Redox regulation of sirtuin-1 by S-glutathiolation.

abstract：:Tetrahydrobiopterin (BH4) functions as a cofactor for several important enzyme systems, and considerable evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of cardiovascular health and disease. BH4 bioavailability is determined by a balance of enzymatic de novo synthe...

journal_title：Antioxidants & redox signaling

authors： Bendall JK,Douglas G,McNeill E,Channon KM,Crabtree MJ

更新日期：2014-06-20 00:00:00

abstract：: Significance: Streptococcus pneumoniae (Spn), a facultative anaerobic Gram-positive human pathogen with increasing rates of penicillin and macrolide resistance, is a major cause of lower respiratory tract infections worldwide. Pneumococci are a primary agent of severe pneum...

journal_title：Antioxidants & redox signaling

authors： Mraheil MA,Toque HA,La Pietra L,Hamacher J,Phanthok T,Verin A,Gonzales J,Su Y,Fulton D,Eaton DC,Chakraborty T,Lucas R

更新日期：2020-08-14 00:00:00

abstract：SIGNIFICANCE:The understanding of physiological and pathological processes involving protein oxidation, particularly under conditions of aging and oxidative stress, can be aided by proteomic identification of proteins that accumulate oxidative post-translational modifications only if these detected modifications are co...

journal_title：Antioxidants & redox signaling

authors： Feeney MB,Schöneich C

更新日期：2012-12-01 00:00:00

abstract：AIMS:We have tested the hypothesis that selenium (Se)-containing antioxidative enzymes protect thyroid epithelial cells from oxidative damage associated with enzymatic production of hydrogen peroxide required for thyroid hormone biosynthesis. Thyroid epithelial cells therefore express antioxidative enzymes, including c...

journal_title：Antioxidants & redox signaling

authors： Chiu-Ugalde J,Wirth EK,Klein MO,Sapin R,Fradejas-Villar N,Renko K,Schomburg L,Köhrle J,Schweizer U

更新日期：2012-09-15 00:00:00

abstract：:The role of free radicals in aging has been a long-standing theory that has now been extended to include both reactive oxygen and nitrogen species. The original concepts that overwhelming oxidative stress depleted antioxidants and thus damaged intracellular targets is being supplanted by the hypothesis that the reacti...

journal_title：Antioxidants & redox signaling

authors： Darley-Usmar V,Starke-Reed PE

更新日期：2000-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) have multifaceted roles in the orchestration of plant gene expression and gene-product regulation. Cellular redox homeostasis is considered to be an "integrator" of information from metabolism and the environment controlling plant growth and acclimation responses, as well as cell suicide ...

journal_title：Antioxidants & redox signaling

authors： Foyer CH,Noctor G

更新日期：2009-04-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular disease, complications of pregnancy, cognitive impairment, and osteoporosis. That elevated homocysteine leads to vascular dysfunction may be the linking factor between these apparently unrelated pathologies. Although a growing body of evidence sugge...

journal_title：Antioxidants & redox signaling

authors： Glushchenko AV,Jacobsen DW

更新日期：2007-11-01 00:00:00

abstract：:Lisinopril is an inhibitor of the renin-angiotensin system. Does lisinopril minimize oxidative damage in spontaneously hypertensive rats (SHR) in comparison with the normotensive genetic controls Wistar Kyoto (WKY)? The authors note that lisinopril contained lipid peroxidation, elevated tissue glutathione levels, and ...

journal_title：Antioxidants & redox signaling

authors： Polizio AH,Peña C

更新日期：2007-03-01 00:00:00

abstract：: Aims: Normal mitochondrial function and integrity are crucial for cellular physiology. Given the paramount role of mitochondrial quality control proteases in these processes, our study focused on investigating mechanisms by which the activity of a key quality control prote...

journal_title：Antioxidants & redox signaling

authors： Bohovych I,Dietz JV,Swenson S,Zahayko N,Khalimonchuk O

更新日期：2019-08-20 00:00:00

abstract：:Tumor necrosis factor (TNF) induces a caspase-independent but mitochondria-dependent cell death process in the mouse fibrosarcoma cell line L929. Mitochondria actively participate in this TNF-induced necrotic cell death by the generation of mitochondrial reactive oxygen species (ROS). The aim of this study was to iden...

journal_title：Antioxidants & redox signaling

authors： Goossens V,Stangé G,Moens K,Pipeleers D,Grooten J

更新日期：1999-10-01 00:00:00

abstract：SIGNIFICANCE:Nicotinamide adenine dinucleotide (NAD+) participates in redox reactions and NAD+-dependent signaling processes, which involve the cleavage of NAD+ coupled to posttranslational modifications of proteins or the production of second messengers. Either as a primary cause or as a secondary component of the pat...

