Renal Mitochondrial Response to Low Temperature in Non-Hibernating and Hibernating Species.

abstract：:Nitric oxide (NO) mediates cellular signaling pathways that regulate a plethora of physiological processes. One of the signaling mechanisms mediated by NO is through S-nitrosylation of cysteine residues in target proteins, which is now regarded as an important redox-based physiological action. Deregulation of the prot...

journal_title：Antioxidants & redox signaling

authors： Shahani N,Sawa A

更新日期：2011-04-15 00:00:00

abstract：:Oxidative stress plays a significant role in the pathogenesis of coronary artery disease (CAD). A p22(phox)-based NAD(P)H oxidase acts as a potent superoxide-generating system in the vasculature. We studied the association of the A640G and the C242T polymorphisms with clinical risk factors, endothelial function, and s...

journal_title：Antioxidants & redox signaling

authors： Zafari AM,Davidoff MN,Austin H,Valppu L,Cotsonis G,Lassègue B,Griendling KK

更新日期：2002-08-01 00:00:00

abstract：:From the initial discovery in 1999 that NADPH oxidases comprise a family of enzymes to our current focus on drug development to treat multiple pathologies related to this enzyme family, progress has been swift and impressive. We have expanded our understanding of the extent of the family, the basic enzymatic biochemis...

journal_title：Antioxidants & redox signaling

authors： San Martin A,Griendling KK

更新日期：2014-06-10 00:00:00

abstract：:Reactive oxygen and nitrogen species inhibit or promote cell proliferation by modulating the cell signaling pathways that dictate decisions between cell survival, proliferation, and death. In the growth factor-dependent pathways that regulate mitogenesis, numerous positive and negative effectors of signaling are influ...

journal_title：Antioxidants & redox signaling

authors： Burch PM,Heintz NH

更新日期：2005-05-01 00:00:00

abstract：SIGNIFICANCE:The rising global prevalence of diabetes and its debilitating complications give rise to significant disability and premature mortality. Due to the silent nature of diabetes and its vascular complications, and limitations in current methods for detection, there is a need for novel biomarkers for early dete...

journal_title：Antioxidants & redox signaling

authors： Fan B,Luk AOY,Chan JCN,Ma RCW

更新日期：2018-10-10 00:00:00

abstract：:Autophagy is a bulk degradation process in which cytosolic proteins and organelles are degraded through lysosomes. To evaluate autophagic flux in cardiac myocytes, we generated adenovirus and cardiac-specific transgenic mice harboring tandem fluorescent mRFP-GFP-LC3. Starvation significantly increased the number of mR...

journal_title：Antioxidants & redox signaling

authors： Hariharan N,Zhai P,Sadoshima J

更新日期：2011-06-01 00:00:00

abstract：:Nitrite, previously considered physiologically irrelevant and a simple end product of endogenous nitric oxide (NO) metabolism, is now envisaged as a reservoir of NO to be activated in response to oxygen (O(2)) depletion. In the first part of this review, we summarize and compare the mechanisms of nitrite-dependent pro...

journal_title：Antioxidants & redox signaling

authors： Castiglione N,Rinaldo S,Giardina G,Stelitano V,Cutruzzolà F

更新日期：2012-08-15 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia and a progressive neurodegeneration that appears to result from multiple pathogenic mechanisms (including protein misfolding/aggregation, involved in both amyloid β-dependent senile plaques and tau-dependent neurofibrillary tangles), metabolic and mitochond...

journal_title：Antioxidants & redox signaling

authors： von Bernhardi R,Eugenín J

更新日期：2012-05-01 00:00:00

abstract：:Increased oxidative stress and impaired heat shock protein (HSP) synthesis may contribute to diabetic nephropathy. The question of whether 8-week thiol antioxidant alpha-lipoic acid (LA) supplementation modulates HSP response and oxidative stress was studied in the kidney of streptozotocin-induced diabetic (SID) and n...

journal_title：Antioxidants & redox signaling

authors： Oksala NK,Lappalainen J,Laaksonen DE,Khanna S,Kaarniranta K,Sen CK,Atalay M

更新日期：2007-04-01 00:00:00

abstract：:An increase of mitochondrial-derived reactive oxygen species (ROS) occurs in nerve growth factor (NGF)-deprived sympathetic neurons undergoing apoptotic death. It has been reported that NGF suppresses increased ROS production by the mitochondria in these cells through a mitogen-activated protein kinase kinase (MEK)/mi...

journal_title：Antioxidants & redox signaling

authors： Kirkland RA,Franklin JL

更新日期：2003-10-01 00:00:00

abstract：: Significance: The tricarboxylic acid (TCA) cycle is a housekeeping metabolic pathway essential for generation of energy and biosynthetic intermediates. Alterations of the TCA cycle play a pivotal role in oncogenesis and inflammation. As such, some metabolic vulnerabilities...

