Axonal mitochondrial clusters containing mutant SOD1 in transgenic models of ALS.

abstract：:Although there is an abundance of evidence suggesting that insulin resistance plays a significant role in the vasculature, the precise mechanistic role involved still remains unclear. In this review, we discuss the current background of insulin resistance in the context of insulin signaling and action in the vasculatu...

journal_title：Antioxidants & redox signaling

authors： Frank GD,Eguchi S,Motley ED

更新日期：2005-07-01 00:00:00

abstract：: Significance: Atherosclerotic cardiovascular diseases (ACVDs) continue to be a primary cause of mortality worldwide in adults aged 35-70 years, occurring more often in countries with lower economic development, and they constitute an ever-growing global burden that has a c...

journal_title：Antioxidants & redox signaling

authors： Gianazza E,Brioschi M,Martinez Fernandez A,Casalnuovo F,Altomare A,Aldini G,Banfi C

更新日期：2021-01-01 00:00:00

abstract：:Tissue oxygen plays a crucial role in maintaining tissue viability and in various diseases, including responses to therapy. Useful knowledge has been gained by methods that can give limited snapshots of tissue oxygen (e.g., oxygen electrodes) or evidence of a history of tissue hypoxia (e.g., EF5) or even indirect evid...

journal_title：Antioxidants & redox signaling

authors： Khan N,Williams BB,Hou H,Li H,Swartz HM

更新日期：2007-08-01 00:00:00

abstract：SIGNIFICANCE:Selenoprotein K (SelK) is an endoplasmic reticulum (ER) membrane protein, and its expression is sensitive to dietary selenium levels. A recently described role for SelK as a cofactor in catalyzing protein palmitoylation reactions provides an important link between low dietary selenium intake and suboptimal...

journal_title：Antioxidants & redox signaling

authors： Fredericks GJ,Hoffmann PR

更新日期：2015-10-01 00:00:00

abstract：:We previously reported a spontaneous development of type 2 diabetes-like phenotypes in glutathione peroxidase-1 (GPX1)-overexpressing (OE) mice. Diet restriction of these mice rescued all their phenotypes, except for hyperinsulinemia and hypersecretion of insulin. This study was to determine whether dietary Se deficie...

journal_title：Antioxidants & redox signaling

authors： Pepper MP,Vatamaniuk MZ,Yan X,Roneker CA,Lei XG

更新日期：2011-02-01 00:00:00

abstract：:Pulmonary surfactant, a complex of lipids and proteins, maintains alveolar integrity and participates in the control of host defense and inflammation in the lung. Surfactant proteins A, B, C, and D are important components of surfactant that play diverse roles in the surface tension reducing as well as host defense an...

journal_title：Antioxidants & redox signaling

authors： Boggaram V

更新日期：2004-02-01 00:00:00

abstract：:Parkinson's disease is characterized by a progressive loss of dopaminergic neurons in the substantia nigra zona compacta, and in other subcortical nuclei associated with a widespread occurrence of Lewy bodies. The causes of cell death in Parkinson's disease are still poorly understood, but a defect in mitochondrial ox...

journal_title：Antioxidants & redox signaling

authors： Sharma SK,Ebadi M

更新日期：2003-06-01 00:00:00

abstract：: Significance: Metabolic syndrome (MetS) represents a cluster of cardiometabolic disorders, which accelerate the risk of developing diabetes, nonalcoholic fatty liver disease, and cardiovascular disorders such as atherosclerosis. Oxidative stress (OxS) and inflammation cont...

journal_title：Antioxidants & redox signaling

authors： Foisy Sauvé M,Spahis S,Delvin E,Levy E

更新日期：2021-01-20 00:00:00

abstract：: Aims: To ascertain if human pericytes produce SPARC (acronym for Secreted Protein Acidic and Cysteine Rich), a matricellular protein implicated in the regulation of cell proliferation, migration, and cell-matrix interactions; clarify if SPARC expression in cardiac pericyte...

journal_title：Antioxidants & redox signaling

authors： Avolio E,Mangialardi G,Slater SC,Alvino VV,Gu Y,Cathery W,Beltrami AP,Katare R,Heesom K,Caputo M,Madeddu P

更新日期：2020-11-23 00:00:00

abstract：:Alteration in neurotrophic factors support and antioxidant defenses in the central nervous system (CNS) along with deficit of ferritin have been associated with idiopathic Parkinson's disease (PD). The objectives were to analyze in the cerebrospinal fluid (CSF) of patients with PD and controls the following: (i) the l...