journal_title：Antioxidants & redox signaling

authors： Pehar M,Harlan BA,Killoy KM,Vargas MR

更新日期：2018-06-20 00:00:00

abstract：AIMS:Oxidative stress is thought to be involved in Friedreich's ataxia (FRDA), yet it has not been demonstrated in the target neurons that are first to degenerate. Using the YG8R mouse model of FRDA, microarray and neuritic growth experiments were carried out in the dorsal root ganglion (DRG), the primary site of neuro...

journal_title：Antioxidants & redox signaling

authors： Shan Y,Schoenfeld RA,Hayashi G,Napoli E,Akiyama T,Iodi Carstens M,Carstens EE,Pook MA,Cortopassi GA

更新日期：2013-11-01 00:00:00

abstract：: Significance: Heme oxygenase-1 (HO-1) is a ubiquitous 32-kDa protein expressed in many tissues and highly inducible. They catalyze the degradation of the heme group and the release of free iron, carbon monoxide, and biliverdin; the latter converted to bilirubin by biliverd...

journal_title：Antioxidants & redox signaling

authors： Medina MV,Sapochnik D,Garcia Solá M,Coso O

更新日期：2020-05-10 00:00:00

abstract：:Protein-DNA interactions play a key role in the regulation of major cellular metabolic pathways, including gene expression, genome replication, and genomic stability. They are mediated through the interactions of regulatory proteins with their specific DNA-binding sites at promoters, enhancers, and replication origins...

journal_title：Antioxidants & redox signaling

authors： Shlomai J

更新日期：2010-11-01 00:00:00

abstract：SIGNIFICANCE:Cystic fibrosis (CF) is the most common lethal genetic disorder in the Caucasian people. It is due to the mutation of cystic fibrosis transmembrane conductance regulator (CFTR) gene located on the long arm of the chromosome 7, which encodes for CFTR protein. The latter, an adenosine triphosphate binding ca...

journal_title：Antioxidants & redox signaling

authors： Kleme ML,Levy E

更新日期：2015-03-01 00:00:00

abstract：:Ebselen is a selanazal drug recently revealed as a highly efficient peroxiredoxin mimic catalyzing the hydroperoxide reduction by the mammalian thioredoxin system [thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH]. The mammalian Trx system is a dehydroascorbic acid reductase recycling ascorbic acid essential...

journal_title：Antioxidants & redox signaling

authors： Zhao R,Holmgren A

更新日期：2004-02-01 00:00:00

abstract：AIMS:An abnormal generation of reactive oxygen species (ROS) is thought to contribute to systemic sclerosis (SSc), fostering autoimmunity, fibrosis, and vascular inflammation. The function of the prototypic damage-associated molecular pattern, high mobility group box 1 (HMGB1), depends on its redox status. Here we inve...

journal_title：Antioxidants & redox signaling

authors： Maugeri N,Rovere-Querini P,Baldini M,Baldissera E,Sabbadini MG,Bianchi ME,Manfredi AA

更新日期：2014-03-01 00:00:00

abstract：:Intestinal detection of nutrients is a crucial step to inform the whole body of the nutritional status. In this paradigm, peripheral information generated by nutrients is transferred to the brain, which in turn controls physiological functions, including glucose metabolism. Here, we investigated the effect of enteric ...

journal_title：Antioxidants & redox signaling

authors： Duparc T,Naslain D,Colom A,Muccioli GG,Massaly N,Delzenne NM,Valet P,Cani PD,Knauf C

更新日期：2011-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) has recently been viewed as an inflammation-dependent systemic disease. Oxidative modifications in the pulmonary microenvironment can result in a number of functional changes in pulmonary tissue as well as in the blood. Studies have been carried out to detect whether oxidat...

journal_title：Antioxidants & redox signaling

authors： Minetti M,Leto TL,Malorni W

更新日期：2008-04-01 00:00:00

abstract：:Changes in the hemodynamic environment (e.g., hypertension, increased blood flow/shear stress) are known to lead to vascular remodeling; however, the underlying mechanisms by which hemodynamic forces control gene expression in vascular cells are not yet completely understood. This review considers how mechanosensitive...

journal_title：Antioxidants & redox signaling

authors： Ungvari Z,Wolin MS,Csiszar A

更新日期：2006-07-01 00:00:00

abstract：SIGNIFICANCE:The thioredoxin (Trx) superfamily proteins, including protein disulfide isomerases (PDI) and Dsb protein family, are major players in oxidative protein folding, which involves native disulfide bond formation. These proteins contain Trx folds with CXXC active sites and fulfill their physiological functions ...

