SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions.

abstract：AIMS:Chronic metabolic impairment and oxidative stress are associated with the pathogenesis of axonal dysfunction in a growing number of neurodegenerative conditions. To investigate the intertwining of both noxious factors, we have chosen the mouse model of adrenoleukodystrophy (X-ALD), which exhibits axonal degenerati...

journal_title：Antioxidants & redox signaling

authors： Galino J,Ruiz M,Fourcade S,Schlüter A,López-Erauskin J,Guilera C,Jove M,Naudi A,García-Arumí E,Andreu AL,Starkov AA,Pamplona R,Ferrer I,Portero-Otin M,Pujol A

更新日期：2011-10-15 00:00:00

abstract：:Increasing evidence indicates that disequilibrium of the alveolar oxidant-antioxidant balance may play a role in the pathogenesis of chronic fibrosing lung diseases. Excessive production of oxidants and a differential regulation of antioxidant enzymes have been described under these conditions. We characterized for th...

journal_title：Antioxidants & redox signaling

authors： Markart P,Luboeinski T,Korfei M,Schmidt R,Wygrecka M,Mahavadi P,Mayer K,Wilhelm J,Seeger W,Guenther A,Ruppert C

更新日期：2009-02-01 00:00:00

abstract：:Myocardial infarction triggers an inflammatory cascade that results in healing and replacement of the damaged tissue with scar. Cardiomyocyte necrosis triggers innate immune mechanisms eliciting Toll-like receptor- mediated responses, activating the complement cascade and generating reactive oxygen species. Subsequent...

journal_title：Antioxidants & redox signaling

authors： Frangogiannis NG

更新日期：2006-11-01 00:00:00

abstract：:The role of free radicals in aging has been a long-standing theory that has now been extended to include both reactive oxygen and nitrogen species. The original concepts that overwhelming oxidative stress depleted antioxidants and thus damaged intracellular targets is being supplanted by the hypothesis that the reacti...

journal_title：Antioxidants & redox signaling

authors： Darley-Usmar V,Starke-Reed PE

更新日期：2000-10-01 00:00:00

abstract：:Molecular chaperones play key roles in protein quality control, signal transduction, proliferation, and cell death, and confer cytoprotection and assure survival after environmental stress. The heat-shock response is implicated in a variety of conditions including ischemic diseases, infection and immunity, neurodegene...

journal_title：Antioxidants & redox signaling

authors： Putics A,Végh EM,Csermely P,Soti C

更新日期：2008-01-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a gasotransmitter with multifaceted physiological functions, including the regulation of glucose metabolism. Methylglyoxal (MG) is an intermediate of glucose metabolism and plays an important role in the pathogenesis of insulin resistance syndromes. In the present study, we investigated the...

journal_title：Antioxidants & redox signaling

authors： Chang T,Untereiner A,Liu J,Wu L

更新日期：2010-05-01 00:00:00

abstract：AIMS:Here we report that chromatin, the complex and dynamic eukaryotic DNA packaging structure, is able to sense cellular redox changes. Histone H3, the only nucleosomal protein that possesses cysteine(s), can be modified by glutathione (GSH). RESULTS:Using Biotin labeled glutathione ethyl ester (BioGEE) treatment of ...

journal_title：Antioxidants & redox signaling

authors： García-Giménez JL,Òlaso G,Hake SB,Bönisch C,Wiedemann SM,Markovic J,Dasí F,Gimeno A,Pérez-Quilis C,Palacios O,Capdevila M,Viña J,Pallardó FV

更新日期：2013-10-20 00:00:00

abstract：AIMS:Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known safety in humans using a hippocampal neuroblast line expressing a reporter...

journal_title：Antioxidants & redox signaling

authors： Aleyasin H,Karuppagounder SS,Kumar A,Sleiman S,Basso M,Ma T,Siddiq A,Chinta SJ,Brochier C,Langley B,Haskew-Layton R,Bane SL,Riggins GJ,Gazaryan I,Starkov AA,Andersen JK,Ratan RR

更新日期：2015-01-10 00:00:00

abstract：:Reactive oxygen species (ROS) generated within the vascular wall trigger low-density lipoprotein (LDL) oxidation, lipid peroxidation, and carbonyl stress that are involved in atherogenesis. We recently reported that the antihypertensive drug, hydralazine, exhibits carbonyl scavenger and antiatherogenic properties, but...

journal_title：Antioxidants & redox signaling

authors： Bouguerne B,Belkheiri N,Bedos-Belval F,Vindis C,Uchida K,Duran H,Grazide MH,Baltas M,Salvayre R,Nègre-Salvayre A

