-) production via NADPH oxidase and c-Jun NH(2)-terminal kinase (JNK-1 and JNK-2) signaling. In bovine aortic endothelial cells, ...

journal_title：Antioxidants & redox signaling

authors： Takabe W,Jen N,Ai L,Hamilton R,Wang S,Holmes K,Dharbandi F,Khalsa B,Bressler S,Barr ML,Li R,Hsiai TK

更新日期：2011-09-01 00:00:00

abstract：AIMS:Recent studies suggest that the molybdenum enzymes xanthine oxidase, aldehyde oxidase, and mARC exhibit nitrite reductase activity at low oxygen pressures. However, inhibition studies of xanthine oxidase in humans have failed to block nitrite-dependent changes in blood flow, leading to continued exploration for ot...

journal_title：Antioxidants & redox signaling

authors： Wang J,Krizowski S,Fischer-Schrader K,Niks D,Tejero J,Sparacino-Watkins C,Wang L,Ragireddy V,Frizzell S,Kelley EE,Zhang Y,Basu P,Hille R,Schwarz G,Gladwin MT

更新日期：2015-08-01 00:00:00

abstract：:Autophagy is a bulk degradation process in which cytosolic proteins and organelles are degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we generated adenovirus and cardiac-specific transgenic mice harboring tandem fluorescent mRFP-GFP-LC3. Starvation significantly increased the number of mR...

journal_title：Antioxidants & redox signaling

authors： Hariharan N,Zhai P,Sadoshima J

更新日期：2011-06-01 00:00:00

abstract：AIMS:Astrocytes have been revealed as a controller of synaptic plasticity and memory via releasing gliotransmitters. Our recent findings showed that reactive sulfur species (RSS), including hydrogen sulfide (H2S) and polysulfide (H2Sn), regulated the availability of d-serine, which is a well-known gliotransmitter that ...

journal_title：Antioxidants & redox signaling

authors： Luo H,Wu PF,Han QQ,Cao Y,Deng SL,Wang J,Deng Q,Wang F,Chen JG

更新日期：2019-06-01 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：:The ability of iron to accept or donate electrons, coupled with the ability of oxygen to act as an electron acceptor, renders both elements essential to normal cellular biology. However, these same chemical properties allow free iron in solution to generate toxic free radicals, particularly in combination with oxygen....

journal_title：Antioxidants & redox signaling

authors： Mole DR

更新日期：2010-04-01 00:00:00

abstract：:An increase of mitochondrial-derived reactive oxygen species (ROS) occurs in nerve growth factor (NGF)-deprived sympathetic neurons undergoing apoptotic death. It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen-activated protein kinase kinase (MEK)/mi...

journal_title：Antioxidants & redox signaling

authors： Kirkland RA,Franklin JL

更新日期：2003-10-01 00:00:00

abstract：:The phagocytic NADPH oxidase is recognized as a critical component of innate immunity, responsible for generation of microbicidal reactive oxygen species (ROS). This enzyme is one representative of the Nox family of oxidases (Nox1-Nox5, Duox1, and Duox2) that exhibit diverse expression patterns and appear to serve a v...

journal_title：Antioxidants & redox signaling

authors： Leto TL,Geiszt M

更新日期：2006-09-01 00:00:00

abstract：AIMS:Cigarette smoke (CS)-mediated acquired cystic fibrosis transmembrane conductance regulator (CFTR)-dysfunction, autophagy-impairment, and resulting inflammatory-oxidative/nitrosative stress leads to chronic obstructive pulmonary disease (COPD)-emphysema pathogenesis. Moreover, nitric oxide (NO) signaling regulates ...

journal_title：Antioxidants & redox signaling

authors： Bodas M,Silverberg D,Walworth K,Brucia K,Vij N

更新日期：2017-09-01 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is frequently observed in Alzheimer's disease (AD) and is characterized by deposition of amyloid beta (Aβ) in leptomeningeal and cortical brain vasculature. In 40% of AD cases, Aβ mainly accumulates in cortical capillaries, a phenomenon referred to as capillary CAA (capCAA). The aim o...