journal_title：Antioxidants & redox signaling

authors： Martín de Pablos A,García-Moreno JM,Fernández E

更新日期：2015-10-10 00:00:00

abstract：AIMS:Abnormal accumulation of α-synuclein aggregates is one of the key pathological features of many neurodegenerative movement disorders and dementias. These pathological aggregates propagate into larger brain regions as the disease progresses, with the associated clinical symptoms becoming increasingly severe and com...

journal_title：Antioxidants & redox signaling

authors： Bae EJ,Ho DH,Park E,Jung JW,Cho K,Hong JH,Lee HJ,Kim KP,Lee SJ

更新日期：2013-03-01 00:00:00

abstract：:Redox dysregulation originating from metabolic alterations and dependence on mitogenic and survival signaling through reactive oxygen species represents a specific vulnerability of malignant cells that can be selectively targeted by redox chemotherapeutics. This review will present an update on drug discovery, target ...

journal_title：Antioxidants & redox signaling

authors： Wondrak GT

更新日期：2009-12-01 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor for cardiovascular disease, stroke, and thrombosis. Several animal models of hyperhomocysteinemia have been developed by using both dietary and genetic approaches. These animal models have provided considerable insight into the mechanisms underlying the adverse vascular effects of...

journal_title：Antioxidants & redox signaling

authors： Dayal S,Lentz SR

更新日期：2007-11-01 00:00:00

abstract：:The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calor...

journal_title：Antioxidants & redox signaling

authors： Redman LM,Ravussin E

更新日期：2011-01-15 00:00:00

abstract：:Disruption of the oxidant/antioxidant balance in the lung is thought to be a key step in the development of many airway pathologies. Hence, antioxidant enzymes play key roles in controlling or preventing pulmonary diseases related to oxidative stress. The superoxide dismutases (SOD) are a family of enzymes that play a...

journal_title：Antioxidants & redox signaling

authors： Gao F,Kinnula VL,Myllärniemi M,Oury TD

更新日期：2008-02-01 00:00:00

abstract：: Significance: Streptococcus pneumoniae (Spn), a facultative anaerobic Gram-positive human pathogen with increasing rates of penicillin and macrolide resistance, is a major cause of lower respiratory tract infections worldwide. Pneumococci are a primary agent of severe pneum...

journal_title：Antioxidants & redox signaling

authors： Mraheil MA,Toque HA,La Pietra L,Hamacher J,Phanthok T,Verin A,Gonzales J,Su Y,Fulton D,Eaton DC,Chakraborty T,Lucas R

更新日期：2020-08-14 00:00:00

abstract：AIMS:The immune system is critical for protection against infections and cancer, but requires scrupulous regulation to limit self-reactivity and autoimmunity. Our group has utilized a manganese porphyrin catalytic antioxidant (MnTE-2-PyP(5+), MnP) as a potential immunoregulatory therapy for type 1 diabetes. MnP has pre...

journal_title：Antioxidants & redox signaling

authors： Delmastro-Greenwood MM,Votyakova T,Goetzman E,Marre ML,Previte DM,Tovmasyan A,Batinic-Haberle I,Trucco MM,Piganelli JD

更新日期：2013-12-01 00:00:00

abstract：:The Arc two-component system is a complex signal transduction system that plays a key role in regulating energy metabolism at the level of transcription in bacteria. This system comprises the ArcB protein, a tripartite membrane-associated sensor kinase, and the ArcA protein, a typical response regulator. Under anoxic ...

journal_title：Antioxidants & redox signaling

authors： Malpica R,Sandoval GR,Rodríguez C,Franco B,Georgellis D

更新日期：2006-05-01 00:00:00

abstract：SIGNIFICANCE:There are accruing concerns on potential genotoxic agents present in the environment including low-dose ionizing radiation (LDIR) that naturally exists on earth's surface and atmosphere and is frequently used in medical diagnosis and nuclear industry. Although its long-term health risk is being evaluated a...

journal_title：Antioxidants & redox signaling

authors： Alexandrou AT,Li JJ

更新日期：2014-03-20 00:00:00

abstract：:The diabetogenic agent alloxan is a triketone that selectively destroys pancreatic beta cells. To investigate the importance of the triketone structure of alloxan for its cytotoxic potency, alloxan was compared with ninhydrin, also a triketone, and the amino derivative of alloxan uramil, which is not a triketone, beca...

