Signaling by the arc two-component system provides a link between the redox state of the quinone pool and gene expression.

abstract：:Apoptosis is a highly regulated process essential for the development and homeostasis of multicellular organisms. Whereas caspases, a large family of intracellular cysteine proteases, play central roles in the execution of apoptosis, other proapoptotic and antiapoptotic regulators such as the members of the Bcl-2 fami...

journal_title：Antioxidants & redox signaling

authors： Takeda K,Naguro I,Nishitoh H,Matsuzawa A,Ichijo H

更新日期：2011-08-01 00:00:00

abstract：:This work rests on our previous report (J Cereb Blood Flow Metab 30: 1275-1287, 2010) recognizing that glutamate (Glu) oxaloacetate transaminase (GOT) is induced when brain tissue hypoxia is corrected during acute ischemic stroke (AIS). GOT can metabolize Glu into tricarboxylic acid cycle intermediates and may therefo...

journal_title：Antioxidants & redox signaling

authors： Rink C,Gnyawali S,Peterson L,Khanna S

更新日期：2011-05-15 00:00:00

abstract：:Although much is known about how TNF-alpha induces apoptosis in the presence of inhibitors of protein synthesis, little is known about how it induces apoptosis without these inhibitors. In this report we investigated temporal sequence of events induced by TNF-alpha in the absence of protein synthesis. Regardless of wh...

journal_title：Antioxidants & redox signaling

authors： Shakibaei M,Sung B,Sethi G,Aggarwal BB

更新日期：2010-09-15 00:00:00

abstract：SIGNIFICANCE:A wealth of fluorescent reporters and imaging systems are now available to characterize dynamic physiological processes in living cells with high spatiotemporal resolution. The most reliable probes for quantitative measurements show shifts in their excitation or emission spectrum, rather than just a change...

journal_title：Antioxidants & redox signaling

authors： Fricker MD

更新日期：2016-05-01 00:00:00

abstract：SIGNIFICANCE:Many cardiovascular disorders are accompanied by a deregulated cellular redox balance resulting in elevated levels of intracellular reactive oxygen species (ROS). One major antioxidative cellular molecule is thioredoxin-1 (Trx-1). Its indispensability is demonstrated by the embryonic lethality of Trx-1 def...

journal_title：Antioxidants & redox signaling

authors： Zschauer TC,Matsushima S,Altschmied J,Shao D,Sadoshima J,Haendeler J

更新日期：2013-03-20 00:00:00

abstract：AIM:Epithelial-mesenchymal transition (EMT) is characterized by the acquisition of invasive fibroblast-like morphology by epithelial cells that are highly polarized. EMT is recognized as a crucial mechanism in cancer progression and metastasis. In this study, we sought to assess the involvement of manganese superoxide ...

journal_title：Antioxidants & redox signaling

authors： Loo SY,Hirpara JL,Pandey V,Tan TZ,Yap CT,Lobie PE,Thiery JP,Goh BC,Pervaiz S,Clément MV,Kumar AP

更新日期：2016-08-20 00:00:00

abstract：: Significance: Hypertension is characterized as the imbalance of vasoconstriction and vasodilatation. Hypertension is influenced by genetic variation and environmental risk factors, such as unhealthy diet. Clinical trial results suggest that increasing intake of foods rich ...

journal_title：Antioxidants & redox signaling

authors： Wang H,Li Q,Zhu Y,Zhang X

更新日期：2020-06-12 00:00:00

abstract：AIMS:The usefulness of estrogen replacement therapy (ERT) in preventing oxidative stress associated with menopause is controversial. We aimed to study if there is a critical time window for effective treatment of the effects of ovariectomy with estrogens at the molecular, metabolic, and cellular level. RESULTS:Our mai...

journal_title：Antioxidants & redox signaling

authors： López-Grueso R,Gambini J,Abdelaziz KM,Monleón D,Díaz A,El Alami M,Bonet-Costa V,Borrás C,Viña J

更新日期：2014-01-10 00:00:00

abstract：:The development of multidrug resistance to cancer chemotherapy is a major obstacle to the effective treatment of human malignancies. It has been established that membrane proteins, notably multidrug resistance (MDR), multidrug resistance protein (MRP), and breast cancer resistance protein (BCRP) of the ATP binding cas...

journal_title：Antioxidants & redox signaling

authors： Kuo MT

更新日期：2009-01-01 00:00:00

abstract：SIGNIFICANCE:Therapeutic hypothermia is commonly applied to limit ischemic injury in organ transplantation, during cardiac and brain surgery and after cardiopulmonary resuscitation. In these procedures, the kidneys are particularly at risk for ischemia/reperfusion injury (IRI), likely due to their high rate of metaboli...