journal_title：Antioxidants & redox signaling

authors： Carrano A,Hoozemans JJ,van der Vies SM,Rozemuller AJ,van Horssen J,de Vries HE

更新日期：2011-09-01 00:00:00

abstract：:This brief review first touches on the origins of the earth's oxygen. It then identifies and locates the principal oxygen sensor in vertebrates, the carotid body (CB). The CB is unique in that in human subjects, it is the only sensor of lower than normal levels in the partial pressure of oxygen (hypoxia, HH). Another ...

journal_title：Antioxidants & redox signaling

authors： Fitzgerald RS,Shirahata M,Balbir A,Grossman CE

更新日期：2007-06-01 00:00:00

abstract：:The decision to remove or refold oxidized, denatured, or misfolded proteins by heat shock protein 70 and its binding partners is critical to determine cell fate under pathophysiological conditions. Overexpression of the ubiquitin ligase C-terminus of HSC70 interacting protein (CHIP) can compensate for failure of other...

journal_title：Antioxidants & redox signaling

authors： Stankowski JN,Zeiger SL,Cohen EL,DeFranco DB,Cai J,McLaughlin B

更新日期：2011-05-15 00:00:00

abstract：:It was recently found that age-related changes in SMP30 expression can be modulated by antioxidative action. In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter...

journal_title：Antioxidants & redox signaling

authors： Jung KJ,Maruyama N,Ishigami A,Yu BP,Chung HY

更新日期：2006-03-01 00:00:00

abstract：SIGNIFICANCE:Fetal lung development takes place in hypoxia meaning that premature birth is hyperoxia for the prematurely born infant. The most common respiratory morbidity afflicting premature infants is bronchopulmonary dysplasia (BPD). Pathophysiologically, BPD represents the impact of injury, including O2 toxicity, ...

journal_title：Antioxidants & redox signaling

authors： Tipple TE

更新日期：2014-11-01 00:00:00

abstract：SIGNIFICANCE:Changes in shear stress associated with alterations in blood flow initiate a signaling cascade that modulates the vascular phenotype. Shear stress is "sensed" by the endothelium via a mechanosensitive complex on the endothelial cell (EC) membrane that has been characterized as a "mechanosome" consisting of...

journal_title：Antioxidants & redox signaling

authors： Chatterjee S,Fisher AB

更新日期：2014-02-20 00:00:00

abstract：AIMS:Glutathione peroxidase (GPX) mimic ebselen and superoxide dismutase (SOD) mimic copper diisopropylsalicylate (CuDIPs) were used to rescue impaired glucose-stimulated insulin secretion (GSIS) in islets of GPX1 and(or) SOD1-knockout mice. RESULTS:Ebselen improved GSIS in islets of all four tested genotypes. The res...

journal_title：Antioxidants & redox signaling

authors： Wang X,Yun JW,Lei XG

更新日期：2014-01-10 00:00:00

abstract：AIMS:Oxidative stress is thought to be involved in Friedreich's ataxia (FRDA), yet it has not been demonstrated in the target neurons that are first to degenerate. Using the YG8R mouse model of FRDA, microarray and neuritic growth experiments were carried out in the dorsal root ganglion (DRG), the primary site of neuro...

journal_title：Antioxidants & redox signaling

authors： Shan Y,Schoenfeld RA,Hayashi G,Napoli E,Akiyama T,Iodi Carstens M,Carstens EE,Pook MA,Cortopassi GA

更新日期：2013-11-01 00:00:00

abstract：SIGNIFICANCE:Lysosomes are organelles in which cellular degradation occurs in a controlled manner, separated from other cellular components. As several pathways terminate in the lysosome, lysosomal dysfunction has a profound impact on cell homeostasis, resulting in manifold pathological situations, including infectious...

journal_title：Antioxidants & redox signaling

authors： Boya P

更新日期：2012-09-01 00:00:00

abstract：:Vitamin K epoxide, a by-product of the carboxylation of blood coagulation factors, is reduced to vitamin K by an enzymatic system possessing vitamin K epoxide reductase (VKOR) activity. This system is the target of coumarin-derived drugs widely used in thrombosis therapy and prophylaxis. Recently, the key protein of t...