journal_title：Antioxidants & redox signaling

authors： Scagliola A,Mainini F,Cardaci S

更新日期：2020-04-20 00:00:00

abstract：:Glutathione peroxidases and thioredoxin reductases are the main selenoproteins expressed by endothelial cells. These enzymes reduce hydroperoxides, their role in endothelial cell physiology, however, by far exceeds prevention of oxidative damage. Reactive oxygen and nitrogen species, especially superoxide, hydroperoxi...

journal_title：Antioxidants & redox signaling

authors： Brigelius-Flohé R,Banning A,Schnurr K

更新日期：2003-04-01 00:00:00

abstract：:Efficient extracellular hemoglobin (Hb) clearance is essential to prevent oxidative- and nitrosative-mediated toxicity. CD163 belongs to group B of the scavenger receptor cysteine-rich (SRCR) protein family found on the surface of monocytes and macrophages and is responsible for Hb-haptoglobin (Hp) complex uptake. Hb ...

journal_title：Antioxidants & redox signaling

authors： Schaer DJ,Alayash AI,Buehler PW

更新日期：2007-07-01 00:00:00

abstract：SIGNIFICANCE:The precise role and impact of reactive oxygen species (ROS) in stem cells, which are essential for lifelong tissue homeostasis and regeneration, remain of significant interest to the field. The long-term regenerative potential of a stem cell compartment is determined by the delicate balance between quiesc...

journal_title：Antioxidants & redox signaling

authors： Tan DQ,Suda T

更新日期：2018-07-10 00:00:00

abstract：AIMS:The immune system is critical for protection against infections and cancer, but requires scrupulous regulation to limit self-reactivity and autoimmunity. Our group has utilized a manganese porphyrin catalytic antioxidant (MnTE-2-PyP(5+), MnP) as a potential immunoregulatory therapy for type 1 diabetes. MnP has pre...

journal_title：Antioxidants & redox signaling

authors： Delmastro-Greenwood MM,Votyakova T,Goetzman E,Marre ML,Previte DM,Tovmasyan A,Batinic-Haberle I,Trucco MM,Piganelli JD

更新日期：2013-12-01 00:00:00

abstract：SIGNIFICANCE:Currently, calcific aortic valve disease (CAVD) is only treatable through surgical intervention because the specific mechanisms leading to the disease remain unclear. In this review, we explore the forces and structure of the valve, as well as the mechanosensors and downstream signaling in the valve endoth...

journal_title：Antioxidants & redox signaling

authors： Fernández Esmerats J,Heath J,Jo H

更新日期：2016-09-01 00:00:00

abstract：:The intraerythrocytic protozoan parasite Plasmodium falciparum is responsible for more than 500 million clinical cases of tropical malaria annually. Although exposed to high fluxes of reactive oxygen species, Plasmodium lacks the antioxidant enzymes catalase and glutathione peroxidase. Thus, the parasite depends on th...

journal_title：Antioxidants & redox signaling

authors： Nickel C,Rahlfs S,Deponte M,Koncarevic S,Becker K

更新日期：2006-07-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) plays a crucial role in tissue pathological changes such as brain injuries. Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, via mitogen-activated protein kinases and nuclear fact...

journal_title：Antioxidants & redox signaling

authors： Hsieh HL,Wang HH,Wu CY,Yang CM

更新日期：2010-12-15 00:00:00

abstract：AIMS:We have tested the hypothesis that selenium (Se)-containing antioxidative enzymes protect thyroid epithelial cells from oxidative damage associated with enzymatic production of hydrogen peroxide required for thyroid hormone biosynthesis. Thyroid epithelial cells therefore express antioxidative enzymes, including c...

journal_title：Antioxidants & redox signaling

authors： Chiu-Ugalde J,Wirth EK,Klein MO,Sapin R,Fradejas-Villar N,Renko K,Schomburg L,Köhrle J,Schweizer U

更新日期：2012-09-15 00:00:00

abstract：:Aging of somatic cells can be defined as the gradual loss of the information embedded in the global and local properties of complex macromolecular networks. This loss of information may reflect the dynamic interplay between stochastic factors, such as the accumulation of unrepaired somatic damage, and gene-encoded pro...

journal_title：Antioxidants & redox signaling

authors： Suh Y,Vijg J

更新日期：2006-03-01 00:00:00

abstract：AIMS:Abnormal accumulation of α-synuclein aggregates is one of the key pathological features of many neurodegenerative movement disorders and dementias. These pathological aggregates propagate into larger brain regions as the disease progresses, with the associated clinical symptoms becoming increasingly severe and com...