journal_title：Antioxidants & redox signaling

authors： Dugbartey GJ,Hardenberg MC,Kok WF,Boerema AS,Carey HV,Staples JF,Henning RH,Bouma HR

更新日期：2017-09-20 00:00:00

abstract：AIMS:Myocardial ischemia/reperfusion (I/R) is associated with mitochondrial dysfunction and subsequent cardiomyocyte death. The generation of excessive quantities of reactive oxygen species (ROS) and resultant damage to mitochondrial enzymes is considered an important mechanism underlying reperfusion injury. Mitochondr...

journal_title：Antioxidants & redox signaling

authors： Gorenkova N,Robinson E,Grieve DJ,Galkin A

更新日期：2013-11-01 00:00:00

abstract：:Transforming growth factor-betas (TGF-beta) regulate a wide variety of cellular functions in normal development and are involved in both tissue homeostasis and disease pathogenesis. The regulation of the TGF-beta family of growth factors is unique because they are targeted to the extracellular matrix in a biologically...

journal_title：Antioxidants & redox signaling

authors： Koli K,Myllärniemi M,Keski-Oja J,Kinnula VL

更新日期：2008-02-01 00:00:00

abstract：: Significance: Metabolic syndrome (MetS) represents a cluster of cardiometabolic disorders, which accelerate the risk of developing diabetes, nonalcoholic fatty liver disease, and cardiovascular disorders such as atherosclerosis. Oxidative stress (OxS) and inflammation cont...

journal_title：Antioxidants & redox signaling

authors： Foisy Sauvé M,Spahis S,Delvin E,Levy E

更新日期：2021-01-20 00:00:00

abstract：:From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemis...

journal_title：Antioxidants & redox signaling

authors： San Martin A,Griendling KK

更新日期：2014-06-10 00:00:00

abstract：:The ability to couple photosynthetic electron transport and redox poise to plastid gene expression enables plants to respond to environmental conditions and coordinate nuclear and chloroplast activities in order to maintain photosynthetic efficiency. The plastid redox regulatory system serves as a paradigm for underst...

journal_title：Antioxidants & redox signaling

authors： Barnes D,Mayfield SP

更新日期：2003-02-01 00:00:00

abstract：:Peroxisomes are multifunctional organelles with an important role in the generation and decomposition of reactive oxygen species (ROS). In this review, the ROS-producing enzymes, as well as the antioxidative defense system in mammalian peroxisomes, are described. In addition, various conditions leading to disturbances...

journal_title：Antioxidants & redox signaling

authors： Antonenkov VD,Grunau S,Ohlmeier S,Hiltunen JK

更新日期：2010-08-15 00:00:00

abstract：AIMS:Protein aggregation and oxidative stress are both key pathogenic processes in Parkinson's disease, although the mechanism by which misfolded proteins induce oxidative stress and neuronal death remains unknown. In this study, we describe how aggregation of alpha-synuclein (α-S) from its monomeric form to its solubl...

journal_title：Antioxidants & redox signaling

authors： Deas E,Cremades N,Angelova PR,Ludtmann MH,Yao Z,Chen S,Horrocks MH,Banushi B,Little D,Devine MJ,Gissen P,Klenerman D,Dobson CM,Wood NW,Gandhi S,Abramov AY

更新日期：2016-03-01 00:00:00

abstract：: Significance: Streptococcus pneumoniae (Spn), a facultative anaerobic Gram-positive human pathogen with increasing rates of penicillin and macrolide resistance, is a major cause of lower respiratory tract infections worldwide. Pneumococci are a primary agent of severe pneum...

journal_title：Antioxidants & redox signaling

authors： Mraheil MA,Toque HA,La Pietra L,Hamacher J,Phanthok T,Verin A,Gonzales J,Su Y,Fulton D,Eaton DC,Chakraborty T,Lucas R

更新日期：2020-08-14 00:00:00

abstract：:Peroxiredoxins (Prxs) are a family of peroxidases that reduce peroxides, with a conserved cysteine residue (the peroxidatic Cys) serving as the site of oxidation by peroxides. Peroxides oxidize the peroxidatic Cys-SH to Cys-SOH, which then reacts with another cysteine residue (typically the resolving Cys [C(R)]) to fo...

journal_title：Antioxidants & redox signaling

authors： Rhee SG,Woo HA

更新日期：2011-08-01 00:00:00

abstract：:Protein and amine halogenation is a type of oxidative stress induced by phagocytic overstimulation, and its role in Parkinson's disease (PD) has not been discerned. We have detected that advanced oxidized protein products, markers of protein halogenation, are reliably enhanced in serum of patients with PD (n=60) relat...

journal_title：Antioxidants & redox signaling

authors： García-Moreno JM,Martín de Pablos A,García-Sánchez MI,Méndez-Lucena C,Damas-Hermoso F,Rus M,Chacón J,Fernández E