更新日期：2011-06-01 00:00:00

abstract：UNLABELLED:The paracellular cleft within epithelia/endothelia is sealed by tight junction (TJ) proteins. Their extracellular loops (ECLs) are assumed to control paracellular permeability and are targets of pathogenes. We demonstrated that claudin-1 is crucial for paracellular tightening. Its ECL1 is essential for the s...

journal_title：Antioxidants & redox signaling

authors： Dabrowski S,Staat C,Zwanziger D,Sauer RS,Bellmann C,Günther R,Krause E,Haseloff RF,Rittner H,Blasig IE

更新日期：2015-01-01 00:00:00

abstract：SIGNIFICANCE:Currently, calcific aortic valve disease (CAVD) is only treatable through surgical intervention because the specific mechanisms leading to the disease remain unclear. In this review, we explore the forces and structure of the valve, as well as the mechanosensors and downstream signaling in the valve endoth...

journal_title：Antioxidants & redox signaling

authors： Fernández Esmerats J,Heath J,Jo H

更新日期：2016-09-01 00:00:00

abstract：:In this study, we sought to investigate the putative association of the oxidized metabolites derived from linoleic acid (OXFAs) with pediatric nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). We studied 80 obese adolescents (age 13.3 ± 3.31 years; body mass index 33.0 ± 6.79 kg/m(2)), who underwent ...

journal_title：Antioxidants & redox signaling

authors： Santoro N,Caprio S,Giannini C,Kim G,Kursawe R,Pierpont B,Shaw MM,Feldstein AE

更新日期：2014-01-10 00:00:00

abstract：:Loss of redox homeostasis and formation of excessive free radicals play an important role in the pathogenesis of kidney disease and hypertension. Free radicals such as reactive oxygen species (ROS) are necessary in physiologic processes. However, loss of redox homeostasis contributes to proinflammatory and profibrotic...

journal_title：Antioxidants & redox signaling

authors： Nistala R,Whaley-Connell A,Sowers JR

更新日期：2008-12-01 00:00:00

abstract：:Autophagy is a bulk degradation process in which cytosolic proteins and organelles are degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we generated adenovirus and cardiac-specific transgenic mice harboring tandem fluorescent mRFP-GFP-LC3. Starvation significantly increased the number of mR...

journal_title：Antioxidants & redox signaling

authors： Hariharan N,Zhai P,Sadoshima J

更新日期：2011-06-01 00:00:00

abstract：SIGNIFICANCE:Evidence is emerging that parenteral administration of high-dose vitamin C may warrant development as an adjuvant therapy for patients with sepsis. RECENT ADVANCES:Sepsis increases risk of death and disability, but its treatment consists only of supportive therapies because no specific therapy is availabl...

journal_title：Antioxidants & redox signaling

authors： Wilson JX

更新日期：2013-12-10 00:00:00

abstract：SIGNIFICANCE:Ionizing radiation is a vital component in the oncologist's arsenal for the treatment of cancer. Approximately 50% of all cancer patients will receive some form of radiation therapy as part of their treatment regimen. DNA is considered the major cellular target of ionizing radiation and can be damaged dire...

journal_title：Antioxidants & redox signaling

authors： Holley AK,Miao L,St Clair DK,St Clair WH

更新日期：2014-04-01 00:00:00

abstract：SIGNIFICANCE:Cardiovascular diseases are the main cause of death worldwide and pose an immense economical burden. In most cases, the underlying problem is vascular occlusion by atherosclerotic plaques. Importantly, different cell types of the vascular wall and the immune system play crucial roles in atherosclerosis at ...

journal_title：Antioxidants & redox signaling

authors： Kohlgrüber S,Upadhye A,Dyballa-Rukes N,McNamara CA,Altschmied J

更新日期：2017-05-01 00:00:00

abstract：:Reactive oxygen species (ROS) such as superoxide anion (O2-*) and hydrogen peroxide (H2O2) can be produced by vascular endothelium and smooth muscle cells under diverse physiological and pathophysiological situations. These species are known to exert various deleterious effects by which they might induce changes in va...

journal_title：Antioxidants & redox signaling

authors： Tanguy S,Boucher F,Toufektsian MC,Besse S,de Leiris J

更新日期：2000-07-01 00:00:00

abstract：:Epidemiological studies have shown that advancing age is associated with an increased prevalence of cardiovascular disease (CVD). Vascular smooth muscle cells (VSMC) comprise the major arterial cell population, and changes in VSMC behavior, function, and redox status with age contribute to alterations in vascular remo...