journal_title：Antioxidants & redox signaling

authors： Bae EJ,Ho DH,Park E,Jung JW,Cho K,Hong JH,Lee HJ,Kim KP,Lee SJ

更新日期：2013-03-01 00:00:00

abstract：:Epithelial to mesenchymal transition (EMT) is a fundamental process, paradigmatic of the concept of cell plasticity, that leads epithelial cells to lose their polarization and specialized junctional structures, to undergo cytoskeleton reorganization, and to acquire morphological and functional features of mesenchymal-...

journal_title：Antioxidants & redox signaling

authors： Cannito S,Novo E,di Bonzo LV,Busletta C,Colombatto S,Parola M

更新日期：2010-06-15 00:00:00

abstract：:This Forum issue "Heme Oxygenase" (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual rol...

journal_title：Antioxidants & redox signaling

authors： Facchinetti MM

更新日期：2020-06-10 00:00:00

abstract：:Trisulfides and other oligosulfides are widely distributed in the biological world. In plants, for example, garlic, trisulfides are associated with potentially beneficial properties. However, an extra neutral sulfur atom covalently bound between the two sulfur atoms of a pair of cysteines is not a common post-translat...

journal_title：Antioxidants & redox signaling

authors： Nielsen RW,Tachibana C,Hansen NE,Winther JR

更新日期：2011-07-01 00:00:00

abstract：: Aims: Autophagy is a catabolic process required for the maintenance of cardiac health. Insulin and insulin-like growth factor 1 (IGF-1) are potent inhibitors of autophagy and as such, one would predict that autophagy will be increased in the insulin-resistant/diabetic hear...

journal_title：Antioxidants & redox signaling

authors： Pires KM,Torres NS,Buffolo M,Gunville R,Schaaf C,Davis K,Selzman CH,Gottlieb RA,Boudina S

更新日期：2019-08-20 00:00:00

abstract：:Vitamin K epoxide, a by-product of the carboxylation of blood coagulation factors, is reduced to vitamin K by an enzymatic system possessing vitamin K epoxide reductase (VKOR) activity. This system is the target of coumarin-derived drugs widely used in thrombosis therapy and prophylaxis. Recently, the key protein of t...

journal_title：Antioxidants & redox signaling

authors： Oldenburg J,Bevans CG,Müller CR,Watzka M

更新日期：2006-03-01 00:00:00

abstract：AIMS:Peripheral artery disease is caused by the restriction or occlusion of arteries supplying the leg. Better understanding of the molecular mechanisms underpinning tissue response to ischemia is urgently needed to improve therapeutic options. The aim of this study is to investigate hypoxia-induced miR-210 regulation ...

journal_title：Antioxidants & redox signaling

authors： Zaccagnini G,Maimone B,Di Stefano V,Fasanaro P,Greco S,Perfetti A,Capogrossi MC,Gaetano C,Martelli F

更新日期：2014-09-10 00:00:00

abstract：:Cerebral amyloid angiopathy (CAA) is frequently observed in Alzheimer's disease (AD) and is characterized by deposition of amyloid beta (Aβ) in leptomeningeal and cortical brain vasculature. In 40% of AD cases, Aβ mainly accumulates in cortical capillaries, a phenomenon referred to as capillary CAA (capCAA). The aim o...

journal_title：Antioxidants & redox signaling

authors： Carrano A,Hoozemans JJ,van der Vies SM,Rozemuller AJ,van Horssen J,de Vries HE

更新日期：2011-09-01 00:00:00

abstract：AIMS:Nuclear factor-erythroid-related factor 2 (Nrf2) is a critical transcriptional factor that is used in regulating cellular defense against oxidative stress. This study is aimed at investigating new interacting protein partners of Nrf2 using One-strep tag pull-down coupled with LTQ Orbitrap LC/MS/MS, and at examinin...

journal_title：Antioxidants & redox signaling

authors： Kim JH,Xu EY,Sacks DB,Lee J,Shu L,Xia B,Kong AN

更新日期：2013-07-10 00:00:00

abstract：AIMS:Adenosine triphosphate (ATP) synthase uses chemiosmotic energy across the inner mitochondrial membrane to convert adenosine diphosphate and orthophosphate into ATP, whereas genetic deletion of Sirt3 decreases mitochondrial ATP levels. Here, we investigate the mechanistic connection between SIRT3 and energy homeost...

journal_title：Antioxidants & redox signaling

authors： Vassilopoulos A,Pennington JD,Andresson T,Rees DM,Bosley AD,Fearnley IM,Ham A,Flynn CR,Hill S,Rose KL,Kim HS,Deng CX,Walker JE,Gius D

更新日期：2014-08-01 00:00:00