journal_title：Antioxidants & redox signaling

authors： Lu J,Holmgren A

更新日期：2014-07-20 00:00:00

abstract：:Chronic inflammation is a driving force for gastric carcinogenesis. Reactive oxygen species (ROS) generated during the inflammatory process generates DNA damage that is processed through the DNA repair pathways. In this study, we profiled key DNA repair proteins (single-strand-selective monofunctional uracil-DNA glyco...

journal_title：Antioxidants & redox signaling

authors： Abdel-Fatah T,Arora A,Gorguc I,Abbotts R,Beebeejaun S,Storr S,Mohan V,Hawkes C,Soomro I,Lobo DN,Parsons SL,Madhusudan S

更新日期：2013-06-20 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the progressive development of involuntary choreiform movements, cognitive impairment, neuropsychiatric symptoms, and premature death. These phenotypes reflect neuronal dysfunction and ultimately death in selected brain regions, the...

journal_title：Antioxidants & redox signaling

authors： Browne SE,Beal MF

更新日期：2006-11-01 00:00:00

abstract：SIGNIFICANCE:Chronic myeloid leukemia (CML) involves the malignant transformation of hematopoietic stem cells, defined largely by the Philadelphia chromosome and expression of the breakpoint cluster region-Abelson (BCR-ABL) oncoprotein. Pharmacological tyrosine kinase inhibitors (TKIs), including imatinib mesylate, hav...

journal_title：Antioxidants & redox signaling

authors： Tortorella SM,Hung A,Karagiannis TC

更新日期：2015-06-01 00:00:00

abstract：AIMS:Large doses of intraperitoneally injected basic amino acids, L-arginine, or L-ornithine, induce acute pancreatitis in rodents, although the mechanisms mediating pancreatic toxicity remain unknown. Another basic amino acid, L-lysine, was also shown to cause pancreatic acinar cell injury. The aim of the study was to...

journal_title：Antioxidants & redox signaling

authors： Biczó G,Hegyi P,Dósa S,Shalbuyeva N,Berczi S,Sinervirta R,Hracskó Z,Siska A,Kukor Z,Jármay K,Venglovecz V,Varga IS,Iványi B,Alhonen L,Wittmann T,Gukovskaya A,Takács T,Rakonczay Z Jr

更新日期：2011-11-15 00:00:00

abstract：:Cellular compartments differ dramatically in their redox potentials. This translates directly into variations in the extent of disulfide bond formation within proteins, depending on their cellular localization. It has long been assumed that proteins that are present in the reducing environment of the cytosol do not po...

journal_title：Antioxidants & redox signaling

authors： Linke K,Jakob U

更新日期：2003-08-01 00:00:00

abstract：: Significance: Hypertension is characterized as the imbalance of vasoconstriction and vasodilatation. Hypertension is influenced by genetic variation and environmental risk factors, such as unhealthy diet. Clinical trial results suggest that increasing intake of foods rich ...

journal_title：Antioxidants & redox signaling

authors： Wang H,Li Q,Zhu Y,Zhang X

更新日期：2020-06-12 00:00:00

abstract：:Studies from many laboratories have shown that overexpression of manganese superoxide dismutase (MnSOD) inhibits the growth of numerous tumor cell types. The inhibition of tumor cell growth can be attributed to the increase in the steady-state levels of H2O2 as a result of the increased dismuting activity of MnSOD. He...

journal_title：Antioxidants & redox signaling

authors： Kim KH,Rodriguez AM,Carrico PM,Melendez JA

更新日期：2001-06-01 00:00:00

abstract：:It is well accepted that atherosclerosis occurs in a site-specific manner especially at branch points where disturbed blood flow (d-flow) predisposes to the development of plaques. Investigations both in vivo and in vitro have shown that d-flow is pro-atherogenic by promoting oxidative and inflammatory states in the a...

journal_title：Antioxidants & redox signaling

authors： Nigro P,Abe J,Berk BC

更新日期：2011-09-01 00:00:00

abstract：AIMS:To evaluate mechanisms underlying modulation of inflammatory chemokines in primary human keratinocytes (normal human epidermal keratinocytes) and repair-related processes in wound models by plant polyphenols (PPs) with antioxidant and superoxide scavenging properties (verbascoside [Vb], resveratrol [Rv], polydatin...

journal_title：Antioxidants & redox signaling

authors： Pastore S,Lulli D,Fidanza P,Potapovich AI,Kostyuk VA,De Luca C,Mikhal'chik E,Korkina LG

更新日期：2012-02-15 00:00:00