journal_title：Antioxidants & redox signaling

authors： Elsner M,Gurgul-Convey E,Lenzen S

更新日期：2008-04-01 00:00:00

abstract：:Toxic renal failure induced by gentamicin, glycerol, or cisplatin, as well as ischemic renal failure in vivo and hypoxia/reoxygenation of tubular epithelial cells in vitro, induces the production of reactive oxygen metabolites (ROM). Generation of ROM is responsible for the induction of tubular epithelial cell death, ...

journal_title：Antioxidants & redox signaling

authors： Basnakian AG,Kaushal GP,Shah SV

更新日期：2002-12-01 00:00:00

abstract：:Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants, pro-oxidants, antioxidants, and chemopreventive agents. After phosphorylation and dissociation from the cytoplasmic inhibitor, Kelch-...

journal_title：Antioxidants & redox signaling

authors： Cho HY,Reddy SP,Kleeberger SR

更新日期：2006-01-01 00:00:00

abstract：: Aims: In this study, we investigate the role of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in autoimmune diseases. We focus on oxidative regulation at the interaction between antigen-presenting cells (APCs) and T cells, and consequent effect of ROS a...

journal_title：Antioxidants & redox signaling

authors： Zhong J,Yau ACY,Holmdahl R

更新日期：2020-01-20 00:00:00

abstract：SIGNIFICANCE:A mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow--hypoxic vasodilation--occur in an attempt to restore oxygen supply. Nitric oxide (NO) is a major signaling...

journal_title：Antioxidants & redox signaling

authors： Umbrello M,Dyson A,Feelisch M,Singer M

更新日期：2013-11-10 00:00:00

abstract：:Cyclotides are plant proteins with exceptional stability owing to the presence of a cyclic backbone and three disulfide bonds arranged in a cystine knot motif. Accordingly, they have been proposed as templates to stabilize bioactive epitopes in drug-design applications. The two main subfamilies, referred to as the Möb...

journal_title：Antioxidants & redox signaling

authors： Gunasekera S,Daly NL,Clark RJ,Craik DJ

更新日期：2009-05-01 00:00:00

abstract：:Aging of somatic cells can be defined as the gradual loss of the information embedded in the global and local properties of complex macromolecular networks. This loss of information may reflect the dynamic interplay between stochastic factors, such as the accumulation of unrepaired somatic damage, and gene-encoded pro...

journal_title：Antioxidants & redox signaling

authors： Suh Y,Vijg J

更新日期：2006-03-01 00:00:00

abstract：:Hypoxia induces the stress protein heme oxygenase-1 (HO-1), which participates in cellular adaptation. The molecular pathways that regulate ho-1 gene expression under hypoxia may involve mitogen activated protein kinase (MAPK) signaling and reactive oxygen. Hypoxia (8 h) increased HO-1 mRNA in rat pulmonary aortic end...

journal_title：Antioxidants & redox signaling

authors： Ryter SW,Xi S,Hartsfield CL,Choi AM

更新日期：2002-08-01 00:00:00

abstract：AIMS:Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases involved in oxidant defense and signal transduction. Despite much study, the precise roles of conserved residues remain poorly defined. In this study, we carried out extensive functional and structural characterization of 10 variants of such residues ...

journal_title：Antioxidants & redox signaling

authors： Nelson KJ,Perkins A,Van Swearingen AED,Hartman S,Brereton AE,Parsonage D,Salsbury FR Jr,Karplus PA,Poole LB

更新日期：2018-03-01 00:00:00

abstract：:Protein and amine halogenation is a type of oxidative stress induced by phagocytic overstimulation, and its role in Parkinson's disease (PD) has not been discerned. We have detected that advanced oxidized protein products, markers of protein halogenation, are reliably enhanced in serum of patients with PD (n=60) relat...

journal_title：Antioxidants & redox signaling

authors： García-Moreno JM,Martín de Pablos A,García-Sánchez MI,Méndez-Lucena C,Damas-Hermoso F,Rus M,Chacón J,Fernández E

更新日期：2013-04-10 00:00:00

abstract：:The role of free radicals in aging has been a long-standing theory that has now been extended to include both reactive oxygen and nitrogen species. The original concepts that overwhelming oxidative stress depleted antioxidants and thus damaged intracellular targets is being supplanted by the hypothesis that the reacti...

journal_title：Antioxidants & redox signaling

authors： Darley-Usmar V,Starke-Reed PE

更新日期：2000-10-01 00:00:00