更新日期：2013-04-10 00:00:00

abstract：: Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays a significant role in the control of redox balance, which is crucial in cancer cells. NRF2 a...

journal_title：Antioxidants & redox signaling

authors： Smolková K,Mikó E,Kovács T,Leguina-Ruzzi A,Sipos A,Bai P

更新日期：2020-11-01 00:00:00

abstract：AIMS:The purpose of this study was to investigate differential nicotinamide adenine dinucleotide phosphate, reduced (NADPH) production between radiation-sensitive and -resistant head and neck squamous cell carcinoma (HNSCC) cell lines and whether these differences are predictive of sensitivity to the chemotherapeutic β...

journal_title：Antioxidants & redox signaling

authors： Lewis JE,Costantini F,Mims J,Chen X,Furdui CM,Boothman DA,Kemp ML

更新日期：2018-10-01 00:00:00

abstract：SIGNIFICANCE:Mitochondrial function is central to a wide range of biological processes in health and disease and there is considerable interest in developing small molecules that are taken up by mitochondria and act as either probes of mitochondrial function or therapeutics in vivo. RECENT ADVANCES:Various strategies ...

journal_title：Antioxidants & redox signaling

authors： Smith RA,Hartley RC,Murphy MP

更新日期：2011-12-15 00:00:00

abstract：:Apoptosis mediates the precise and programmed natural death of neurons and is a physiologically important process in neurogenesis during maturation of the central nervous system. However, premature apoptosis and/or an aberration in apoptosis regulation is implicated in the pathogenesis of neurodegeneration, a multifac...

journal_title：Antioxidants & redox signaling

authors： Okouchi M,Ekshyyan O,Maracine M,Aw TY

更新日期：2007-08-01 00:00:00

abstract：AIM:The present study was designed to explore the effects of hydrogen sulfide (H2S) on Ca(2+) homeostasis in rat pancreatic acini. RESULTS:Sodium hydrosulfide (NaHS; an H2S donor) induced a biphasic increase in the intracellular Ca(2+) concentration ([Ca(2+)]i) in a dose-dependent manner. The NaHS-induced [Ca(2+)]i el...

journal_title：Antioxidants & redox signaling

authors： Moustafa A,Habara Y

更新日期：2014-02-10 00:00:00

abstract：:In this study, we sought to investigate the putative association of the oxidized metabolites derived from linoleic acid (OXFAs) with pediatric nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). We studied 80 obese adolescents (age 13.3 ± 3.31 years; body mass index 33.0 ± 6.79 kg/m(2)), who underwent ...

journal_title：Antioxidants & redox signaling

authors： Santoro N,Caprio S,Giannini C,Kim G,Kursawe R,Pierpont B,Shaw MM,Feldstein AE

更新日期：2014-01-10 00:00:00

abstract：SIGNIFICANCE:Chronic noncommunicable diseases (NCDs) are the leading causes of disability and death worldwide. NCDs mainly comprise diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and neurological degenerative diseases, which kill more than 80% of population, especially the el...

journal_title：Antioxidants & redox signaling

authors： Pacifici F,Della Morte D,Capuani B,Pastore D,Bellia A,Sbraccia P,Di Daniele N,Lauro R,Lauro D

更新日期：2019-01-20 00:00:00

abstract：:Our laboratory demonstrated that hyperhomocysteinemia accelerates atherosclerosis in mouse models through ER stress and activation of the unfolded protein response (UPR). In this study, we tested the hypothesis that homocysteine-induced ER stress may arise from ER-Ca(2+) disequilibria. We found that homocysteine-induc...

journal_title：Antioxidants & redox signaling

authors： Dickhout JG,Sood SK,Austin RC

更新日期：2007-11-01 00:00:00

abstract：: Significance: Humans cannot synthesize ascorbic acid (AscH2) (vitamin C), so deficiencies in dietary AscH2 cause the life-threatening disease of scurvy and many other diseases. After oral ingestion, plasma AscH2 concentrations are strictly controlled by transporters, which...

journal_title：Antioxidants & redox signaling

authors： Pozzer D,Invernizzi RW,Blaauw B,Cantoni O,Zito E

更新日期：2020-01-22 00:00:00

abstract：:Sirtuin-1 (SIRT1) is an NAD(+)-dependent protein deacetylase that is sensitive to oxidative signals. Our purpose was to determine whether SIRT1 activity is sensitive to the low molecular weight nitrosothiol, S-nitrosoglutathione (GSNO), which can transduce oxidative signals into physiological responses. SIRT1 formed m...

journal_title：Antioxidants & redox signaling

authors： Zee RS,Yoo CB,Pimentel DR,Perlman DH,Burgoyne JR,Hou X,McComb ME,Costello CE,Cohen RA,Bachschmid MM

更新日期：2010-10-01 00:00:00