journal_title：Antioxidants & redox signaling

authors： Li M,Fukagawa NK

更新日期：2010-03-01 00:00:00

abstract：:Mitochondrial uncoupling proteins (UCPs), a subfamily of the mitochondrial transporter family, are related by sequence homology to UCP1. This protein, which is located in the inner mitochondrial membrane, dissipates the proton gradient between the intermembrane space and the mitochondrial matrix to uncouple electron t...

journal_title：Antioxidants & redox signaling

authors： Kim-Han JS,Dugan LL

更新日期：2005-09-01 00:00:00

abstract：: Significance: Unique to the branched-chain aminotransferase (BCAT) proteins is their redox-active CXXC motif. Subjected to post-translational modification by reactive oxygen species and reactive nitrogen species, these proteins have the potential to adopt numerous cellular...

journal_title：Antioxidants & redox signaling

authors： Conway ME

更新日期：2020-08-03 00:00:00

abstract：:It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides through their Se-independent glutathione peroxidase activity and that these enzymes can also detoxify lipid peroxidation end products such as 4-hydroxynonenal (4-HNE). In this article, recent studies suggesting that the Alpha clas...

journal_title：Antioxidants & redox signaling

authors： Sharma R,Yang Y,Sharma A,Awasthi S,Awasthi YC

更新日期：2004-04-01 00:00:00

abstract：AIM:The present study was designed to explore the effects of hydrogen sulfide (H2S) on Ca(2+) homeostasis in rat pancreatic acini. RESULTS:Sodium hydrosulfide (NaHS; an H2S donor) induced a biphasic increase in the intracellular Ca(2+) concentration ([Ca(2+)]i) in a dose-dependent manner. The NaHS-induced [Ca(2+)]i el...

journal_title：Antioxidants & redox signaling

authors： Moustafa A,Habara Y

更新日期：2014-02-10 00:00:00

abstract：:Signal transduction via PI 3-kinases plays an important role in regulating the cellular processes of cell growth, survival, proliferation, and motility. The stimulated generation of reactive oxygen species is a necessary component of the signal transduction mechanisms by which many growth factors and cytokines activat...

journal_title：Antioxidants & redox signaling

authors： Leslie NR

更新日期：2006-09-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：:The ability to couple photosynthetic electron transport and redox poise to plastid gene expression enables plants to respond to environmental conditions and coordinate nuclear and chloroplast activities in order to maintain photosynthetic efficiency. The plastid redox regulatory system serves as a paradigm for underst...

journal_title：Antioxidants & redox signaling

authors： Barnes D,Mayfield SP

更新日期：2003-02-01 00:00:00

abstract：AIMS:Oxidative stress is thought to be involved in Friedreich's ataxia (FRDA), yet it has not been demonstrated in the target neurons that are first to degenerate. Using the YG8R mouse model of FRDA, microarray and neuritic growth experiments were carried out in the dorsal root ganglion (DRG), the primary site of neuro...

journal_title：Antioxidants & redox signaling

authors： Shan Y,Schoenfeld RA,Hayashi G,Napoli E,Akiyama T,Iodi Carstens M,Carstens EE,Pook MA,Cortopassi GA

更新日期：2013-11-01 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor for cardiovascular disease, stroke, and thrombosis. Several animal models of hyperhomocysteinemia have been developed by using both dietary and genetic approaches. These animal models have provided considerable insight into the mechanisms underlying the adverse vascular effects of...

journal_title：Antioxidants & redox signaling

authors： Dayal S,Lentz SR

更新日期：2007-11-01 00:00:00

abstract：:Transforming growth factor-betas (TGF-beta) regulate a wide variety of cellular functions in normal development and are involved in both tissue homeostasis and disease pathogenesis. The regulation of the TGF-beta family of growth factors is unique because they are targeted to the extracellular matrix in a biologically...

journal_title：Antioxidants & redox signaling

authors： Koli K,Myllärniemi M,Keski-Oja J,Kinnula VL

更新日期：2008-02-01 00:00:00

abstract：SIGNIFICANCE:Heart disease is the primary cause of death in the industrialized world. Cardiac failure is dictated by an uncompensated reduction in the number of viable and fully functional cardiomyocytes. While current pharmacological therapies alleviate the symptoms associated with cardiac deterioration, heart transpl...

journal_title：Antioxidants & redox signaling

authors： Goichberg P,Chang J,Liao R,Leri A

更新日期：2014-11-10 00:00:00