journal_title：Antioxidants & redox signaling

authors： Oldenburg J,Bevans CG,Müller CR,Watzka M

更新日期：2006-03-01 00:00:00

abstract：:Tumor necrosis factor (TNF) induces a caspase-independent but mitochondria-dependent cell death process in the mouse fibrosarcoma cell line L929. Mitochondria actively participate in this TNF-induced necrotic cell death by the generation of mitochondrial reactive oxygen species (ROS). The aim of this study was to iden...

journal_title：Antioxidants & redox signaling

authors： Goossens V,Stangé G,Moens K,Pipeleers D,Grooten J

更新日期：1999-10-01 00:00:00

abstract：SIGNIFICANCE:Hydrogen sulfide (H2S) is likely to join nitric oxide (NO) and carbon monoxide (CO) as the third gaseous transmitter, influencing an array of intracellular signaling cascades. Thus, H2S is implicated in numerous physiological processes and in the pathology of various diseases. RECENT ADVANCES:H2S-donating...

journal_title：Antioxidants & redox signaling

authors： Kashfi K

更新日期：2014-02-10 00:00:00

abstract：: Aims: To ascertain if human pericytes produce SPARC (acronym for Secreted Protein Acidic and Cysteine Rich), a matricellular protein implicated in the regulation of cell proliferation, migration, and cell-matrix interactions; clarify if SPARC expression in cardiac pericyte...

journal_title：Antioxidants & redox signaling

authors： Avolio E,Mangialardi G,Slater SC,Alvino VV,Gu Y,Cathery W,Beltrami AP,Katare R,Heesom K,Caputo M,Madeddu P

更新日期：2020-11-23 00:00:00

abstract：:The superoxide-generating NADPH oxidase NOX1 is thought to be involved in signaling by the angiotensin II-receptor AT1R. However, underlying signaling steps are poorly understood. In this study, we investigated the effect of AngII on aortic smooth muscle from wild-type and NOX1-deficient mice. NOX1-deficient cells sho...

journal_title：Antioxidants & redox signaling

authors： Basset O,Deffert C,Foti M,Bedard K,Jaquet V,Ogier-Denis E,Krause KH

更新日期：2009-10-01 00:00:00

abstract：:Clinical heart failure has been defined for a long time as a clinical syndrome with symptoms and signs including shortness of breath, cyanosis, ascites, and edema. However, in recent years, with the thought of promoting early diagnosis and heart-failure prevention, the concept of heart failure has often been defined s...

journal_title：Antioxidants & redox signaling

authors： Jameel MN,Zhang J

更新日期：2009-08-01 00:00:00

abstract：AIM:Antrodia Camphorate (AC) is a mushroom that is widely used in Asian countries to prevent and treat various diseases, including liver diseases. However, the active ingredients that contribute to the biological functions remain elusive. The purpose of the present study is to test the hepatoprotective effect of Antcin...

journal_title：Antioxidants & redox signaling

authors： Huo Y,Win S,Than TA,Yin S,Ye M,Hu H,Kaplowitz N

更新日期：2017-02-10 00:00:00

abstract：:Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by redox chemotherapeutics. This review will present an update on drug discovery, target ...

journal_title：Antioxidants & redox signaling

authors： Wondrak GT

更新日期：2009-12-01 00:00:00

abstract：:Heme oxygenase-1 is the rate-limiting enzyme for the degradation of the prooxidant heme. Previously, we showed that an E-box within the HO-1 promoter is crucial for the regulation of HO-1 expression in primary hepatocytes. Further to investigate the importance of this E-box, we determined the regulatory capacity of th...

journal_title：Antioxidants & redox signaling

authors： Samoylenko A,Dimova EY,Horbach T,Teplyuk N,Immenschuh S,Kietzmann T

更新日期：2008-07-01 00:00:00

abstract：SIGNIFICANCE:Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis. Recent Advances: The aim of this review is to...

journal_title：Antioxidants & redox signaling

authors： Feliers D,Lee HJ,Kasinath BS

更新日期：2016-11-01 00:00:00